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- Antibody Data
- Antigen structure
- References [109]
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- Immunohistochemistry [2]
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- Product number
- 15848-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15848-1-AP, RRID:AB_10597100
- Product name
- INS antibody
- Antibody type
- Polyclonal
- Description
- INS antibody (Cat. #15848-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CD99-targeted immunomagnetic negative selection: A novel strategy for high-purity pancreatic islet isolation in murine models.
Antimicrobial peptide chensinin-1b attenuates T2DM progression in atherosclerotic ApoE(-/-) mice.
Lighting up PNETs: Creating Murine Models with a Novel Bioluminescent Cell Line.
ISG15 Mediates Oxidative Stress Modulation in T2DM Patients by Directly Targeting PIK3R2.
WFS1-related isolated diabetes induced by a WFS1 missense mutation: focus on the isolated diabetes phenotype.
Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles.
Antimony induces oxidative stress to impair enteroendocrine cells and disrupt glucose homeostasis.
Single-cell multi-omic analyses highlight the essential role of NKX2.2-CLEC16A/endosomal pathway for human pancreatic differentiation and function.
Dapansutrile preserves pancreatic beta-cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis.
Klotho protects INS-1 pancreatic β-cells from senescence and enhances mitochondrial function.
Anti-inflammatory mechanism of total flavonoids from Polygala fallax Hemsl. based on network pharmacology, molecular docking, and experimental validation.
Car@PLGA-NPs target gut microbiota-ER stress axis to combat diabetes.
Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling.
Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility.
Oxymatrine attenuates the type 1 diabetes mellitus via negative regulation of the follicular helper T cells.
Quercetin's regulation of glucose and lipid metabolism in gestational diabetes mellitus: role of the PCSK9/LDLR axis.
Injectable self-healing hydrogels loaded with islet-integrated microfiber scaffolds for islet transplantation in diabetes mellitus.
A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes.
Enteroendocrine Cells Sense Sucrose and Alter Enteric Neuron Excitability via Insulin Signaling.
Low-dose bisphenol AF exerts slight effects on glycolipid metabolism but causes metabolic disorders under the stress of Western diet in mice.
The IsletTester Mouse: An Immunodeficient Model With Stable Hyperglycemia for the Study of Human Islets.
12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice.
Hypusinated and unhypusinated isoforms of the translation factor eIF5A exert distinct effects in models of pancreas development and function.
Chayote pectin regulates blood glucose through the gut-liver axis: Gut microbes/SCFAs/FoxO1 signaling pathways.
Changes in the gut microbiota and derived fecal metabolites may play a role in tacrolimus-induced diabetes in mice.
Boosting the engraftment of subcutaneously transplanted pancreatic islets by nanofat.
12-Lipoxygenase Inhibition Improves Glycemia and Obesity-associated Inflammation in Male Human Gene Replacement Mice.
Differential lipid signaling from CD4(+) and CD8(+) T cells contributes to type 1 diabetes development.
Comparative Ability of Various Immunosuppressants as Adjuvants on the Activity of T1D Vaccine.
12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice.
Pancreatic islet cells in microfluidic-spun hydrogel microfibers for the treatment of diabetes.
Cancer-Associated Endocrine Cells Participate in Pancreatic Carcinogenesis.
Role of Peptidyl Arginine Deiminase 4-Dependent Macrophage Extracellular Trap Formation in Type 1 Diabetes Pathogenesis.
Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice.
CK2 activity is crucial for proper glucagon expression.
Effects of three Huanglian-derived polysaccharides on the gut microbiome and fecal metabolome of high-fat diet/streptozocin-induced type 2 diabetes mice.
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats.
SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells.
Hesperidin Protects Against High-Fat Diet-Induced Lipotoxicity in Rats by Inhibiting Pyroptosis.
Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis.
Effects of glucokinase haploinsufficiency on the pancreatic β-cell mass and function of long-term high-fat, high-sucrose diet-fed mice.
RANKL/RANK contributes to the pathological process of type 2 diabetes mellitus through TRAF3 activation of NIK.
12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice.
OSGEP regulates islet β-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice.
Xelaglifam, a novel GPR40/FFAR1 agonist, exhibits enhanced β-arrestin recruitment and sustained glycemic control for type 2 diabetes.
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.
Generation of rat forebrain tissues in mice.
Fagopyrum tataricum ethanol extract ameliorates symptoms of hyperglycemia by regulating gut microbiota in type 2 diabetes mellitus mice.
Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes.
Sulfated fuco-manno-glucuronogalactan alleviates pancreatic beta cell senescence via PI3K/AKT/FoxO1 pathway.
Metabolomics analysis of islet regeneration in partial pancreatectomy mice reveals increased levels of long-chain fatty acids and activated cAMP signaling pathway.
Bacteroides ovatus accelerates metformin-induced vitamin B12 deficiency in type 2 diabetes patients by accumulating cobalamin.
Toceranib phosphate (Palladia) reverses type 1 diabetes by preserving islet function in mice.
Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice.
Combined therapy of GABA and sitagliptin prevents high-fat diet impairment of beta-cell function.
Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo.
Experimental Periodontitis Deteriorates Cognitive Function and Impairs Insulin Signaling in a Streptozotocin-Induced Alzheimer's Disease Rat Model.
Shenlian (SL) Decoction, a Traditional Chinese Medicine Compound, May Ameliorate Blood Glucose via Mediating the Gut Microbiota in db/db Mice.
∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α Axis.
Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion.
The potential mechanism of Liu-Wei-Di-Huang Pills in treatment of type 2 diabetic mellitus: from gut microbiota to short-chain fatty acids metabolism.
Type IIB PKA is highly expressed in β cells and controls cell proliferation via regulating Cyclin D1 expression.
Isolation of mouse pancreatic islet Procr(+) progenitors and long-term expansion of islet organoids in vitro.
Deficiency of M-LP/Mpv17L leads to development of β-cell hyperplasia and improved glucose tolerance via activation of the Wnt and TGF-β pathways.
Stem Cell Therapy Improves Human Islet Graft Survival in Mice via Regulation of Macrophages.
Engineering of hybrid spheroids of mesenchymal stem cells and drug depots for immunomodulating effect in islet xenotransplantation.
