Explore
Validate
Learn
Western blot
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- NB100-205 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-205, RRID:AB_10002829
- Product name
- Rabbit Polyclonal SMC1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100 ul
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C. Do not freeze.
Submitted references Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators.
Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines.
Synergistic cytotoxicity of the DNA alkylating agent busulfan, nucleoside analogs and suberoylanilide hydroxamic acid in lymphoma cell lines.
Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53.
The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodeling.
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Role of ATM in the telomere response to the G-quadruplex ligand 360A.
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.
Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells.
Analysis of the ataxia telangiectasia mutated-mediated DNA damage response in murine cerebellar neurons.
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.
ATM-dependent CHK2 activation induced by anticancer agent, irofulven.
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.
Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.
Valdez BC, Li Y, Murray D, Ji J, Liu Y, Popat U, Champlin RE, Andersson BS
Experimental hematology 2015 Jun;43(6):448-61.e2
Experimental hematology 2015 Jun;43(6):448-61.e2
Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines.
Valdez BC, Nieto Y, Murray D, Li Y, Wang G, Champlin RE, Andersson BS
Experimental hematology 2012 Oct;40(10):800-10
Experimental hematology 2012 Oct;40(10):800-10
Synergistic cytotoxicity of the DNA alkylating agent busulfan, nucleoside analogs and suberoylanilide hydroxamic acid in lymphoma cell lines.
Valdez BC, Murray D, Nieto Y, Li Y, Wang G, Champlin RE, Andersson BS
Leukemia & lymphoma 2012 May;53(5):973-81
Leukemia & lymphoma 2012 May;53(5):973-81
Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53.
Williamson CT, Kubota E, Hamill JD, Klimowicz A, Ye R, Muzik H, Dean M, Tu L, Gilley D, Magliocco AM, McKay BC, Bebb DG, Lees-Miller SP
EMBO molecular medicine 2012 Jun;4(6):515-27
EMBO molecular medicine 2012 Jun;4(6):515-27
The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodeling.
Valdez BC, Li Y, Murray D, Champlin RE, Andersson BS
Biochemical pharmacology 2011 Jan 15;81(2):222-32
Biochemical pharmacology 2011 Jan 15;81(2):222-32
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
Williamson CT, Muzik H, Turhan AG, Zamò A, O'Connor MJ, Bebb DG, Lees-Miller SP
Molecular cancer therapeutics 2010 Feb;9(2):347-57
Molecular cancer therapeutics 2010 Feb;9(2):347-57
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Li T, Chanda D, Zhang Y, Choi HS, Chiang JY
Journal of lipid research 2010 Apr;51(4):832-42
Journal of lipid research 2010 Apr;51(4):832-42
Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y
Molecular and cellular biology 2010 Apr;30(7):1620-33
Molecular and cellular biology 2010 Apr;30(7):1620-33
Role of ATM in the telomere response to the G-quadruplex ligand 360A.
Pennarun G, Granotier C, Hoffschir F, Mandine E, Biard D, Gauthier LR, Boussin FD
Nucleic acids research 2008 Mar;36(5):1741-54
Nucleic acids research 2008 Mar;36(5):1741-54
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.
Pereg Y, Lam S, Teunisse A, Biton S, Meulmeester E, Mittelman L, Buscemi G, Okamoto K, Taya Y, Shiloh Y, Jochemsen AG
Molecular and cellular biology 2006 Sep;26(18):6819-31
Molecular and cellular biology 2006 Sep;26(18):6819-31
Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells.
Biton S, Dar I, Mittelman L, Pereg Y, Barzilai A, Shiloh Y
The Journal of biological chemistry 2006 Jun 23;281(25):17482-91
The Journal of biological chemistry 2006 Jun 23;281(25):17482-91
Analysis of the ataxia telangiectasia mutated-mediated DNA damage response in murine cerebellar neurons.
Dar I, Biton S, Shiloh Y, Barzilai A
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Jul 19;26(29):7767-74
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Jul 19;26(29):7767-74
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.
Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J
The Journal of cell biology 2006 Apr 24;173(2):195-206
The Journal of cell biology 2006 Apr 24;173(2):195-206
ATM-dependent CHK2 activation induced by anticancer agent, irofulven.
Wang J, Wiltshire T, Wang Y, Mikell C, Burks J, Cunningham C, Van Laar ES, Waters SJ, Reed E, Wang W
The Journal of biological chemistry 2004 Sep 17;279(38):39584-92
The Journal of biological chemistry 2004 Sep 17;279(38):39584-92
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.
Goodarzi AA, Jonnalagadda JC, Douglas P, Young D, Ye R, Moorhead GB, Lees-Miller SP, Khanna KK
The EMBO journal 2004 Nov 10;23(22):4451-61
The EMBO journal 2004 Nov 10;23(22):4451-61
Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.
Kurz EU, Douglas P, Lees-Miller SP
The Journal of biological chemistry 2004 Dec 17;279(51):53272-81
The Journal of biological chemistry 2004 Dec 17;279(51):53272-81
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: SMC1 [p Ser957] Antibody [NB100-205] - Whole cell extracts from HeLa cells (30 ug/lane) that were irradiated with 10 Gy of ionizing radiation or mock irradiated. Irradiated lysate was then treated with calf intestinal phosphatase (CIP) or left untreated. Antibody used at 0.1 ug/ml.
