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- Product number
- 13268-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13268-1-AP, RRID:AB_2123444
- Product name
- IDO1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IDO1 antibody (Cat. #13268-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Development of Au(x)Cu(y)Pd(z) Nanocomposites as Therapeutic Agents: Enhancing Cancer Treatment through Autophagy Modulation and Immune-Associated Effects.
Rhubarb ameliorates ischemic stroke-induced tryptophan-kynurenine metabolic reprogramming and neuroinflammation via modulation of the IDO-1/TREM-1 pathway.
Multi-omics reveals an association of the gut butyrate-IDO1-tryptophan axis with Yinchenhaotang plus Zexietang-ameliorated NASH in a microbiota-dependent manner.
TRIM21 Alleviates Alcoholic Liver Fibrosis by Inhibiting Ferroptosis Through Regulation of IDO1 Ubiquitination.
Endometrial microbiota in maternal-fetal tolerance: An in vitro study of extravillous trophoblasts and uNK cells.
Isoliquiritigenin Inhibits Triple-Negative Breast Cancer Progression via Targeting the IRF5/SLC7A5/IDO1-Mediated Tryptophan Metabolism Pathway.
Epigallocatechin gallate inhibited IFN-β induced MUC5AC overexpression in airway epithelial cells by modulating JAK1 mediated STAT1 and ERK pathways activation.
Phospholipase A2 group IIA activates Indoleamine 2,3-dioxygenase 1 to drive the progression of pulmonary fibrosis.
Aryl hydrocarbon receptor-ligand hexachlorobenzene promotes immunosuppression leading to mammary tumor growth and metastasis in a HER2-positive syngeneic mouse model.
Umbelliferone Alleviates Sleep Deprivation Induced Cognitive Impairment through the Modulation of Gut Microbiota.
IDO Activation Affects BDNF/TrkB Signaling Pathway, Oxidative Stress, and Mitochondrial Enzymatic Activities in Temporal Lobe Epilepsy.
Huo Po Xia Ling decoction exerts preventive and improvement effects on gastric precancerous lesions by remodeling gut microbiota and associated metabolites.
L-Kynurenine regulates immune response in ICIs-associated myocarditis via JAK/STAT pathway.
1, 8-Cineole Ameliorated Staphylococcus aureus-Induced Pneumonia through Modulation of TRP-KYN and Arginine-NO Reprogramming.
HDLR-SR-BI Expression and Cholesterol Uptake are Regulated via Indoleamine-2,3-dioxygenase 1 in Macrophages under Inflammation.
Therapeutic targeting of the Tryptophan-Kynurenine Axis for HTR-8/SVneo trophoblast proliferation and migration in unexplained recurrent spontaneous abortion†.
Indoleamine 2, 3-dioxygenase 1 inhibition mediates the therapeutic effects in Parkinson's disease mice by modulating inflammation and neurogenesis in a gut microbiota dependent manner.
α9 Nicotinic Acetylcholine Receptor Promotes Tumor Proliferation and Suppresses Ferroptosis in Triple-Negative Breast Cancer.
IDO1 improves postischemic neovascularization in aged mice by boosting endothelial NAD(+) de novo synthesis and curbing endothelial senescence.
Nanoplastics Chronic Toxicity in Mice: Disturbing the Homeostasis of Tryptophan Metabolism in Gut-Lung-Microbiota Axis.
Kai-Xin-San ameliorates fluoxetine-resistant depressive-like behaviors by modulating tryptophan-kynurenine metabolic homeostasis in a rodent model.
SLC7A5 regulates tryptophan uptake and PD‑L1 expression levels via the kynurenine pathway in ovarian cancer.
Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism.
Muribaculum intestinale-derived 3-hydroxybutyric acid from Heterophyllin B attenuated pulmonary fibrosis through IDO1-mediated ferroptosis.
IDO1 modulates pain sensitivity and comorbid anxiety in chronic migraine through microglial activation and synaptic pruning.
5-Methoxytryptophan attenuates hypobaric hypoxia induced acute lung injury by alleviating lipid peroxidation via targeting peroxiredoxin 6.
Dauricine Inhibits Macrophages M2 Polarization and Regulates the Progression and Ferroptosis via HCK/IDO1 in Urinary Bladder Cancer.
Activation of NMDAR/Ca(2+)/CaKMII/ROS pathway by Brucella induced neuronal cell apoptosis.
Indoleamine 2,3-dioxygenase can improve ovarian function in premature ovarian insufficiency via aromatic hydrocarbon receptor and regulatory T cells†.
3-Hydroxypropionaldehyde modulates tryptophan metabolism to activate AhR signaling and alleviate ethanol-induced liver injury.
Burn-Induced Gut Microbiota Dysbiosis Aggravates Skeletal Muscle Atrophy by Tryptophan-Kynurenine Mediated AHR Pathway Activation.
Ethyl acetate extract from Herpetospermun cardigerum wall. Ameliorated concanavalin A-induced autoimmune hepatitis in mice by reprofiling gut microenvironment to modulate IDO1/KYN and PI3K/AKT/NF-κB pathways.
Lactobacillus Johnsonii YH1136 alleviates schizophrenia-like behavior in mice: a gut-microbiota-brain axis hypothesis study.
Vitamin D(3) alleviates intestinal injury in necrotizing enterocolitis and lipopolysaccharide-induced inflammatory response in dendritic cells in rats.
Single-cell RNA sequencing highlights the immunosuppression of IDO1(+) macrophages in the malignant transformation of oral leukoplakia.
CircSEC24B activates autophagy and induces chemoresistance of colorectal cancer via OTUB1-mediated deubiquitination of SRPX2.
Rifaximin ameliorates influenza A virus infection-induced lung barrier damage by regulating gut microbiota.
Dual targeting of wild-type p53 and gut microbiota by Magnolol represses key metabolic process and kills CRC cells.
Artemisia argyi essential oil alleviates asthma by regulating 5-LOX-CysLTs and IDO-1-KYN pathways: Insights from metabolomics.
Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction.
A novel antidepressant homogeneous polysaccharide YLP-1 from Millettia pulchra ameliorates tryptophan metabolism and SCFAs through modulating gut microbiota.
YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes.
Mesenchymal stem cells pretreated with interferon-gamma attenuate renal fibrosis by enhancing regulatory T cell induction.
Tumor-associated neutrophils suppress CD8(+) T cell immunity in urothelial bladder carcinoma through the COX-2/PGE2/IDO1 Axis.
Retention of stress susceptibility in the mdx mouse model of Duchenne muscular dystrophy after PGC-1α overexpression or ablation of IDO1 or CD38.
Kynurenine in IDO1(high) cancer cell-derived extracellular vesicles promotes angiogenesis by inducing endothelial mitophagy in ovarian cancer.