Melatonin Promotes the Therapeutic Effect of Mesenchymal Stem Cells on Type 2 Diabetes Mellitus by Regulating TGF-β Pathway.
Neu-P11 - a novel melatonin receptor agonist, could improve the features of type-2 diabetes mellitus in rats.
JunD Regulates Pancreatic β-Cells Function by Altering Lipid Accumulation.
Meteorin-Like Ameliorates β Cell Function by Inhibiting β Cell Apoptosis of and Promoting β Cell Proliferation via Activating the WNT/β-Catenin Pathway.
SNAPIN Regulates Cell Cycle Progression to Promote Pancreatic β Cell Growth.
Glucokinase is required for high-starch diet-induced β-cell mass expansion in mice.
HGF can reduce accumulation of inflammation and regulate glucose homeostasis in T2D mice.
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Morphological and biochemical changes in the pancreas associated with acute systemic hypoxia.
12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes.
Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.
Advanced glycation end products activated endothelial-to-mesenchymal transition in pancreatic islet endothelial cells and triggered islet fibrosis in diabetic mice.
Glucokinase Inactivation Paradoxically Ameliorates Glucose Intolerance by Increasing β-Cell Mass in db/db Mice.
Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus.
Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus.
The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation.
Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress.
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes.
Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr(+) Progenitors.
Localized Controlled Release of Bilirubin from β-Cyclodextrin-Conjugated ε-Polylysine To Attenuate Oxidative Stress and Inflammation in Transplanted Islets.
FABP4 inhibitor attenuates inflammation and endoplasmic reticulum stress of islet in leptin receptor knockout rats.
Mint3 is dispensable for pancreatic and kidney functions in mice.
Using Recombinant Human Collagen With Basic Fibroblast Growth Factor to Provide a Simulated Extracellular Matrix Microenvironment for the Revascularization and Attachment of Islets to the Transplantation Region.
TLR4 gene in the regulation of periodontitis and its molecular mechanism.
Rotenone protects against β-cell apoptosis and attenuates type 1 diabetes mellitus.
Upregulation of vitamin D-binding protein is associated with changes in insulin production in pancreatic beta-cells exposed to p,p'-DDT and p,p'-DDE.
Salsalate Prevents β-Cell Dedifferentiation in OLETF Rats with Type 2 Diabetes through Notch1 Pathway.
Expression of P2X1 receptors in somatostatin-containing cells in mouse gastrointestinal tract and pancreatic islets of both mouse and human.
AWRK6, a Novel GLP-1 Receptor Agonist, Attenuates Diabetes by Stimulating Insulin Secretion.
The Synergy of Two Factors on Insulin Expression.
Hepatitis B X-interacting protein promotes the formation of the insulin gene-transcribing protein complex Pdx-1/Neurod1 in animal pancreatic β-cells.
Differential protein analysis of serum exosomes post-intravenous immunoglobulin therapy in patients with Kawasaki disease.
Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer's Disease-like Neurotoxicity.
Secretory expression and surface display of a new and biologically active single-chain insulin (SCI-59) analog by lactic acid bacteria.
The effect of cholesteryl ester transfer protein on pancreatic beta cell dysfunction in mice.
Insulin signaling disruption in male mice due to perinatal bisphenol A exposure: Role of insulin signaling in the brain.
Bisphenol A disrupts glucose transport and neurophysiological role of IR/IRS/AKT/GSK3β axis in the brain of male mice.
Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis.
Effects of Bisphenol A on glucose homeostasis and brain insulin signaling pathways in male mice.
CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion.
Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1.
Display of human proinsulin on the Bacillus subtilis spore surface for oral administration.
Tendons from non-diabetic humans and rats harbor a population of insulin-producing, pancreatic beta cell-like cells.
Liu J, Li D, Huang J, Hu Y, Zhang L
PloS one 2026;21(3):e0344446
PloS one 2026;21(3):e0344446
Antimicrobial peptide chensinin-1b attenuates T2DM progression in atherosclerotic ApoE(-/-) mice.
Qiu Z, Fan F, Li Z, Sun Y, Shang D
Diabetic medicine : a journal of the British Diabetic Association 2026 May;43(5):e70232
Diabetic medicine : a journal of the British Diabetic Association 2026 May;43(5):e70232
Lighting up PNETs: Creating Murine Models with a Novel Bioluminescent Cell Line.
Moccia MC, Nation R, Hess T, Topper GV, Kalola A, Wang M, Sofield H, Saleh Z, Zhao X, Li Y, Spitz F, Gao T, Hong YK
Annals of surgical oncology 2026 May;33(5):4376-4387
Annals of surgical oncology 2026 May;33(5):4376-4387
ISG15 Mediates Oxidative Stress Modulation in T2DM Patients by Directly Targeting PIK3R2.
He MQ, Liu J, Guan GP, Liu H, Luo LP, Fu YW, Wan XX, Jin P
BioFactors (Oxford, England) 2026 Mar-Apr;52(2):e70103
BioFactors (Oxford, England) 2026 Mar-Apr;52(2):e70103
WFS1-related isolated diabetes induced by a WFS1 missense mutation: focus on the isolated diabetes phenotype.
Huang M, Wei Q, Qin Y, Qin L, Shao Y, Wang S, Qu X, Yang T, Zhang M
Orphanet journal of rare diseases 2026 Mar 27;21(1)
Orphanet journal of rare diseases 2026 Mar 27;21(1)
Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles.
Enriquez JR, Zhou Z, Nelson JB, Huang F, Figatner KT, Chakraborty A, Pratuangtham S, Xi B, May SC, Tirrell MV, Tersey SA, Fang Y, Mirmira RG
Cell reports. Medicine 2026 Mar 17;7(3):102634
Cell reports. Medicine 2026 Mar 17;7(3):102634
Antimony induces oxidative stress to impair enteroendocrine cells and disrupt glucose homeostasis.
Jin L, Zhu L, Wu C, Jin W, Liu K, Peng J, Xu X, Ge X, Zhu Y, Sheng X, Bai R, Chen G
Journal of hazardous materials 2026 Jan 1;501:140617
Journal of hazardous materials 2026 Jan 1;501:140617
Single-cell multi-omic analyses highlight the essential role of NKX2.2-CLEC16A/endosomal pathway for human pancreatic differentiation and function.
