13300-1-AP

antibody from Proteintech Group

Targeting: TRIB3 C20orf97, dJ1103G7.3, TRB3

Provider product page for 13300-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [48]
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Validations
Western blot [1]

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Product number: 13300-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13300-1-AP, RRID:AB_10641988
Product name: TRIB3 antibody
Antibody type: Polyclonal
Description: KD/KO validated TRIB3 antibody (Cat. #13300-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TRIB3 protein structure - 13300-1-AP shown in red.

Submitted references Acid Ceramidase Inhibition Disrupts Ceramide Homeostasis and Induces Mitochondrial Apoptosis in IDH1-Mutant Oligodendroglioma.

Larion M, Muley H, Zaibaq F, Zhang M, Davis D, Kruhlak M, Mathur S, Lita A, Song H, Zhang W, Wong Z, Harmon T, Zhang L, Cam-El Makranz C, Li A, Karadimov G, Lang F, Herold-Mende C, Yang C, Dowdy T
Research square 2026 Mar 25;

TRIB3 Promotes Laryngeal Cancer Progression via Regulating Ubiquitination of PPARα.

Cheng Z, Yue K, Wang W, Jiang C, Qiang H, Jiang Z, Huang L
Biochemical genetics 2026 Feb 21;

TRIB3 Is a Hub Gene in Steatohepatitis and Aggravates Lipid Deposition and Inflammation in Hepatocytes.

Xia W, Xiao L, Cheng H, Feng Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:1111-1124

TRIB3 promotes endometrial cancer progression through interacting with E2F1 and enhancing PKM2-mediated tumor glycolysis.

Geng F, Wang Y, Cui G, Fan M
Gynecologic oncology 2025 Nov;202:41-52

RNA N(6)-methyladenosine demethylase FTO promotes diabetic wound healing through TRIB3-mediated autophagy in an m(6)A-YTHDF2-dependent manner.

Dong Z, Li S, Huang Y, Chen T, Ding Y, Tan Q
Cell death & disease 2025 Mar 29;16(1):222

MDA5 protein mediating persistent ER stress/unfolded protein response contributes to endothelial-mesenchymal-transition of lung microvascular endothelial cell in dermatomyositis.

Zhao LQ, Yang XQ, Niu Q, Feng X, Zhang HD, Ye SY, Jiang LJ, Yu F, Ye H, Ma WL
Cell communication and signaling : CCS 2025 Mar 23;23(1):149

MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation.

Wang T, Rao D, Fu C, Sun Z, Luo Y, Lu J, Jin J, Li H, Fan F, Liang H, Huang W, Xia L
Clinical and molecular hepatology 2025 Jul;31(3):1032-1057

TRIB3 regulates Cx43 expression in human granulosa cells via the Wnt/β-catenin signaling pathway: an in vitro study.

Zhu Z, Dong J, Liu W, Xia L, Niu Z
Journal of ovarian research 2025 Jul 2;18(1):139

Genome-Wide Mendelian Randomization Identifies Ferroptosis-Related Drug Targets for Alzheimer's Disease.

Wang Y, Song X, Wang R, Xu X, Du Y, Chen G, Mei J
Journal of Alzheimer's disease reports 2024;8(1):1185-1197

Thirdhand smoke exposure promotes gastric tumor development in mouse and human.

Jiang C, Chen L, Ye C, Schick SF, Jacob P 3rd, Zhuang Y, Inman JL, Chen C, Gundel LA, Chang H, Snijders AM, Zou X, Mao JH, Hang B, Wang P
Environment international 2024 Sep;191:108986

Tribbles pseudokinase 3 promoted renal fibrosis by regulating the expression of DNA damage-inducible transcript 3 in diabetic nephropathy.

Kong L, Kong L, Li P, Gao L, Ma H, Shi B
Biomolecules & biomedicine 2024 Oct 17;24(6):1559-1570

Piperlongumine, a natural alkaloid from Piper longum L. ameliorates metabolic-associated fatty liver disease by antagonizing the thromboxane A(2) receptor.

Dai Y, Chen J, Fang J, Liang S, Zhang H, Li H, Chen W
Biochemical pharmacology 2024 Nov;229:116518

Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas.

Zeng S, Wang Y, Ai L, Huang L, Liu Z, He C, Bai Q, Li Y
Clinical and experimental pharmacology & physiology 2024 Mar;51(3):e13843

TRIB3 promotes malignancy of head and neck squamous cell carcinoma via inhibiting ferroptosis.

