Antibody data
- Antibody Data
- Antigen structure
- References [36]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 13690-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13690-1-AP, RRID:AB_2149326
- Product name
- NEDD4L antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NEDD4L antibody (Cat. #13690-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Candesartan upregulates angiotensin-converting enzyme 2 in kidneys of male animals by decreased ubiquitination.
The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
Maternal fiber-rich diet promotes early-life intestinal development in offspring through milk-derived extracellular vesicles carrying miR-146a-5p.
DOPAMINE D4 RECEPTOR DOWN-REGULATES RENAL SODIUM CHLORIDE COTRANSPORTER VIA UBIQUITINATION-ASSOCIATED LYSOSOME DEGRADATION.
ITFG2, an immune-modulatory protein, targets ATP 5b to maintain mitochondrial function in myocardial infarction.
E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the β-catenin/HIF-1α positive feedback loop in chronic rhinosinusitis with nasal polyps.
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis.
Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.
Genetic analysis of periventricular nodular heterotopia 7 caused by a novel NEDD4L missense mutation: Case and literature summary.
A novel variant in the FBP1 gene causes fructose-1,6-bisphosphatase deficiency through increased ubiquitination.
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms' tumor 1 expression in cultured human podocytes.
ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2.
Renal CD81 interacts with sodium potassium 2 chloride cotransporter and sodium chloride cotransporter in rats with lipopolysaccharide-induced preeclampsia.
Paeoniflorin Regulates NEDD4L/STAT3 Pathway to Induce Ferroptosis in Human Glioma Cells.
Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures.
Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy.
Targeted Degradation of 53BP1 Using Ubiquitin Variant Induced Proximity.
LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2.
TH5487, a small molecule inhibitor of OGG1, attenuates pulmonary fibrosis by NEDD4L-mediated OGG1 degradation.
PTENα is responsible for protection of brain against oxidative stress during aging.
Piezo2 channel in nodose ganglia neurons is essential in controlling hypertension in a pathway regulated directly by Nedd4-2.
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Exosomes Derived From Macrophages Enhance Aerobic Glycolysis and Chemoresistance in Lung Cancer by Stabilizing c-Myc via the Inhibition of NEDD4L.
JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin αvβ3 signaling.
The correlation between NEDD4L and HIF-1α levels as a gastric cancer prognostic marker.
USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.
Ehrlichia chaffeensis TRP120 Moonlights as a HECT E3 Ligase Involved in Self- and Host Ubiquitination To Influence Protein Interactions and Stability for Intracellular Survival.
20-Hydroxyeicosatetraenoic acid regulates the expression of Nedd4‑2 in kidney and liver through a neddylation modification pathway.
Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.
Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway.
YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation.
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.
Wang P, Ren Z, Wang W, Liu M, Jia Y, Zhang M, Xue Y, Zhang C, Xu J, Wang C, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 31;38(6):e23537
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 31;38(6):e23537
The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
Wang Y, Li X, Guan X, Song Z, Liu H, Guan Z, Wang J, Zhu L, Zhang D, Zhao L, Xie P, Wei X, Shang N, Liu Y, Jin Z, Ji Z, Dai G
International journal of molecular sciences 2024 Feb 27;25(5)
International journal of molecular sciences 2024 Feb 27;25(5)
Maternal fiber-rich diet promotes early-life intestinal development in offspring through milk-derived extracellular vesicles carrying miR-146a-5p.
Lu D, Liu Y, Kang L, Zhang X, Hu J, Ye H, Huang B, Wu Y, Zhao J, Dai Z, Wang J, Han D
Journal of nanobiotechnology 2024 Feb 16;22(1):65
Journal of nanobiotechnology 2024 Feb 16;22(1):65
DOPAMINE D4 RECEPTOR DOWN-REGULATES RENAL SODIUM CHLORIDE COTRANSPORTER VIA UBIQUITINATION-ASSOCIATED LYSOSOME DEGRADATION.
Zhang M, Liu M, Ren Z, Wang W, Upadhyay K, Asico LA, Armando I, Jia Y, Wang P, Xue Y, Wang X
bioRxiv : the preprint server for biology 2024 Feb 16;
bioRxiv : the preprint server for biology 2024 Feb 16;
ITFG2, an immune-modulatory protein, targets ATP 5b to maintain mitochondrial function in myocardial infarction.
Bi FF, Cao M, Pan QM, Jing ZH, Lv LF, Liu F, Tian H, Yu T, Li TY, Li XL, Liang HH, Shan HL, Zhou YH
Biochemical pharmacology 2024 Aug;226:116338
Biochemical pharmacology 2024 Aug;226:116338
E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the β-catenin/HIF-1α positive feedback loop in chronic rhinosinusitis with nasal polyps.
Chen SY, Liu PQ, Qin DX, Lv H, Zhou HQ, Xu Y
Acta pharmacologica Sinica 2024 Apr;45(4):831-843
Acta pharmacologica Sinica 2024 Apr;45(4):831-843
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
Yuan J, Lv T, Yang J, Wu Z, Yan L, Yang J, Shi Y, Jiang L
Cellular and molecular gastroenterology and hepatology 2023;15(2):307-325
Cellular and molecular gastroenterology and hepatology 2023;15(2):307-325
A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis.