Synergistic action of gemcitabine and celecoxib in promoting the antitumor efficacy of anti-programmed death-1 monoclonal antibody by triggering immunogenic cell death.
Impaired tryptophan metabolism by type 2 inflammation in epithelium worsening asthma.
Reprogrammed IDO-Induced Immunosuppressive Microenvironment Synergizes with Immunogenic Magnetothermodynamics for Improved Cancer Therapy.
CD58 Alterations Govern Antitumor Immune Responses by Inducing PDL1 and IDO in Diffuse Large B-Cell Lymphoma.
Coprococcus eutactus screened from healthy adolescent attenuates chronic restraint stress-induced depression-like changes in adolescent mice: Potential roles in the microbiome and neurotransmitter modulation.
Bushen Antai recipe alleviates embryo absorption by enhancing immune tolerance and angiogenesis at the maternal-fetal interface via mobilizing MDSCs in abortion-prone mice.
Bushen Antai recipe ameliorates immune microenvironment and maternal-fetal vascularization in STAT3-deficient abortion-prone mice.
Indoleamine 2, 3-dioxygenase-transfected bone marrow-derived mesenchymal stem cells promote corneal allograft survival by inhibiting T cell proliferation: A rat study.
Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption.
Indoleamine-2,3-dioxygenase (IDO) Mediates the Suppression of T Cells by IFN-γ Primed Mesenchymal Stromal Cells in the Treatment of Psoriasis-Like Inflammation.
MGP(+) and IDO1(+) tumor-associated macrophages facilitate immunoresistance in breast cancer revealed by single-cell RNA sequencing.
Bisphenol F exposure induces depression-like changes: Roles of the kynurenine metabolic pathway along the "liver-brain" axis.
Validation of a Proteomic-Based Prognostic Model for Breast Cancer and Immunological Analysis.
IDO1 Promotes the Progression of NSCLC by Regulating the Polarization of M2 Macrophages.
Deletion of enzymes for de novo NAD(+) biosynthesis accelerated ovarian aging.
Effect of radiation fractionation on IDO1 via the NF-κB/COX2 axis in non-small cell lung cancer.
DSS-induced acute colitis causes dysregulated tryptophan metabolism in brain: an involvement of gut microbiota.
Apigenin improves cytotoxicity of antiretroviral drugs against HTLV-1 infected cells through the modulation of AhR signaling.
Novel long non-coding RNAs associated with inflammation and macrophage activation in human.
Alpinia oxyphylla Miq. volatile oil ameliorates depressive behaviors and inhibits neuroinflammation in CUMS-exposed mice by inhibiting the TLR4-medicated MyD88/NF-κB signaling pathway.
Research on the anti-ageing mechanism of Prunella vulgaris L.
Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure.
Targeting the STAT5A/IDO1 axis overcomes radioresistance and reverses the immunosuppressive tumor microenvironment in NSCLC.
Kuqin ameliorates Lipopolysaccharide-induced acute lung injury by regulating indoleamine 2,3-dioxygenase 1 and Akkermansia muciniphila.
Serum Response Factor-Regulated IDO1/Kyn-Ahr Pathway Promotes Tumorigenesis of Oral Squamous Cell Carcinoma.
DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota.
Cassane diterpenoid ameliorates dextran sulfate sodium-induced experimental colitis by regulating gut microbiota and suppressing tryptophan metabolism.
Therapeutic efficacy of human adipose mesenchymal stem cells in Crohn's colon fibrosis is improved by IFN-γ and kynurenic acid priming through indoleamine 2,3-dioxygenase-1 signaling.
Blockage of the IDO1 pathway by charge-switchable nanoparticles amplifies immunogenic cell death for enhanced cancer immunotherapy.
Inhibitory and Stimulatory Effects of IL-32 on HIV-1 Infection.
Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
RSAD2 Is an Effective Target for High-Yield Vaccine Production in MDCK Cells.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Regulation of the kynurenine/serotonin pathway by berberine and the underlying effect in the hippocampus of the chronic unpredictable mild stress mice.
Fusobacterium nucleatum promotes the development of acute liver failure by inhibiting the NAD(+) salvage metabolic pathway.
Mitigation Effects of Selenium Nanoparticles on Depression-Like Behavior Induced by Fluoride in Mice via the JAK2-STAT3 Pathway.
Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway.
Impact of the combination of sintilimab and chemotherapy on the tumor and paratumor PD-L1, IDO, TIM-3, FOXP3+ and CD8 expressions in patients with advanced esophageal squamous cell carcinoma.
Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.
The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase.
Predicting Panel of Metabolism and Immune-Related Genes for the Prognosis of Human Ovarian Cancer.
Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy.
Elevated mRNA Level of Y-Box Binding Protein 1 Indicates Unfavorable Prognosis Correlated with Macrophage Infiltration and T Cell Exhaustion in Luminal Breast Cancer.
Cang-Ai Volatile Oil Ameliorates Depressive Behavior Induced by Chronic Stress Through IDO-Mediated Tryptophan Degradation Pathway.
Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas.
IDO1 as a new immune biomarker for diabetic nephropathy and its correlation with immune cell infiltration.
Total glycosides from stems of Cistanche tubulosa alleviate depression-like behaviors: bidirectional interaction of the phytochemicals and gut microbiota.
GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer.
Tryptophan potentiates CD8(+) T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation.
Mifepristone regulates Tregs function mediated by dendritic cells through suppressing the expression of TGF-β.
Plasmacytoid Dendritic Cells Protect Against Middle Cerebral Artery Occlusion Induced Brain Injury by Priming Regulatory T Cells.
Combined Metabolomic Analysis of Plasma and Tissue Reveals a Prognostic Risk Score System and Metabolic Dysregulation in Esophageal Squamous Cell Carcinoma.
IDO1 Expression Increased After Neoadjuvant Therapy Predicts Poor Pathologic Response and Prognosis in Esophageal Squamous Cell Carcinoma.
Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells.
Nrf2 modulates immunosuppressive ability and cellular senescence of human umbilical cord mesenchymal stem cells.
Prunella vulgaris L. attenuates experimental autoimmune thyroiditis by inducing indoleamine 2,3-dioxygenase 1 expression and regulatory T cell expansion.
1,25(OH)(2)D(3) mitigate cancer-related fatigue in tumor-bearing mice: Integrating network pharmacological analysis.
Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor.
Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons.
Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.
Multiple myeloma cell-derived IL-32γ increases the immunosuppressive function of macrophages by promoting indoleamine 2,3-dioxygenase (IDO) expression.
Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.
Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.
Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide.
Impact of mismatch-repair deficiency on the colorectal cancer immune microenvironment.
Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery.
Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B.
Interferon-γ regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity.
Yang LX, Chiu YC, Chen YL, Chen TY, Tsai YT, Chin YC, Yeh YL, Wang YJ, Huang CC, Chen RJ, Liao MY
ACS applied materials & interfaces 2026 Mar 18;18(10):14540-14557
ACS applied materials & interfaces 2026 Mar 18;18(10):14540-14557
Rhubarb ameliorates ischemic stroke-induced tryptophan-kynurenine metabolic reprogramming and neuroinflammation via modulation of the IDO-1/TREM-1 pathway.
Liu X, Wang X, Wang Y, Zhu H, Xiang Q, Li Q, Wang X, Xu W, Jiang M, Wang W, Gao J, Wang T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158133
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158133
Multi-omics reveals an association of the gut butyrate-IDO1-tryptophan axis with Yinchenhaotang plus Zexietang-ameliorated NASH in a microbiota-dependent manner.
Liu W, Sha X, Zhao N, Liu B, Yang G, Jia L, Sui G
Chinese medicine 2026 Jan 21;21(1):44
Chinese medicine 2026 Jan 21;21(1):44
TRIM21 Alleviates Alcoholic Liver Fibrosis by Inhibiting Ferroptosis Through Regulation of IDO1 Ubiquitination.
Zhong W, Luo L, Liu Y, Huang F, Meng Q, Deng G, Li Y, Liu X, Tong G, Xing Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71773
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71773
Endometrial microbiota in maternal-fetal tolerance: An in vitro study of extravillous trophoblasts and uNK cells.
Takada K, Takeda Y, Bae J, Trinh QD, Kim DW, Hayakawa S, Komine-Aizawa S
Journal of reproductive immunology 2026 Apr 1;175:104884
Journal of reproductive immunology 2026 Apr 1;175:104884
Isoliquiritigenin Inhibits Triple-Negative Breast Cancer Progression via Targeting the IRF5/SLC7A5/IDO1-Mediated Tryptophan Metabolism Pathway.
Duan S, Li X, Song C, Wu S, Tang Y, Bao Q, Li N, Tang H
Oncology research 2025;33(11):3543-3556
Oncology research 2025;33(11):3543-3556
Epigallocatechin gallate inhibited IFN-β induced MUC5AC overexpression in airway epithelial cells by modulating JAK1 mediated STAT1 and ERK pathways activation.
Chen Q, Li X, Ma J, Li W, Wang X, Ni Z
Biochemical pharmacology 2025 Sep;239:117077
Biochemical pharmacology 2025 Sep;239:117077
Phospholipase A2 group IIA activates Indoleamine 2,3-dioxygenase 1 to drive the progression of pulmonary fibrosis.
Wang L, Lv W, Mao H, Chen Q, Ma Y, Zhang L, Ruan Y, Zhang C
Free radical biology & medicine 2025 Sep;237:251-269
Free radical biology & medicine 2025 Sep;237:251-269
Aryl hydrocarbon receptor-ligand hexachlorobenzene promotes immunosuppression leading to mammary tumor growth and metastasis in a HER2-positive syngeneic mouse model.
Zárate LV, Peña Agudelo JA, Miret NV, Nicola Candia AJ, Pérez Kϋper M, Pontillo CA, Chiappini FA, Candolfi M, Randi AS
Environmental toxicology and pharmacology 2025 Sep;118:104796
Environmental toxicology and pharmacology 2025 Sep;118:104796
Umbelliferone Alleviates Sleep Deprivation Induced Cognitive Impairment through the Modulation of Gut Microbiota.
Jiang Y, Ni Z, Dai H, Luo X, Xing J, Wang R, Zhang X
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24155-24168
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24155-24168
IDO Activation Affects BDNF/TrkB Signaling Pathway, Oxidative Stress, and Mitochondrial Enzymatic Activities in Temporal Lobe Epilepsy.
Xu J, Wei L, Fu J, Kong Z, Cai L
Current issues in molecular biology 2025 Sep 16;47(9)
Current issues in molecular biology 2025 Sep 16;47(9)
Huo Po Xia Ling decoction exerts preventive and improvement effects on gastric precancerous lesions by remodeling gut microbiota and associated metabolites.
Song Y, Qiao Y, Gao S, Cao M, Shan Y, Mao J, Chi X, Chang L, Shan B, Huo B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157131
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157131
L-Kynurenine regulates immune response in ICIs-associated myocarditis via JAK/STAT pathway.
He X, Zhang J, Zhang Y, Li H, Chen Y, Zhang H, Pan J, Zhou Y, Zhang S, Cheng L
International immunopharmacology 2025 May 27;156:114676
International immunopharmacology 2025 May 27;156:114676
1, 8-Cineole Ameliorated Staphylococcus aureus-Induced Pneumonia through Modulation of TRP-KYN and Arginine-NO Reprogramming.
Cao Q, Liu L, Ma X, Zhong C, Tang M, Liu M, Qu LB, Wei B, Xu X
Journal of agricultural and food chemistry 2025 May 14;73(19):11670-11683
Journal of agricultural and food chemistry 2025 May 14;73(19):11670-11683
HDLR-SR-BI Expression and Cholesterol Uptake are Regulated via Indoleamine-2,3-dioxygenase 1 in Macrophages under Inflammation.
Chini A, Guha P, Rishi A, Bhat N, Covarrubias A, Martinez V, Devejian L, Nguyen BN, Mandal SS
Langmuir : the ACS journal of surfaces and colloids 2025 May 13;41(18):11253-11271
Langmuir : the ACS journal of surfaces and colloids 2025 May 13;41(18):11253-11271
Therapeutic targeting of the Tryptophan-Kynurenine Axis for HTR-8/SVneo trophoblast proliferation and migration in unexplained recurrent spontaneous abortion†.
Jin P, Lu X, Wang L, Chen Y, Yang L, Yin Y, Shen Y, Ni X, Chen D, Zhang Y, Chen Y
Biology of reproduction 2025 May 13;112(5):969-980
Biology of reproduction 2025 May 13;112(5):969-980
Indoleamine 2, 3-dioxygenase 1 inhibition mediates the therapeutic effects in Parkinson's disease mice by modulating inflammation and neurogenesis in a gut microbiota dependent manner.
Qiao CM, Ma XY, Tan LL, Xia YM, Li T, Wu J, Cui C, Zhao WJ, Shen YQ
Experimental neurology 2025 Mar;385:115142
Experimental neurology 2025 Mar;385:115142
α9 Nicotinic Acetylcholine Receptor Promotes Tumor Proliferation and Suppresses Ferroptosis in Triple-Negative Breast Cancer.
