Antibody data
- Antibody Data
- Antigen structure
- References [71]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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Validation data
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- Product number
- 66198-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- INS antibody
- Antibody type
- Monoclonal
- Description
- INS antibody (Cat. #66198-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 4B6A7
- Vial size
- 20ul, 150ul
Submitted references The vagus nerve activated by inflammation co-transmits acute visceral pain via the NTS-PVN pathway.
A sulfated manno-glucuronan ameliorates β-cell dysfunction in type 2 diabetes by targeting ALDH1A3.
PRDX6 derived from umbilical cord mesenchymal stem cells improves severe acute pancreatitis by regulating macrophage polarization via inhibiting the ROS/P65/IRF7 axis.
PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to β cell function and metabolic disease.
Phosphoglycerate kinase 1 as a potential biomarker and therapeutic target for diabetic sarcopenia.
CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human.
Role of small intronic RNAs in the crosstalk between immune cells and β-cells during type 1 diabetes development.
Dapansutrile preserves pancreatic beta-cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis.
Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus.
Subaqueous acoustic pressure system based one day heterotypic pseudo-islet spheroid formation with adipose derived stem cells for graft survival-related function enhancement.
Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation.
Ramulus Mori (Sangzhi) alkaloids enhance pancreatic β-Cell maturation and function by targeting the CD81/endoplasmic reticulum stress pathway.
Cdk5 Contributes to Diabetic Islet β Cell and Kidney Injury by Impairing Autophagy.
SPARC-modified mesenchymal stem cells promote recovery of β-cells and insulin secretion by calcium ion homeostasis.
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease.
The Kv2.2 channel mediates the inhibition of prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells.
Protocol for renal subcapsular islet transplantation in diabetic mice to induce long-term immune tolerance.
Huanglian-Renshen-Decoction Maintains Islet β-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine.
A novel subcutaneous islet transplantation method using a bioabsorbable medical device to facilitate the creation of a highly vascularized transplantation site.
NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats.
Tailoring cell therapies for diabetic metabolic phenotypes: a comparative study on the efficacy of various umbilical cord-derived cell regimens.
RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation.
Sex-Specific Differences in the Revascularization of Grafted Pancreatic Islets.
Effect of tumor microenvironment in pancreatic cancer on the loss of β-cell mass: implications for type 3c diabetes.
RAGE deficiency obstructs high uric acid-induced oxidative stress and inflammatory response.
Effect and underlying mechanism of Huangjing Qianshi decoction in pre-diabetes mouse model.
Identification of claudin-2 as a promising biomarker for early diagnosis of pre-diabetes.
Expression profiles of cadherin 17 and claudin 18.2 in comparison with peptide hormonal expression in pancreatic neuroendocrine tumours: Implications for targeted immunotherapy.
Eldecalcitol ameliorates diabetic osteoporosis and glucolipid metabolic disorder by promoting Treg cell differentiation through SOCE.
Implications of endoplasmic reticulum stress and beta-cell loss in immunodeficient diabetic NRG-Akita mice for understanding monogenic diabetes.
Cancer-Associated Endocrine Cells Participate in Pancreatic Carcinogenesis.
Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2.
Conditioned Media from Deer Antler Stem Cells Effectively Alleviate Type 1 Diabetes Mellitus Possibly via Inhibiting the NF-κB Signaling Pathway.
Elucidation of the anti-β-cell dedifferentiation mechanism of a modified Da Chaihu Decoction by an integrative approach of network pharmacology and experimental verification.
LncRNA Malat1 regulates iPSC-derived β-cell differentiation by targeting the miR-15b-5p/Ihh axis.
OSGEP regulates islet β-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice.
Buddleoside-rich Chrysanthemum indicum L. extract modulates macrophage-mediated inflammation to prevent metabolic syndrome induced by unhealthy diet.
Mesenchymal stromal cells ameliorate mitochondrial dysfunction in α cells and hyperglucagonemia in type 2 diabetes via SIRT1/FoxO3a signaling.
Berberine enhances the function of db/db mice islet β cell through GLP-1/GLP-1R/PKA signaling pathway in intestinal L cell and islet α cell.
PAQR9 regulates glucose homeostasis in diabetic mice and modulates insulin secretion in β cells in vitro under stress conditions.
Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2(+)/CaMK2 signaling pathway.
Thyroid hormone treatment counteracts cellular phenotypical remodeling in diabetic organs.
BCAS2 Participates in Insulin Synthesis and Secretion via mRNA Alternative Splicing in Mice.
Vascular endothelial growth factor B improves impaired glucose tolerance through insulin-mediated inhibition of glucagon secretion.
Effects of gradient high-field static magnetic fields on diabetic mice.
Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy.
Selenium Nanodots (SENDs) as Antioxidants and Antioxidant-Prodrugs to Rescue Islet β Cells in Type 2 Diabetes Mellitus by Restoring Mitophagy and Alleviating Endoplasmic Reticulum Stress.
Fufang-zhenzhu-tiaozhi formula protects islet against injury and promotes β cell regeneration in diabetic mice.
Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis.
Metabolic effects of CCL5 deficiency in lean and obese mice.
Short-Clustered Maltodextrin Activates Ileal Glucose-Sensing and Induces Glucagon-like Peptide 1 Secretion to Ameliorate Glucose Homeostasis in Type 2 Diabetic Mice.
Troxerutin attenuates insulin resistance via pancreatic IL-22/JAK1/STAT3 signaling activation in dihydrotestosterone-induced polycystic ovary syndrome rats.
cGAS-STING mediates cytoplasmic mitochondrial-DNA-induced inflammatory signal transduction during accelerated senescence of pancreatic β-cells induced by metabolic stress.
Type IIB PKA is highly expressed in β cells and controls cell proliferation via regulating Cyclin D1 expression.
Dendrobium officinale leaf polysaccharides ameliorated hyperglycemia and promoted gut bacterial associated SCFAs to alleviate type 2 diabetes in adult mice.
Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes.
NAG-1/GDF15 protects against streptozotocin-induced type 1 diabetes by inhibiting apoptosis, preserving beta-cell function, and suppressing inflammation in pancreatic islets.
SDF-1 inhibits the dedifferentiation of islet β cells in hyperglycaemia by up-regulating FoxO1 via binding to CXCR4.
Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns.
Mesenchymal stem cell-conditioned medium alleviates high fat-induced hyperglucagonemia via miR-181a-5p and its target PTEN/AKT signaling.
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.
Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.
Lipoxin A4 promotes adipogenic differentiation and browning of mouse embryonic fibroblasts.
Stomach secretes estrogen in response to the blood triglyceride levels.
Green light exposure aggravates high-fat diet feeding-induced hepatic steatosis and pancreatic dysfunction in male mice.
Novel Short-Clustered Maltodextrin as a Dietary Starch Substitute Attenuates Metabolic Dysregulation and Restructures Gut Microbiota in db/db Mice.
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Mitomycin C treatment improves pancreatic islet graft longevity in intraportal islet transplantation by suppressing proinflammatory response.
Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure.
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Zhao YT, Zheng ZK, Yang XH, Duan YJ, Xie X, Chen L, Xu YZ, Zheng Y, Liu YQ, Zhao YY, Tang XQ, Shi JM, Xie JD, Qin C, Xin WJ, Wu Y, Deng J, Xu T
Brain, behavior, and immunity 2026 Mar 31;136:106551
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A sulfated manno-glucuronan ameliorates β-cell dysfunction in type 2 diabetes by targeting ALDH1A3.
Zhang W, Zhang F, Zou X, Wu N, He S, Lu L, Xu C, Xu W, Jin W, Zhou J
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PRDX6 derived from umbilical cord mesenchymal stem cells improves severe acute pancreatitis by regulating macrophage polarization via inhibiting the ROS/P65/IRF7 axis.
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Free radical biology & medicine 2026 Jan;242:573-588
PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to β cell function and metabolic disease.
Fan J, Zhang X, Zhang J, Zhao T, Burley SK, Zheng XFS
Cell reports 2026 Jan 27;45(1):116811
Cell reports 2026 Jan 27;45(1):116811
Phosphoglycerate kinase 1 as a potential biomarker and therapeutic target for diabetic sarcopenia.
Li F, Wang Q, Li R, Gao Y, Wang Y, Chen Q
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CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human.
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Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus.