Guo Q, Xin M, Lu Q, Feng D, Yang V, Peng LF, Whelan KA, Hu W, Wu S, Yang X, Wang H, Rothberg BS, Gamero AM, Gerhard GS, Gao B, Yang L
Theranostics 2023;13(7):2210-2225
Theranostics 2023;13(7):2210-2225
Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.
Guo Y, Cui Y, Li Y, Jin X, Wang D, Lei M, Chen F, Liu Y, Xu J, Yao G, Zeng G, Chen X
Cancer communications (London, England) 2023 May;43(5):582-612
Cancer communications (London, England) 2023 May;43(5):582-612
Genetic analysis of periventricular nodular heterotopia 7 caused by a novel NEDD4L missense mutation: Case and literature summary.
Liu J, Hu J, Duan Y, Qin R, Guo C, Zhou H, Liu H, Liu C
Molecular genetics & genomic medicine 2023 Jul;11(7):e2169
Molecular genetics & genomic medicine 2023 Jul;11(7):e2169
A novel variant in the FBP1 gene causes fructose-1,6-bisphosphatase deficiency through increased ubiquitination.
Liang X, Liu X, Li W, Zhang L, Zhang B, Lai G, Zhao Y
Archives of biochemistry and biophysics 2023 Jul 1;742:109619
Archives of biochemistry and biophysics 2023 Jul 1;742:109619
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms' tumor 1 expression in cultured human podocytes.
Tabei A, Sakairi T, Hamatani H, Ohishi Y, Watanabe M, Nakasatomi M, Ikeuchi H, Kaneko Y, Kopp JB, Hiromura K
American journal of physiology. Renal physiology 2023 Jul 1;325(1):F121-F133
American journal of physiology. Renal physiology 2023 Jul 1;325(1):F121-F133
ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2.
Cao HJ, Jiang H, Ding K, Qiu XS, Ma N, Zhang FK, Wang YK, Zheng QW, Xia J, Ni QZ, Xu S, Zhu B, Ding XF, Chen TW, Qiu L, Chen W, Li ZG, Zhou B, Feng WM, Xie D, Li JJ
Cell death and differentiation 2023 Feb;30(2):383-396
Cell death and differentiation 2023 Feb;30(2):383-396
Renal CD81 interacts with sodium potassium 2 chloride cotransporter and sodium chloride cotransporter in rats with lipopolysaccharide-induced preeclampsia.
Wang P, Zhu G, Wu Q, Shen L, Liu D, Wang Z, Wang W, Ren Z, Jia Y, Liu M, Xue Y, Ji D, Hu Y, Yu Y, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22834
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22834
Paeoniflorin Regulates NEDD4L/STAT3 Pathway to Induce Ferroptosis in Human Glioma Cells.
Nie XH, Qiu S, Xing Y, Xu J, Lu B, Zhao SF, Li YT, Su ZZ
Journal of oncology 2022;2022:6093216
Journal of oncology 2022;2022:6093216
Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures.
Liu X, Zhang L, Zhang H, Liang X, Zhang B, Tu J, Zhao Y
Frontiers in molecular neuroscience 2022;15:919718
Frontiers in molecular neuroscience 2022;15:919718
Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy.
Zhang H, Fu T, Sun J, Zou S, Qiu S, Zhang J, Su S, Shi C, Li DP, Xu Y
Frontiers in pharmacology 2022;13:942769
Frontiers in pharmacology 2022;13:942769
Targeted Degradation of 53BP1 Using Ubiquitin Variant Induced Proximity.
Aminu B, Fux J, Mallette E, Petersen N, Zhang W
Biomolecules 2022 Mar 22;12(4)
Biomolecules 2022 Mar 22;12(4)
LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2.
Wang J, He Z, Liu X, Xu J, Jiang X, Quan G, Jiang J
Cell death & disease 2022 Aug 18;13(8):718
Cell death & disease 2022 Aug 18;13(8):718
TH5487, a small molecule inhibitor of OGG1, attenuates pulmonary fibrosis by NEDD4L-mediated OGG1 degradation.
Ling H, Song C, Fang Y, Yin Y, Wu Z, Wang Y, Xu Z, Gao S, Li A, Liu G
Chemico-biological interactions 2022 Aug 1;362:109999
Chemico-biological interactions 2022 Aug 1;362:109999
PTENα is responsible for protection of brain against oxidative stress during aging.
Wang P, Li R, Yuan Y, Zhu M, Liu Y, Jin Y, Yin Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Oct;35(10):e21943
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Oct;35(10):e21943
Piezo2 channel in nodose ganglia neurons is essential in controlling hypertension in a pathway regulated directly by Nedd4-2.
