27458-1-AP

antibody from Proteintech Group

Targeting: NLRP3 AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCU, MWS, NALP3, PYPAF1

Provider product page for 27458-1-AP

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [44]
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Product number: 27458-1-AP - Provider product page
Provider: Proteintech Group
Product name: NLRP3 antibody
Antibody type: Polyclonal
Description: NLRP3 antibody (Cat. #27458-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

NLRP3 protein structure - 27458-1-AP shown in red.

Submitted references Astragaloside IV attenuates renal tubule injury in DKD rats via suppression of CD36-mediated NLRP3 inflammasome activation.

Li X, Dong X, Zhang L, Zhang S, Huang W, Wang C, Huo Z, Li X, Zhang X, Jia X, Chen G, Kuang B
Frontiers in pharmacology 2024;15:1285797

Reversal of cholestatic liver disease by the inhibition of sphingosine 1-phosphate receptor 2 signaling.

Cao H, Chen L, Zeng Z, Wu X, Lei Y, Jia W, Yue G, Yi B, Li YJ, Shi Y
PeerJ 2024;12:e16744

Quercetin Ameliorates Cognitive Impairment in Depression by Targeting HSP90 to Inhibit NLRP3 Inflammasome Activation.

Du L, Fan X, Yang Y, Wu S, Liu Y
Molecular neurobiology 2024 Sep;61(9):6628-6641

Pellino1 orchestrates gut-kidney axis to perpetuate septic acute kidney injury through activation of STING pathway and NLRP3 inflammasome.

Jia Y, Zhu G, Qiu C, Lai JM, Shen Y, Jin SW, Yang X, Zhu HP, Hu BC, Ye XM, Mo SJ
Life sciences 2024 May 15;345:122604

Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway.

Che J, Wang H, Dong J, Wu Y, Zhang H, Fu L, Zhang J
CNS neuroscience & therapeutics 2024 Mar;30(3):e14454

Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway.

Li G, Liu X, Sun X, Huang L, Kuang W, Ou J, Zhang J, Zhang Z, Li H, Tang H, Feng C, Gu L, Yang C, Peili W, Wang J
Environment international 2024 Mar;185:108543

Riboflavin Attenuates Fluoride-Induced Testicular Injury via Interleukin 17A-Mediated Classical Pyroptosis.

Li X, Yang J, Luo H, Qiao Y, Zhao L, Cheng C, Fu W, Tan Y, Wang J, Liang C, Zhang J
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6143-6154

Triclosan induces liver injury in long-life exposed mice via activation of TLR4/NF-κB/NLRP3 pathway.

Peng Y, Cui H, Shu C, Wei Z, Ni X, Liu J
Ecotoxicology and environmental safety 2024 Mar 15;273:116115

A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis.

Wang D, Zhang L, He D, Zhang Y, Zhao L, Miao Z, Cheng W, Zhu C, Shao Y, Ge G, Zhu H, Jin H, Zhang W, Pan H
Materials today. Bio 2024 Jun;26:101081

Protective role of hydrogen sulfide against diabetic cardiomyopathy by inhibiting pyroptosis and myocardial fibrosis.

Liu M, Zeng C, Zhang Y, Xin Y, Deng S, Hu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116613

The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation.

Luo F, Li H, Ma W, Cao J, Chen Q, Lu F, Qiu M, Zhou P, Xia Z, Zeng K, Zhan J, Zhou T, Luo Q, Pan W, Zhang L, Lin C, Huang Y, Zhang L, Yang D, Zhao H
Cellular & molecular immunology 2024 Jan;21(1):60-79

Modified Guo-Min decoction ameliorates PM2.5-induced lung injury by inhibition of PI3K-AKT and MAPK signaling pathways.

Wang H, Wang G, Meng Y, Liu Y, Yao X, Feng C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155211

Gentianine alleviates dextran sulfate sodium-induced ulcerative colitis via inhibition of TLR4/NLRP3-mediated pyroptosis.

Li YX, Lv L, Li SL, Qian HH
International immunopharmacology 2024 Jan 5;126:111214

Monotropein induces autophagy through activation of the NRF2/PINK axis, thereby alleviating sepsis-induced colonic injury.