Li F, Li R, Deng H
Frontiers in pharmacology 2025;16:1521416
Frontiers in pharmacology 2025;16:1521416
Subaqueous acoustic pressure system based one day heterotypic pseudo-islet spheroid formation with adipose derived stem cells for graft survival-related function enhancement.
Hyun J, Park J, Song J, Yoo C, Jang S, Lee SY, An J, Park HS, Jung S, Kong D, Cho JH, Lee TI, Park KD, Im GB, Jeong JH, Park HJ, Lee DY, Bhang SH
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The Journal of physiology 2025 Sep 10;
The Journal of physiology 2025 Sep 10;
Ramulus Mori (Sangzhi) alkaloids enhance pancreatic β-Cell maturation and function by targeting the CD81/endoplasmic reticulum stress pathway.
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The Kv2.2 channel mediates the inhibition of prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells.
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eLife 2025 Mar 3;13
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Protocol for renal subcapsular islet transplantation in diabetic mice to induce long-term immune tolerance.
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STAR protocols 2025 Jun 20;6(2):103729
STAR protocols 2025 Jun 20;6(2):103729
Huanglian-Renshen-Decoction Maintains Islet β-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine.
Wu WB, Gao F, Tang YH, Wang HZ, Dong H, Lu FE, Yuan F
Chinese journal of integrative medicine 2025 Jan;31(1):39-48
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A novel subcutaneous islet transplantation method using a bioabsorbable medical device to facilitate the creation of a highly vascularized transplantation site.
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NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats.
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Ecotoxicology and environmental safety 2025 Jan 1;289:117504
Tailoring cell therapies for diabetic metabolic phenotypes: a comparative study on the efficacy of various umbilical cord-derived cell regimens.
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RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation.
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Molecular metabolism 2025 Aug;98:102175
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Sex-Specific Differences in the Revascularization of Grafted Pancreatic Islets.
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Journal of gastroenterology 2025 Apr;60(4):512-525
RAGE deficiency obstructs high uric acid-induced oxidative stress and inflammatory response.
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International immunopharmacology 2025 Apr 4;151:114316
Effect and underlying mechanism of Huangjing Qianshi decoction in pre-diabetes mouse model.
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Identification of claudin-2 as a promising biomarker for early diagnosis of pre-diabetes.
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Frontiers in pharmacology 2024;15:1370708
Expression profiles of cadherin 17 and claudin 18.2 in comparison with peptide hormonal expression in pancreatic neuroendocrine tumours: Implications for targeted immunotherapy.
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Eldecalcitol ameliorates diabetic osteoporosis and glucolipid metabolic disorder by promoting Treg cell differentiation through SOCE.
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Conditioned Media from Deer Antler Stem Cells Effectively Alleviate Type 1 Diabetes Mellitus Possibly via Inhibiting the NF-κB Signaling Pathway.
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Frontiers in bioscience (Landmark edition) 2024 Mar 11;29(3):96
Frontiers in bioscience (Landmark edition) 2024 Mar 11;29(3):96
Elucidation of the anti-β-cell dedifferentiation mechanism of a modified Da Chaihu Decoction by an integrative approach of network pharmacology and experimental verification.
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Journal of ethnopharmacology 2024 Mar 1;321:117481
LncRNA Malat1 regulates iPSC-derived β-cell differentiation by targeting the miR-15b-5p/Ihh axis.
Wang Y, Ding H, Guo C, Bao Q, Li D, Xiong Y
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Cellular signalling 2024 Jan;113:110975
OSGEP regulates islet β-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice.
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Nature communications 2024 Dec 2;15(1):10479
Nature communications 2024 Dec 2;15(1):10479
Buddleoside-rich Chrysanthemum indicum L. extract modulates macrophage-mediated inflammation to prevent metabolic syndrome induced by unhealthy diet.
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BMC complementary medicine and therapies 2024 Aug 23;24(1):315
BMC complementary medicine and therapies 2024 Aug 23;24(1):315
Mesenchymal stromal cells ameliorate mitochondrial dysfunction in α cells and hyperglucagonemia in type 2 diabetes via SIRT1/FoxO3a signaling.
