M02148
antibody from Boster Biological Technology
Targeting: SMC1A
DXS423E, KIAA0178, SB1.8, SMC1L1, Smcb
Antibody data
- Antibody Data
- Antigen structure
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- Validations [0]
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- Product number
- M02148 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-SMC1 SMC1A Rabbit Monoclonal Antibody
- Antibody type
- Monoclonal
- Description
- Monoclonal antibody for SMC1/SMC1A detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IF, IHC, ICC, WB. Reactive species: Human, Mouse, Rat SMC1/SMC1A information: Molecular Weight: 143233 MW; Subcellular Localization: Nucleus . Chromosome . Chromosome, centromere, kinetochore . Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere- kinetochore complex at the kinetochore region during mitosis.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Antibody clone number
- GHE-19
- Vial size
- 100ug/vial
- Concentration
- 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
- Storage
- At -20°C for one year. Avoid repeated freezing and thawing.
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