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LearnNB100-116
antibody from Novus Biologicals
Targeting: APEX1
APE, APE-1, APEN, APEX, APX, HAP1, REF-1, REF1
Western blot
ELISA Immunocytochemistry Immunoprecipitation Immunohistochemistry Gel shift Proximity ligation assay Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [94]
- Comments [0]
- Validations
- Western blot [3]
- Immunohistochemistry [2]
- Chromatin Immunoprecipitation [1]
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- Product number
- NB100-116 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-116, RRID:AB_10080558
- Product name
- Mouse Monoclonal APE Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Mouse
- Antigen sequence
The epitope is within amino acids 8
0-100.- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Altered expression of DNA damage repair genes in the brain tissue of mice conceived by in vitro fertilization.
Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer.
Inactivation of XPF Sensitizes Cancer Cells to Gemcitabine.
The endonuclease APE1 processes miR-92b formation, thereby regulating expression of the tumor suppressor LDLR in cervical cancer cells.
Decreased APE-1 by Nitroxoline Enhances Therapeutic Effect in a Temozolomide-resistant Glioblastoma: Correlation with Diffusion Weighted Imaging.
The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways.
Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination.
ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1.
APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC.
The long noncoding RNA ROCKI regulates inflammatory gene expression.
Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.
The extracellular role of DNA damage repair protein APE1 in regulation of IL-6 expression.
Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity.
Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A.
Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist.
Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response.
Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET).
Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy.
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses.
Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics.
Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair.
Altered Secretory Activity of APE1/Ref-1 D148E Variants Identified in Human Patients With Bladder Cancer.
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells.
Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation.
Unilateral ureteral obstruction induces DNA repair by APE1.
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition.
KDM1A triggers androgen-induced miRNA transcription via H3K4me2 demethylation and DNA oxidation.
A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide.
Prognostic value of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in breast cancer.
HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β.
Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis.
Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma.
Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expression.
Silencing of APE1 enhances sensitivity of human hepatocellular carcinoma cells to radiotherapy in vitro and in a xenograft model.
The impact of ovarian stimulation on the expression of candidate reprogramming genes in mouse preimplantation embryos.
Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance.
Base excision DNA repair defect in thioredoxin-1 (Trx1)-deficient cells.
Downregulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 enhances the sensitivity of human pancreatic cancer cells to radiotherapy in vitro.
Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma.
Paradoxical relationship between Mn superoxide dismutase deficiency and radiation-induced cognitive defects.
Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neurons.
Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.
Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) is an indicator of energy disruption in neurons.
Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex.
Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction.
CIAPIN1 nuclear accumulation predicts poor clinical outcome in epithelial ovarian cancer.
Human AP endonuclease/redox factor APE1/ref-1 modulates mitochondrial function after oxidative stress by regulating the transcriptional activity of NRF1.
Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription.
Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys.
Reduced mRNA and protein expression of the genomic caretaker RAD9A in primary fibroblasts of individuals with childhood and independent second cancer.
Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma.
Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity.
Nm23-H1 protein binds to APE1 at AP sites and stimulates AP endonuclease activity following ionizing radiation of the human lung cancer A549 cells.
S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity.
Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer.
Senescence evasion by MCF-7 human breast tumor-initiating cells.
The nuclear matrix shell proteome of human epidermis.
Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response.
Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection.
Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage.
Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice.
Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres.
Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase.
Role of Ape1 and base excision repair in the radioresponse and heat-radiosensitization of HeLa Cells.
Nuclear protein-induced bending and flexing of the hypoxic response element of the rat vascular endothelial growth factor promoter.
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.
The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine.
Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways.
Redox effector factor-1, combined with reactive oxygen species, plays an important role in the transformation of JB6 cells.
Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma.
Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.
Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (gemcitabine and beta-D-arabinofuranosylcytosine).
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors.
Oxidants in signal transduction: impact on DNA integrity and gene expression.
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life.
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.
Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNA.
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition.
Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency.
Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair.
Decline of nuclear and mitochondrial oxidative base excision repair activity in late passage human diploid fibroblasts.
