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MMP12
Matrix metallopeptidase 12HME
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
Top validated antibodies |
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| Proteintech Group |  22989-1-AP |
13 references | Polyclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | MA5-24851 |
1 references | Monoclonal |
WB
IHC
FC
OA
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| Novus Biologicals | DDX0281P-100 |
3 references | Monoclonal |
WB
EL
IP
IHC
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| Abgent | AP6196a |
2 references | Polyclonal |
WB
ICC
IHC
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| antibodies-online | ABIN441256 |
1 references | Polyclonal |
WB
ICC
IHC
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