13268-1-AP

antibody from Proteintech Group

Targeting: IDO1 IDO, INDO

Provider product page for 13268-1-AP

Western blot

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [62]
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Product number: 13268-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13268-1-AP, RRID:AB_2123444
Product name: IDO1 antibody
Antibody type: Polyclonal
Description: KD/KO validated IDO1 antibody (Cat. #13268-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IDO1 protein structure - 13268-1-AP shown in red.

Submitted references Dual targeting of wild-type p53 and gut microbiota by Magnolol represses key metabolic process and kills CRC cells.

Ji H, Qiao O, Zhang Y, Wang W, Han X, Zhang X, Liu C, Gao W
Phytotherapy research : PTR 2024 Oct;38(10):4982-4998

YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes.

Huang J, Wang X, Li N, Fan W, Li X, Zhou Q, Liu J, Li W, Zhang Z, Liu X, Zeng S, Yang H, Tian M, Yang P, Hou S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(19):e2308031

Retention of stress susceptibility in the mdx mouse model of Duchenne muscular dystrophy after PGC-1α overexpression or ablation of IDO1 or CD38.

Johnson EE, Southern WM, Doud B, Steiger B, Razzoli M, Bartolomucci A, Ervasti JM
Human molecular genetics 2024 Mar 20;33(7):594-611

Kynurenine in IDO1(high) cancer cell-derived extracellular vesicles promotes angiogenesis by inducing endothelial mitophagy in ovarian cancer.

Ying X, Zheng X, Zhang X, Yin Y, Wang X
Journal of translational medicine 2024 Mar 11;22(1):267

Bushen Antai recipe alleviates embryo absorption by enhancing immune tolerance and angiogenesis at the maternal-fetal interface via mobilizing MDSCs in abortion-prone mice.

Liu Z, Geng Y, Huang Y, Hu R, Li F, Ding J, Ma W, Dong H, Song K, Xu X, Wu X, Song Y, Zhang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155164

Bushen Antai recipe ameliorates immune microenvironment and maternal-fetal vascularization in STAT3-deficient abortion-prone mice.

Liu Z, Song Y, Hu R, Geng Y, Huang Y, Li F, Ma W, Dong H, Song K, Ding J, Xu X, Wu X, Zhang M, Zhong Z
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116889

Indoleamine 2, 3-dioxygenase-transfected bone marrow-derived mesenchymal stem cells promote corneal allograft survival by inhibiting T cell proliferation: A rat study.

Ke H, Zhang W, Xu W, Cao Q, Li L, Liu H
Transplant immunology 2024 Feb;82:101960

MGP(+) and IDO1(+) tumor-associated macrophages facilitate immunoresistance in breast cancer revealed by single-cell RNA sequencing.

Chang K, Jiao Y, Zhang B, Hou L, He X, Wang D, Li D, Li R, Wang Z, Fan P, Zhang J
International immunopharmacology 2024 Apr 20;131:111818

Bisphenol F exposure induces depression-like changes: Roles of the kynurenine metabolic pathway along the "liver-brain" axis.

Yu Z, Lin Y, Wu L, Wang L, Fan Y, Xu L, Zhang L, Wu W, Tao J, Huan F, Liu W, Wang J, Gao R
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123356

IDO1 Promotes the Progression of NSCLC by Regulating the Polarization of M2 Macrophages.

Chen X, Yao J, Zhang MY, Li R, Liu X, Qu YQ
International journal of general medicine 2023;16:1713-1733

Deletion of enzymes for de novo NAD(+) biosynthesis accelerated ovarian aging.

Yang Q, Li H, Wang H, Chen W, Zeng X, Luo X, Xu J, Sun Y
Aging cell 2023 Sep;22(9):e13904

Effect of radiation fractionation on IDO1 via the NF-κB/COX2 axis in non-small cell lung cancer.

Lan Y, Pi W, Zhou Z, Meng Y, DanMei, Xu Y, Xia X, WeiWang, Yang H, Spring Kong FM
International immunopharmacology 2023 Nov;124(Pt B):110956

DSS-induced acute colitis causes dysregulated tryptophan metabolism in brain: an involvement of gut microbiota.

Zhao LP, Wu J, Quan W, Zhou Y, Hong H, Niu GY, Ting-Li, Huang SB, Qiao CM, Zhao WJ, Cui C, Shen YQ
The Journal of nutritional biochemistry 2023 May;115:109282

Apigenin improves cytotoxicity of antiretroviral drugs against HTLV-1 infected cells through the modulation of AhR signaling.