Feng X, Tian Y, Guo X, Lei JH, Yu J, Zheng C, Chen M, Ding RB, Kwok HF, Luo S, Bao J
Biomolecules 2025 Jun 8;15(6)
Biomolecules 2025 Jun 8;15(6)
IDO1 improves postischemic neovascularization in aged mice by boosting endothelial NAD(+) de novo synthesis and curbing endothelial senescence.
Chen M, Chen J, Liu Y, Chen J, Yao M, Wang X, Zhang J, Pan M, Zhou J, Bai Y
Redox biology 2025 Jul;84:103695
Redox biology 2025 Jul;84:103695
Nanoplastics Chronic Toxicity in Mice: Disturbing the Homeostasis of Tryptophan Metabolism in Gut-Lung-Microbiota Axis.
Wu Y, Yao Y, Shen Y, Bai H, Zhang L, Zhang C
Small (Weinheim an der Bergstrasse, Germany) 2025 Jul;21(26):e2412286
Small (Weinheim an der Bergstrasse, Germany) 2025 Jul;21(26):e2412286
Kai-Xin-San ameliorates fluoxetine-resistant depressive-like behaviors by modulating tryptophan-kynurenine metabolic homeostasis in a rodent model.
Yao L, Jing R, Wang C, Wang Y, Li X, Wu X, Wang Y, Liu L, Mu L, Liu P, Hu Y
Journal of ethnopharmacology 2025 Jul 24;351:120011
Journal of ethnopharmacology 2025 Jul 24;351:120011
SLC7A5 regulates tryptophan uptake and PD‑L1 expression levels via the kynurenine pathway in ovarian cancer.
Jiang R, Jin B, Sun Y, Chen Z, Wan D, Feng J, Ying L, Peng C, Gu L
Oncology letters 2025 Jan;29(1):26
Oncology letters 2025 Jan;29(1):26
Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism.
Sheng Y, Qiao C, Zhang Z, Shi X, Yang L, Xi R, Yu J, Liu W, Zhang G, Wang F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(3):e2409310
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(3):e2409310
Muribaculum intestinale-derived 3-hydroxybutyric acid from Heterophyllin B attenuated pulmonary fibrosis through IDO1-mediated ferroptosis.
Chen C, Wang J, Cheng M, Xie H, Li W, Zhang C
Pharmacological research 2025 Feb;212:107587
Pharmacological research 2025 Feb;212:107587
IDO1 modulates pain sensitivity and comorbid anxiety in chronic migraine through microglial activation and synaptic pruning.
Hu J, Ji WJ, Liu GY, Su XH, Zhu JM, Hong Y, Xiong YF, Zhao YY, Li WP, Xie W
Journal of neuroinflammation 2025 Feb 18;22(1):42
Journal of neuroinflammation 2025 Feb 18;22(1):42
5-Methoxytryptophan attenuates hypobaric hypoxia induced acute lung injury by alleviating lipid peroxidation via targeting peroxiredoxin 6.
Lai X, Wan X, Bao X, Yang Q, Zhang W, Tan Y, Cai X, Wang Z, Li Y, Liu C, Deng Z, Zheng P, Tian D, Chen M, Yin H, Xu G, Huang Q, Zhang Z, Xia H, Deng F
Redox biology 2025 Dec;88:103922
Redox biology 2025 Dec;88:103922
Dauricine Inhibits Macrophages M2 Polarization and Regulates the Progression and Ferroptosis via HCK/IDO1 in Urinary Bladder Cancer.
Gong J, Sun D, Zheng Y, Mao C, Yu B, Li X, Xuan Y
Food science & nutrition 2025 Dec;13(12):e71341
Food science & nutrition 2025 Dec;13(12):e71341
Activation of NMDAR/Ca(2+)/CaKMII/ROS pathway by Brucella induced neuronal cell apoptosis.
Liu M, Yu H, Wang Y, Shi S, Liu H, Cao X, Sun L, Yang H, Zhang Z
Journal of neuroimmunology 2025 Aug 15;405:578620
Journal of neuroimmunology 2025 Aug 15;405:578620
Indoleamine 2,3-dioxygenase can improve ovarian function in premature ovarian insufficiency via aromatic hydrocarbon receptor and regulatory T cells†.
Hu A, Mu Y, Huang G, Wang Z, Zhao S, Xu W, Chen P, Guo X
Biology of reproduction 2025 Aug 13;113(2):331-344
Biology of reproduction 2025 Aug 13;113(2):331-344
3-Hydroxypropionaldehyde modulates tryptophan metabolism to activate AhR signaling and alleviate ethanol-induced liver injury.
Liu C, Wang Y, Sheng L, Zhang Y, Luo G, Ruan XZ, Chen Y, Huang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156445
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156445
Burn-Induced Gut Microbiota Dysbiosis Aggravates Skeletal Muscle Atrophy by Tryptophan-Kynurenine Mediated AHR Pathway Activation.
Gao S, Leng Y, Qiu Z, Li K, Li J, Peng J, Xie W, Lei S, Xia Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2409296
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2409296
Ethyl acetate extract from Herpetospermun cardigerum wall. Ameliorated concanavalin A-induced autoimmune hepatitis in mice by reprofiling gut microenvironment to modulate IDO1/KYN and PI3K/AKT/NF-κB pathways.
Xiao Y, Luo T, Duan C, Wang X, Yang Y, Li R, Deng J, Zhao Q
Journal of ethnopharmacology 2025 Apr 9;345:119578
Journal of ethnopharmacology 2025 Apr 9;345:119578
Lactobacillus Johnsonii YH1136 alleviates schizophrenia-like behavior in mice: a gut-microbiota-brain axis hypothesis study.
Zheng L, Xin J, Ye H, Sun N, Gan B, Gong X, Bao S, Xiang M, Wang H, Ni X, Li H, Zhang T
BMC microbiology 2025 Apr 2;25(1):191
BMC microbiology 2025 Apr 2;25(1):191
Vitamin D(3) alleviates intestinal injury in necrotizing enterocolitis and lipopolysaccharide-induced inflammatory response in dendritic cells in rats.
Ke B, Li C, Li S, Yan J, Sun L
Turkish journal of medical sciences 2024;54(5):1165-1174
Turkish journal of medical sciences 2024;54(5):1165-1174
Single-cell RNA sequencing highlights the immunosuppression of IDO1(+) macrophages in the malignant transformation of oral leukoplakia.
Zhang Y, Zhang J, Zhao S, Xu Y, Huang Y, Liu S, Su P, Wang C, Li Y, Li H, Yang P, Yang C
Theranostics 2024;14(12):4787-4805
Theranostics 2024;14(12):4787-4805
CircSEC24B activates autophagy and induces chemoresistance of colorectal cancer via OTUB1-mediated deubiquitination of SRPX2.
