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IDO1
Indoleamine 2,3-dioxygenase 1IDO, INDO
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. [provided by RefSeq, Feb 2011]
Top validated antibodies |
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| Invitrogen Antibodies |  711778 |
2 references | Polyclonal |
WB
ICC
IHC
FC
OA
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| OriGene | UM500091 |
1 references | Monoclonal |
WB
ICC
IHC
OA
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| LSBio | LS-C338094 |
Monoclonal |
WB
ICC
IHC
|
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| Proteintech Group | 13268-1-AP |
62 references | Polyclonal |
WB
EL
IHC
|
|
| Atlas Antibodies | HPA023072 |
8 references | Polyclonal |
WB
IHC
|
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