Decline of nuclear and mitochondrial oxidative base excision repair activity in late passage human diploid fibroblasts.
Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing.
Implication of p53 in base excision DNA repair: in vivo evidence.
X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance.
DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance.
DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance.
Histology-specific expression of a DNA repair protein in pediatric rhabdomyosarcomas.
Histology-specific expression of a DNA repair protein in pediatric rhabdomyosarcomas.
Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.
Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer.
A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA.
Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors.
Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers.
Hu M, Lou Y, Liu S, Mao Y, Le F, Wang L, Li L, Wang Q, Li H, Lou H, Wang N, Jin F
Molecular human reproduction 2020 Mar 26;26(3):141-153
Molecular human reproduction 2020 Mar 26;26(3):141-153
Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer.
Song H, Zeng J, Roychoudhury S, Biswas P, Mohapatra B, Ray S, Dowlatshahi K, Wang J, Band V, Talmon G, Bhakat KK
Molecular cancer therapeutics 2020 Jan;19(1):258-269
Molecular cancer therapeutics 2020 Jan;19(1):258-269
Inactivation of XPF Sensitizes Cancer Cells to Gemcitabine.
George JW, Bessho M, Bessho T
Journal of nucleic acids 2019;2019:6357609
Journal of nucleic acids 2019;2019:6357609
The endonuclease APE1 processes miR-92b formation, thereby regulating expression of the tumor suppressor LDLR in cervical cancer cells.
Sun Y, Feng Y, Zhang G, Xu Y
Therapeutic advances in medical oncology 2019;11:1758835919855859
Therapeutic advances in medical oncology 2019;11:1758835919855859
Decreased APE-1 by Nitroxoline Enhances Therapeutic Effect in a Temozolomide-resistant Glioblastoma: Correlation with Diffusion Weighted Imaging.
Cho HR, Kumari N, Thakur N, Vu HT, Kim H, Choi SH
Scientific reports 2019 Nov 12;9(1):16613
Scientific reports 2019 Nov 12;9(1):16613
The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways.
Cho W, Jin X, Pang J, Wang Y, Mivechi NF, Moskophidis D
Molecular and cellular biology 2019 May 1;39(9)
Molecular and cellular biology 2019 May 1;39(9)
Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination.
Frossi B, Antoniali G, Yu K, Akhtar N, Kaplan MH, Kelley MR, Tell G, Pucillo CEM
The Journal of biological chemistry 2019 Mar 29;294(13):5198-5207
The Journal of biological chemistry 2019 Mar 29;294(13):5198-5207
ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1.
Lee YR, Joo HK, Lee EO, Cho HS, Choi S, Kim CS, Jeon BH
International journal of molecular sciences 2019 Jun 28;20(13)
International journal of molecular sciences 2019 Jun 28;20(13)
APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC.
Malfatti MC, Gerratana L, Dalla E, Isola M, Damante G, Di Loreto C, Puglisi F, Tell G
Journal of experimental & clinical cancer research : CR 2019 Jul 15;38(1):309
Journal of experimental & clinical cancer research : CR 2019 Jul 15;38(1):309
The long noncoding RNA ROCKI regulates inflammatory gene expression.
Zhang Q, Chao TC, Patil VS, Qin Y, Tiwari SK, Chiou J, Dobin A, Tsai CM, Li Z, Dang J, Gupta S, Urdahl K, Nizet V, Gingeras TR, Gaulton KJ, Rana TM
The EMBO journal 2019 Apr 15;38(8)
The EMBO journal 2019 Apr 15;38(8)
Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.
Antoniali G, Serra F, Lirussi L, Tanaka M, D'Ambrosio C, Zhang S, Radovic S, Dalla E, Ciani Y, Scaloni A, Li M, Piazza S, Tell G
Nature communications 2017 Oct 6;8(1):797
Nature communications 2017 Oct 6;8(1):797
The extracellular role of DNA damage repair protein APE1 in regulation of IL-6 expression.
Nath S, Roychoudhury S, Kling MJ, Song H, Biswas P, Shukla A, Band H, Joshi S, Bhakat KK
Cellular signalling 2017 Nov;39:18-31
Cellular signalling 2017 Nov;39:18-31
Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity.
