INS

gene product
IDDM1, IDDM2
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
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AntibodyRefsTypeAVIWBELICCIPIHCFC
Novus Biologicals
192 antibodies
Abgent
17 antibodies
NSJ Bioreagents
12 antibodies
Biorbyt
82 antibodies
GeneTex
43 antibodies
NovoPro Bioscience Inc.
17 antibodies
antibodies-online
501 antibodies