22989-1-AP

antibody from Proteintech Group

Targeting: MMP12 HME

Provider product page for 22989-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [29]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

Submit

Product number: 22989-1-AP - Provider product page
Provider: Proteintech Group
Product name: MMP12 antibody
Antibody type: Polyclonal
Description: MMP12 antibody (Cat. #22989-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MMP12 protein structure - 22989-1-AP shown in red.

Submitted references Expression Profiles of Matrix Metalloproteinases and Their Inhibitors in Nasal Polyps.

Duan C, Yu X, Feng X, Shi L, Wang D
Journal of inflammation research 2024;17:29-39

Characterization of a novel rabbit model of Peyronie's disease.

Gundogdu G, Nguyen T, Namasivayam A, Starek S, Gelman J, Mauney JR
International journal of impotence research 2024 May;36(3):269-274

Dimethyl α-Ketoglutarate Promotes the Synthesis of Collagen and Inhibits Metalloproteinases in HaCaT Cells.

Yu BY, Eom DH, Kim HW, Jeong YJ, Keum YS
Biomolecules & therapeutics 2024 Mar 1;32(2):240-248

Macrophage-derived MMP12 promotes fibrosis through sustained damage to endothelial cells.

Zhou X, Zhang C, Yang S, Yang L, Luo W, Zhang W, Zhang X, Chao J
Journal of hazardous materials 2024 Jan 5;461:132733

Integrative analysis of network pharmacology and proteomics reveal the protective effect of Xiaoqinglong Decotion on neutrophilic asthma.

Liao G, Yan Q, Zhang M, Zhang X, Yang J, Huang H, Liu X, Jiang Y, Gong J, Zhan S, Li D, Huang X
Journal of ethnopharmacology 2024 Aug 10;330:118102

MicroRNA Let-7 Induces M2 Macrophage Polarization in COPD Emphysema Through the IL-6/STAT3 Pathway.

Liu T, Zhang Z, Shen W, Wu Y, Bian T
International journal of chronic obstructive pulmonary disease 2023;18:575-591

Integrated multi-omics analyses reveal the altered transcriptomic characteristics of pulmonary macrophages in immunocompromised hosts with Pneumocystis pneumonia.

Wang Y, Li K, Zhao W, Liu Y, Li T, Yang HQ, Tong Z, Song N
Frontiers in immunology 2023;14:1179094

Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence.

Choi I, Wang M, Yoo S, Xu P, Seegobin SP, Li X, Han X, Wang Q, Peng J, Zhang B, Yue Z
Nature cell biology 2023 Jul;25(7):963-974

Metformin Directly Binds to MMP-9 to Improve Plaque Stability.

Chen X, Wang S, Xu W, Zhao M, Zhang Y, Xiao H
Journal of cardiovascular development and disease 2023 Jan 30;10(2)

NCOA4-Mediated Ferroptosis in Bronchial Epithelial Cells Promotes Macrophage M2 Polarization in COPD Emphysema.

Liu J, Zhang Z, Yang Y, Di T, Wu Y, Bian T
International journal of chronic obstructive pulmonary disease 2022;17:667-681

Tranexamic acid reduces endometrial cancer effects through the production of angiostatin.

Hiramoto K, Yamate Y
Journal of Cancer 2022;13(5):1603-1610

In-depth analysis of the expression and functions of signal transducers and activators of transcription in human ovarian cancer.

Gong X, Liu X
Frontiers in oncology 2022;12:1054647

Fusobacterium nucleatum exacerbates chronic obstructive pulmonary disease in elastase-induced emphysematous mice.

Suzuki R, Kamio N, Kaneko T, Yonehara Y, Imai K
FEBS open bio 2022 Mar;12(3):638-648

Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis.

Yi C, Liu J, Deng W, Luo C, Qi J, Chen M, Xu H
Journal of neuroinflammation 2022 Apr 5;19(1):78

Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging.

Chen J, Fan ZX, Zhu DC, Guo YL, Ye K, Dai D, Guo Z, Hu ZQ, Miao Y, Qu Q
Frontiers in cell and developmental biology 2021;9:728188

Matrix Metalloproteinase MMP-12 Promotes Macrophage Transmigration Across Intestinal Epithelial Tight Junctions and Increases Severity of Experimental Colitis.