Roychoudhury S, Nath S, Song H, Hegde ML, Bellot LJ, Mantha AK, Sengupta S, Ray S, Natarajan A, Bhakat KK
Molecular and cellular biology 2017 Mar 15;37(6)
Molecular and cellular biology 2017 Mar 15;37(6)
Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A.
Yang C, Sengupta S, Hegde PM, Mitra J, Jiang S, Holey B, Sarker AH, Tsai MS, Hegde ML, Mitra S
Nucleic acids research 2017 Jan 25;45(2):739-748
Nucleic acids research 2017 Jan 25;45(2):739-748
Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist.
Wang H, Cai S, Bailey BJ, Reza Saadatzadeh M, Ding J, Tonsing-Carter E, Georgiadis TM, Zachary Gunter T, Long EC, Minto RE, Gordon KR, Sen SE, Cai W, Eitel JA, Waning DL, Bringman LR, Wells CD, Murray ME, Sarkaria JN, Gelbert LM, Jones DR, Cohen-Gadol AA, Mayo LD, Shannon HE, Pollok KE
Journal of neurosurgery 2017 Feb;126(2):446-459
Journal of neurosurgery 2017 Feb;126(2):446-459
Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response.
Moreli JB, Santos JH, Lorenzon-Ojea AR, Corrêa-Silva S, Fortunato RS, Rocha CR, Rudge MV, Damasceno DC, Bevilacqua E, Calderon IM
International journal of biological sciences 2016;12(4):466-77
International journal of biological sciences 2016;12(4):466-77
Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET).
Nikitaki Z, Nikolov V, Mavragani IV, Mladenov E, Mangelis A, Laskaratou DA, Fragkoulis GI, Hellweg CE, Martin OA, Emfietzoglou D, Hatzi VI, Terzoudi GI, Iliakis G, Georgakilas AG
Free radical research 2016 Nov;50(sup1):S64-S78
Free radical research 2016 Nov;50(sup1):S64-S78
Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy.
Kelley MR, Wikel JH, Guo C, Pollok KE, Bailey BJ, Wireman R, Fishel ML, Vasko MR
The Journal of pharmacology and experimental therapeutics 2016 Nov;359(2):300-309
The Journal of pharmacology and experimental therapeutics 2016 Nov;359(2):300-309
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses.
Akhter N, Takeda Y, Nara H, Araki A, Ishii N, Asao N, Asao H
The Journal of biological chemistry 2016 Nov 4;291(45):23672-23680
The Journal of biological chemistry 2016 Nov 4;291(45):23672-23680
Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics.
Szczesny B, Marcatti M, Zatarain JR, Druzhyna N, Wiktorowicz JE, Nagy P, Hellmich MR, Szabo C
Scientific reports 2016 Nov 3;6:36125
Scientific reports 2016 Nov 3;6:36125
Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair.
Sengupta S, Mantha AK, Song H, Roychoudhury S, Nath S, Ray S, Bhakat KK
Oncotarget 2016 Nov 15;7(46):75197-75209
Oncotarget 2016 Nov 15;7(46):75197-75209
Altered Secretory Activity of APE1/Ref-1 D148E Variants Identified in Human Patients With Bladder Cancer.
Lee YR, Lim JS, Shin JH, Choi S, Joo HK, Jeon BH
International neurourology journal 2016 May;20(Suppl 1):S30-37
International neurourology journal 2016 May;20(Suppl 1):S30-37
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells.
Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, Lopes M
Nature communications 2016 Feb 15;7:10660
Nature communications 2016 Feb 15;7:10660
Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation.
Bhakat KK, Sengupta S, Adeniyi VF, Roychoudhury S, Nath S, Bellot LJ, Feng D, Mantha AK, Sinha M, Qiu S, Luxon BA
Oncotarget 2016 Apr 19;7(16):22590-604
Oncotarget 2016 Apr 19;7(16):22590-604
Unilateral ureteral obstruction induces DNA repair by APE1.
