GTX62029

antibody from GeneTex

Targeting: SMC1A DXS423E, KIAA0178, SB1.8, SMC1L1, Smcb

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

GTX62029

Provider

GeneTex

Proper citation

GeneTex Cat#GTX62029, RRID:AB_10621685

Product name

SMC1 (phospho Ser957) antibody [EP2857Y]

Antibody type

Monoclonal

Antigen

A phospho specific peptide corresponding to residues surrounding serine 957 of human SMC1 was used as an immunogen.

Host

Rabbit

Isotype

IgG

Vial size

100µl

Storage

Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

References

Submitted references

Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage.

Quek H, Luff J, Cheung K, Kozlov S, Gatei M, Lee CS, Bellingham MC, Noakes PG, Lim YC, Barnett NL, Dingwall S, Wolvetang E, Mashimo T, Roberts TL, Lavin MF
Journal of leukocyte biology 2017 Apr;101(4):927-947

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RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.

Gatei M, Kijas AW, Biard D, Dörk T, Lavin MF
Human molecular genetics 2014 Aug 15;23(16):4232-48

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Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.

Puccini J, Shalini S, Voss AK, Gatei M, Wilson CH, Hiwase DK, Lavin MF, Dorstyn L, Kumar S
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 3;110(49):19920-5