66198-1-Ig

antibody from Proteintech Group

Targeting: INS IDDM1, IDDM2

Provider product page for 66198-1-Ig

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [38]
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Validations
Immunohistochemistry [1]

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Product number: 66198-1-Ig - Provider product page
Provider: Proteintech Group
Product name: INS antibody
Antibody type: Monoclonal
Description: INS antibody (Cat. #66198-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 4B6A7
Vial size: 20ul, 150ul

INS protein structure - 66198-1-Ig shown in red.

Submitted references Identification of claudin-2 as a promising biomarker for early diagnosis of pre-diabetes.

Songtao Y, Fangyu L, Jie C, Li Y
Frontiers in pharmacology 2024;15:1370708

Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2.

Chen X, Zhou Q, Chen H, Bai J, An R, Zhang K, Zhang X, An H, Zhang J, Wang Y, Li M
Antioxidants (Basel, Switzerland) 2024 Mar 27;13(4)

Conditioned Media from Deer Antler Stem Cells Effectively Alleviate Type 1 Diabetes Mellitus Possibly via Inhibiting the NF-κB Signaling Pathway.

Wang D, Ren J, Li J, Li X, Ying J, Jiang T, Wang Z, Pan Z, Guo Q, Li C, Zhang G
Frontiers in bioscience (Landmark edition) 2024 Mar 11;29(3):96

Elucidation of the anti-β-cell dedifferentiation mechanism of a modified Da Chaihu Decoction by an integrative approach of network pharmacology and experimental verification.

Chen H, Guo J, Cai Y, Zhang C, Wei F, Sun H, Cheng C, Liu W, He Z
Journal of ethnopharmacology 2024 Mar 1;321:117481

LncRNA Malat1 regulates iPSC-derived β-cell differentiation by targeting the miR-15b-5p/Ihh axis.

Wang Y, Ding H, Guo C, Bao Q, Li D, Xiong Y
Cellular signalling 2024 Jan;113:110975

Berberine enhances the function of db/db mice islet β cell through GLP-1/GLP-1R/PKA signaling pathway in intestinal L cell and islet α cell.

Wu W, Xia Q, Guo Y, Wang H, Dong H, Lu F, Yuan F
Frontiers in pharmacology 2023;14:1228722

PAQR9 regulates glucose homeostasis in diabetic mice and modulates insulin secretion in β cells in vitro under stress conditions.

Li Z, Lin Y, Zhuo S, Chen J, Chen L, Wang S, Chen Y
Molecular and cellular endocrinology 2023 Sep 15;575:112032

Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2(+)/CaMK2 signaling pathway.

Li Y, Li R, Luo X, Xu F, Yang M, Zheng L, Wu Q, Jiang W, Li Y
Molecular medicine reports 2023 Oct;28(4)

Thyroid hormone treatment counteracts cellular phenotypical remodeling in diabetic organs.

Lavecchia AM, Mantzouratou P, Cerullo D, Locatelli M, Conti S, Tironi M, Sangalli F, Corna D, Zoja C, Remuzzi G, Xinaris C
iScience 2023 Oct 20;26(10):107826

BCAS2 Participates in Insulin Synthesis and Secretion via mRNA Alternative Splicing in Mice.

Chen X, Xie X, Li J, Sun L, Lv Z, Yao X, Li L, Jin H, Cui S, Liu J
Endocrinology 2023 Nov 20;165(1)

Vascular endothelial growth factor B improves impaired glucose tolerance through insulin-mediated inhibition of glucagon secretion.

Li YQ, Zhang LY, Zhao YC, Xu F, Hu ZY, Wu QH, Li WH, Li YN
World journal of diabetes 2023 Nov 15;14(11):1643-1658

Effects of gradient high-field static magnetic fields on diabetic mice.

Yu B, Song C, Feng CL, Zhang J, Wang Y, Zhu YM, Zhang L, Ji XM, Tian XF, Cheng GF, Chen WL, Zablotskii V, Wang H, Zhang X
Zoological research 2023 Mar 18;44(2):249-258

Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy.