Chen G, Ma X, Jiang L, Zhou Z, Li Q, Deng Q, Li Y, He Y, Wang Y, Wang X, Liao N, Pu J, Wu W, Fu J, Zhu S
Cell reports 2026 Feb 24;45(2):116990
Cell reports 2026 Feb 24;45(2):116990
Dapansutrile preserves pancreatic beta-cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis.
Wu Y, Fu H, Zhu M, Yao Y, Jin L, Lin X, Zhou J
Diabetes, obesity & metabolism 2026 Apr;28(4):3054-3069
Diabetes, obesity & metabolism 2026 Apr;28(4):3054-3069
Klotho protects INS-1 pancreatic β-cells from senescence and enhances mitochondrial function.
Wang Z, Ni Y, Lou YR, Prud'homme GJ, Wang Q
Frontiers in aging 2025;6:1512322
Frontiers in aging 2025;6:1512322
Anti-inflammatory mechanism of total flavonoids from Polygala fallax Hemsl. based on network pharmacology, molecular docking, and experimental validation.
Liao C, Su H, Li F, Wang C, Yang S, Qin Z, Li N
Frontiers in immunology 2025;16:1690388
Frontiers in immunology 2025;16:1690388
Car@PLGA-NPs target gut microbiota-ER stress axis to combat diabetes.
Zhao W, Chen L, Qing J, Zhao Z, Xiong L, Tong P, Huang Z, Chen Y
Frontiers in cellular and infection microbiology 2025;15:1667023
Frontiers in cellular and infection microbiology 2025;15:1667023
Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling.
Kong W, Lu WJ, Dubey M, Suryawanshi RK, Vijayakumar S, Jeong Y, Gombar S, Diehn M, Shin K, Ott M, Chien YH, Sarin KY, Desai TJ, Beachy PA
Cell 2025 Sep 4;188(18):5020-5038.e20
Cell 2025 Sep 4;188(18):5020-5038.e20
Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility.
Webster KL, Puente AA, Enriquez JR, Sarkar S, Nakayasu ES, Webb-Robertson BM, Bramer LM, Figatner K, Pratuangtham S, Wu W, Evans-Molina C, Tse HM, Roy S, Piganelli JD, Hammes SR, Tersey SA, Mirmira RG
bioRxiv : the preprint server for biology 2025 Oct 7;
bioRxiv : the preprint server for biology 2025 Oct 7;
Oxymatrine attenuates the type 1 diabetes mellitus via negative regulation of the follicular helper T cells.
Yue X, Wang S, Cui Z, Zhang Y
European journal of pharmacology 2025 Nov 5;1006:178127
European journal of pharmacology 2025 Nov 5;1006:178127
Quercetin's regulation of glucose and lipid metabolism in gestational diabetes mellitus: role of the PCSK9/LDLR axis.
Hong L, Xia S, Chen N, Wang Z, Li Z
Nutrition & metabolism 2025 Nov 24;22(1):159
Nutrition & metabolism 2025 Nov 24;22(1):159
Injectable self-healing hydrogels loaded with islet-integrated microfiber scaffolds for islet transplantation in diabetes mellitus.
Huan Z, Li J, Cao X, Lu M, Yu Y, Li L
Science bulletin 2025 Nov 15;70(21):3589-3599
Science bulletin 2025 Nov 15;70(21):3589-3599
A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes.
Chen M, Peng Y, Hu Y, Kang Z, Chen T, Zhang Y, Chen X, Li Q, Yuan Z, Wu Y, Xu H, Zhou G, Liu T, Zhou H, Yuan C, Huang W, Zhang W
Acta pharmaceutica Sinica. B 2025 May;15(5):2511-2528
Acta pharmaceutica Sinica. B 2025 May;15(5):2511-2528
Enteroendocrine Cells Sense Sucrose and Alter Enteric Neuron Excitability via Insulin Signaling.
Snyder JR, Ahmed M, Bhave S, Hotta R, Koppes RA, Goldstein AM, Koppes AN
Advanced biology 2025 Mar;9(3):e2300566
Advanced biology 2025 Mar;9(3):e2300566
Low-dose bisphenol AF exerts slight effects on glycolipid metabolism but causes metabolic disorders under the stress of Western diet in mice.
Guo C, Lv L, Chen X, Wang H, Song S, Li Y, Qin Z
Environmental pollution (Barking, Essex : 1987) 2025 Mar 15;369:125861
Environmental pollution (Barking, Essex : 1987) 2025 Mar 15;369:125861
The IsletTester Mouse: An Immunodeficient Model With Stable Hyperglycemia for the Study of Human Islets.
Waite EL, Tigue M, Yu M, Lahori D, Kelly K, May CL, Naji A, Roman J, Doliba N, Avrahami D, Nguyen-Ngoc KV, Sander M, Glaser B, Kaestner KH
Diabetes 2025 Mar 1;74(3):332-342
Diabetes 2025 Mar 1;74(3):332-342
12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice.
Kaylan KB, Nargis T, Figatner K, Wang JE, Pratuangtham S, Chakraborty A, Casimiro I, Nadler JL, Boxer MB, Maloney DJ, Anderson RM, Mirmira RG, Tersey SA
bioRxiv : the preprint server for biology 2025 Jan 13;
bioRxiv : the preprint server for biology 2025 Jan 13;
Hypusinated and unhypusinated isoforms of the translation factor eIF5A exert distinct effects in models of pancreas development and function.
Anderson CM, Kulkarni A, Maier B, Huang F, Figatner K, Chakraborty A, Pratuangtham S, May SC, Tersey SA, Anderson RM, Mirmira RG
The Journal of biological chemistry 2025 Feb;301(2):108209
The Journal of biological chemistry 2025 Feb;301(2):108209
Chayote pectin regulates blood glucose through the gut-liver axis: Gut microbes/SCFAs/FoxO1 signaling pathways.