Sales D, Lin E, Stoffel V, Dickson S, Khan ZK, Beld J, Jain P
NeuroImmune pharmacology and therapeutics 2023 Mar 25;2(1):49-62

Novel long non-coding RNAs associated with inflammation and macrophage activation in human.

Chini A, Guha P, Malladi VS, Guo Z, Mandal SS
Scientific reports 2023 Mar 10;13(1):4036

Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure.

Yin J, Zhao Z, Huang J, Xiao Y, Rehmutulla M, Zhang B, Zhang Z, Xiang M, Tong Q, Zhang Y
Cell discovery 2023 Jul 25;9(1):77

Targeting the STAT5A/IDO1 axis overcomes radioresistance and reverses the immunosuppressive tumor microenvironment in NSCLC.

Yang Y, Zheng X, Ni P, Li D, Dan Q, Wang X, Wang Y, Sun Y, Liu K, Dong Z, Ge H
International journal of oncology 2023 Jan;62(1)

Kuqin ameliorates Lipopolysaccharide-induced acute lung injury by regulating indoleamine 2,3-dioxygenase 1 and Akkermansia muciniphila.

Xiong S, Sun H, Lu C, He J, Wu Z, Wang Y, Zheng Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114073

Serum Response Factor-Regulated IDO1/Kyn-Ahr Pathway Promotes Tumorigenesis of Oral Squamous Cell Carcinoma.

Xu M, Zhu F, Yin Q, Yin H, Fang S, Luo G, Huang J, Huang W, Liu F, Zhong M, Deng X
Cancers 2023 Feb 19;15(4)

DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota.

Zhao LP, Wu J, Quan W, Zhou Y, Hong H, Niu GY, Li T, Huang SB, Qiao CM, Zhao WJ, Cui C, Shen YQ
Frontiers in immunology 2022;13:1089200

Cassane diterpenoid ameliorates dextran sulfate sodium-induced experimental colitis by regulating gut microbiota and suppressing tryptophan metabolism.

Liu T, Ning Z, Liu P, Gao H
Frontiers in immunology 2022;13:1045901

Therapeutic efficacy of human adipose mesenchymal stem cells in Crohn's colon fibrosis is improved by IFN-γ and kynurenic acid priming through indoleamine 2,3-dioxygenase-1 signaling.

Ye Y, Zhang X, Su D, Ren Y, Cheng F, Yao Y, Shi G, Ji Y, Chen S, Shi P, Dai L, Su X, Deng H
Stem cell research & therapy 2022 Sep 8;13(1):465

Blockage of the IDO1 pathway by charge-switchable nanoparticles amplifies immunogenic cell death for enhanced cancer immunotherapy.

Shi M, Zhang J, Wang Y, Han Y, Zhao X, Hu H, Qiao M, Chen D
Acta biomaterialia 2022 Sep 15;150:353-366

Inhibitory and Stimulatory Effects of IL-32 on HIV-1 Infection.

Nasser H, Takahashi N, Eltalkhawy YM, Reda O, Lotfi S, Nasu K, Sakuragi JI, Suzu S
Journal of immunology (Baltimore, Md. : 1950) 2022 Sep 1;209(5):970-978

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.

Kim YS, Ko B, Kim DJ, Tak J, Han CY, Cho JY, Kim W, Kim SG
Nature communications 2022 Oct 14;13(1):6080

RSAD2 Is an Effective Target for High-Yield Vaccine Production in MDCK Cells.

Qiao Z, Liao Y, Pei M, Qiu Z, Liu Z, Jin D, Zhang J, Ma Z, Yang X
Viruses 2022 Nov 21;14(11)

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.

Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690

Regulation of the kynurenine/serotonin pathway by berberine and the underlying effect in the hippocampus of the chronic unpredictable mild stress mice.

Wang Q, Sun YN, Zou CM, Zhang TL, Li Z, Liu M, Shi BY, Shi SS, Yu CY, Wei TM
Behavioural brain research 2022 Mar 26;422:113764

Fusobacterium nucleatum promotes the development of acute liver failure by inhibiting the NAD(+) salvage metabolic pathway.

Cao P, Chen Q, Shi C, Wang L, Gong Z
Gut pathogens 2022 Jun 28;14(1):29

Mitigation Effects of Selenium Nanoparticles on Depression-Like Behavior Induced by Fluoride in Mice via the JAK2-STAT3 Pathway.