Wang D, Li Y, Chang W, Feng M, Yang Y, Zhu X, Liu Z, Fu Y
Cell death & disease 2024 Sep 27;15(9):693
Cell death & disease 2024 Sep 27;15(9):693
Rifaximin ameliorates influenza A virus infection-induced lung barrier damage by regulating gut microbiota.
Zhang Y, Chen Y, Xia J, Li L, Chang L, Luo H, Ping J, Qiao W, Su J
Applied microbiology and biotechnology 2024 Sep 19;108(1):469
Applied microbiology and biotechnology 2024 Sep 19;108(1):469
Dual targeting of wild-type p53 and gut microbiota by Magnolol represses key metabolic process and kills CRC cells.
Ji H, Qiao O, Zhang Y, Wang W, Han X, Zhang X, Liu C, Gao W
Phytotherapy research : PTR 2024 Oct;38(10):4982-4998
Phytotherapy research : PTR 2024 Oct;38(10):4982-4998
Artemisia argyi essential oil alleviates asthma by regulating 5-LOX-CysLTs and IDO-1-KYN pathways: Insights from metabolomics.
Rong Y, Tang M, Liu L, Ma X, Liu M, Qu L, Liao X, Jiang Q, Zhang N, Xu X
Journal of ethnopharmacology 2024 Oct 28;333:118458
Journal of ethnopharmacology 2024 Oct 28;333:118458
Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction.
Liu Y, Chen S, Wan X, Wang R, Luo H, Chang C, Dai P, Gan Y, Guo Y, Hou Y, Sun Y, Teng Y, Cui X, Liu M
Cancer communications (London, England) 2024 Nov;44(11):1261-1286
Cancer communications (London, England) 2024 Nov;44(11):1261-1286
A novel antidepressant homogeneous polysaccharide YLP-1 from Millettia pulchra ameliorates tryptophan metabolism and SCFAs through modulating gut microbiota.
Yu M, Cai CC, Huang YF, Zhu YD, Luo XY, Kong XY, Zhang WT, Li HJ, Fang JX, Zou ZM
Carbohydrate polymers 2024 Nov 15;344:122527
Carbohydrate polymers 2024 Nov 15;344:122527
YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes.
Huang J, Wang X, Li N, Fan W, Li X, Zhou Q, Liu J, Li W, Zhang Z, Liu X, Zeng S, Yang H, Tian M, Yang P, Hou S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(19):e2308031
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(19):e2308031
Mesenchymal stem cells pretreated with interferon-gamma attenuate renal fibrosis by enhancing regulatory T cell induction.
Kurawaki S, Nakashima A, Ishiuchi N, Kanai R, Maeda S, Sasaki K, Masaki T
Scientific reports 2024 May 4;14(1):10251
Scientific reports 2024 May 4;14(1):10251
Tumor-associated neutrophils suppress CD8(+) T cell immunity in urothelial bladder carcinoma through the COX-2/PGE2/IDO1 Axis.
Ouyang Y, Zhong W, Xu P, Wang B, Zhang L, Yang M, Chen J, Li H, Li S, Chen X, Xu L, Ou Z, Wu D, Lin Y, Wang C, Huang J, Lin T
British journal of cancer 2024 Mar;130(5):880-891
British journal of cancer 2024 Mar;130(5):880-891
Retention of stress susceptibility in the mdx mouse model of Duchenne muscular dystrophy after PGC-1α overexpression or ablation of IDO1 or CD38.
Johnson EE, Southern WM, Doud B, Steiger B, Razzoli M, Bartolomucci A, Ervasti JM
Human molecular genetics 2024 Mar 20;33(7):594-611
Human molecular genetics 2024 Mar 20;33(7):594-611
Kynurenine in IDO1(high) cancer cell-derived extracellular vesicles promotes angiogenesis by inducing endothelial mitophagy in ovarian cancer.
Ying X, Zheng X, Zhang X, Yin Y, Wang X
Journal of translational medicine 2024 Mar 11;22(1):267
Journal of translational medicine 2024 Mar 11;22(1):267
Synergistic action of gemcitabine and celecoxib in promoting the antitumor efficacy of anti-programmed death-1 monoclonal antibody by triggering immunogenic cell death.
Zhu X, Zhang W, Yu Z, Yang X, Li L, Chen C, Djumanazarov T, Piquemal D, Yusupbekov AA, Zheng Y
Translational cancer research 2024 Jun 30;13(6):3031-3045
Translational cancer research 2024 Jun 30;13(6):3031-3045
Impaired tryptophan metabolism by type 2 inflammation in epithelium worsening asthma.
Miao Y, Zhong C, Bao S, Wei K, Wang W, Li N, Bai C, Chen W, Tang H
iScience 2024 Jun 21;27(6):109923
iScience 2024 Jun 21;27(6):109923
Reprogrammed IDO-Induced Immunosuppressive Microenvironment Synergizes with Immunogenic Magnetothermodynamics for Improved Cancer Therapy.
Wang X, Yan B, Li H, Yuan J, Guo J, Wang S, Dai P, Liu X
ACS applied materials & interfaces 2024 Jun 19;16(24):30671-30684
ACS applied materials & interfaces 2024 Jun 19;16(24):30671-30684
CD58 Alterations Govern Antitumor Immune Responses by Inducing PDL1 and IDO in Diffuse Large B-Cell Lymphoma.
Xu X, Zhang Y, Lu Y, Zhang X, Zhao C, Wang J, Guan Q, Feng Y, Gao M, Yu J, Song Z, Liu X, Golchehre Z, Li L, Ren W, Pan-Hammarström Q, Zhang H, Wang X
Cancer research 2024 Jul 2;84(13):2123-2140
Cancer research 2024 Jul 2;84(13):2123-2140
Coprococcus eutactus screened from healthy adolescent attenuates chronic restraint stress-induced depression-like changes in adolescent mice: Potential roles in the microbiome and neurotransmitter modulation.
Xu L, Wang S, Wu L, Cao H, Fan Y, Wang X, Yu Z, Zhou M, Gao R, Wang J
Journal of affective disorders 2024 Jul 1;356:737-752
Journal of affective disorders 2024 Jul 1;356:737-752
Bushen Antai recipe alleviates embryo absorption by enhancing immune tolerance and angiogenesis at the maternal-fetal interface via mobilizing MDSCs in abortion-prone mice.
Liu Z, Geng Y, Huang Y, Hu R, Li F, Ding J, Ma W, Dong H, Song K, Xu X, Wu X, Song Y, Zhang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155164
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155164
Bushen Antai recipe ameliorates immune microenvironment and maternal-fetal vascularization in STAT3-deficient abortion-prone mice.