Guo Q, Wang X, Ke J, Hou X, Shen G, Li S, Chen H, Cui Q, Yu J, Luo Q, Liu H, Chen A, Liu Y, Zhang Z
Food research international (Ottawa, Ont.) 2025 Feb;202:115706
Food research international (Ottawa, Ont.) 2025 Feb;202:115706
Changes in the gut microbiota and derived fecal metabolites may play a role in tacrolimus-induced diabetes in mice.
Qian M, Jiang Z, Xu C, Wang L, Hu N
Future microbiology 2025 Feb;20(3):237-246
Future microbiology 2025 Feb;20(3):237-246
Boosting the engraftment of subcutaneously transplanted pancreatic islets by nanofat.
Wrublewsky S, Bickelmann C, Meßmer LS, Wilden C, Berhorst C, Prates-Roma L, Morgan B, Rother S, Menger MD, Laschke MW, Weinzierl A, Ampofo E
Diabetes, obesity & metabolism 2025 Dec;27(12):7258-7274
Diabetes, obesity & metabolism 2025 Dec;27(12):7258-7274
12-Lipoxygenase Inhibition Improves Glycemia and Obesity-associated Inflammation in Male Human Gene Replacement Mice.
Kaylan KB, Nargis T, Figatner K, Wang JE, Pratuangtham S, Chakraborty A, Casimiro I, Nadler JL, Boxer MB, Maloney DJ, Anderson RM, Mirmira RG, Tersey SA
Endocrinology 2025 Apr 22;166(6)
Endocrinology 2025 Apr 22;166(6)
Differential lipid signaling from CD4(+) and CD8(+) T cells contributes to type 1 diabetes development.
White TD, Almutairi A, Gai-Tusing Y, Stephenson DJ, Stephenson BD, Chalfant CE, Lei X, Lu B, Hammock BD, DiLorenzo TP, Ramanadham S
Frontiers in immunology 2024;15:1444639
Frontiers in immunology 2024;15:1444639
Comparative Ability of Various Immunosuppressants as Adjuvants on the Activity of T1D Vaccine.
Wang X, Xie M, Li T, Shi J, Wu M, Zhang S, Sun J, Hu Y
Vaccines 2024 Sep 29;12(10)
Vaccines 2024 Sep 29;12(10)
12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice.
Nargis T, Muralidharan C, Enriquez JR, Wang JE, Kaylan K, Chakraborty A, Pratuangtham S, Figatner K, Nelson JB, May SC, Nadler JL, Boxer MB, Maloney DJ, Tersey SA, Mirmira RG
bioRxiv : the preprint server for biology 2024 Oct 29;
bioRxiv : the preprint server for biology 2024 Oct 29;
Pancreatic islet cells in microfluidic-spun hydrogel microfibers for the treatment of diabetes.
Huan Z, Li J, Guo J, Yu Y, Li L
Acta biomaterialia 2024 Oct 1;187:149-160
Acta biomaterialia 2024 Oct 1;187:149-160
Cancer-Associated Endocrine Cells Participate in Pancreatic Carcinogenesis.
Chen Y, Yin X, Xu R, Ruze R, Song J, Yin C, Hu C, Wang C, Xu Q, Zhao Y
Gastroenterology 2024 Nov;167(6):1167-1182.e23
Gastroenterology 2024 Nov;167(6):1167-1182.e23
Role of Peptidyl Arginine Deiminase 4-Dependent Macrophage Extracellular Trap Formation in Type 1 Diabetes Pathogenesis.
Shen Y, Shi R, Lu S, Wang Y, Zhou Z, Wu C, You Q, Fan H, Wu J
Diabetes 2024 Nov 1;73(11):1862-1874
Diabetes 2024 Nov 1;73(11):1862-1874
Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice.
Muralidharan C, Huang F, Enriquez JR, Wang JE, Nelson JB, Nargis T, May SC, Chakraborty A, Figatner KT, Navitskaya S, Anderson CM, Calvo V, Surguladze D, Mulvihill MJ, Yi X, Sarkar S, Oakes SA, Webb-Robertson BM, Sims EK, Staschke KA, Eizirik DL, Nakayasu ES, Stokes ME, Tersey SA, Mirmira RG
bioRxiv : the preprint server for biology 2024 Jun 3;
bioRxiv : the preprint server for biology 2024 Jun 3;
CK2 activity is crucial for proper glucagon expression.
Ampofo E, Pack M, Wrublewsky S, Boewe AS, Spigelman AF, Koch H, MacDonald PE, Laschke MW, Montenarh M, Götz C
Diabetologia 2024 Jul;67(7):1368-1385
Diabetologia 2024 Jul;67(7):1368-1385
Effects of three Huanglian-derived polysaccharides on the gut microbiome and fecal metabolome of high-fat diet/streptozocin-induced type 2 diabetes mice.
Wang J, An G, Peng X, Zhong F, Zhao K, Qi L, Ma Y
International journal of biological macromolecules 2024 Jul;273(Pt 1):133060
International journal of biological macromolecules 2024 Jul;273(Pt 1):133060
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats.
Wang R, Feng W, Wang Y, Jiang Y, Lin Y, Chen X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166889
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166889
SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells.
Kalnytska O, Qvist P, Kunz S, Conrad T, Willnow TE, Schmidt V
iScience 2024 Jan 19;27(1):108725
iScience 2024 Jan 19;27(1):108725
Hesperidin Protects Against High-Fat Diet-Induced Lipotoxicity in Rats by Inhibiting Pyroptosis.
Luo R, Hu Y, Wang L, Wang W, Wang P, Ke Z, Lou D, Tian W
Journal of medicinal food 2024 Feb;27(2):154-166
Journal of medicinal food 2024 Feb;27(2):154-166
Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis.
Lu P, Xu J, Shen X, Sun J, Liu M, Niu N, Wang Q, Xue J
Cell reports 2024 Feb 27;43(2):113703
Cell reports 2024 Feb 27;43(2):113703
Effects of glucokinase haploinsufficiency on the pancreatic β-cell mass and function of long-term high-fat, high-sucrose diet-fed mice.
Shigesawa I, Nakamura A, Yamauchi Y, Kawata S, Miyazaki A, Nomoto H, Kameda H, Terauchi Y, Atsumi T
Journal of diabetes investigation 2024 Dec;15(12):1732-1742
Journal of diabetes investigation 2024 Dec;15(12):1732-1742
RANKL/RANK contributes to the pathological process of type 2 diabetes mellitus through TRAF3 activation of NIK.