Yang J, Li H, Hao Z, Jing X, Zhao Y, Cheng X, Ma H, Wang J, Wang J
ACS applied materials & interfaces 2022 Jan 26;14(3):3685-3700

Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway.

Sriwastva MK, Deng ZB, Wang B, Teng Y, Kumar A, Sundaram K, Mu J, Lei C, Dryden GW, Xu F, Zhang L, Yan J, Zhang X, Park JW, Merchant ML, Egilmez NK, Zhang HG
EMBO reports 2022 Feb 3;23(3):e53365

Impact of the combination of sintilimab and chemotherapy on the tumor and paratumor PD-L1, IDO, TIM-3, FOXP3+ and CD8 expressions in patients with advanced esophageal squamous cell carcinoma.

Zhang S, Cai H, Huang J, Wang G
Thoracic cancer 2022 Dec;13(23):3284-3294

Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.

Zhang Y, Li Y, Chen X, Chen X, Chen C, Wang L, Dong X, Wang G, Gu R, Li F, Han F, Chen D
Journal of medicinal chemistry 2022 Aug 25;65(16):11214-11228

The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase.

Mudhish EA, Siddique AB, Ebrahim HY, Abdelwahed KS, King JA, El Sayed KA
Nutrients 2022 Apr 4;14(7)

Predicting Panel of Metabolism and Immune-Related Genes for the Prognosis of Human Ovarian Cancer.

Zhang L, Sun W, Ren W, Zhang J, Xu G
Frontiers in cell and developmental biology 2021;9:690542

Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy.

Deng N, Hu J, Hong Y, Ding Y, Xiong Y, Wu Z, Xie W
Frontiers in cellular neuroscience 2021;15:638854

Elevated mRNA Level of Y-Box Binding Protein 1 Indicates Unfavorable Prognosis Correlated with Macrophage Infiltration and T Cell Exhaustion in Luminal Breast Cancer.

Lv Z, Xue C, Zhang L, Sun J, Bo C
Cancer management and research 2021;13:6411-6428

Cang-Ai Volatile Oil Ameliorates Depressive Behavior Induced by Chronic Stress Through IDO-Mediated Tryptophan Degradation Pathway.

Zhang K, Lei N, Li M, Li J, Li C, Shen Y, Guo P, Xiong L, Xie Y
Frontiers in psychiatry 2021;12:791991

Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas.

Yang P, Wang K, Zhang C, Wang Z, Liu Q, Wang J, Jiang T, Shan X
Cancer immunology, immunotherapy : CII 2021 Sep;70(9):2589-2600

IDO1 as a new immune biomarker for diabetic nephropathy and its correlation with immune cell infiltration.

Yu K, Li D, Xu F, Guo H, Feng F, Ding Y, Wan X, Sun N, Zhang Y, Fan J, Liu L, Yang H, Yang X
International immunopharmacology 2021 May;94:107446

Total glycosides from stems of Cistanche tubulosa alleviate depression-like behaviors: bidirectional interaction of the phytochemicals and gut microbiota.

Fan L, Peng Y, Wang J, Ma P, Zhao L, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153471

Tryptophan potentiates CD8(+) T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation.

Qin R, Zhao C, Wang CJ, Xu W, Zhao JY, Lin Y, Yuan YY, Lin PC, Li Y, Zhao S, Huang Y
Journal for immunotherapy of cancer 2021 Jul;9(7)

GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer.

Wei JL, Wu SY, Yang YS, Xiao Y, Jin X, Xu XE, Hu X, Li DQ, Jiang YZ, Shao ZM
Journal for immunotherapy of cancer 2021 Jul;9(7)

Mifepristone regulates Tregs function mediated by dendritic cells through suppressing the expression of TGF-β.

Li Y, Cao L, Qian Z, Guo Q, Niu X, Huang L
Immunopharmacology and immunotoxicology 2021 Feb;43(1):85-93

Plasmacytoid Dendritic Cells Protect Against Middle Cerebral Artery Occlusion Induced Brain Injury by Priming Regulatory T Cells.

Chen C, Chencheng Z, Cuiying L, Xiaokun G
Frontiers in cellular neuroscience 2020;14:8

Combined Metabolomic Analysis of Plasma and Tissue Reveals a Prognostic Risk Score System and Metabolic Dysregulation in Esophageal Squamous Cell Carcinoma.