Qiang J, Yang R, Li X, Xu X, Zhou M, Ji X, Lu Y, Dong Z
International immunopharmacology 2024 Jan 25;127:111432

Dopamine Receptor 1 Treatment Promotes Epithelial Repair of Corneal Injury by Inhibiting NOD-Like Receptor Protein 3-Associated Inflammation.

Li L, Yu Y, Zhuang Z, Wu Q, Lin S, Hu J
Investigative ophthalmology & visual science 2024 Jan 2;65(1):49

Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.

Tang S, Lai N, Xu L
Brain research 2024 Jan 1;1822:148666

KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling.

Chen Y, Sun L, Liu H, Li J, Guo L, Wang Z
Immunity, inflammation and disease 2024 Feb;12(2):e1199

Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis.

Liu B, Xian Y, Chen X, Shi Y, Dong J, Yang L, An X, Shen T, Wu W, Ma Y, He Y, Gong W, Peng R, Lin J, Liu N, Guo B, Jiang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307338

Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor.

Huang HJ, Lee YH, Sung LC, Chen YJ, Chiu YJ, Chiu HW, Zheng CM
Computational and structural biotechnology journal 2023;21:3490-3502

DDX3X Deficiency Attenuates Pyroptosis Induced by Oxygen-glucose Deprivation/Reoxygenation in N2a Cells.

Liu Y, Gui Y, Tang H, Yu J, Yuan Z, Liu L, Ma X, Li C
Current neurovascular research 2023;20(2):197-206

Identification of core cuprotosis-correlated biomarkers in abdominal aortic aneurysm immune microenvironment based on bioinformatics.

Hu J, Xue S, Xu Z, Wu Z, Xu X, Wang X, Liu G, Lu X, Li B, Liu X
Frontiers in immunology 2023;14:1138126

Apelin-Overexpressing Neural Stem Cells in Conjunction with a Silk Fibroin Nanofiber Scaffold for the Treatment of Traumatic Brain Injury.

Li T, Tang Q, Xu J, Ye X, Chen K, Zhong J, Zhu J, Lu S, Zhu T
Stem cells and development 2023 Sep;32(17-18):539-553

Sodium thiosulfate ameliorates atopic dermatitis via inhibiting the activation of NLRP3 inflammasome.

Wang D, Liu Y, Zong X, Li X, Yang S, Zeng Y, Lu J
Biochemical and biophysical research communications 2023 Sep 17;673:160-168

Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis.

Kong X, Zhao Y, Wang X, Yu Y, Meng Y, Yan G, Yu M, Jiang L, Song W, Wang B, Wang X
Chemico-biological interactions 2023 Sep 1;382:110640

RORα overexpression reduced interleukin-33 expression and prevented mast cell degranulation and inflammation by inducing autophagy in allergic rhinitis.

Yu W, Du J, Peng L, Zhang T
Immunity, inflammation and disease 2023 Oct;11(10):e1017

Expression and significance of effector proteins NLRP3 and gasdermin D N-terminal protein in the pyrolysis pathway in breast cancer.

Wu L, Wu X, Liu J, Huang Y, Zhu Q
Medicine 2023 Oct 6;102(40):e35440

Lycium barbarum glycopeptide alleviates neuroinflammation in spinal cord injury via modulating docosahexaenoic acid to inhibiting MAPKs/NF-kB and pyroptosis pathways.

Jiang Z, Zeng Z, He H, Li M, Lan Y, Hui J, Bie P, Chen Y, Liu H, Fan H, Xia H
Journal of translational medicine 2023 Oct 31;21(1):770

Activation of NLRP3 Inflammasome via Drp1 Overexpression in Kupffer Cells Aggravates Ischemia-reperfusion Injury in Hepatic Steatosis.

Zhang L, Wang M, An R, Dai J, Liu S, Chen M, Ding H
Journal of clinical and translational hepatology 2023 Oct 28;11(5):1069-1078

Salvianolic acid B ameliorates retinal deficits in an early-stage Alzheimer's disease mouse model through downregulating BACE1 and Aβ generation.

Wang MD, Zhang S, Liu XY, Wang PP, Zhu YF, Zhu JR, Lv CS, Li SY, Liu SF, Wen L
Acta pharmacologica Sinica 2023 Nov;44(11):2151-2168

TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice.