Yu J, Tian N, Hu Y, Jin T
International immunopharmacology 2024 Dec 5;142(Pt A):113008
International immunopharmacology 2024 Dec 5;142(Pt A):113008
12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice.
Nargis T, Muralidharan C, Enriquez JR, Wang JE, Kaylan KB, Chakraborty A, Pratuangtham S, Figatner K, Nelson JB, May SC, Nadler JL, Boxer MB, Maloney DJ, Tersey SA, Mirmira RG
JCI insight 2024 Dec 20;9(24)
JCI insight 2024 Dec 20;9(24)
OSGEP regulates islet β-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice.
Liu Y, Yang X, Zhou J, Yang H, Yang R, Zhu P, Zhou R, Wu T, Gao Y, Ye Z, Li X, Liu R, Zhang W, Zhou H, Li Q
Nature communications 2024 Dec 2;15(1):10479
Nature communications 2024 Dec 2;15(1):10479
Xelaglifam, a novel GPR40/FFAR1 agonist, exhibits enhanced β-arrestin recruitment and sustained glycemic control for type 2 diabetes.
Yoon J, Lee DG, Song H, Hong D, Park JS, Hong C, An KM, Lee JW, Park JT, Yoon H, Tak J, Kim SG
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117044
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117044
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.
Li J, Zhang S, Sun Y, Li J, Feng Z, Li H, Zhang M, Yan T, Han J, Duan Y
EMBO reports 2024 Apr;25(4):2097-2117
EMBO reports 2024 Apr;25(4):2097-2117
Generation of rat forebrain tissues in mice.
Huang J, He B, Yang X, Long X, Wei Y, Li L, Tang M, Gao Y, Fang Y, Ying W, Wang Z, Li C, Zhou Y, Li S, Shi L, Choi S, Zhou H, Guo F, Yang H, Wu J
Cell 2024 Apr 25;187(9):2129-2142.e17
Cell 2024 Apr 25;187(9):2129-2142.e17
Fagopyrum tataricum ethanol extract ameliorates symptoms of hyperglycemia by regulating gut microbiota in type 2 diabetes mellitus mice.
Ge X, Liu T, Chen Z, Zhang J, Yin X, Huang Z, Chen L, Zhao C, Shao R, Xu W
Food & function 2023 Sep 19;14(18):8487-8503
Food & function 2023 Sep 19;14(18):8487-8503
Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes.
Sims EK, Kulkarni A, Hull A, Woerner SE, Cabrera S, Mastrandrea LD, Hammoud B, Sarkar S, Nakayasu ES, Mastracci TL, Perkins SM, Ouyang F, Webb-Robertson BJ, Enriquez JR, Tersey SA, Evans-Molina C, Long SA, Blanchfield L, Gerner EW, Mirmira RG, DiMeglio LA
Cell reports. Medicine 2023 Nov 21;4(11):101261
Cell reports. Medicine 2023 Nov 21;4(11):101261
Sulfated fuco-manno-glucuronogalactan alleviates pancreatic beta cell senescence via PI3K/AKT/FoxO1 pathway.
Zhang W, Wu N, Wang H, Mao G, Yan X, Zhang F, Linhardt RJ, Jin W, Zhou J
International journal of biological macromolecules 2023 May 1;236:123846
International journal of biological macromolecules 2023 May 1;236:123846
Metabolomics analysis of islet regeneration in partial pancreatectomy mice reveals increased levels of long-chain fatty acids and activated cAMP signaling pathway.
Wu D, Jiang Y, Wang Z, Ni Y, Ma A, Zhou Y, Liu R, Lou YR, Wang Q
Biochemical and biophysical research communications 2023 Jul 30;667:34-42
Biochemical and biophysical research communications 2023 Jul 30;667:34-42
Bacteroides ovatus accelerates metformin-induced vitamin B12 deficiency in type 2 diabetes patients by accumulating cobalamin.
Chen M, Shu Y, Li Q, Kang Z, Liu T, Zhou H, Huang W, Zhang W
NPJ biofilms and microbiomes 2023 Jul 24;9(1):51
NPJ biofilms and microbiomes 2023 Jul 24;9(1):51
Toceranib phosphate (Palladia) reverses type 1 diabetes by preserving islet function in mice.
Kishi K, Yonezawa T, Kaji N, Goto M, Nonoshita Y, Iio A, Tsuru Y, Hori M
The Journal of veterinary medical science 2023 Jul 17;85(7):781-789
The Journal of veterinary medical science 2023 Jul 17;85(7):781-789
Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice.
Yan F, Liu J, Chen MX, Zhang Y, Wei SJ, Jin H, Nie J, Fu XL, Shi JS, Zhou SY, Jin F
Neural regeneration research 2023 Jan;18(1):183-188
Neural regeneration research 2023 Jan;18(1):183-188
Combined therapy of GABA and sitagliptin prevents high-fat diet impairment of beta-cell function.
Wang Z, Fan L, Ni Y, Wu D, Ma A, Zhao Y, Li J, Cui Q, Zhou Y, Zhang L, Lou YR, Prud'homme GJ, Wang Q
Molecular and cellular endocrinology 2023 Jan 1;559:111755
Molecular and cellular endocrinology 2023 Jan 1;559:111755
Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo.
Wu SY, Wu HT, Wang YC, Chang CJ, Shan YS, Wu SR, Chiu YC, Hsu CL, Juan HF, Lan KY, Chu CW, Lee YR, Lan SH, Liu HS
Autophagy 2023 Apr;19(4):1239-1257
Autophagy 2023 Apr;19(4):1239-1257
Experimental Periodontitis Deteriorates Cognitive Function and Impairs Insulin Signaling in a Streptozotocin-Induced Alzheimer's Disease Rat Model.
Duan L, Qian X, Wang Q, Huang L, Ge S
Journal of Alzheimer's disease : JAD 2022;88(1):57-74
Journal of Alzheimer's disease : JAD 2022;88(1):57-74
Shenlian (SL) Decoction, a Traditional Chinese Medicine Compound, May Ameliorate Blood Glucose via Mediating the Gut Microbiota in db/db Mice.
