Tissue expression
Cell line expression
Protein structure
INS
InsulinIDDM1, IDDM2
This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020]
Top validated antibodies |
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Proteintech Group | 15848-1-AP | 42 references | Polyclonal |
WB
EL
ICC
IHC |
|
Novus Biologicals | NBP2-34738-0.1 mg | Monoclonal |
WB
EL
ICC
IP
IHC
FC |
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Invitrogen Antibodies | AHB0052 | 78 references | Polyclonal |
WB
EL
IHC
BN
OA
|
|
GeneTex | GTX80204 | 1 references | Monoclonal |
EL
ICC
IHC
RA |
|
Atlas Antibodies | HPA004932 | 2 references | Polyclonal |
WB
IHC |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider