MINK1

This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Description

misshapen-like kinase 1

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

17:p13.2 (4833388 - 4898061)

Ensembl ID

ENSG00000141503  (ver. 84.38)

Orthologs

Mouse Mink1: ENSMUSG00000020827

UniProt

Q8N4C8

neXtProt

NX_Q8N4C8

Human splice variants
Mouse splice variants