Aamann MD, Nørregaard R, Kristensen ML, Stevnsner T, Frøkiær J
American journal of physiology. Renal physiology 2016 Apr 15;310(8):F763-F776
American journal of physiology. Renal physiology 2016 Apr 15;310(8):F763-F776
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition.
Bonora M, Wieckowsk MR, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L, Pinton P
Oncogene 2015 Mar 19;34(12):1608
Oncogene 2015 Mar 19;34(12):1608
KDM1A triggers androgen-induced miRNA transcription via H3K4me2 demethylation and DNA oxidation.
Yang S, Zhang J, Zhang Y, Wan X, Zhang C, Huang X, Huang W, Pu H, Pei C, Wu H, Huang Y, Huang S, Li Y
The Prostate 2015 Jun 15;75(9):936-46
The Prostate 2015 Jun 15;75(9):936-46
A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide.
Pojo M, Gonçalves CS, Xavier-Magalhães A, Oliveira AI, Gonçalves T, Correia S, Rodrigues AJ, Costa S, Pinto L, Pinto AA, Lopes JM, Reis RM, Rocha M, Sousa N, Costa BM
Oncotarget 2015 Apr 10;6(10):7657-74
Oncotarget 2015 Apr 10;6(10):7657-74
Prognostic value of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in breast cancer.
Woo J, Park H, Sung SH, Moon BI, Suh H, Lim W
PloS one 2014;9(6):e99528
PloS one 2014;9(6):e99528
HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β.
Fang Q, Inanc B, Schamus S, Wang XH, Wei L, Brown AR, Svilar D, Sugrue KF, Goellner EM, Zeng X, Yates NA, Lan L, Vens C, Sobol RW
Nature communications 2014 Nov 26;5:5513
Nature communications 2014 Nov 26;5:5513
Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis.
Karmahapatra SK, Saha T, Adhikari S, Woodrick J, Roy R
Molecular and cellular biochemistry 2014 Mar;388(1-2):185-93
Molecular and cellular biochemistry 2014 Mar;388(1-2):185-93
Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma.
Xie J, Zhang L, Li M, Du J, Zhou L, Yang S, Zeng L, Li Z, Wang G, Wang D
BMC cancer 2014 Jan 8;14:11
BMC cancer 2014 Jan 8;14:11
Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expression.
Sengupta S, Mitra S, Bhakat KK
PloS one 2013;8(7):e68467
PloS one 2013;8(7):e68467
Silencing of APE1 enhances sensitivity of human hepatocellular carcinoma cells to radiotherapy in vitro and in a xenograft model.
Cun Y, Dai N, Xiong C, Li M, Sui J, Qian C, Li Z, Wang D
PloS one 2013;8(2):e55313
PloS one 2013;8(2):e55313
The impact of ovarian stimulation on the expression of candidate reprogramming genes in mouse preimplantation embryos.
Linke M, May A, Reifenberg K, Haaf T, Zechner U
Cytogenetic and genome research 2013;139(2):71-9
Cytogenetic and genome research 2013;139(2):71-9
Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance.
Madlener S, Ströbel T, Vose S, Saydam O, Price BD, Demple B, Saydam N
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 29;110(44):17844-9
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 29;110(44):17844-9
Base excision DNA repair defect in thioredoxin-1 (Trx1)-deficient cells.
Kim HL, Koedrith P, Lee SM, Kim YJ, Seo YR
Mutation research 2013 Nov-Dec;751-752:1-7
Mutation research 2013 Nov-Dec;751-752:1-7
Downregulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 enhances the sensitivity of human pancreatic cancer cells to radiotherapy in vitro.
Chen S, Xiong G, Wu S, Mo J
Cancer biotherapy & radiopharmaceuticals 2013 Mar;28(2):169-76
Cancer biotherapy & radiopharmaceuticals 2013 Mar;28(2):169-76
Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma.
Yang Z, Misner B, Ji H, Poulos TL, Silverman RB, Meyskens FL, Yang S
Antioxidants & redox signaling 2013 Aug 10;19(5):433-47
Antioxidants & redox signaling 2013 Aug 10;19(5):433-47
Paradoxical relationship between Mn superoxide dismutase deficiency and radiation-induced cognitive defects.