Liu Z, Song Y, Hu R, Geng Y, Huang Y, Li F, Ma W, Dong H, Song K, Ding J, Xu X, Wu X, Zhang M, Zhong Z
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116889
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116889
Indoleamine 2, 3-dioxygenase-transfected bone marrow-derived mesenchymal stem cells promote corneal allograft survival by inhibiting T cell proliferation: A rat study.
Ke H, Zhang W, Xu W, Cao Q, Li L, Liu H
Transplant immunology 2024 Feb;82:101960
Transplant immunology 2024 Feb;82:101960
Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption.
Ouyang F, Li Y, Wang H, Liu X, Tan X, Xie G, Zeng J, Zeng G, Luo Q, Zhou H, Chen S, Hou K, Fang J, Zhang X, Zhou L, Li Y, Gao A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2406026
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2406026
Indoleamine-2,3-dioxygenase (IDO) Mediates the Suppression of T Cells by IFN-γ Primed Mesenchymal Stromal Cells in the Treatment of Psoriasis-Like Inflammation.
Zhu W, Qi C, Shi C, Yang H, Shi F, Ding Y
Frontiers in bioscience (Landmark edition) 2024 Dec 5;29(12):411
Frontiers in bioscience (Landmark edition) 2024 Dec 5;29(12):411
MGP(+) and IDO1(+) tumor-associated macrophages facilitate immunoresistance in breast cancer revealed by single-cell RNA sequencing.
Chang K, Jiao Y, Zhang B, Hou L, He X, Wang D, Li D, Li R, Wang Z, Fan P, Zhang J
International immunopharmacology 2024 Apr 20;131:111818
International immunopharmacology 2024 Apr 20;131:111818
Bisphenol F exposure induces depression-like changes: Roles of the kynurenine metabolic pathway along the "liver-brain" axis.
Yu Z, Lin Y, Wu L, Wang L, Fan Y, Xu L, Zhang L, Wu W, Tao J, Huan F, Liu W, Wang J, Gao R
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123356
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123356
Validation of a Proteomic-Based Prognostic Model for Breast Cancer and Immunological Analysis.
Yu Y, Dong L, Dong C, Zhang X
International journal of genomics 2023;2023:1738750
International journal of genomics 2023;2023:1738750
IDO1 Promotes the Progression of NSCLC by Regulating the Polarization of M2 Macrophages.
Chen X, Yao J, Zhang MY, Li R, Liu X, Qu YQ
International journal of general medicine 2023;16:1713-1733
International journal of general medicine 2023;16:1713-1733
Deletion of enzymes for de novo NAD(+) biosynthesis accelerated ovarian aging.
Yang Q, Li H, Wang H, Chen W, Zeng X, Luo X, Xu J, Sun Y
Aging cell 2023 Sep;22(9):e13904
Aging cell 2023 Sep;22(9):e13904
Effect of radiation fractionation on IDO1 via the NF-κB/COX2 axis in non-small cell lung cancer.
Lan Y, Pi W, Zhou Z, Meng Y, DanMei, Xu Y, Xia X, WeiWang, Yang H, Spring Kong FM
International immunopharmacology 2023 Nov;124(Pt B):110956
International immunopharmacology 2023 Nov;124(Pt B):110956
DSS-induced acute colitis causes dysregulated tryptophan metabolism in brain: an involvement of gut microbiota.
Zhao LP, Wu J, Quan W, Zhou Y, Hong H, Niu GY, Ting-Li, Huang SB, Qiao CM, Zhao WJ, Cui C, Shen YQ
The Journal of nutritional biochemistry 2023 May;115:109282
The Journal of nutritional biochemistry 2023 May;115:109282
Apigenin improves cytotoxicity of antiretroviral drugs against HTLV-1 infected cells through the modulation of AhR signaling.
Sales D, Lin E, Stoffel V, Dickson S, Khan ZK, Beld J, Jain P
NeuroImmune pharmacology and therapeutics 2023 Mar 25;2(1):49-62
NeuroImmune pharmacology and therapeutics 2023 Mar 25;2(1):49-62
Novel long non-coding RNAs associated with inflammation and macrophage activation in human.
Chini A, Guha P, Malladi VS, Guo Z, Mandal SS
Scientific reports 2023 Mar 10;13(1):4036
Scientific reports 2023 Mar 10;13(1):4036
Alpinia oxyphylla Miq. volatile oil ameliorates depressive behaviors and inhibits neuroinflammation in CUMS-exposed mice by inhibiting the TLR4-medicated MyD88/NF-κB signaling pathway.
Wu B, Gan A, Wang R, Lin F, Yan T, Jia Y
Journal of chemical neuroanatomy 2023 Jul;130:102270
Journal of chemical neuroanatomy 2023 Jul;130:102270
Research on the anti-ageing mechanism of Prunella vulgaris L.
Li P, Lv X, Wang J, Zhang C, Zhao J, Yang Y
Scientific reports 2023 Jul 31;13(1):12398
Scientific reports 2023 Jul 31;13(1):12398
Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure.
Yin J, Zhao Z, Huang J, Xiao Y, Rehmutulla M, Zhang B, Zhang Z, Xiang M, Tong Q, Zhang Y
Cell discovery 2023 Jul 25;9(1):77
Cell discovery 2023 Jul 25;9(1):77
Targeting the STAT5A/IDO1 axis overcomes radioresistance and reverses the immunosuppressive tumor microenvironment in NSCLC.
Yang Y, Zheng X, Ni P, Li D, Dan Q, Wang X, Wang Y, Sun Y, Liu K, Dong Z, Ge H
International journal of oncology 2023 Jan;62(1)
International journal of oncology 2023 Jan;62(1)
Kuqin ameliorates Lipopolysaccharide-induced acute lung injury by regulating indoleamine 2,3-dioxygenase 1 and Akkermansia muciniphila.
Xiong S, Sun H, Lu C, He J, Wu Z, Wang Y, Zheng Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114073
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114073
Serum Response Factor-Regulated IDO1/Kyn-Ahr Pathway Promotes Tumorigenesis of Oral Squamous Cell Carcinoma.
Xu M, Zhu F, Yin Q, Yin H, Fang S, Luo G, Huang J, Huang W, Liu F, Zhong M, Deng X
Cancers 2023 Feb 19;15(4)
Cancers 2023 Feb 19;15(4)
DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota.
Zhao LP, Wu J, Quan W, Zhou Y, Hong H, Niu GY, Li T, Huang SB, Qiao CM, Zhao WJ, Cui C, Shen YQ
Frontiers in immunology 2022;13:1089200
Frontiers in immunology 2022;13:1089200
Cassane diterpenoid ameliorates dextran sulfate sodium-induced experimental colitis by regulating gut microbiota and suppressing tryptophan metabolism.
