Antibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- FAB4227A-025 - Provider product page
- Provider
- R&D Systems
- Product name
- Human/Mouse CXCR7/RDC-1 APC-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human CXCR7/RDC-1 in flow cytometry of five distinct human CXCR7 transfectants, but not their respective parental lines.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Red dye
- Antigen sequence
P25106
- Isotype
- IgG
- Antibody clone number
- 11G8
- Vial size
- 25 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12.
Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis.
Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12.
Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis.
CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia.
Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo.
CXCR7 protein is not expressed on human or mouse leukocytes.
Del Molino Del Barrio I, Wilkins GC, Meeson A, Ali S, Kirby JA
International journal of molecular sciences 2018 Nov 14;19(11)
International journal of molecular sciences 2018 Nov 14;19(11)
Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis.
Armas-González E, Domínguez-Luis MJ, Díaz-Martín A, Arce-Franco M, Castro-Hernández J, Danelon G, Hernández-Hernández V, Bustabad-Reyes S, Cantabrana A, Uguccioni M, Díaz-González F
Arthritis research & therapy 2018 Jun 7;20(1):114
Arthritis research & therapy 2018 Jun 7;20(1):114
Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12.
Benredjem B, Girard M, Rhainds D, St-Onge G, Heveker N
The Journal of biological chemistry 2017 Jan 6;292(1):31-42
The Journal of biological chemistry 2017 Jan 6;292(1):31-42
Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis.
Yu PF, Huang Y, Xu CL, Lin LY, Han YY, Sun WH, Hu GH, Rabson AB, Wang Y, Shi YF
Oncogene 2017 Feb 9;36(6):840-849
Oncogene 2017 Feb 9;36(6):840-849
CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia.
Arieta Kuksin C, Gonzalez-Perez G, Minter LM
Blood 2015 Mar 26;125(13):2087-94
Blood 2015 Mar 26;125(13):2087-94
Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo.
Maussang D, Mujić-Delić A, Descamps FJ, Stortelers C, Vanlandschoot P, Stigter-van Walsum M, Vischer HF, van Roy M, Vosjan M, Gonzalez-Pajuelo M, van Dongen GA, Merchiers P, van Rompaey P, Smit MJ
The Journal of biological chemistry 2013 Oct 11;288(41):29562-72
The Journal of biological chemistry 2013 Oct 11;288(41):29562-72
CXCR7 protein is not expressed on human or mouse leukocytes.
Berahovich RD, Zabel BA, Penfold ME, Lewén S, Wang Y, Miao Z, Gan L, Pereda J, Dias J, Slukvin II, McGrath KE, Jaen JC, Schall TJ
Journal of immunology (Baltimore, Md. : 1950) 2010 Nov 1;185(9):5130-9
Journal of immunology (Baltimore, Md. : 1950) 2010 Nov 1;185(9):5130-9
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of CXCR7/RDC-1 in MCF-7 Human Cell Line by Flow Cytometry. MCF-7 human breast cancer cell line was stained with Mouse Anti-Human/Mouse CXCR7/RDC-1 APC-conjugated Mono-clonal Antibody (Catalog # FAB4227A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.