ADAM28

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two transcript variants. The shorter version encodes a secreted isoform, while the longer version encodes a transmembrane isoform. [provided by RefSeq, Jul 2008]

Description

ADAM metallopeptidase domain 28

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, Protein evidence (Kim et al 2014)

Chromosome

8:p21.2 (24294040 - 24359018)

Ensembl ID

ENSG00000042980  (ver. 84.38)

Orthologs

Mouse Adam28: ENSMUSG00000014725

UniProt

Q9UKQ2

neXtProt

NX_Q9UKQ2

Human splice variants
Mouse splice variants