10203-1-AP
antibody from Proteintech Group
Targeting: APEX1
APE, APE-1, APEN, APEX, APX, HAP1, REF-1, REF1
Antibody data
- Antibody Data
- Antigen structure
- References [23]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10203-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10203-1-AP, RRID:AB_2057927
- Product name
- APEX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated APEX1 antibody (Cat. #10203-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1.
APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy.
Multiply Guaranteed Catalytic DNA Circuit for Cancer-Cell-Selective Imaging of miRNA and Robust Evaluation of Drug Resistance.
APEX1 predicts poor prognosis of gallbladder cancer and affects biological properties of CD133(+) GBC-SD cells via upregulating Jagged1.
APE1 promotes radiation resistance against radiation-induced pyroptosis by inhibiting the STING pathway in lung adenocarcinoma.
Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.
Transient neurogenesis in ischemic cortex from Sox2(+) astrocytes.
NEDD4 attenuates oxidized low‑density lipoprotein‑induced inflammation and dysfunction in vascular endothelial cells via regulating APEX1 expression.
Apurinic/apyrimidinic endonuclease 1 regulates palmitic acid-mediated apoptosis in cardiomyocytes via endoplasmic reticulum stress.
E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma.
Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension.
Recruitment of DNA to tumor-derived microvesicles.
Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer.
LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression.
miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway.
MicroRNA-765 sensitizes osteosarcoma cells to cisplatin via downregulating APE1 expression.
Screening and identification of critical transcription factors involved in the protection of cardiomyocytes against hydrogen peroxide-induced damage by Yixin-shu.
An integrated approach to identify critical transcription factors in the protection against hydrogen peroxide-induced oxidative stress by Danhong injection.
Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease.
Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.
miR-130a can predict response to temozolomide in patients with glioblastoma multiforme, independently of O6-methylguanine-DNA methyltransferase.
Induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline exposure.
Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination.
Chen S, Zhang W, Li X, Cao Z, Liu C
Cell death & disease 2024 Jan 20;15(1):78
Cell death & disease 2024 Jan 20;15(1):78
APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy.
Du Y, Zhou Y, Yan X, Pan F, He L, Guo Z, Hu Z
Cell death and differentiation 2024 Apr;31(4):431-446
Cell death and differentiation 2024 Apr;31(4):431-446
Multiply Guaranteed Catalytic DNA Circuit for Cancer-Cell-Selective Imaging of miRNA and Robust Evaluation of Drug Resistance.
Wang Z, Shang Y, Zhu Y, He Y, Chen Y, Liu X, Wang F
Analytical chemistry 2024 Apr 9;96(14):5560-5569
Analytical chemistry 2024 Apr 9;96(14):5560-5569
APEX1 predicts poor prognosis of gallbladder cancer and affects biological properties of CD133(+) GBC-SD cells via upregulating Jagged1.
Wu Z, Liu Z, Sun Y, Yuan Y, Zou Q, Wen Y, Luo J, Liu R
Journal of Cancer 2023;14(8):1443-1457
Journal of Cancer 2023;14(8):1443-1457
APE1 promotes radiation resistance against radiation-induced pyroptosis by inhibiting the STING pathway in lung adenocarcinoma.
Zhou J, Wei Z, Yang C, Jia D, Pan B, Zeng Y, Sun D, Yu Y
Translational oncology 2023 Oct;36:101749
Translational oncology 2023 Oct;36:101749
Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.
Nguyen DD, Kim E, Le NT, Ding X, Jaiswal RK, Kostlan RJ, Nguyen TNT, Shiva O, Le MT, Chai W
Science advances 2023 May 10;9(19):eadd8023
Science advances 2023 May 10;9(19):eadd8023
Transient neurogenesis in ischemic cortex from Sox2(+) astrocytes.
Yang JL, Fan H, Fu FF, Guo BL, Huang Y, Sun L, Wang WT, Xing JL, Hu XT, Ding YQ, Zhang K, Hu YZ, Wang YZ
Neural regeneration research 2023 Jul;18(7):1521-1526
Neural regeneration research 2023 Jul;18(7):1521-1526
NEDD4 attenuates oxidized low‑density lipoprotein‑induced inflammation and dysfunction in vascular endothelial cells via regulating APEX1 expression.
Xu H, Tan L, Qu Q, Zhang W
Experimental and therapeutic medicine 2023 Feb;25(2):88
Experimental and therapeutic medicine 2023 Feb;25(2):88
Apurinic/apyrimidinic endonuclease 1 regulates palmitic acid-mediated apoptosis in cardiomyocytes via endoplasmic reticulum stress.
Fan J, Liu M, Li X, Gao S, Wang Y, Li A, Chen L, Zhou D, Chen H, Xu Z, Wu Z, Wu K
Biochemical and biophysical research communications 2023 Apr 2;650:123-131
Biochemical and biophysical research communications 2023 Apr 2;650:123-131
E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma.
Chen M, Zhao Z, Wu L, Huang J, Yu P, Qian J, Ni T, Zhao C
Cell death & disease 2022 Sep 12;13(9):784
Cell death & disease 2022 Sep 12;13(9):784
Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension.
Wang R, Guo Y, Li L, Luo M, Peng L, Lv D, Cheng Z, Xue Q, Wang L, Huang J
Genes & diseases 2022 May;9(3):753-765
Genes & diseases 2022 May;9(3):753-765
Recruitment of DNA to tumor-derived microvesicles.
Clancy JW, Sheehan CS, Boomgarden AC, D'Souza-Schorey C
Cell reports 2022 Mar 1;38(9):110443
Cell reports 2022 Mar 1;38(9):110443
Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer.
Long K, Gu L, Li L, Zhang Z, Li E, Zhang Y, He L, Pan F, Guo Z, Hu Z
Cell death & disease 2021 May 18;12(6):503
Cell death & disease 2021 May 18;12(6):503
LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression.
Huang T, Wang YJ, Huang MT, Guo Y, Yang LC, Liu XJ, Tan WY, Long JH
Cell death & disease 2021 Apr 19;12(5):410
Cell death & disease 2021 Apr 19;12(5):410
miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway.
Takagawa Y, Gen Y, Muramatsu T, Tanimoto K, Inoue J, Harada H, Inazawa J
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jun 3;28(6):1494-1505
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jun 3;28(6):1494-1505
MicroRNA-765 sensitizes osteosarcoma cells to cisplatin via downregulating APE1 expression.
Liang W, Li C, Li M, Wang D, Zhong Z
OncoTargets and therapy 2019;12:7203-7214
OncoTargets and therapy 2019;12:7203-7214
Screening and identification of critical transcription factors involved in the protection of cardiomyocytes against hydrogen peroxide-induced damage by Yixin-shu.
Zhang J, Geng Y, Guo F, Zhang F, Liu M, Song L, Ma Y, Li D, Zhang Y, Xu H, Yang H
Scientific reports 2017 Oct 24;7(1):13867
Scientific reports 2017 Oct 24;7(1):13867
An integrated approach to identify critical transcription factors in the protection against hydrogen peroxide-induced oxidative stress by Danhong injection.
Zhang J, Guo F, Wei J, Xian M, Tang S, Zhao Y, Liu M, Song L, Geng Y, Yang H, Ding C, Huang L
Free radical biology & medicine 2017 Nov;112:480-493
Free radical biology & medicine 2017 Nov;112:480-493
Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease.
Suganya R, Chakraborty A, Miriyala S, Hazra TK, Izumi T
DNA repair 2015 Mar;27:40-8
DNA repair 2015 Mar;27:40-8
Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.
Dong H, Shi Q, Song X, Fu J, Hu L, Xu D, Su C, Xia X, Song E, Song Y
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6
miR-130a can predict response to temozolomide in patients with glioblastoma multiforme, independently of O6-methylguanine-DNA methyltransferase.
Chen H, Li X, Li W, Zheng H
Journal of translational medicine 2015 Feb 21;13:69
Journal of translational medicine 2015 Feb 21;13:69
Induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline exposure.
Ma H, Wang J, Abdel-Rahman SZ, Boor PJ, Khan MF
Toxicology and applied pharmacology 2013 Mar 15;267(3):276-83
Toxicology and applied pharmacology 2013 Mar 15;267(3):276-83
Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination.
Masani S, Han L, Yu K
Molecular and cellular biology 2013 Apr;33(7):1468-73
Molecular and cellular biology 2013 Apr;33(7):1468-73
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10203-1-AP(APEX1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using APEX1 antibody 10203-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10203-1-AP(APEX1 antibody) at dilution of 1:100 (under 25x lens)
- Sample type
- tissue