Song J, Wang L, Wang L, Guo X, He Q, Cui C, Hu H, Zang N, Yang M, Yan F, Liang K, Wang C, Liu F, Sun Y, Sun Z, Lai H, Hou X, Chen L
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Stem cells translational medicine 2024 Aug 16;13(8):776-790
Berberine enhances the function of db/db mice islet β cell through GLP-1/GLP-1R/PKA signaling pathway in intestinal L cell and islet α cell.
Wu W, Xia Q, Guo Y, Wang H, Dong H, Lu F, Yuan F
Frontiers in pharmacology 2023;14:1228722
Frontiers in pharmacology 2023;14:1228722
PAQR9 regulates glucose homeostasis in diabetic mice and modulates insulin secretion in β cells in vitro under stress conditions.
Li Z, Lin Y, Zhuo S, Chen J, Chen L, Wang S, Chen Y
Molecular and cellular endocrinology 2023 Sep 15;575:112032
Molecular and cellular endocrinology 2023 Sep 15;575:112032
Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2(+)/CaMK2 signaling pathway.
Li Y, Li R, Luo X, Xu F, Yang M, Zheng L, Wu Q, Jiang W, Li Y
Molecular medicine reports 2023 Oct;28(4)
Molecular medicine reports 2023 Oct;28(4)
Thyroid hormone treatment counteracts cellular phenotypical remodeling in diabetic organs.
Lavecchia AM, Mantzouratou P, Cerullo D, Locatelli M, Conti S, Tironi M, Sangalli F, Corna D, Zoja C, Remuzzi G, Xinaris C
iScience 2023 Oct 20;26(10):107826
iScience 2023 Oct 20;26(10):107826
BCAS2 Participates in Insulin Synthesis and Secretion via mRNA Alternative Splicing in Mice.
Chen X, Xie X, Li J, Sun L, Lv Z, Yao X, Li L, Jin H, Cui S, Liu J
Endocrinology 2023 Nov 20;165(1)
Endocrinology 2023 Nov 20;165(1)
Vascular endothelial growth factor B improves impaired glucose tolerance through insulin-mediated inhibition of glucagon secretion.
Li YQ, Zhang LY, Zhao YC, Xu F, Hu ZY, Wu QH, Li WH, Li YN
World journal of diabetes 2023 Nov 15;14(11):1643-1658
World journal of diabetes 2023 Nov 15;14(11):1643-1658
Effects of gradient high-field static magnetic fields on diabetic mice.
Yu B, Song C, Feng CL, Zhang J, Wang Y, Zhu YM, Zhang L, Ji XM, Tian XF, Cheng GF, Chen WL, Zablotskii V, Wang H, Zhang X
Zoological research 2023 Mar 18;44(2):249-258
Zoological research 2023 Mar 18;44(2):249-258
Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy.
Thoduvayil S, Weerakkody JS, Sundaram RVK, Topper M, Bera M, Coleman J, Li X, Mariappan M, Ramakrishnan S
Cell calcium 2023 Jul;113:102766
Cell calcium 2023 Jul;113:102766
Selenium Nanodots (SENDs) as Antioxidants and Antioxidant-Prodrugs to Rescue Islet β Cells in Type 2 Diabetes Mellitus by Restoring Mitophagy and Alleviating Endoplasmic Reticulum Stress.
Huang Q, Liu Z, Yang Y, Yang Y, Huang T, Hong Y, Zhang J, Chen Q, Zhao T, Xiao Z, Gong X, Jiang Y, Peng J, Nan Y, Ai K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(19):e2300880
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(19):e2300880
Fufang-zhenzhu-tiaozhi formula protects islet against injury and promotes β cell regeneration in diabetic mice.
Chen X, Yin J, Zhong Q, Wang K, Zhang X, Liang M, Lin Q, Wang H, Wang W, Wang L, Hu X, Bei W, Guo J
Journal of ethnopharmacology 2023 Jan 30;301:115791
Journal of ethnopharmacology 2023 Jan 30;301:115791
Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis.
Tang Q, Shi W, Liu M, Tang L, Ren W, Shi S
Clinical science (London, England : 1979) 2023 Aug 14;137(15):1195-1208
Clinical science (London, England : 1979) 2023 Aug 14;137(15):1195-1208
Metabolic effects of CCL5 deficiency in lean and obese mice.