Corniola R, Zou Y, Leu D, Fike JR, Huang TT
PloS one 2012;7(11):e49367
PloS one 2012;7(11):e49367
Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neurons.
Hill JW, Poddar R, Thompson JF, Rosenberg GA, Yang Y
Neuroscience 2012 Sep 18;220:277-90
Neuroscience 2012 Sep 18;220:277-90
Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.
Siddiqui A, Rivera-Sánchez S, Castro Mdel R, Acevedo-Torres K, Rane A, Torres-Ramos CA, Nicholls DG, Andersen JK, Ayala-Torres S
Free radical biology & medicine 2012 Oct 1;53(7):1478-88
Free radical biology & medicine 2012 Oct 1;53(7):1478-88
Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) is an indicator of energy disruption in neurons.
Singh S, Englander EW
Free radical biology & medicine 2012 Nov 1;53(9):1782-90
Free radical biology & medicine 2012 Nov 1;53(9):1782-90
Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex.
Sengupta S, Chattopadhyay R, Mantha AK, Mitra S, Bhakat KK
Journal of hypertension 2012 May;30(5):917-25
Journal of hypertension 2012 May;30(5):917-25
Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction.
Mantha AK, Dhiman M, Taglialatela G, Perez-Polo RJ, Mitra S
Journal of neuroscience research 2012 Jun;90(6):1230-9
Journal of neuroscience research 2012 Jun;90(6):1230-9
CIAPIN1 nuclear accumulation predicts poor clinical outcome in epithelial ovarian cancer.
Cai X, Wang J, Xin X
World journal of surgical oncology 2012 Jun 19;10:112
World journal of surgical oncology 2012 Jun 19;10:112
Human AP endonuclease/redox factor APE1/ref-1 modulates mitochondrial function after oxidative stress by regulating the transcriptional activity of NRF1.
Li M, Vascotto C, Xu S, Dai N, Qing Y, Zhong Z, Tell G, Wang D
Free radical biology & medicine 2012 Jul 15;53(2):237-48
Free radical biology & medicine 2012 Jul 15;53(2):237-48
Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription.
Clark DW, Phang T, Edwards MG, Geraci MW, Gillespie MN
Free radical biology & medicine 2012 Jul 1;53(1):51-9
Free radical biology & medicine 2012 Jul 1;53(1):51-9
Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys.
Castro Mdel R, Suarez E, Kraiselburd E, Isidro A, Paz J, Ferder L, Ayala-Torres S
Experimental gerontology 2012 Jan;47(1):29-37
Experimental gerontology 2012 Jan;47(1):29-37
Reduced mRNA and protein expression of the genomic caretaker RAD9A in primary fibroblasts of individuals with childhood and independent second cancer.
Weis E, Schoen H, Victor A, Spix C, Ludwig M, Schneider-Raetzke B, Kohlschmidt N, Bartsch O, Gerhold-Ay A, Boehm N, Grus F, Haaf T, Galetzka D
PloS one 2011;6(10):e25750
PloS one 2011;6(10):e25750
Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma.
Bobola MS, Jankowski PP, Gross ME, Schwartz J, Finn LS, Blank A, Ellenbogen RG, Silber JR
International journal of cancer 2011 Nov 15;129(10):2370-9
International journal of cancer 2011 Nov 15;129(10):2370-9
Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity.
Jaiswal AS, Narayan S
Biochemistry 2011 Mar 22;50(11):1901-9
Biochemistry 2011 Mar 22;50(11):1901-9
Nm23-H1 protein binds to APE1 at AP sites and stimulates AP endonuclease activity following ionizing radiation of the human lung cancer A549 cells.
Zhang ZM, Yang XQ, Wang D, Wang G, Yang ZZ, Qing Y, Yang ZX, Li MX, Xiang DB
Cell biochemistry and biophysics 2011 Dec;61(3):561-72
Cell biochemistry and biophysics 2011 Dec;61(3):561-72
S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity.