Liu T, Ning Z, Liu P, Gao H
Frontiers in immunology 2022;13:1045901
Frontiers in immunology 2022;13:1045901
Therapeutic efficacy of human adipose mesenchymal stem cells in Crohn's colon fibrosis is improved by IFN-γ and kynurenic acid priming through indoleamine 2,3-dioxygenase-1 signaling.
Ye Y, Zhang X, Su D, Ren Y, Cheng F, Yao Y, Shi G, Ji Y, Chen S, Shi P, Dai L, Su X, Deng H
Stem cell research & therapy 2022 Sep 8;13(1):465
Stem cell research & therapy 2022 Sep 8;13(1):465
Blockage of the IDO1 pathway by charge-switchable nanoparticles amplifies immunogenic cell death for enhanced cancer immunotherapy.
Shi M, Zhang J, Wang Y, Han Y, Zhao X, Hu H, Qiao M, Chen D
Acta biomaterialia 2022 Sep 15;150:353-366
Acta biomaterialia 2022 Sep 15;150:353-366
Inhibitory and Stimulatory Effects of IL-32 on HIV-1 Infection.
Nasser H, Takahashi N, Eltalkhawy YM, Reda O, Lotfi S, Nasu K, Sakuragi JI, Suzu S
Journal of immunology (Baltimore, Md. : 1950) 2022 Sep 1;209(5):970-978
Journal of immunology (Baltimore, Md. : 1950) 2022 Sep 1;209(5):970-978
Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
Kim YS, Ko B, Kim DJ, Tak J, Han CY, Cho JY, Kim W, Kim SG
Nature communications 2022 Oct 14;13(1):6080
Nature communications 2022 Oct 14;13(1):6080
RSAD2 Is an Effective Target for High-Yield Vaccine Production in MDCK Cells.
Qiao Z, Liao Y, Pei M, Qiu Z, Liu Z, Jin D, Zhang J, Ma Z, Yang X
Viruses 2022 Nov 21;14(11)
Viruses 2022 Nov 21;14(11)
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Regulation of the kynurenine/serotonin pathway by berberine and the underlying effect in the hippocampus of the chronic unpredictable mild stress mice.
Wang Q, Sun YN, Zou CM, Zhang TL, Li Z, Liu M, Shi BY, Shi SS, Yu CY, Wei TM
Behavioural brain research 2022 Mar 26;422:113764
Behavioural brain research 2022 Mar 26;422:113764
Fusobacterium nucleatum promotes the development of acute liver failure by inhibiting the NAD(+) salvage metabolic pathway.
Cao P, Chen Q, Shi C, Wang L, Gong Z
Gut pathogens 2022 Jun 28;14(1):29
Gut pathogens 2022 Jun 28;14(1):29
Mitigation Effects of Selenium Nanoparticles on Depression-Like Behavior Induced by Fluoride in Mice via the JAK2-STAT3 Pathway.
Yang J, Li H, Hao Z, Jing X, Zhao Y, Cheng X, Ma H, Wang J, Wang J
ACS applied materials & interfaces 2022 Jan 26;14(3):3685-3700
ACS applied materials & interfaces 2022 Jan 26;14(3):3685-3700
Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway.
Sriwastva MK, Deng ZB, Wang B, Teng Y, Kumar A, Sundaram K, Mu J, Lei C, Dryden GW, Xu F, Zhang L, Yan J, Zhang X, Park JW, Merchant ML, Egilmez NK, Zhang HG
EMBO reports 2022 Feb 3;23(3):e53365
EMBO reports 2022 Feb 3;23(3):e53365
Impact of the combination of sintilimab and chemotherapy on the tumor and paratumor PD-L1, IDO, TIM-3, FOXP3+ and CD8 expressions in patients with advanced esophageal squamous cell carcinoma.
Zhang S, Cai H, Huang J, Wang G
Thoracic cancer 2022 Dec;13(23):3284-3294
Thoracic cancer 2022 Dec;13(23):3284-3294
Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.
Zhang Y, Li Y, Chen X, Chen X, Chen C, Wang L, Dong X, Wang G, Gu R, Li F, Han F, Chen D
Journal of medicinal chemistry 2022 Aug 25;65(16):11214-11228
Journal of medicinal chemistry 2022 Aug 25;65(16):11214-11228
The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase.
Mudhish EA, Siddique AB, Ebrahim HY, Abdelwahed KS, King JA, El Sayed KA
Nutrients 2022 Apr 4;14(7)
Nutrients 2022 Apr 4;14(7)
Predicting Panel of Metabolism and Immune-Related Genes for the Prognosis of Human Ovarian Cancer.
Zhang L, Sun W, Ren W, Zhang J, Xu G
Frontiers in cell and developmental biology 2021;9:690542
Frontiers in cell and developmental biology 2021;9:690542
Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy.
Deng N, Hu J, Hong Y, Ding Y, Xiong Y, Wu Z, Xie W
Frontiers in cellular neuroscience 2021;15:638854
Frontiers in cellular neuroscience 2021;15:638854
Elevated mRNA Level of Y-Box Binding Protein 1 Indicates Unfavorable Prognosis Correlated with Macrophage Infiltration and T Cell Exhaustion in Luminal Breast Cancer.
Lv Z, Xue C, Zhang L, Sun J, Bo C
Cancer management and research 2021;13:6411-6428
Cancer management and research 2021;13:6411-6428
Cang-Ai Volatile Oil Ameliorates Depressive Behavior Induced by Chronic Stress Through IDO-Mediated Tryptophan Degradation Pathway.
Zhang K, Lei N, Li M, Li J, Li C, Shen Y, Guo P, Xiong L, Xie Y
Frontiers in psychiatry 2021;12:791991
Frontiers in psychiatry 2021;12:791991
Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas.
Yang P, Wang K, Zhang C, Wang Z, Liu Q, Wang J, Jiang T, Shan X
Cancer immunology, immunotherapy : CII 2021 Sep;70(9):2589-2600
Cancer immunology, immunotherapy : CII 2021 Sep;70(9):2589-2600
IDO1 as a new immune biomarker for diabetic nephropathy and its correlation with immune cell infiltration.
Yu K, Li D, Xu F, Guo H, Feng F, Ding Y, Wan X, Sun N, Zhang Y, Fan J, Liu L, Yang H, Yang X
International immunopharmacology 2021 May;94:107446
International immunopharmacology 2021 May;94:107446
Total glycosides from stems of Cistanche tubulosa alleviate depression-like behaviors: bidirectional interaction of the phytochemicals and gut microbiota.
Fan L, Peng Y, Wang J, Ma P, Zhao L, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153471
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153471
GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer.