Sun RX, Huang WJ, Xiao Y, Wang DD, Mu GH, Nan H, Ni BR, Huang XQ, Wang HC, Liu YF, Fu Q, Zhao JX
Journal of diabetes research 2022;2022:7802107
Journal of diabetes research 2022;2022:7802107
∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α Axis.
Chen Q, Chen X, Jia Z, Du Y, Zhang S, Xu W, Pan B, Lou J, Zhou J, Zhou J, Sun J
Oxidative medicine and cellular longevity 2022;2022:1231970
Oxidative medicine and cellular longevity 2022;2022:1231970
Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion.
Jiang S, Xu CM, Yao S, Zhang R, Li XZ, Zhang RZ, Xie TY, Xing YQ, Zhang Q, Zhou XJ, Liao L, Dong JJ
Frontiers in endocrinology 2022;13:905703
Frontiers in endocrinology 2022;13:905703
The potential mechanism of Liu-Wei-Di-Huang Pills in treatment of type 2 diabetic mellitus: from gut microbiota to short-chain fatty acids metabolism.
Yi ZY, Chen L, Wang Y, He D, Zhao D, Zhang SH, Yu R, Huang JH
Acta diabetologica 2022 Oct;59(10):1295-1308
Acta diabetologica 2022 Oct;59(10):1295-1308
Type IIB PKA is highly expressed in β cells and controls cell proliferation via regulating Cyclin D1 expression.
Jiang Y, Zhu L, Wu D, Ni Y, Huang C, Ye H, Yang Y, Liu R, Li Y
The FEBS journal 2022 May;289(10):2865-2876
The FEBS journal 2022 May;289(10):2865-2876
Isolation of mouse pancreatic islet Procr(+) progenitors and long-term expansion of islet organoids in vitro.
Wang J, Wang D, Chen X, Yuan S, Bai L, Liu C, Zeng YA
Nature protocols 2022 May;17(5):1359-1384
Nature protocols 2022 May;17(5):1359-1384
Deficiency of M-LP/Mpv17L leads to development of β-cell hyperplasia and improved glucose tolerance via activation of the Wnt and TGF-β pathways.
Iida R, Ueki M, Yasuda T
Biochimica et biophysica acta. Molecular basis of disease 2022 Mar 1;1868(3):166318
Biochimica et biophysica acta. Molecular basis of disease 2022 Mar 1;1868(3):166318
Stem Cell Therapy Improves Human Islet Graft Survival in Mice via Regulation of Macrophages.
Gou W, Hua W, Swaby L, Cui W, Green E, Morgan KA, Strange C, Wang H
Diabetes 2022 Dec 1;71(12):2642-2655
Diabetes 2022 Dec 1;71(12):2642-2655
Engineering of hybrid spheroids of mesenchymal stem cells and drug depots for immunomodulating effect in islet xenotransplantation.
Nguyen TT, Pham DV, Park J, Phung CD, Nepal MR, Pandit M, Shrestha M, Son Y, Joshi M, Jeong TC, Park PH, Choi DY, Chang JH, Kim JH, Kim JR, Kim IK, Yong CS, Kim JO, Sung JH, Jiang HL, Kim HS, Yook S, Jeong JH
Science advances 2022 Aug 26;8(34):eabn8614
Science advances 2022 Aug 26;8(34):eabn8614
Melatonin Promotes the Therapeutic Effect of Mesenchymal Stem Cells on Type 2 Diabetes Mellitus by Regulating TGF-β Pathway.
Li B, Cheng X, Aierken A, Du J, He W, Zhang M, Tan N, Kou Z, Peng S, Jia W, Tang H, Hua J
Frontiers in cell and developmental biology 2021;9:722365
Frontiers in cell and developmental biology 2021;9:722365
Neu-P11 - a novel melatonin receptor agonist, could improve the features of type-2 diabetes mellitus in rats.
Li X, He J, Li X, Li Y, Zhou Y, Cai S
Endokrynologia Polska 2021;72(6):634-642
Endokrynologia Polska 2021;72(6):634-642
JunD Regulates Pancreatic β-Cells Function by Altering Lipid Accumulation.
Wang K, Cui Y, Lin P, Yao Z, Sun Y
Frontiers in endocrinology 2021;12:689845
Frontiers in endocrinology 2021;12:689845
Meteorin-Like Ameliorates β Cell Function by Inhibiting β Cell Apoptosis of and Promoting β Cell Proliferation via Activating the WNT/β-Catenin Pathway.
Hu W, Wang R, Sun B
Frontiers in pharmacology 2021;12:627147
Frontiers in pharmacology 2021;12:627147
SNAPIN Regulates Cell Cycle Progression to Promote Pancreatic β Cell Growth.
Jiang M, Kuang Z, He Y, Cao Y, Yu T, Cheng J, Liu W, Wang W
Frontiers in endocrinology 2021;12:624309
Frontiers in endocrinology 2021;12:624309
Glucokinase is required for high-starch diet-induced β-cell mass expansion in mice.
Tsuchida K, Nakamura A, Miyoshi H, Yang K, Yamauchi Y, Kawata S, Omori K, Takahashi K, Kitao N, Nomoto H, Kameda H, Cho KY, Seino Y, Terauchi Y, Atsumi T
Journal of diabetes investigation 2021 Sep;12(9):1545-1554
Journal of diabetes investigation 2021 Sep;12(9):1545-1554
HGF can reduce accumulation of inflammation and regulate glucose homeostasis in T2D mice.
Yan L, He X, Tang Y, Zhao X, Luo G, Wang X
Journal of physiology and biochemistry 2021 Nov;77(4):613-624
Journal of physiology and biochemistry 2021 Nov;77(4):613-624
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Guo X, Cui C, Song J, He Q, Zang N, Hu H, Wang X, Li D, Wang C, Hou X, Li X, Liang K, Yan F, Chen L
Molecular and cellular endocrinology 2021 Nov 1;537:111425
Molecular and cellular endocrinology 2021 Nov 1;537:111425
Morphological and biochemical changes in the pancreas associated with acute systemic hypoxia.
