66528-1-Ig

antibody from Proteintech Group

Targeting: IDO1 IDO, INDO

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

66528-1-Ig

Provider

Proteintech Group

Product name

IDO1 antibody

Antibody type

Monoclonal

Description

IDO1 antibody (Cat. #66528-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3G2G11

Vial size

20ul, 150ul

References

Submitted references

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A novel photosensitizer-based photodynamic therapy reprograms the Kynurenine-AhR axis to boost antitumor immunity in breast cancer.

Liu Y, Hong G, Liu T, Liu H
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Computer assisted discovery of novel nicotinamide phosphoribosyltransferase agonists to combat muscle atrophy.

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HIFU postoperative hypoxia-activated metal-organic frameworks modulate the tumor microenvironment to augment immunotherapy.

Luo C, Wu D, Peng S, Xu S, Zhang D, Huang X, Qin W, Li H, Li H
Journal of nanobiotechnology 2026 Feb 1;24(1)

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Synergistic photodynamic therapy and IDO inhibition via a self-assembled nanomedicine potentiates PD-L1 blockade in gastrointestinal cancers.

Zhang Y, Wu J, Zhang Q, Liang P, Lin Y, Yang Z, Zheng C, Chen X, Li D, Feng X
Biomaterials advances 2026 Aug;185:214849

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Excessive progesterone impairs mouse decidualization via the Kyn-AhR pathway.

Luo HN, Yang HY, Wang ZM, Luo JM, Zhang TT, Yang ZM
Frontiers in cell and developmental biology 2025;13:1622998

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Tryptophan metabolic dysregulation drives immune activation and cartilage degradation in osteoarthritis: Functional validation integrated with transcriptomic and single-cell RNA sequencing.

Hou W, Chang Y, Zheng Z, Liang H
Biochemical and biophysical research communications 2025 Sep 30;782:152497

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Therapeutic targeting of the Tryptophan-Kynurenine Axis for HTR-8/SVneo trophoblast proliferation and migration in unexplained recurrent spontaneous abortion†.

Jin P, Lu X, Wang L, Chen Y, Yang L, Yin Y, Shen Y, Ni X, Chen D, Zhang Y, Chen Y
Biology of reproduction 2025 May 13;112(5):969-980

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IDO1-mediated AhR activation up-regulates pentose phosphate pathway via NRF2 to inhibit ferroptosis in lung cancer.

Zhan J, Chen Y, Liu Y, Chen Y, Li Z, Li X, He Z, Meng F, Qian X, Yang L, Yang Q
Biochemical pharmacology 2025 Jun;236:116913

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IDO1 inhibitors block septic cytokine storm by suppressing the IDO1-AHR-CYP1A1 axis.

Chen Y, Ying J, Li Z, He ZNT, Zhan J, Liang H, Liu Y, Chen Y, Li X, Zhu T, Kuang C, Lu G, Yang Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jun;187:118054

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Thrombin-induced kynurenine 3-monooxygenase causes variations in the kynurenine pathway, leading to neurological deficits in a murine intracerebral hemorrhage model.

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Journal of pharmacological sciences 2025 Feb;157(2):65-74

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Novel Indoleamine-2,3-Dioxygenase-Targeted Pt(IV) Prodrugs Regulate the Tumor Immune Microenvironment to Achieve Chemoimmunotherapy In Vitro and In Vivo.

Li Z, Liu XM, Tan F, Wang JQ, Qiao X, Feng YK, Xu JY, Hao JH
Journal of medicinal chemistry 2025 Feb 27;68(4):4352-4372

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Role of indoleamine 2,3-Dioxygenase 1 in modulating the malignant biological behavior of cervical cancer cells through the Tryptophan-Kynurenine pathway.

Zhang S, Wang L, Xu SY, Zhang YY, Li KX, Wang L, Chen Y, Chen Q
Journal of molecular histology 2025 Aug 22;56(5):276

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Alleviation of Microglia Mediating Hippocampal Neuron Impairments and Depression-Related Behaviors by Urolithin B via the SIRT1-FOXO1 Pathway.

Liu C, Zhao D, Yu G, Du H, Xu L, Cao Y, Cui M, Wang W, Wang D, Liu J, Meng F, Hu F, Li W, Du J, Li C
CNS neuroscience & therapeutics 2025 Apr;31(4):e70379

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Indoleamine 2,3-dioxygenase 1 alters the proportions of B cell subpopulations in the microenvironment of acute myeloid leukemia.

Yao Y, Liu YY, Li JF, Chen YS, Shi L, Shen Y, Yang LL, Yang Q
Molecular biomedicine 2025 Apr 16;6(1):23

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Signals from intestinal microbiota mediate the crosstalk between the lung-gut axis in an influenza infection mouse model.

Zhang Y, Wan Y, Xin X, Qiao Y, Qiao W, Ping J, Su J
Frontiers in immunology 2024;15:1435180

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Tryptophan in the mouse diet is essential for embryo implantation and decidualization.