Kim YJ, Kim D, Illuzzi JL, Delaplane S, Su D, Bernier M, Gross ML, Georgiadis MM, Wilson DM 3rd
Journal of molecular biology 2011 Dec 2;414(3):313-26
Journal of molecular biology 2011 Dec 2;414(3):313-26
Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer.
Singh-Gupta V, Joiner MC, Runyan L, Yunker CK, Sarkar FH, Miller S, Gadgeel SM, Konski AA, Hillman GG
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011 Apr;6(4):688-98
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011 Apr;6(4):688-98
Senescence evasion by MCF-7 human breast tumor-initiating cells.
Karimi-Busheri F, Rasouli-Nia A, Mackey JR, Weinfeld M
Breast cancer research : BCR 2010;12(3):R31
Breast cancer research : BCR 2010;12(3):R31
The nuclear matrix shell proteome of human epidermis.
Warters RL, Cassidy PB, Sunseri JA, Parsawar K, Zhuplatov SB, Kramer GF, Leachman SA
Journal of dermatological science 2010 May;58(2):113-22
Journal of dermatological science 2010 May;58(2):113-22
Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response.
Ray S, Lee C, Hou T, Bhakat KK, Brasier AR
Molecular endocrinology (Baltimore, Md.) 2010 Feb;24(2):391-401
Molecular endocrinology (Baltimore, Md.) 2010 Feb;24(2):391-401
Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection.
Chattopadhyay R, Bhattacharyya A, Crowe SE
Cancer research 2010 Apr 1;70(7):2799-808
Cancer research 2010 Apr 1;70(7):2799-808
Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage.
Jelezcova E, Trivedi RN, Wang XH, Tang JB, Brown AR, Goellner EM, Schamus S, Fornsaglio JL, Sobol RW
Mutation research 2010 Apr 1;686(1-2):57-67
Mutation research 2010 Apr 1;686(1-2):57-67
Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice.
Unnikrishnan A, Raffoul JJ, Patel HV, Prychitko TM, Anyangwe N, Meira LB, Friedberg EC, Cabelof DC, Heydari AR
Free radical biology & medicine 2009 Jun 1;46(11):1488-99
Free radical biology & medicine 2009 Jun 1;46(11):1488-99
Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres.
May A, Kirchner R, Müller H, Hartmann P, El Hajj N, Tresch A, Zechner U, Mann W, Haaf T
Biology of reproduction 2009 Jan;80(1):194-202
Biology of reproduction 2009 Jan;80(1):194-202
Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase.
Jones LE Jr, Ying L, Hofseth AB, Jelezcova E, Sobol RW, Ambs S, Harris CC, Espey MG, Hofseth LJ, Wyatt MD
Carcinogenesis 2009 Dec;30(12):2123-9
Carcinogenesis 2009 Dec;30(12):2123-9
Role of Ape1 and base excision repair in the radioresponse and heat-radiosensitization of HeLa Cells.
Batuello CN, Kelley MR, Dynlacht JR
Anticancer research 2009 Apr;29(4):1319-25
Anticancer research 2009 Apr;29(4):1319-25
Nuclear protein-induced bending and flexing of the hypoxic response element of the rat vascular endothelial growth factor promoter.
Breit JF, Ault-Ziel K, Al-Mehdi AB, Gillespie MN
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 Jan;22(1):19-29
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 Jan;22(1):19-29
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.
Chattopadhyay R, Das S, Maiti AK, Boldogh I, Xie J, Hazra TK, Kohno K, Mitra S, Bhakat KK
Molecular and cellular biology 2008 Dec;28(23):7066-80
Molecular and cellular biology 2008 Dec;28(23):7066-80
The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine.
Lam W, Leung CH, Bussom S, Cheng YC
Molecular pharmacology 2007 Sep;72(3):536-44
Molecular pharmacology 2007 Sep;72(3):536-44
Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways.
Kundu CN, Balusu R, Jaiswal AS, Narayan S
Carcinogenesis 2007 Oct;28(10):2089-95
Carcinogenesis 2007 Oct;28(10):2089-95
Redox effector factor-1, combined with reactive oxygen species, plays an important role in the transformation of JB6 cells.