Morioka F, Tani N, Ikeda T, Hirokawa T, Ikeda K, Shida A, Aoki Y, Ishikawa T
Human cell 2021 Mar;34(2):400-418
Human cell 2021 Mar;34(2):400-418
12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes.
Kulkarni A, Pineros AR, Walsh MA, Casimiro I, Ibrahim S, Hernandez-Perez M, Orr KS, Glenn L, Nadler JL, Morris MA, Tersey SA, Mirmira RG, Anderson RM
JCI insight 2021 Jul 22;6(14)
JCI insight 2021 Jul 22;6(14)
Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.
Bao S, Zheng H, Chen C, Zhang Y, Bao L, Yang B, Hou Y, Chen Y, Zhang Q, Pi J, Fu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Dec;158:112633
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Dec;158:112633
Advanced glycation end products activated endothelial-to-mesenchymal transition in pancreatic islet endothelial cells and triggered islet fibrosis in diabetic mice.
Tsai PS, Chiu CY, Sheu ML, Yang CY, Lan KC, Liu SH
Chemico-biological interactions 2021 Aug 25;345:109562
Chemico-biological interactions 2021 Aug 25;345:109562
Glucokinase Inactivation Paradoxically Ameliorates Glucose Intolerance by Increasing β-Cell Mass in db/db Mice.
Omori K, Nakamura A, Miyoshi H, Yamauchi Y, Kawata S, Takahashi K, Kitao N, Nomoto H, Kameda H, Cho KY, Terauchi Y, Atsumi T
Diabetes 2021 Apr;70(4):917-931
Diabetes 2021 Apr;70(4):917-931
Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus.
Zhang C, Han X, Yang L, Fu J, Sun C, Huang S, Xiao W, Gao Y, Liang Q, Wang X, Luo F, Lu W, Zhou Y
Theranostics 2020;10(24):10908-10924
Theranostics 2020;10(24):10908-10924
Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus.
Lv W, Graves DT, He L, Shi Y, Deng X, Zhao Y, Dong X, Ren Y, Liu X, Xiao E, Zhang Y
Theranostics 2020;10(14):6500-6516
Theranostics 2020;10(14):6500-6516
The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation.
Tada S, Anazawa T, Shindo T, Yamane K, Inoguchi K, Fujimoto N, Nagai K, Masui T, Okajima H, Takaori K, Sumi S, Uemoto S
Transplantation direct 2020 Sep;6(9):e591
Transplantation direct 2020 Sep;6(9):e591
Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress.
Yao X, Li K, Liang C, Zhou Z, Wang J, Wang S, Liu L, Yu CL, Song ZB, Bao YL, Zheng LH, Sun Y, Wang G, Huang Y, Yi J, Sun L, Li Y
The Journal of biological chemistry 2020 Sep 11;295(37):12975-12992
The Journal of biological chemistry 2020 Sep 11;295(37):12975-12992
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes.
Yu M, Agarwal D, Korutla L, May CL, Wang W, Griffith NN, Hering BJ, Kaestner KH, Velazquez OC, Markmann JF, Vallabhajosyula P, Liu C, Naji A
Nature metabolism 2020 Oct;2(10):1013-1020
Nature metabolism 2020 Oct;2(10):1013-1020
Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr(+) Progenitors.
Wang D, Wang J, Bai L, Pan H, Feng H, Clevers H, Zeng YA
Cell 2020 Mar 19;180(6):1198-1211.e19
Cell 2020 Mar 19;180(6):1198-1211.e19
Localized Controlled Release of Bilirubin from β-Cyclodextrin-Conjugated ε-Polylysine To Attenuate Oxidative Stress and Inflammation in Transplanted Islets.
Yao Q, Huang ZW, Zhai YY, Yue M, Luo LZ, Xue PP, Han YH, Xu HL, Kou L, Zhao YZ
ACS applied materials & interfaces 2020 Feb 5;12(5):5462-5475
ACS applied materials & interfaces 2020 Feb 5;12(5):5462-5475
FABP4 inhibitor attenuates inflammation and endoplasmic reticulum stress of islet in leptin receptor knockout rats.
Yao F, Jiang DD, Guo WH, Guo LS, Gao MM, Bai Y, Wang X, Zhang LS
European review for medical and pharmacological sciences 2020 Dec;24(24):12808-12820
European review for medical and pharmacological sciences 2020 Dec;24(24):12808-12820
Mint3 is dispensable for pancreatic and kidney functions in mice.
Chung Y, Saitoh Y, Hayashi T, Fukui Y, Terada N, Seiki M, Murakami Y, Sakamoto T
Biochemistry and biophysics reports 2020 Dec;24:100872
Biochemistry and biophysics reports 2020 Dec;24:100872
Using Recombinant Human Collagen With Basic Fibroblast Growth Factor to Provide a Simulated Extracellular Matrix Microenvironment for the Revascularization and Attachment of Islets to the Transplantation Region.
Zhu Q, Lu C, Jiang X, Yao Q, Jiang X, Huang Z, Jiang Y, Peng L, Fu H, Zhao Y
Frontiers in pharmacology 2019;10:1536
Frontiers in pharmacology 2019;10:1536
TLR4 gene in the regulation of periodontitis and its molecular mechanism.
Qi W, Yang X, Ye N, Li S, Han Q, Huang J, Wu B
Experimental and therapeutic medicine 2019 Sep;18(3):1961-1966
Experimental and therapeutic medicine 2019 Sep;18(3):1961-1966
Rotenone protects against β-cell apoptosis and attenuates type 1 diabetes mellitus.
Wu M, Chen W, Zhang S, Huang S, Zhang A, Zhang Y, Jia Z
Apoptosis : an international journal on programmed cell death 2019 Dec;24(11-12):879-891
Apoptosis : an international journal on programmed cell death 2019 Dec;24(11-12):879-891
Upregulation of vitamin D-binding protein is associated with changes in insulin production in pancreatic beta-cells exposed to p,p'-DDT and p,p'-DDE.