Chen ST, Ran F, Shi WW, Liu CK, Wang PC, Luo HN, Yang ZM
Frontiers in endocrinology 2024;15:1356914

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Tryptophan deficiency induced by indoleamine 2,3-dioxygenase 1 results in glucose transporter 1-dependent promotion of aerobic glycolysis in pancreatic cancer.

Liang H, Zhan J, Chen Y, Xing Z, He ZNT, Liu Y, Li X, Chen Y, Li Z, Kuang C, Yang D, Yang Q
MedComm 2024 May;5(5):e555

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IDO1 Inhibitor RY103 Suppresses Trp-GCN2-Mediated Angiogenesis and Counters Immunosuppression in Glioblastoma.

Xing Z, Li X, He ZNT, Fang X, Liang H, Kuang C, Li A, Yang Q
Pharmaceutics 2024 Jun 28;16(7)

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Aristolochic acid I promotes renal tubulointerstitial fibrosis by up-regulating expression of indoleamine 2,3-dioxygenase-1 (IDO1).

Chen L, Cheng S, Ying J, Zhang Q, Wang C, Wu H, Wang Y, Zhang H, Wang J, Ye J, Zhang L
Toxicology letters 2024 Dec;402:44-55

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Integrated omics revealed the altered colonic microenvironment after inhibition of peripheral serotonin synthesis by LP533401.

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Cannabidiol Suppresses Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence through Modulating Tryptophan Catabolism.

Mudhish EA, Ebrahim HY, Helal IE, Alhowiriny AT, El Sayed KA
ACS pharmacology & translational science 2024 Dec 13;7(12):3902-3913

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Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes to lipid deposition in nonalcoholic steatohepatitis.

Wu C, Li J, Jia H, Zhao J, Qin M, Shi H, Liu C, Lin J, Cai M, Gu Y, Liu B, Gao L
Journal of gastroenterology 2024 Apr;59(4):342-356

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Rifaximin ameliorates depression-like behaviour in chronic unpredictable mild stress rats by regulating intestinal microbiota and hippocampal tryptophan metabolism.

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Journal of affective disorders 2023 May 15;329:30-41

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Efficient tumor synergistic chemoimmunotherapy by self-augmented ROS-responsive immunomodulatory polymeric nanodrug.

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Journal of nanobiotechnology 2023 Mar 16;21(1):93

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Navoximod modulates local HSV-1 replication to reshape tumor immune microenvironment for enhanced immunotherapy via an injectable hydrogel.

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High-fat diet-disturbed gut microbiota-colonocyte interactions contribute to dysregulating peripheral tryptophan-kynurenine metabolism.

Sun P, Wang M, Liu YX, Li L, Chai X, Zheng W, Chen S, Zhu X, Zhao S
Microbiome 2023 Jul 19;11(1):154

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Inhibitory effect of Dendrobium officinale polysaccharide on oxidative damage of glial cells in aging mice by regulating gut microbiota.

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International journal of biological macromolecules 2023 Aug 30;247:125787

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Detection of the role of intestinal flora and tryptophan metabolism involved in antidepressant-like actions of crocetin based on a multi-omics approach.

Lin S, Li Q, Xu Z, Chen Z, Tao Y, Tong Y, Wang T, Chen S, Wang P
Psychopharmacology 2022 Nov;239(11):3657-3677

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IDO1 can impair NK cells function against non-small cell lung cancer by downregulation of NKG2D Ligand via ADAM10.

Fang X, Guo L, Xing Z, Shi L, Liang H, Li A, Kuang C, Tao B, Yang Q
Pharmacological research 2022 Mar;177:106132

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Panax notoginseng saponins prevent colitis-associated colorectal cancer via inhibition IDO1 mediated immune regulation.

Li XM, Yuan DY, Liu YH, Zhu L, Qin HK, Yang YB, Li Y, Yan F, Wang YJ
Chinese journal of natural medicines 2022 Apr;20(4):258-269

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Combination of Geniposide and Eleutheroside B Exerts Antidepressant-like Effect on Lipopolysaccharide-Induced Depression Mice Model.

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Chinese journal of integrative medicine 2021 Jul;27(7):534-541

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Parkinson's Disease in Mouse: Potential Association between Neurotransmitter Disturbance and Gut Microbiota Dysbiosis.

Zhu Y, Huan F, Wang J, Xie X, Yu G, Wang X, Jiang L, Gao R, Xiao H, Ding H, Wang J
ACS chemical neuroscience 2020 Oct 21;11(20):3366-3376

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Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model.

Zhang B, Wang PP, Hu KL, Li LN, Yu X, Lu Y, Chang HS
Molecules (Basel, Switzerland) 2019 May 28;24(11)

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Fr‑HMGB1 and ds‑HMGB1 activate the kynurenine pathway via different mechanisms in association with depressive‑like behavior.

Wang B, Lian YJ, Su WJ, Liu LL, Li JM, Jiang CL, Wang YX
Molecular medicine reports 2019 Jul;20(1):359-367

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The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression.

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eLife 2018 Aug 22;7