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antibody from Novus Biologicals
Targeting: NLRP3
AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCU, MWS, NALP3, PYPAF1
Western blot
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Immunohistochemistry [4]
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- Product number
- NBP1-90207 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-90207, RRID:AB_11026693
- Product name
- Rabbit Polyclonal NLRP3/NALP3 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human NLRP3/NALP3 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Comparison of Inhibitory Capacities of 6-, 8- and 10-Gingerols/Shogaols on the Canonical NLRP3 Inflammasome-Mediated IL-1β Secretion.
Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages.
Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production.
Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome.
Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.
Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.
Ho SC, Chang YH
Molecules (Basel, Switzerland) 2018 Feb 21;23(2)
Molecules (Basel, Switzerland) 2018 Feb 21;23(2)
Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages.
L'homme L, Esser N, Riva L, Scheen A, Paquot N, Piette J, Legrand-Poels S
Journal of lipid research 2013 Nov;54(11):2998-3008
Journal of lipid research 2013 Nov;54(11):2998-3008
Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production.
Haneklaus M, Gerlic M, Kurowska-Stolarska M, Rainey AA, Pich D, McInnes IB, Hammerschmidt W, O'Neill LA, Masters SL
Journal of immunology (Baltimore, Md. : 1950) 2012 Oct 15;189(8):3795-9
Journal of immunology (Baltimore, Md. : 1950) 2012 Oct 15;189(8):3795-9
Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome.
Abdul-Sater AA, Saïd-Sadier N, Padilla EV, Ojcius DM
Microbes and infection 2010 Aug;12(8-9):652-661
Microbes and infection 2010 Aug;12(8-9):652-661
Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.
Saïd-Sadier N, Padilla E, Langsley G, Ojcius DM
PloS one 2010 Apr 2;5(4):e10008
PloS one 2010 Apr 2;5(4):e10008
Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.
Abdul-Sater AA, Koo E, Häcker G, Ojcius DM
The Journal of biological chemistry 2009 Sep 25;284(39):26789-96
The Journal of biological chemistry 2009 Sep 25;284(39):26789-96
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: NLRP3/NALP3 Antibody [NBP1-90207] - Staining of human lung shows moderate cytoplasmic positivity in macrophages.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: NLRP3/NALP3 Antibody [NBP1-90207] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: NLRP3/NALP3 Antibody [NBP1-90207] - Staining of human spleen shows cytoplasmic positivity in lymphoid cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: NLRP3/NALP3 Antibody [NBP1-90207] - Staining of human tonsil shows moderate cytoplasmic positivity in non - germinal center cells.