Thoduvayil S, Weerakkody JS, Sundaram RVK, Topper M, Bera M, Coleman J, Li X, Mariappan M, Ramakrishnan S
Cell calcium 2023 Jul;113:102766

Selenium Nanodots (SENDs) as Antioxidants and Antioxidant-Prodrugs to Rescue Islet β Cells in Type 2 Diabetes Mellitus by Restoring Mitophagy and Alleviating Endoplasmic Reticulum Stress.

Huang Q, Liu Z, Yang Y, Yang Y, Huang T, Hong Y, Zhang J, Chen Q, Zhao T, Xiao Z, Gong X, Jiang Y, Peng J, Nan Y, Ai K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(19):e2300880

Fufang-zhenzhu-tiaozhi formula protects islet against injury and promotes β cell regeneration in diabetic mice.

Chen X, Yin J, Zhong Q, Wang K, Zhang X, Liang M, Lin Q, Wang H, Wang W, Wang L, Hu X, Bei W, Guo J
Journal of ethnopharmacology 2023 Jan 30;301:115791

Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis.

Tang Q, Shi W, Liu M, Tang L, Ren W, Shi S
Clinical science (London, England : 1979) 2023 Aug 14;137(15):1195-1208

Metabolic effects of CCL5 deficiency in lean and obese mice.

Zhou H, Liao X, Zeng Q, Zhang H, Song J, Hu W, Sun X, Ding Y, Wang D, Xiao Y, Deng T
Frontiers in immunology 2022;13:1059687

Short-Clustered Maltodextrin Activates Ileal Glucose-Sensing and Induces Glucagon-like Peptide 1 Secretion to Ameliorate Glucose Homeostasis in Type 2 Diabetic Mice.

Kong H, Yu L, Li C, Ban X, Gu Z, Li Z
Journal of agricultural and food chemistry 2022 Oct 5;70(39):12604-12619

Troxerutin attenuates insulin resistance via pancreatic IL-22/JAK1/STAT3 signaling activation in dihydrotestosterone-induced polycystic ovary syndrome rats.

Gao Z, Wang G, Ma X, Tan H, Zhang C, Yin X, Suo F, Yao R, Yan X
American journal of physiology. Endocrinology and metabolism 2022 Nov 1;323(5):E405-E417

cGAS-STING mediates cytoplasmic mitochondrial-DNA-induced inflammatory signal transduction during accelerated senescence of pancreatic β-cells induced by metabolic stress.

Hu H, Zhao R, He Q, Cui C, Song J, Guo X, Zang N, Yang M, Zou Y, Yang J, Li J, Wang L, Xia L, Wang L, He F, Hou X, Yan F, Chen L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22266

Type IIB PKA is highly expressed in β cells and controls cell proliferation via regulating Cyclin D1 expression.

Jiang Y, Zhu L, Wu D, Ni Y, Huang C, Ye H, Yang Y, Liu R, Li Y
The FEBS journal 2022 May;289(10):2865-2876

Dendrobium officinale leaf polysaccharides ameliorated hyperglycemia and promoted gut bacterial associated SCFAs to alleviate type 2 diabetes in adult mice.

Fang J, Lin Y, Xie H, Farag MA, Feng S, Li J, Shao P
Food chemistry: X 2022 Mar 30;13:100207

Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes.

Piñeros AR, Kulkarni A, Gao H, Orr KS, Glenn L, Huang F, Liu Y, Gannon M, Syed F, Wu W, Anderson CM, Evans-Molina C, McDuffie M, Nadler JL, Morris MA, Mirmira RG, Tersey SA
Cell reports 2022 Jun 28;39(13):111011

NAG-1/GDF15 protects against streptozotocin-induced type 1 diabetes by inhibiting apoptosis, preserving beta-cell function, and suppressing inflammation in pancreatic islets.

Wang Y, Chen J, Sang T, Chen C, Peng H, Lin X, Zhao Q, Chen S, Eling T, Wang X
Molecular and cellular endocrinology 2022 Jun 1;549:111643

SDF-1 inhibits the dedifferentiation of islet β cells in hyperglycaemia by up-regulating FoxO1 via binding to CXCR4.

Chen XY, Shi YX, Huang YP, Ding M, Shen QL, Li CJ, Lin JN
Journal of cellular and molecular medicine 2022 Feb;26(3):750-763

Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns.

