GAB3

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Description

GRB2 associated binding protein 3

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Nucleoplasm, Nuclear speckles, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

X (154675249 - 154751583)

Ensembl ID

ENSG00000160219  (ver. 103.38)

Orthologs

Mouse Gab3: ENSMUSG00000032750

UniProt

Q8WWW8

neXtProt

NX_Q8WWW8

Human splice variants
Mouse splice variants

Protein structure