Nighot M, Ganapathy AS, Saha K, Suchanec E, Castillo EF, Gregory A, Shapiro S, Ma T, Nighot P
Journal of Crohn's & colitis 2021 Oct 7;15(10):1751-1765

MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice.

Song M, Zhang S, Tao Z, Li J, Shi Y, Xiong Y, Zhang W, Liu C, Chen S
Biomaterials 2021 Nov;278:121183

Metalloelastase-12 is involved in the temporomandibular joint inflammatory response as well as cartilage degradation by aggrecanases in STR/Ort mice.

Yamashita-Futani Y, Jokaji R, Ooi K, Kobayashi K, Kanakis I, Liu K, Kawashiri S, Bou-Gharios G, Nakamura H
Biomedical reports 2021 Jun;14(6):51

Splenectomy enhances the Ly6C(low) phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis.

Zheng Z, Wang H, Li L, Zhang S, Zhang C, Zhang H, Ji F, Liu X, Zhu K, Kong G, Li Z
International immunopharmacology 2020 Sep;86:106762

Matrix metalloprotease-mediated cleavage of neural glial-related cell adhesion molecules activates quiescent olfactory stem cells via EGFR.

Chen ZH, Luo XC, Yu CR, Huang L
Molecular and cellular neurosciences 2020 Oct;108:103552

Severe elastolysis in hereditary gelsolin (AGel) amyloidosis.

Koskelainen S, Zhao F, Kalimo H, Baumann M, Kiuru-Enari S
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2020 Jun;27(2):81-88

Margatoxin mitigates CCl4‑induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling.

Wu BM, Liu JD, Li YH, Li J
International journal of molecular medicine 2020 Jan;45(1):103-114

Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway.

Guan R, Wang J, Cai Z, Li Z, Wang L, Li Y, Xu J, Li D, Yao H, Liu W, Deng B, Lu W
Redox biology 2020 Jan;28:101356

Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages.

Boytard L, Hadi T, Silvestro M, Qu H, Kumpfbeck A, Sleiman R, Fils KH, Alebrahim D, Boccalatte F, Kugler M, Corsica A, Gelb BE, Jacobowitz G, Miller G, Bellini C, Oakes J, Silvestre JS, Zangi L, Ramkhelawon B
Nature communications 2020 Aug 27;11(1):4311

Andrographolide attenuates oxidative stress injury in cigarette smoke extract exposed macrophages through inhibiting SIRT1/ERK signaling.

Zhang XF, Ding MJ, Cheng C, Zhang Y, Xiang SY, Lu J, Liu ZB
International immunopharmacology 2020 Apr;81:106230

Role of PM(2.5) in the development and progression of COPD and its mechanisms.

Zhao J, Li M, Wang Z, Chen J, Zhao J, Xu Y, Wei X, Wang J, Xie J
Respiratory research 2019 Jun 13;20(1):120

Exosomal zinc transporter ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer.

Jin H, Liu P, Wu Y, Meng X, Wu M, Han J, Tan X
Cancer science 2018 Sep;109(9):2946-2956

The Role of Angiotensin II in Parietal Epithelial Cell Proliferation and Crescent Formation in Glomerular Diseases.

Rizzo P, Novelli R, Rota C, Gagliardini E, Ruggiero B, Rottoli D, Benigni A, Remuzzi G
The American journal of pathology 2017 Nov;187(11):2441-2450

Oridonin inhibits gefitinib-resistant lung cancer cells by suppressing EGFR/ERK/MMP-12 and CIP2A/Akt signaling pathways.

Xiao X, He Z, Cao W, Cai F, Zhang L, Huang Q, Fan C, Duan C, Wang X, Wang J, Liu Y
International journal of oncology 2016 Jun;48(6):2608-18

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 22989-1-AP( MMP12 Antibody) at dilution of 1:600
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MMP12 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human MMP12. This antibody recognizes human, mouse antigen. The MMP12 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 22989-1-AP.pdf

: Show more