Chen L, Lin W, Zhang H, Geng S, Le Z, Wan F, Huang Q, Chen H, Liu X, Lu JJ, Kong L
Cell death & disease 2024 Mar 1;15(3):178

Emodin suppresses adipogenesis of bone marrow derived mesenchymal stem cells from aplastic anemia via increasing TRIB3 expression.

Zhang X, Liu L, Wang J, Yao M, Liu L, Liu H, Ren S, Wei P, Cheng P, Li X, Zhang H, Chen M
Tissue & cell 2024 Feb;86:102287

ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis.

Hattori T, Fundora KA, Hamamoto K, Opozda DM, Liang X, Liu X, Zhang J, Uzun Y, Takahashi Y, Wang HG
Autophagy 2024 Feb;20(2):349-364

Comprehensive pan-cancer analysis unveils the significant prognostic value and potential role in immune microenvironment modulation of TRIB3.

Hu C, Li Q, Xiang L, Luo Y, Li S, An J, Yu X, Zhang G, Chen Y, Wang Y, Wang D
Computational and structural biotechnology journal 2024 Dec;23:234-250

TRIB3 promotes the growth of oral squamous cell carcinoma by regulating JNK/JUN-mediated aerobic glycolysis.

Meng Z, Wang Y, Wang X, Han X
Archives of oral biology 2024 Aug;164:105977

Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.

Dai Y, Xu R, Chen J, Fang J, Zhang H, Li H, Chen W
British journal of pharmacology 2024 Apr;181(7):967-986

Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors.

Muley H, Dowdy T, Zaibaq F, Karadimov G, Li A, Song H, Zhang M, Zhang W, Wong Z, Zhang L, Lita A, Larion M
bioRxiv : the preprint server for biology 2024 Apr 29;

A prognostic risk model for programmed cell death and revealing TRIB3 as a promising apoptosis suppressor in renal cell carcinoma.

Fu Q, Yi B, Su Q, Huang Y, Wang L, Zhang Z
Aging 2023 Nov 22;15(22):13213-13238

Tanshinone IIA inhibits endometrial carcinoma growth through the MAPK/ERK/TRIB3 pathway.

Zhang W, Liu M, Ji Y, Yu D, Ma C, Zhao J, Qu P
Archives of biochemistry and biophysics 2023 Jul 15;743:109655

Hsa_circRNA_0008028 Deficiency Ameliorates High Glucose-Induced Proliferation, Calcification, and Autophagy of Vascular Smooth Muscle Cells via miR-182-5p/TRIB3 Axis.

Shi L, Li Y, Shi M, Li X, Li G, Cen J, Liu D, Wei C, Lin Y
Oxidative medicine and cellular longevity 2022;2022:5142381

A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon endoplasmic reticulum stress.

Márton M, Bánhegyi G, Gyöngyösi N, Kálmán EÉ, Pettkó-Szandtner A, Káldi K, Kapuy O
FEBS open bio 2022 Nov;12(11):2065-2082

Perfluorooctanoic acid promotes pancreatic β cell dysfunction and apoptosis through ER stress and the ATF4/CHOP/TRIB3 pathway.

He X, Wu D, Xu Y, Zhang Y, Sun Y, Chang X, Zhu Y, Tang W
Environmental science and pollution research international 2022 Dec;29(56):84532-84545

Dietary saturated fatty acid palmitate promotes cartilage lesions and activates the unfolded protein response pathway in mouse knee joints.

Tan L, Harper LR, Armstrong A, Carlson CS, Yammani RR
PloS one 2021;16(2):e0247237

TRIB3 regulates FSHR expression in human granulosa cells under high levels of free fatty acids.

Wang N, Si C, Xia L, Wu X, Zhao S, Xu H, Ding Z, Niu Z
Reproductive biology and endocrinology : RB&E 2021 Sep 9;19(1):139

sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis.

Zhao Y, Yang X, Li S, Zhang B, Li S, Wang X, Wang Y, Jia C, Chang Y, Wei W
Stem cell research & therapy 2021 Oct 9;12(1):535

Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.

Huang T, Xu T, Wang Y, Zhou Y, Yu D, Wang Z, He L, Chen Z, Zhang Y, Davidson D, Dai Y, Hang C, Liu X, Yan C
Autophagy 2021 Nov;17(11):3592-3606

p62/sequestosome 1 attenuates methylmercury-induced endoplasmic reticulum stress in mouse embryonic fibroblasts.

Takanezawa Y, Nakamura R, Sugimoto T, Ohshiro Y, Uraguchi S, Kiyono M
Toxicology letters 2021 Dec 15;353:93-99

TRB3 mediates vascular remodeling by activating the MAPK signaling pathway in hypoxic pulmonary hypertension.

