Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS1922 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS1922, RRID:AB_1662234
- Product name
- DNA pol Ï« (K111) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 81-130 of Human DNA pol Ï«.
- Description
- DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol Ï«, ÉÇ, Ñ´ and ÷ are involved in DNA replication and repair. DNA pol Ñ´ and DNA pol ÷ are multisubunit enzymes, with DNA pol Ñ´ consisting of two subunits: p125, which interacts with the sliding DNA clamp protein PCNA; and p50. The nuclear-encoded DNA pol ÎÛ is the only DNA polymerase required for the replication of the mitochondrial DNA. DNA pol ø is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis. DNA pol IJ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of DNA pol ¦Á (K111) pAb at 1:500 dilutionLane1:MCF-7 cell lysateLane2:NIH-3T3 cell lysateLane3:H9C2 cell lysate