Pavlíková N, Daniel P, Šrámek J, Jelínek M, Šrámková V, Němcová V, Balušíková K, Halada P, Kovář J
Scientific reports 2019 Dec 2;9(1):18026
Scientific reports 2019 Dec 2;9(1):18026
Salsalate Prevents β-Cell Dedifferentiation in OLETF Rats with Type 2 Diabetes through Notch1 Pathway.
Han F, Li X, Yang J, Liu H, Zhang Y, Yang X, Yang S, Chang B, Chen L, Chang B
Aging and disease 2019 Aug;10(4):719-730
Aging and disease 2019 Aug;10(4):719-730
Expression of P2X1 receptors in somatostatin-containing cells in mouse gastrointestinal tract and pancreatic islets of both mouse and human.
Ji R, Zhu J, Wang D, Sui QQ, Knight GE, Burnstock G, Yuan H, Xiang Z
Purinergic signalling 2018 Sep;14(3):285-298
Purinergic signalling 2018 Sep;14(3):285-298
AWRK6, a Novel GLP-1 Receptor Agonist, Attenuates Diabetes by Stimulating Insulin Secretion.
Wang Q, Zhao C, Jin L, Zhang H, Miao Q, Liu H, Zhang D
International journal of molecular sciences 2018 Oct 7;19(10)
International journal of molecular sciences 2018 Oct 7;19(10)
The Synergy of Two Factors on Insulin Expression.
Luo Y, Xu Y, Wang ZY, Li X, Xing WB, Zhang TC
Cellular reprogramming 2018 Feb;20(1):49-54
Cellular reprogramming 2018 Feb;20(1):49-54
Hepatitis B X-interacting protein promotes the formation of the insulin gene-transcribing protein complex Pdx-1/Neurod1 in animal pancreatic β-cells.
Li H, Wang Z, Li Y, Fang R, Wang H, Shi H, Zhang X, Zhang W, Ye L
The Journal of biological chemistry 2018 Feb 9;293(6):2053-2065
The Journal of biological chemistry 2018 Feb 9;293(6):2053-2065
Differential protein analysis of serum exosomes post-intravenous immunoglobulin therapy in patients with Kawasaki disease.
Zhang L, Song QF, Jin JJ, Huang P, Wang ZP, Xie XF, Gu XQ, Gao XJ, Jia HL
Cardiology in the young 2017 Nov;27(9):1786-1796
Cardiology in the young 2017 Nov;27(9):1786-1796
Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer's Disease-like Neurotoxicity.
Wang T, Xie C, Yu P, Fang F, Zhu J, Cheng J, Gu A, Wang J, Xiao H
Scientific reports 2017 Aug 8;7(1):7497
Scientific reports 2017 Aug 8;7(1):7497
Secretory expression and surface display of a new and biologically active single-chain insulin (SCI-59) analog by lactic acid bacteria.
Mao R, Wu D, Hu S, Zhou K, Wang M, Wang Y
Applied microbiology and biotechnology 2017 Apr;101(8):3259-3271
Applied microbiology and biotechnology 2017 Apr;101(8):3259-3271
The effect of cholesteryl ester transfer protein on pancreatic beta cell dysfunction in mice.
Guo W, Gong Y, Fu Z, Fu J, Sun Y, Ju X, Chang Y, Wang W, Zhu X, Gao B, Liu X, Yang T, Zhou H
Nutrition & metabolism 2016;13:21
Nutrition & metabolism 2016;13:21
Insulin signaling disruption in male mice due to perinatal bisphenol A exposure: Role of insulin signaling in the brain.
Fang F, Gao Y, Wang T, Chen D, Liu J, Qian W, Cheng J, Gao R, Wang J, Xiao H
Toxicology letters 2016 Mar 14;245:59-67
Toxicology letters 2016 Mar 14;245:59-67
Bisphenol A disrupts glucose transport and neurophysiological role of IR/IRS/AKT/GSK3β axis in the brain of male mice.
Li J, Wang Y, Fang F, Chen D, Gao Y, Liu J, Gao R, Wang J, Xiao H
Environmental toxicology and pharmacology 2016 Apr;43:7-12
Environmental toxicology and pharmacology 2016 Apr;43:7-12
Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis.
Karki A, Humphrey SE, Steele RE, Hess DA, Taparowsky EJ, Konieczny SF
PloS one 2015;10(12):e0145724
PloS one 2015;10(12):e0145724
Effects of Bisphenol A on glucose homeostasis and brain insulin signaling pathways in male mice.
Fang F, Chen D, Yu P, Qian W, Zhou J, Liu J, Gao R, Wang J, Xiao H
General and comparative endocrinology 2015 Feb 1;212:44-50
General and comparative endocrinology 2015 Feb 1;212:44-50
CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion.
Zheng H, Fu J, Xue P, Zhao R, Dong J, Liu D, Yamamoto M, Tong Q, Teng W, Qu W, Zhang Q, Andersen ME, Pi J
Antioxidants & redox signaling 2015 Apr 1;22(10):819-31
Antioxidants & redox signaling 2015 Apr 1;22(10):819-31
Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1.
Maneva-Radicheva L, Amatya C, Parker C, Ellefson J, Radichev I, Raghavan A, Charles ML, Williams MS, Robbins MS, Savinov AY
PloS one 2014;9(9):e107213
PloS one 2014;9(9):e107213
Display of human proinsulin on the Bacillus subtilis spore surface for oral administration.
Feng F, Hu P, Chen L, Tang Q, Lian C, Yao Q, Chen K
Current microbiology 2013 Jul;67(1):1-8
Current microbiology 2013 Jul;67(1):1-8
Tendons from non-diabetic humans and rats harbor a population of insulin-producing, pancreatic beta cell-like cells.
Lehner C, Gehwolf R, Wagner A, Resch H, Hirzinger C, Augat P, Stephan D, Aigner L, Rivera FJ, Bauer HC, Tempfer H
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2012 Jun;44(7):506-10
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2012 Jun;44(7):506-10
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- BxPC-3 cells were subjected to SDS PAGE followed by western blot with 15848-1-AP(INS antibody) at dilution of 1:10000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas using 15848-1-AP(INS antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Insulin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Insulin. This antibody recognizes human,mouse,rat antigen. The Insulin antibody has been validated for the following applications: ELISA, WB, IHC analysis.