Yang S, Misner BJ, Chiu RJ, Meyskens FL Jr
Carcinogenesis 2007 Nov;28(11):2382-90
Carcinogenesis 2007 Nov;28(11):2382-90
Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma.
Maki A, Kono H, Gupta M, Asakawa M, Suzuki T, Matsuda M, Fujii H, Rusyn I
Annals of surgical oncology 2007 Mar;14(3):1182-90
Annals of surgical oncology 2007 Mar;14(3):1182-90
Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.
Raffoul JJ, Banerjee S, Singh-Gupta V, Knoll ZE, Fite A, Zhang H, Abrams J, Sarkar FH, Hillman GG
Cancer research 2007 Mar 1;67(5):2141-9
Cancer research 2007 Mar 1;67(5):2141-9
Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (gemcitabine and beta-D-arabinofuranosylcytosine).
Lam W, Park SY, Leung CH, Cheng YC
Molecular pharmacology 2006 May;69(5):1607-14
Molecular pharmacology 2006 May;69(5):1607-14
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors.
Bobola MS, Finn LS, Ellenbogen RG, Geyer JR, Berger MS, Braga JM, Meade EH, Gross ME, Silber JR
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Oct 15;11(20):7405-14
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Oct 15;11(20):7405-14
Oxidants in signal transduction: impact on DNA integrity and gene expression.
Ziel KA, Grishko V, Campbell CC, Breit JF, Wilson GL, Gillespie MN
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005 Mar;19(3):387-94
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005 Mar;19(3):387-94
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life.
Elchuri S, Oberley TD, Qi W, Eisenstein RS, Jackson Roberts L, Van Remmen H, Epstein CJ, Huang TT
Oncogene 2005 Jan 13;24(3):367-80
Oncogene 2005 Jan 13;24(3):367-80
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.
Yang S, Irani K, Heffron SE, Jurnak F, Meyskens FL Jr
Molecular cancer therapeutics 2005 Dec;4(12):1923-35
Molecular cancer therapeutics 2005 Dec;4(12):1923-35
Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNA.
Marenstein DR, Wilson DM 3rd, Teebor GW
DNA repair 2004 May 4;3(5):527-33
DNA repair 2004 May 4;3(5):527-33
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition.
Wang D, Luo M, Kelley MR
Molecular cancer therapeutics 2004 Jun;3(6):679-86
Molecular cancer therapeutics 2004 Jun;3(6):679-86
Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency.
Cabelof DC, Raffoul JJ, Nakamura J, Kapoor D, Abdalla H, Heydari AR
The Journal of biological chemistry 2004 Aug 27;279(35):36504-13
The Journal of biological chemistry 2004 Aug 27;279(35):36504-13
Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair.
Raffoul JJ, Cabelof DC, Nakamura J, Meira LB, Friedberg EC, Heydari AR
The Journal of biological chemistry 2004 Apr 30;279(18):18425-33
The Journal of biological chemistry 2004 Apr 30;279(18):18425-33
Decline of nuclear and mitochondrial oxidative base excision repair activity in late passage human diploid fibroblasts.
Shen GP, Galick H, Inoue M, Wallace SS
DNA repair 2003 Jun 11;2(6):673-93
DNA repair 2003 Jun 11;2(6):673-93
Decline of nuclear and mitochondrial oxidative base excision repair activity in late passage human diploid fibroblasts.
Shen GP, Galick H, Inoue M, Wallace SS
DNA repair 2003 Jun 11;2(6):673-93
DNA repair 2003 Jun 11;2(6):673-93
Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing.
Fishel ML, Seo YR, Smith ML, Kelley MR
Cancer research 2003 Feb 1;63(3):608-15
Cancer research 2003 Feb 1;63(3):608-15
Implication of p53 in base excision DNA repair: in vivo evidence.
Seo YR, Fishel ML, Amundson S, Kelley MR, Smith ML
Oncogene 2002 Jan 24;21(5):731-7
Oncogene 2002 Jan 24;21(5):731-7
X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance.
