Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 331112 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#331112, RRID:AB_1227617
- Product name
- Biotin anti-human/mouse CXCR7
- Antibody type
- Monoclonal
- Antigen
- Human CXCR7 transfectant
- Description
- CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor for the entry of HIV-1. Binding of ligand to CXCR7 induces proliferation and migration of immature neurons, glia and their precursors. CXCR7 expression occurs on a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells. Surface expression of CXCR7 was also reported to be on tumor cells, activated endothelial cells, fetal liver cells, and few other cell types.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Biotin
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- CXCR7 transfected L1.2 cells were stained with biotinylated CXCR7 (clone 8F11-M16) (filled histogram) or biotinylated mouse IgG2b isotype control (open histogram), followed by Sav-PE.
- Conjugate
- Biotin