Gao Z, Lv H, Wang Y, Xie Y, Guan M, Xu Y
Molecular medicine (Cambridge, Mass.) 2023 Nov 27;29(1):160

Pulsatilla chinensis saponins improve SCFAs regulating GPR43-NLRP3 signaling pathway in the treatment of ulcerative colitis.

Li Z, Song Y, Xu W, Chen J, Zhou R, Yang M, Zhu G, Luo X, Ai Z, Liu Y, Su D
Journal of ethnopharmacology 2023 May 23;308:116215

Conditioned medium from bone marrow mesenchymal stem cells relieves spinal cord injury through suppression of Gal-3/NLRP3 and M1 microglia/macrophage polarization.

Wang Y, Wang X, Zou Z, Hu Y, Li S, Wang Y
Pathology, research and practice 2023 Mar;243:154331

Achyranthoside D attenuates chondrocyte loss and inflammation in osteoarthritis via targeted regulation of Wnt3a.

Xie W, Qi S, Dou L, Wang L, Wang X, Bi R, Li N, Zhang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154663

Prodigiosin improves acute lung injury in a rat model of rheumatoid arthritis via down-regulating the nuclear factor kappaB/nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 signaling pathway.

Chen P, Wu H, Bian T, Yang L, Jiang H
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2023 Feb;74(1)

Rutin ameliorates gout via reducing XOD activity, inhibiting ROS production and NLRP3 inflammasome activation in quail.

Wu H, Wang Y, Huang J, Li Y, Lin Z, Zhang B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114175

Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells.

Wan Y, Yu Y, Yu C, Luo J, Wen S, Shen L, Wei G, Hua Y
Renal failure 2023 Dec;45(1):2221138

Baicalin Weakens the Porcine ExPEC-Induced Inflammatory Response in 3D4/21 Cells by Inhibiting the Expression of NF-κB/MAPK Signaling Pathways and Reducing NLRP3 Inflammasome Activation.

Zong B, Xiao Y, Ren M, Wang P, Fu S, Qiu Y
Microorganisms 2023 Aug 21;11(8)

USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.

Shi S, Pan X, Chen M, Zhang L, Zhang S, Wang X, Shi S, Chen Z, Lin W, Jiang Y
Hepatology communications 2023 Aug 1;7(8)

Knockdown of the long non‑coding RNA MALAT1 ameliorates TNF‑α‑mediated endothelial cell pyroptosis via the miR‑30c‑5p/Cx43 axis.

Yang ZJ, Liu R, Han XJ, Qiu CL, Dong GL, Liu ZQ, Liu LH, Luo Y, Jiang LP
Molecular medicine reports 2023 Apr;27(4)

Exosomes Derived from Endothelial Cells Inhibit Neointimal Hyperplasia Induced by Carotid Artery Injury in Rats via ROS-NLRP3 Inflammasome Pathway.

Yang SY, Deng WW, Zhao RZ, Long XP, Wang DM, Guo HH, Jiang LX, Chen WM, Shi B
Bulletin of experimental biology and medicine 2023 Apr;174(6):762-767

Epimedium Aqueous Extract Ameliorates Cerebral Ischemia/Reperfusion Injury through Inhibiting ROS/NLRP3-Mediated Pyroptosis.

Wu X, Wei J, Yi Y, Shu G, He Z, Gong Q, Gao J
Antioxidants (Basel, Switzerland) 2023 Apr 25;12(5)

Overnutrition-induced gout: An immune response to NLRP3 inflammasome dysregulation by XOD activity increased in quail.

Wu H, Wang Y, Ren Z, Li Y, Huang J, Lin Z, Zhang B
Frontiers in immunology 2022;13:1074867

Modified Baihu decoction therapeutically remodels gut microbiota to inhibit acute gouty arthritis.

Wang X, Long H, Chen M, Zhou Z, Wu Q, Xu S, Li G, Lu Z
Frontiers in physiology 2022;13:1023453

Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.

He W, Ye S, Zeng C, Xue S, Hu X, Zhang X, Gao S, Xiong Y, He X, Vivalda S, Li L, Wang Y, Ye Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR

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