Liu X, Li D, Liu Z, Song Y, Zhang B, Zang Y, Zhang W, Niu Y, Shen C
Burns : journal of the International Society for Burn Injuries 2022 Dec;48(8):1922-1932

Mesenchymal stem cell-conditioned medium alleviates high fat-induced hyperglucagonemia via miR-181a-5p and its target PTEN/AKT signaling.

Song J, He Q, Guo X, Wang L, Wang J, Cui C, Hu H, Yang M, Cui Y, Zang N, Yan F, Liu F, Sun Y, Liang K, Qin J, Zhao R, Wang C, Sun Z, Hou X, Li W, Chen L
Molecular and cellular endocrinology 2021 Nov 1;537:111445

Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.

Guo X, Cui C, Song J, He Q, Zang N, Hu H, Wang X, Li D, Wang C, Hou X, Li X, Liang K, Yan F, Chen L
Molecular and cellular endocrinology 2021 Nov 1;537:111425

Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.

Zhang X, Wang X, Yuan Z, Radford SJ, Liu C, Libutti SK, Zheng XFS
Cell reports 2021 Mar 16;34(11):108830

Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.

Fujimoto BA, Young M, Nakamura N, Ha H, Carter L, Pitts MW, Torres D, Noh HL, Suk S, Kim JK, Polgar N
The Journal of biological chemistry 2021 Jan-Jun;296:100482

Lipoxin A4 promotes adipogenic differentiation and browning of mouse embryonic fibroblasts.

Wang Q, Jin F, Zhang J, Li Z, Yu D
In vitro cellular & developmental biology. Animal 2021 Dec;57(10):953-961

Stomach secretes estrogen in response to the blood triglyceride levels.

Ito T, Yamamoto Y, Yamagishi N, Kanai Y
Communications biology 2021 Dec 7;4(1):1364

Green light exposure aggravates high-fat diet feeding-induced hepatic steatosis and pancreatic dysfunction in male mice.

Zhang S, Xu M, Shen Z, Shang C, Zhang W, Chen S, Liu C
Ecotoxicology and environmental safety 2021 Dec 1;225:112802

Novel Short-Clustered Maltodextrin as a Dietary Starch Substitute Attenuates Metabolic Dysregulation and Restructures Gut Microbiota in db/db Mice.

Kong H, Yu L, Gu Z, Li C, Ban X, Cheng L, Hong Y, Li Z
Journal of agricultural and food chemistry 2020 Nov 4;68(44):12400-12412

Involvement of Estrogen Receptor-α in the Activation of Nrf2-Antioxidative Signaling Pathways by Silibinin in Pancreatic β-Cells.

Chu C, Gao X, Li X, Zhang X, Ma R, Jia Y, Li D, Wang D, Xu F
Biomolecules & therapeutics 2020 Mar 1;28(2):163-171

Mitomycin C treatment improves pancreatic islet graft longevity in intraportal islet transplantation by suppressing proinflammatory response.

Yamane K, Anazawa T, Tada S, Fujimoto N, Inoguchi K, Emoto N, Nagai K, Masui T, Okajima H, Takaori K, Sumi S, Uemoto S
Scientific reports 2020 Jul 21;10(1):12086

Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure.

Zhang J, An H, Ni K, Chen B, Li H, Li Y, Sheng G, Zhou C, Xie M, Chen S, Zhou T, Yang G, Chen X, Wu G, Jin S, Li M
Cell death & disease 2019 Apr 11;10(4):321

Chronic oscillating glucose challenges disarrange innate immune homeostasis to potentiate the variation of neutrophil-lymphocyte ratio in rats with or without hidden diabetes mellitus.

Yang G, Yan R, Tong H, Zhang J, Chen B, Xue X, Wang J, Chu M, Jin S, Li M
Diabetes, metabolic syndrome and obesity : targets and therapy 2018;11:277-288

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Insulin antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human Insulin. This antibody recognizes human, mouse antigen. The Insulin antibody has been validated for the following applications: ELISA, IHC analysis.
Appendix: 66198-1-Ig.pdf

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