HPA012878

antibody from Atlas Antibodies

Targeting: NLRP3 AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCU, MWS, NALP3, PYPAF1

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA012878

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA012878, RRID:AB_1846752

Product name

Anti-NLRP3

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human NLRP3, Gene description: NLR family, pyrin domain containing 3, Alternative Gene Names: AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCU, MWS, NALP3, PYPAF1, Validated applications: IHC, Uniprot ID: Q96P20, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.1 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Increased inflammasome protein expression identified in microglia from postmortem brains with schizophrenia

Gober R, Dallmeier J, Davis D, Brzostowicki D, de Rivero Vaccari J, Cyr B, Barreda A, Sun X, Gultekin S, Garamszegi S, Scott W, Vontell R
Journal of Neuropathology & Experimental Neurology 2024;83(11):951-966

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Lipopolysaccharide (LPS) stimulation of Pancreatic Ductal Adenocarcinoma (PDAC) and macrophages activates the NLRP3 inflammasome that influences the levels of pro-inflammatory cytokines in a co-culture model

Sivam H, Chin B, Gan S, Ng J, Gwenhure A, Chan E
Cancer Biology & Therapy 2023;24(1)

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PLK1 inhibition dampens NLRP3 inflammasome–elicited response in inflammatory disease models

Baldrighi M, Doreth C, Li Y, Zhao X, Warner E, Chenoweth H, Kishore K, Umrania Y, Minde D, Thome S, Yu X, Lu Y, Knapton A, Harrison J, Clarke M, Latz E, de Cárcer G, Malumbres M, Ryffel B, Bryant C, Liu J, Lilley K, Mallat Z, Li X
Journal of Clinical Investigation 2023;133(21)

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NLRP3 in tumor-associated macrophages predicts a poor prognosis and promotes tumor growth in head and neck squamous cell carcinoma

Chen L, Wan S, Mao L, Huang C, Bu L, Sun Z
Cancer Immunology, Immunotherapy 2022;72(6):1647-1660

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Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells

Wu R, Högberg J, Adner M, Ramos-Ramírez P, Stenius U, Zheng H
Particle and Fibre Toxicology 2020;17(1)

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Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro

Gritsenko A, Yu S, Martin-Sanchez F, Diaz-del-Olmo I, Nichols E, Davis D, Brough D, Lopez-Castejon G
Frontiers in Immunology 2020;11

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NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

Ershaid N, Sharon Y, Doron H, Raz Y, Shani O, Cohen N, Monteran L, Leider-Trejo L, Ben-Shmuel A, Yassin M, Gerlic M, Ben-Baruch A, Pasmanik-Chor M, Apte R, Erez N
Nature Communications 2019;10(1)

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Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration

Kosmidou C, Efstathiou N, Hoang M, Notomi S, Konstantinou E, Hirano M, Takahashi K, Maidana D, Tsoka P, Young L, Gragoudas E, Olsen T, Morizane Y, Miller J, Vavvas D
Scientific Reports 2018;8(1)

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Regulation of epithelial injury and bile duct obstruction by NLRP3, IL-1R1 in experimental biliary atresia

Yang L, Mizuochi T, Shivakumar P, Mourya R, Luo Z, Gutta S, Bezerra J
Journal of Hepatology 2018;69(5):1136-1144

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MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

Li X, Thome S, Ma X, Amrute-Nayak M, Finigan A, Kitt L, Masters L, James J, Shi Y, Meng G, Mallat Z
Nature Communications 2017;8(1)

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Hypoxia primes human normal prostate epithelial cells and cancer cell lines for the NLRP3 and AIM2 inflammasome activation

Panchanathan R, Liu H, Choubey D
Oncotarget 2016;7(19):28183-28194

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NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

Paramel Varghese G, Folkersen L, Strawbridge R, Halvorsen B, Yndestad A, Ranheim T, Krohg‐Sørensen K, Skjelland M, Espevik T, Aukrust P, Lengquist M, Hedin U, Jansson J, Fransén K, Hansson G, Eriksson P, Sirsjö A
Journal of the American Heart Association 2016;5(5)

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Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells

Panchanathan R, Liu H, Leung Y, Ho S, Choubey D
Molecular and Cellular Endocrinology 2015;415

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Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages

L'homme L, Esser N, Riva L, Scheen A, Paquot N, Piette J, Legrand-Poels S
Journal of Lipid Research 2013;54(11):2998-3008

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Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production

Haneklaus M, Gerlic M, Kurowska-Stolarska M, Rainey A, Pich D, McInnes I, Hammerschmidt W, O’Neill L, Masters S
The Journal of Immunology 2012;189(8):3795-3799

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Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

Unutmaz D, Saïd-Sadier N, Padilla E, Langsley G, Ojcius D
PLoS ONE 2010;5(4):e10008

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Chlamydial infection of monocytes stimulates IL-1β secretion through activation of the NLRP3 inflammasome

Abdul-Sater A, Saïd-Sadier N, Padilla E, Ojcius D
Microbes and Infection 2010;12(8-9):652-661

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Inflammasome-dependent Caspase-1 Activation in Cervical Epithelial Cells Stimulates Growth of the Intracellular Pathogen Chlamydia trachomatis

Abdul-Sater A, Koo E, Häcker G, Ojcius D
Journal of Biological Chemistry 2009;284(39):26789-26796