PCDHGA12

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

Description

Protocadherin gamma subfamily A, 12

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm, Vesicles, Plasma membrane, Cytosol

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins

Chromosome

5 (141430507 - 141512975)

Ensembl ID

ENSG00000253159  (ver. 103.38)

Orthologs

Mouse Pcdhga12: ENSMUSG00000102428

UniProt

O60330

neXtProt

NX_O60330

Human splice variants
Mouse splice variants

Protein structure