Wei JL, Wu SY, Yang YS, Xiao Y, Jin X, Xu XE, Hu X, Li DQ, Jiang YZ, Shao ZM
Journal for immunotherapy of cancer 2021 Jul;9(7)
Journal for immunotherapy of cancer 2021 Jul;9(7)
Tryptophan potentiates CD8(+) T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation.
Qin R, Zhao C, Wang CJ, Xu W, Zhao JY, Lin Y, Yuan YY, Lin PC, Li Y, Zhao S, Huang Y
Journal for immunotherapy of cancer 2021 Jul;9(7)
Journal for immunotherapy of cancer 2021 Jul;9(7)
Mifepristone regulates Tregs function mediated by dendritic cells through suppressing the expression of TGF-β.
Li Y, Cao L, Qian Z, Guo Q, Niu X, Huang L
Immunopharmacology and immunotoxicology 2021 Feb;43(1):85-93
Immunopharmacology and immunotoxicology 2021 Feb;43(1):85-93
Plasmacytoid Dendritic Cells Protect Against Middle Cerebral Artery Occlusion Induced Brain Injury by Priming Regulatory T Cells.
Chen C, Chencheng Z, Cuiying L, Xiaokun G
Frontiers in cellular neuroscience 2020;14:8
Frontiers in cellular neuroscience 2020;14:8
Combined Metabolomic Analysis of Plasma and Tissue Reveals a Prognostic Risk Score System and Metabolic Dysregulation in Esophageal Squamous Cell Carcinoma.
Chen Z, Dai Y, Huang X, Chen K, Gao Y, Li N, Wang D, Chen A, Yang Q, Hong Y, Zeng S, Mao W
Frontiers in oncology 2020;10:1545
Frontiers in oncology 2020;10:1545
IDO1 Expression Increased After Neoadjuvant Therapy Predicts Poor Pathologic Response and Prognosis in Esophageal Squamous Cell Carcinoma.
Jiao R, Zheng X, Sun Y, Feng Z, Song S, Ge H
Frontiers in oncology 2020;10:1099
Frontiers in oncology 2020;10:1099
Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells.
Ebokaiwe AP, Njoya EM, Sheng Y, Zhang Z, Li S, Zhou Z, Qiang Z, Peng T, Hussein AA, Zhang G, Lu X, Li L, Wang F
Toxicology and applied pharmacology 2020 Oct 1;404:115203
Toxicology and applied pharmacology 2020 Oct 1;404:115203
Nrf2 modulates immunosuppressive ability and cellular senescence of human umbilical cord mesenchymal stem cells.
Jie Z, Huan Y, Mengyun W, Yasha L, Huafeng P, Ke Y
Biochemical and biophysical research communications 2020 Jun 11;526(4):1021-1027
Biochemical and biophysical research communications 2020 Jun 11;526(4):1021-1027
Prunella vulgaris L. attenuates experimental autoimmune thyroiditis by inducing indoleamine 2,3-dioxygenase 1 expression and regulatory T cell expansion.
Qiu H, Zhang J, Guo Q, Zhang Y, Zhong X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110288
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110288
1,25(OH)(2)D(3) mitigate cancer-related fatigue in tumor-bearing mice: Integrating network pharmacological analysis.
Zhou YT, Li SS, Ai M, Chen H, Liu YX, Li BY, Zhao Y, Cai WW, Hou B, Ni LL, Xu F, Qiu LY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110256
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110256
Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor.
Huang Z, Wei G, Zeng Z, Huang Y, Huang L, Shen Y, Sun X, Xu C, Zhao C
Theranostics 2019;9(19):5542-5557
Theranostics 2019;9(19):5542-5557
Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons.
Bando H, Lee Y, Sakaguchi N, Pradipta A, Sakamoto R, Tanaka S, Ma JS, Sasai M, Yamamoto M
Frontiers in cellular and infection microbiology 2019;9:140
Frontiers in cellular and infection microbiology 2019;9:140
Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.
Zhang WY, Guo YJ, Han WX, Yang MQ, Wen LP, Wang KY, Jiang P
International immunopharmacology 2019 Feb;67:138-144
International immunopharmacology 2019 Feb;67:138-144
Multiple myeloma cell-derived IL-32γ increases the immunosuppressive function of macrophages by promoting indoleamine 2,3-dioxygenase (IDO) expression.
Yan H, Dong M, Liu X, Shen Q, He D, Huang X, Zhang E, Lin X, Chen Q, Guo X, Chen J, Zheng G, Wang G, He J, Yi Q, Cai Z
Cancer letters 2019 Apr 1;446:38-48
Cancer letters 2019 Apr 1;446:38-48
Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.
Bando H, Sakaguchi N, Lee Y, Pradipta A, Ma JS, Tanaka S, Lai DH, Liu J, Lun ZR, Nishikawa Y, Sasai M, Yamamoto M
Frontiers in immunology 2018;9:2073
Frontiers in immunology 2018;9:2073
Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.
Bando H, Lee Y, Sakaguchi N, Pradipta A, Ma JS, Tanaka S, Cai Y, Liu J, Shen J, Nishikawa Y, Sasai M, Yamamoto M
mBio 2018 Oct 9;9(5)
mBio 2018 Oct 9;9(5)
Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide.
Dang R, Zhou X, Tang M, Xu P, Gong X, Liu Y, Jiao H, Jiang P
European journal of nutrition 2018 Apr;57(3):893-906
European journal of nutrition 2018 Apr;57(3):893-906
Impact of mismatch-repair deficiency on the colorectal cancer immune microenvironment.
Zhang Y, Sun Z, Mao X, Wu H, Luo F, Wu X, Zhou L, Qin J, Zhao L, Bai C
Oncotarget 2017 Oct 17;8(49):85526-85536
Oncotarget 2017 Oct 17;8(49):85526-85536
Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery.
Li Y, Hei M, Xu Y, Qian X, Zhu W
International journal of pharmaceutics 2016 Sep 25;511(2):689-702
International journal of pharmaceutics 2016 Sep 25;511(2):689-702
Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B.
Yoshio S, Sugiyama M, Shoji H, Mano Y, Mita E, Okamoto T, Matsuura Y, Okuno A, Takikawa O, Mizokami M, Kanto T
Hepatology (Baltimore, Md.) 2016 Jan;63(1):83-94
Hepatology (Baltimore, Md.) 2016 Jan;63(1):83-94
Interferon-γ regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity.
Zhang Z, Han Y, Song J, Luo R, Jin X, Mu D, Su S, Ji X, Ren YF, Liu H
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2015 Jan;44(1):15-27
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2015 Jan;44(1):15-27
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IDO1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IDO1. This antibody recognizes human antigen. The IDO1 antibody has been validated for the following applications: ELISA, WB analysis.