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Frontiers in immunology 2022;13:1059687
Frontiers in immunology 2022;13:1059687
Short-Clustered Maltodextrin Activates Ileal Glucose-Sensing and Induces Glucagon-like Peptide 1 Secretion to Ameliorate Glucose Homeostasis in Type 2 Diabetic Mice.
Kong H, Yu L, Li C, Ban X, Gu Z, Li Z
Journal of agricultural and food chemistry 2022 Oct 5;70(39):12604-12619
Journal of agricultural and food chemistry 2022 Oct 5;70(39):12604-12619
Troxerutin attenuates insulin resistance via pancreatic IL-22/JAK1/STAT3 signaling activation in dihydrotestosterone-induced polycystic ovary syndrome rats.
Gao Z, Wang G, Ma X, Tan H, Zhang C, Yin X, Suo F, Yao R, Yan X
American journal of physiology. Endocrinology and metabolism 2022 Nov 1;323(5):E405-E417
American journal of physiology. Endocrinology and metabolism 2022 Nov 1;323(5):E405-E417
cGAS-STING mediates cytoplasmic mitochondrial-DNA-induced inflammatory signal transduction during accelerated senescence of pancreatic β-cells induced by metabolic stress.
Hu H, Zhao R, He Q, Cui C, Song J, Guo X, Zang N, Yang M, Zou Y, Yang J, Li J, Wang L, Xia L, Wang L, He F, Hou X, Yan F, Chen L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22266
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22266
Type IIB PKA is highly expressed in β cells and controls cell proliferation via regulating Cyclin D1 expression.
Jiang Y, Zhu L, Wu D, Ni Y, Huang C, Ye H, Yang Y, Liu R, Li Y
The FEBS journal 2022 May;289(10):2865-2876
The FEBS journal 2022 May;289(10):2865-2876
Dendrobium officinale leaf polysaccharides ameliorated hyperglycemia and promoted gut bacterial associated SCFAs to alleviate type 2 diabetes in adult mice.
Fang J, Lin Y, Xie H, Farag MA, Feng S, Li J, Shao P
Food chemistry: X 2022 Mar 30;13:100207
Food chemistry: X 2022 Mar 30;13:100207
Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes.
Piñeros AR, Kulkarni A, Gao H, Orr KS, Glenn L, Huang F, Liu Y, Gannon M, Syed F, Wu W, Anderson CM, Evans-Molina C, McDuffie M, Nadler JL, Morris MA, Mirmira RG, Tersey SA
Cell reports 2022 Jun 28;39(13):111011
Cell reports 2022 Jun 28;39(13):111011
NAG-1/GDF15 protects against streptozotocin-induced type 1 diabetes by inhibiting apoptosis, preserving beta-cell function, and suppressing inflammation in pancreatic islets.
Wang Y, Chen J, Sang T, Chen C, Peng H, Lin X, Zhao Q, Chen S, Eling T, Wang X
Molecular and cellular endocrinology 2022 Jun 1;549:111643
Molecular and cellular endocrinology 2022 Jun 1;549:111643
SDF-1 inhibits the dedifferentiation of islet β cells in hyperglycaemia by up-regulating FoxO1 via binding to CXCR4.
Chen XY, Shi YX, Huang YP, Ding M, Shen QL, Li CJ, Lin JN
Journal of cellular and molecular medicine 2022 Feb;26(3):750-763
Journal of cellular and molecular medicine 2022 Feb;26(3):750-763
Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns.
Liu X, Li D, Liu Z, Song Y, Zhang B, Zang Y, Zhang W, Niu Y, Shen C
Burns : journal of the International Society for Burn Injuries 2022 Dec;48(8):1922-1932
Burns : journal of the International Society for Burn Injuries 2022 Dec;48(8):1922-1932
Mesenchymal stem cell-conditioned medium alleviates high fat-induced hyperglucagonemia via miR-181a-5p and its target PTEN/AKT signaling.
