M02148

antibody from Boster Biological Technology
Targeting: SMC1A DXS423E, KIAA0178, SB1.8, SMC1L1, Smcb
Provider product page for M02148
Western blot
Immunocytochemistry

Antibody data

Product number
M02148 - Provider product page
Provider
Boster Biological Technology
Product name
Anti-SMC1 SMC1A Rabbit Monoclonal Antibody
Antibody type
Monoclonal
Description
Monoclonal antibody for SMC1/SMC1A detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IF, IHC, ICC, WB. Reactive species: Human, Mouse, Rat SMC1/SMC1A information: Molecular Weight: 143233 MW; Subcellular Localization: Nucleus . Chromosome . Chromosome, centromere, kinetochore . Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere- kinetochore complex at the kinetochore region during mitosis.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Antibody clone number
GHE-19
Vial size
100ug/vial
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage
At -20°C for one year. Avoid repeated freezing and thawing.
SMC1A protein structure - M02148 shown in red.