NLRP3

gene product
AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCU, MWS, NALP3, PYPAF1
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]
More gene data

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710 antibodies from 41 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
54 antibodies
antibodies-online
240 antibodies
R&D Systems
13 antibodies
Boster Biological Technology
3 antibodies
Enzo Life Sciences
2 antibodies
NSJ Bioreagents
5 antibodies
Biorbyt
57 antibodies
Proteintech Group
1 antibody
NovoPro Bioscience Inc.
5 antibodies
Affinity Biosciences
4 antibodies
Atlas Antibodies
2 antibodies
Invitrogen Antibodies
7 antibodies
GeneTex
9 antibodies
Acris Antibodies GmbH
10 antibodies
Aviva Systems Biology
7 antibodies
Arigo
2 antibodies
LifeSpan BioSciences, Inc.
73 antibodies
Abgent
7 antibodies
OriGene
9 antibodies
Abnova Corporation
11 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
St John's Laboratory
9 antibodies
Antibodies.com
2 antibodies
Cell Signaling Technology, Inc
2 antibodies
ProSci
8 antibodies
Sigma-Aldrich
2 antibodies
RabMAbs
5 antibodies
Everest Biotech
3 antibodies
RayBiotech, Inc.
4 antibodies
United States Biological
95 antibodies
MyBioSource
19 antibodies
Miltenyi Biotec
4 antibodies
Creative Biolabs
5 antibodies
Abbexa
7 antibodies
Abbiotec
1 antibody
Signalway Antibody LLC
1 antibody
Creative Diagnostics
4 antibodies
EMD Millipore
2 antibodies
GenWay
2 antibodies
Rockland Immunochemicals, Inc.
1 antibody