Park SY, Lam W, Cheng YC
Cancer research 2002 Jan 15;62(2):459-65
Cancer research 2002 Jan 15;62(2):459-65
DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance.
Schindl M, Oberhuber G, Pichlbauer EG, Obermair A, Birner P, Kelley MR
International journal of oncology 2001 Oct;19(4):799-802
International journal of oncology 2001 Oct;19(4):799-802
DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance.
Schindl M, Oberhuber G, Pichlbauer EG, Obermair A, Birner P, Kelley MR
International journal of oncology 2001 Oct;19(4):799-802
International journal of oncology 2001 Oct;19(4):799-802
Histology-specific expression of a DNA repair protein in pediatric rhabdomyosarcomas.
Thomson B, Tritt R, Davis M, Kelley MR
Journal of pediatric hematology/oncology 2001 May;23(4):234-9
Journal of pediatric hematology/oncology 2001 May;23(4):234-9
Histology-specific expression of a DNA repair protein in pediatric rhabdomyosarcomas.
Thomson B, Tritt R, Davis M, Kelley MR
Journal of pediatric hematology/oncology 2001 May;23(4):234-9
Journal of pediatric hematology/oncology 2001 May;23(4):234-9
Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.
Robertson KA, Bullock HA, Xu Y, Tritt R, Zimmerman E, Ulbright TM, Foster RS, Einhorn LH, Kelley MR
Cancer research 2001 Mar 1;61(5):2220-5
Cancer research 2001 Mar 1;61(5):2220-5
Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer.
Kelley MR, Cheng L, Foster R, Tritt R, Jiang J, Broshears J, Koch M
Clinical cancer research : an official journal of the American Association for Cancer Research 2001 Apr;7(4):824-30
Clinical cancer research : an official journal of the American Association for Cancer Research 2001 Apr;7(4):824-30
A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA.
Chou KM, Kukhanova M, Cheng YC
The Journal of biological chemistry 2000 Oct 6;275(40):31009-15
The Journal of biological chemistry 2000 Oct 6;275(40):31009-15
Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors.
Thomson BG, Tritt R, Davis M, Perlman EJ, Kelley MR
Anticancer research 2000 Nov-Dec;20(6B):4153-7
Anticancer research 2000 Nov-Dec;20(6B):4153-7
Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers.
Moore DH, Michael H, Tritt R, Parsons SH, Kelley MR
Clinical cancer research : an official journal of the American Association for Cancer Research 2000 Feb;6(2):602-9
Clinical cancer research : an official journal of the American Association for Cancer Research 2000 Feb;6(2):602-9
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Simple Western: APE Antibody (13B8E5C2) [NB100-116] - Image shows a specific band for APE1 in 0.1 mg/mL of HeLa lysate. This experiment was performed under reducing conditions using the 12-230kDa separation system. * Non-specific interaction with the 230 kDa Simple Western standard may be seen with this antibody.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: APE Antibody (13B8E5C2) [NB100-116] - Ovarian Cancer cell lines.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: APE Antibody (13B8E5C2) [NB100-116] - Whole cell protein from human HeLa, A431, mouse Neuro2A and rat PC12 cells was separated on a 12% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2.0 ug/mL anti-APE-1 in block buffer and detected with an anti-mouse HRP secondary antibody using chemiluminescence.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: APE Antibody (13B8E5C2) [NB100-116] - APE1 antibody was tested in human breast cancer xenograft using DAB with hematoxylin counterstain.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: APE Antibody (13B8E5C2) [NB100-116] - Immunohistochemical staining of APE1. A. Nuclear staining in the luminal epithelium of normal breast ducts and lobules. B. Low, and C. high nuclear APE1 expression in invasive breast cancer. (magnification x400). Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0099528) licensed under a CC-BY licence.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Chromatin Immunoprecipitation (ChIP): APE Antibody (13B8E5C2) [NB100-116] - Association of p53 and APE1 on p53-binding sites in p21 promoter. Re-ChIP analysis (first IP with alpha-APE1 and the second IP with alpha-p53 antibody) showing simultaneous recruitment of APE1 and p53 in control vs. EPE treated cells; *: p value