Huo L, Gao Y, Zhang D, Wang S, Han Y, Men H, Yang Z, Qin X, Wang R, Kong D, Bai H, Zhang H, Zhang W, Jia Z
Pharmacological research 2021 Feb;164:105391
Pharmacological research 2021 Feb;164:105391
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Dai C, Wu B, Chen Y, Li X, Bai Y, Du Y, Pang Y, Wang YT, Dong Z
Cell death and differentiation 2021 Aug;28(8):2367-2384
Cell death and differentiation 2021 Aug;28(8):2367-2384
Exosomes Derived From Macrophages Enhance Aerobic Glycolysis and Chemoresistance in Lung Cancer by Stabilizing c-Myc via the Inhibition of NEDD4L.
Wang H, Wang L, Pan H, Wang Y, Shi M, Yu H, Wang C, Pan X, Chen Z
Frontiers in cell and developmental biology 2020;8:620603
Frontiers in cell and developmental biology 2020;8:620603
JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin αvβ3 signaling.
Cui J, Shu C, Xu J, Chen D, Li J, Ding K, Chen M, Li A, He J, Shu Y, Yang L, Zhang R, Zhou J
Theranostics 2020;10(18):8036-8050
Theranostics 2020;10(18):8036-8050
The correlation between NEDD4L and HIF-1α levels as a gastric cancer prognostic marker.
Jiang X, Zhang S, Yin Z, Sheng Y, Yan Q, Sun R, Lu M, Zhang Z, Li Y
International journal of medical sciences 2019;16(11):1517-1524
International journal of medical sciences 2019;16(11):1517-1524
USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.
Chen S, Yun F, Yao Y, Cao M, Zhang Y, Wang J, Song X, Qian Y
The Journal of experimental medicine 2018 Nov 5;215(11):2850-2867
The Journal of experimental medicine 2018 Nov 5;215(11):2850-2867
Ehrlichia chaffeensis TRP120 Moonlights as a HECT E3 Ligase Involved in Self- and Host Ubiquitination To Influence Protein Interactions and Stability for Intracellular Survival.
Zhu B, Das S, Mitra S, Farris TR, McBride JW
Infection and immunity 2017 Sep;85(9)
Infection and immunity 2017 Sep;85(9)
20-Hydroxyeicosatetraenoic acid regulates the expression of Nedd4‑2 in kidney and liver through a neddylation modification pathway.
Zhao J, Zhang B, Lai G, Xu R, Chu G, Zhao Y
Molecular medicine reports 2017 Dec;16(6):9671-9677
Molecular medicine reports 2017 Dec;16(6):9671-9677
Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Broix L, Jagline H, Ivanova E, Schmucker S, Drouot N, Clayton-Smith J, Pagnamenta AT, Metcalfe KA, Isidor B, Louvier UW, Poduri A, Taylor JC, Tilly P, Poirier K, Saillour Y, Lebrun N, Stemmelen T, Rudolf G, Muraca G, Saintpierre B, Elmorjani A, Deciphering Developmental Disorders study, Moïse M, Weirauch NB, Guerrini R, Boland A, Olaso R, Masson C, Tripathy R, Keays D, Beldjord C, Nguyen L, Godin J, Kini U, Nischké P, Deleuze JF, Bahi-Buisson N, Sumara I, Hinckelmann MV, Chelly J
Nature genetics 2016 Nov;48(11):1349-1358
Nature genetics 2016 Nov;48(11):1349-1358
Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.
Li Z, Li J, Bi P, Lu Y, Burcham G, Elzey BD, Ratliff T, Konieczny SF, Ahmad N, Kuang S, Liu X
Molecular and cellular biology 2014 Oct 1;34(19):3642-61
Molecular and cellular biology 2014 Oct 1;34(19):3642-61
Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Kito Y, Bai J, Goto N, Okubo H, Adachi Y, Nagayama T, Takeuchi T
International journal of experimental pathology 2014 Feb;95(1):24-8
International journal of experimental pathology 2014 Feb;95(1):24-8
Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway.
Jung S, Li C, Jeong D, Lee S, Ohk J, Park M, Han S, Duan J, Kim C, Yang Y, Kim KI, Lim JS, Kang YS, Lee MS
International journal of oncology 2013 Nov;43(5):1587-95
International journal of oncology 2013 Nov;43(5):1587-95
YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation.
Skouloudaki K, Walz G
PloS one 2012;7(4):e35735
PloS one 2012;7(4):e35735
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
Gao C, Pang L, Ren C, Ma T
Medical oncology (Northwood, London, England) 2012 Sep;29(3):1733-8
Medical oncology (Northwood, London, England) 2012 Sep;29(3):1733-8
Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.
Takeuchi T, Adachi Y, Nagayama T, Furihata M
International journal of experimental pathology 2011 Apr;92(2):79-86
International journal of experimental pathology 2011 Apr;92(2):79-86
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 13690-1-AP(NEDD4L antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 13690-1-AP(NEDD4L antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NEDD4L antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NEDD4L. This antibody recognizes human,mouse,rat antigen. The NEDD4L antibody has been validated for the following applications: ELISA, WB, IHC analysis.