Song J, He Q, Guo X, Wang L, Wang J, Cui C, Hu H, Yang M, Cui Y, Zang N, Yan F, Liu F, Sun Y, Liang K, Qin J, Zhao R, Wang C, Sun Z, Hou X, Li W, Chen L
Molecular and cellular endocrinology 2021 Nov 1;537:111445
Molecular and cellular endocrinology 2021 Nov 1;537:111445
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Guo X, Cui C, Song J, He Q, Zang N, Hu H, Wang X, Li D, Wang C, Hou X, Li X, Liang K, Yan F, Chen L
Molecular and cellular endocrinology 2021 Nov 1;537:111425
Molecular and cellular endocrinology 2021 Nov 1;537:111425
Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.
Zhang X, Wang X, Yuan Z, Radford SJ, Liu C, Libutti SK, Zheng XFS
Cell reports 2021 Mar 16;34(11):108830
Cell reports 2021 Mar 16;34(11):108830
Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.
Fujimoto BA, Young M, Nakamura N, Ha H, Carter L, Pitts MW, Torres D, Noh HL, Suk S, Kim JK, Polgar N
The Journal of biological chemistry 2021 Jan-Jun;296:100482
The Journal of biological chemistry 2021 Jan-Jun;296:100482
Lipoxin A4 promotes adipogenic differentiation and browning of mouse embryonic fibroblasts.
Wang Q, Jin F, Zhang J, Li Z, Yu D
In vitro cellular & developmental biology. Animal 2021 Dec;57(10):953-961
In vitro cellular & developmental biology. Animal 2021 Dec;57(10):953-961
Stomach secretes estrogen in response to the blood triglyceride levels.
Ito T, Yamamoto Y, Yamagishi N, Kanai Y
Communications biology 2021 Dec 7;4(1):1364
Communications biology 2021 Dec 7;4(1):1364
Green light exposure aggravates high-fat diet feeding-induced hepatic steatosis and pancreatic dysfunction in male mice.
Zhang S, Xu M, Shen Z, Shang C, Zhang W, Chen S, Liu C
Ecotoxicology and environmental safety 2021 Dec 1;225:112802
Ecotoxicology and environmental safety 2021 Dec 1;225:112802
Novel Short-Clustered Maltodextrin as a Dietary Starch Substitute Attenuates Metabolic Dysregulation and Restructures Gut Microbiota in db/db Mice.
Kong H, Yu L, Gu Z, Li C, Ban X, Cheng L, Hong Y, Li Z
Journal of agricultural and food chemistry 2020 Nov 4;68(44):12400-12412
Journal of agricultural and food chemistry 2020 Nov 4;68(44):12400-12412
Involvement of Estrogen Receptor-α in the Activation of Nrf2-Antioxidative Signaling Pathways by Silibinin in Pancreatic β-Cells.
Chu C, Gao X, Li X, Zhang X, Ma R, Jia Y, Li D, Wang D, Xu F
Biomolecules & therapeutics 2020 Mar 1;28(2):163-171
Biomolecules & therapeutics 2020 Mar 1;28(2):163-171
Mitomycin C treatment improves pancreatic islet graft longevity in intraportal islet transplantation by suppressing proinflammatory response.
Yamane K, Anazawa T, Tada S, Fujimoto N, Inoguchi K, Emoto N, Nagai K, Masui T, Okajima H, Takaori K, Sumi S, Uemoto S
Scientific reports 2020 Jul 21;10(1):12086
Scientific reports 2020 Jul 21;10(1):12086
Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure.
Zhang J, An H, Ni K, Chen B, Li H, Li Y, Sheng G, Zhou C, Xie M, Chen S, Zhou T, Yang G, Chen X, Wu G, Jin S, Li M
Cell death & disease 2019 Apr 11;10(4):321
Cell death & disease 2019 Apr 11;10(4):321
Chronic oscillating glucose challenges disarrange innate immune homeostasis to potentiate the variation of neutrophil-lymphocyte ratio in rats with or without hidden diabetes mellitus.
Yang G, Yan R, Tong H, Zhang J, Chen B, Xue X, Wang J, Chu M, Jin S, Li M
Diabetes, metabolic syndrome and obesity : targets and therapy 2018;11:277-288
Diabetes, metabolic syndrome and obesity : targets and therapy 2018;11:277-288
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The Insulin antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human Insulin. This antibody recognizes human, mouse antigen. The Insulin antibody has been validated for the following applications: ELISA, IHC analysis.