Tissue expression
Cell line expression
Protein structure
PLP1
Proteolipid protein 1GPM6C, PLP, SPG2
This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]
Top validated antibodies |
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| Invitrogen Antibodies | 3 references | Monoclonal |
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| LSBio | Polyclonal |
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| Novus Biologicals | 1 references | Polyclonal |
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| Antibodies.com | Monoclonal |
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| Abbexa | Polyclonal |
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