NEDD4L

gene product
KIAA0439, NEDD4-2, RSP5
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
69 antibodies
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4 antibodies
NovoPro Bioscience Inc.
1 antibody
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Biorbyt
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2 antibodies
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OriGene
3 antibodies
Invitrogen Antibodies
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2 antibodies
Aviva Systems Biology
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GeneTex
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1 antibody
Creative Diagnostics
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RayBiotech, Inc.
1 antibody
MyBioSource
3 antibodies
RabMAbs
2 antibodies
Sigma-Aldrich
2 antibodies
United States Biological
13 antibodies
EMD Millipore
1 antibody
ProSci
1 antibody