Chen Z, Dai Y, Huang X, Chen K, Gao Y, Li N, Wang D, Chen A, Yang Q, Hong Y, Zeng S, Mao W
Frontiers in oncology 2020;10:1545

IDO1 Expression Increased After Neoadjuvant Therapy Predicts Poor Pathologic Response and Prognosis in Esophageal Squamous Cell Carcinoma.

Jiao R, Zheng X, Sun Y, Feng Z, Song S, Ge H
Frontiers in oncology 2020;10:1099

Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells.

Ebokaiwe AP, Njoya EM, Sheng Y, Zhang Z, Li S, Zhou Z, Qiang Z, Peng T, Hussein AA, Zhang G, Lu X, Li L, Wang F
Toxicology and applied pharmacology 2020 Oct 1;404:115203

Nrf2 modulates immunosuppressive ability and cellular senescence of human umbilical cord mesenchymal stem cells.

Jie Z, Huan Y, Mengyun W, Yasha L, Huafeng P, Ke Y
Biochemical and biophysical research communications 2020 Jun 11;526(4):1021-1027

Prunella vulgaris L. attenuates experimental autoimmune thyroiditis by inducing indoleamine 2,3-dioxygenase 1 expression and regulatory T cell expansion.

Qiu H, Zhang J, Guo Q, Zhang Y, Zhong X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110288

1,25(OH)(2)D(3) mitigate cancer-related fatigue in tumor-bearing mice: Integrating network pharmacological analysis.

Zhou YT, Li SS, Ai M, Chen H, Liu YX, Li BY, Zhao Y, Cai WW, Hou B, Ni LL, Xu F, Qiu LY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110256

Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor.

Huang Z, Wei G, Zeng Z, Huang Y, Huang L, Shen Y, Sun X, Xu C, Zhao C
Theranostics 2019;9(19):5542-5557

Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons.

Bando H, Lee Y, Sakaguchi N, Pradipta A, Sakamoto R, Tanaka S, Ma JS, Sasai M, Yamamoto M
Frontiers in cellular and infection microbiology 2019;9:140

Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.

Zhang WY, Guo YJ, Han WX, Yang MQ, Wen LP, Wang KY, Jiang P
International immunopharmacology 2019 Feb;67:138-144

Multiple myeloma cell-derived IL-32γ increases the immunosuppressive function of macrophages by promoting indoleamine 2,3-dioxygenase (IDO) expression.

Yan H, Dong M, Liu X, Shen Q, He D, Huang X, Zhang E, Lin X, Chen Q, Guo X, Chen J, Zheng G, Wang G, He J, Yi Q, Cai Z
Cancer letters 2019 Apr 1;446:38-48

Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.

Bando H, Sakaguchi N, Lee Y, Pradipta A, Ma JS, Tanaka S, Lai DH, Liu J, Lun ZR, Nishikawa Y, Sasai M, Yamamoto M
Frontiers in immunology 2018;9:2073

Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.

Bando H, Lee Y, Sakaguchi N, Pradipta A, Ma JS, Tanaka S, Cai Y, Liu J, Shen J, Nishikawa Y, Sasai M, Yamamoto M
mBio 2018 Oct 9;9(5)

Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide.

Dang R, Zhou X, Tang M, Xu P, Gong X, Liu Y, Jiao H, Jiang P
European journal of nutrition 2018 Apr;57(3):893-906

Impact of mismatch-repair deficiency on the colorectal cancer immune microenvironment.

Zhang Y, Sun Z, Mao X, Wu H, Luo F, Wu X, Zhou L, Qin J, Zhao L, Bai C
Oncotarget 2017 Oct 17;8(49):85526-85536

Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery.

Li Y, Hei M, Xu Y, Qian X, Zhu W
International journal of pharmaceutics 2016 Sep 25;511(2):689-702

Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B.

Yoshio S, Sugiyama M, Shoji H, Mano Y, Mita E, Okamoto T, Matsuura Y, Okuno A, Takikawa O, Mizokami M, Kanto T
Hepatology (Baltimore, Md.) 2016 Jan;63(1):83-94

Interferon-γ regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity.

Zhang Z, Han Y, Song J, Luo R, Jin X, Mu D, Su S, Ji X, Ren YF, Liu H
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2015 Jan;44(1):15-27

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The IDO1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IDO1. This antibody recognizes human antigen. The IDO1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 13268-1-AP.pdf

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