Cao X, Fang X, Guo M, Li X, He Y, Xie M, Xu Y, Liu X
Respiratory research 2021 Dec 14;22(1):312

TRIB3 promotes hepatocellular carcinoma growth and predicts poor prognosis.

Wang XJ, Li FF, Zhang YJ, Jiang M, Ren WH
Cancer biomarkers : section A of Disease markers 2020;29(3):307-315

Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway.

Wang S, Wang C, Li X, Hu Y, Gou R, Guo Q, Nie X, Liu J, Zhu L, Lin B
Cancer cell international 2020;20:418

Tan L, Register TC, Yammani RR
Aging and disease 2020 Oct;11(5):1091-1102

Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.

Li B, Yao J, Guo K, He F, Chen K, Lin Z, Liu S, Huang J, Wu Q, Fang M, Zeng J, Wu Z
European journal of medicinal chemistry 2020 Oct 15;204:112608

Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress.

Wang F, Liu L, Tong Y, Li L, Liu Y, Gao WQ
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):541-550

Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos.

Poncet N, Halley PA, Lipina C, Gierliński M, Dady A, Singer GA, Febrer M, Shi YB, Yamaguchi TP, Taylor PM, Storey KG
EMBO reports 2020 Jan 7;21(1):e48469

Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles.

Shang GK, Han L, Wang ZH, Liu YP, Yan SB, Sai WW, Wang D, Li YH, Zhang W, Zhong M
Journal of cachexia, sarcopenia and muscle 2020 Aug;11(4):1104-1120

High-fat diet induces endoplasmic reticulum stress to promote chondrocyte apoptosis in mouse knee joints.

Tan L, Harper L, McNulty MA, Carlson CS, Yammani RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5818-5826

TRIB3 suppresses proliferation and invasion and promotes apoptosis of endometrial cancer cells by regulating the AKT signaling pathway.

Qu J, Liu B, Li B, Du G, Li Y, Wang J, He L, Wan X
OncoTargets and therapy 2019;12:2235-2245

TRIB3 Stabilizes High TWIST1 Expression to Promote Rapid APL Progression and ATRA Resistance.

Lin J, Zhang W, Niu LT, Zhu YM, Weng XQ, Sheng Y, Zhu J, Xu J
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Oct 15;25(20):6228-6242

Tribbles Homolog 3 Involved in Radiation Response of Triple Negative Breast Cancer Cells by Regulating Notch1 Activation.

Lee YC, Wang WL, Chang WC, Huang YH, Hong GC, Wang HL, Chou YH, Tseng HC, Lee HT, Li ST, Chen HL, Wu CC, Yang HF, Wang BY, Chang WW
Cancers 2019 Jan 22;11(2)

Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma.

Buondonno I, Gazzano E, Tavanti E, Chegaev K, Kopecka J, Fanelli M, Rolando B, Fruttero R, Gasco A, Hattinger C, Serra M, Riganti C
Cellular and molecular life sciences : CMLS 2019 Feb;76(3):609-625

Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts.

Gazzano E, Buondonno I, Marengo A, Rolando B, Chegaev K, Kopecka J, Saponara S, Sorge M, Hattinger CM, Gasco A, Fruttero R, Brancaccio M, Serra M, Stella B, Fattal E, Arpicco S, Riganti C
Cancer letters 2019 Aug 1;456:29-39

Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer.

Salaroglio IC, Gazzano E, Abdullrahman A, Mungo E, Castella B, Abd-Elrahman GEFA, Massaia M, Donadelli M, Rubinstein M, Riganti C, Kopecka J
Journal of experimental & clinical cancer research : CR 2018 Nov 27;37(1):286

Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma.

Kopecka J, Salaroglio IC, Righi L, Libener R, Orecchia S, Grosso F, Milosevic V, Ananthanarayanan P, Ricci L, Capelletto E, Pradotto M, Napoli F, Di Maio M, Novello S, Rubinstein M, Scagliotti GV, Riganti C
Lung cancer (Amsterdam, Netherlands) 2018 Jun;120:34-45

Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein.

Riganti C, Gazzano E, Gulino GR, Volante M, Ghigo D, Kopecka J
Cancer letters 2015 May 1;360(2):219-26

Transcriptome analysis of genes regulated by cholesterol loading in two strains of mouse macrophages associates lysosome pathway and ER stress response with atherosclerosis susceptibility.

Berisha SZ, Hsu J, Robinet P, Smith JD
PloS one 2013;8(5):e65003

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TRIB3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TRIB3. This antibody recognizes human,mouse,rat antigen. The TRIB3 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 13300-1-AP.pdf

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