12335-1-AP

antibody from Proteintech Group

Targeting: CXCL1 FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1

Provider product page for 12335-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [51]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 12335-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12335-1-AP, RRID:AB_2087568
Product name: CXCL1 antibody
Antibody type: Polyclonal
Description: KD/KO validated CXCL1 antibody (Cat. #12335-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CXCL1 protein structure - 12335-1-AP shown in red.

Submitted references Identification of potential biomarkers of gout through weighted gene correlation network analysis.

Wang X, Yang B, Xiong T, Qiu Y, Qin Y, Liang X, Lu D, Yang X
Frontiers in immunology 2024;15:1367019

CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1-CXCR2 induced NETs.

Xiong G, Chen Z, Liu Q, Peng F, Zhang C, Cheng M, Ling R, Chen S, Liang Y, Chen D, Zhou Q
Journal for immunotherapy of cancer 2024 May 9;12(5)

Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.

Li R, Xiong Z, Ma Y, Li Y, Yang Y, Ma S, Ha C
World journal of surgical oncology 2024 Mar 21;22(1):81

TREM-1 mediates interaction between substantia nigra microglia and peripheral neutrophils.

Shen T, Cui G, Chen H, Huang L, Song W, Zu J, Zhang W, Xu C, Dong L, Zhang Y
Neural regeneration research 2024 Jun 1;19(6):1375-1384

Integrin β1-rich extracellular vesicles of kidney recruit Fn1+ macrophages to aggravate ischemia-reperfusion-induced inflammation.

Wang W, Ren X, Chen X, Hong Q, Cai G
JCI insight 2024 Jan 23;9(2)

Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy.

Yu H, Liu J, Bu X, Ma Z, Yao Y, Li J, Zhang T, Song W, Xiao X, Sun Y, Xiong W, Shi J, Dai P, Xiang B, Duan H, Yan X, Wu F, Zhang WC, Lin D, Hu H, Zhang H, Slack FJ, He HH, Freeman GJ, Wei W, Zhang J
Cell chemical biology 2024 Apr 18;31(4):776-791.e7

Electroacupuncture alleviates ulcerative colitis by targeting CXCL1: evidence from the transcriptome and validation.

Zhang RB, Dong LC, Shen Y, Li HY, Huang Q, Yu SG, Wu QF
Frontiers in immunology 2023;14:1187574

Single-cell transcriptomes reveal a molecular link between diabetic kidney and retinal lesions.

Xu Y, Xiang Z, E W, Lang Y, Huang S, Qin W, Yang J, Chen Z, Liu Z
Communications biology 2023 Sep 5;6(1):912

Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer.

Yang X, Chen X, Zhang S, Fan W, Zhong C, Liu T, Cheng G, Zhu L, Liu Q, Xi Y, Tan W, Lin D, Wu C
Cell reports 2023 Oct 31;42(10):113270

Single-cell analysis reveals immune cellular components in odontogenic keratocysts.

Man QW, Li RF, Liu JF, Zhao Y, Liu B
Oral diseases 2023 Nov;29(8):3420-3432

Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling.

Zheng Y, Wang N, Wang S, Zhang J, Yang B, Wang Z
Journal of experimental & clinical cancer research : CR 2023 May 20;42(1):129

Macrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.

Ye S, Huang H, Xiao Y, Han X, Shi F, Luo W, Chen J, Ye Y, Zhao X, Huang W, Wang Y, Lai D, Liang G, Fu G
Cellular and molecular life sciences : CMLS 2023 Jun 20;80(7):184

Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion.

Huang X, Guo M, Zhang Y, Xie J, Huang R, Zuo Z, Saw PE, Cao M
Glia 2023 Jul;71(7):1607-1625

IL4I1-catalyzed tryptophan metabolites mediate the anti-inflammatory function of cytokine-primed human muscle stem cells.

Zuo M, Fang J, Huang P, Liu S, Hou P, Wang S, Liu Z, Feng C, Cao L, Li P, Shi Y, Shao C
Cell death discovery 2023 Jul 28;9(1):269

PUFAs add fuel to Crohn's disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation.

Wen W, Xu Y, Qian W, Huang L, Gong J, Li Y, Zhu W, Guo Z
Gut microbes 2023 Dec;15(2):2265578

ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells.

Wang M, Wang W, You S, Hou Z, Ji M, Xue N, Du T, Chen X, Jin J
Acta pharmaceutica Sinica. B 2023 Dec;13(12):4733-4747

Regorafenib prevents the development of emphysema in a murine elastase model.

Oh K, Lee GW, Kim HB, Park JH, Shin EY, Kim EG
BMB reports 2023 Aug;56(8):439-444

Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis.

Chen T, Zhang X, Ding X, Feng J, Zhang X, Xie D, Wang X
Molecular oncology 2023 Apr;17(4):695-709

CXCR2 signaling might have a tumor-suppressive role in patients with cholangiocarcinoma.

Yamamoto Y, Sugimoto A, Maruo K, Tsujio G, Sera T, Kushiyama S, Nishimura S, Kuroda K, Togano S, Eguchi S, Tanaka R, Kimura K, Amano R, Ohira M, Yashiro M
PloS one 2022;17(4):e0266027

The Infiltration of Neutrophil Granulocytes Due to Loss of PTEN Was Associated with Poor Response to Immunotherapy in Renal Cell Carcinoma.

Wu F, Chen J, Yao K, Fan D, Wang M, Liu Y, Xin S, Sun Z, Li S, Sun Y, Liu Q
Journal of inflammation research 2022;15:6553-6567

Ethanol promoting the upregulation of C-X-C Motif Chemokine Ligand 1（CXCL1） and C-X-C Motif Chemokine Ligand 6（CXCL6） in models of early alcoholic liver disease.

Jiang Y, Xi Y, Li Y, Zuo Z, Zeng C, Fan J, Zhang D, Tao H, Guo Y
Bioengineered 2022 Mar;13(3):4688-4701

PAD4 controls chemoattractant production and neutrophil trafficking in malaria.

Cela D, Knackstedt SL, Groves S, Rice CM, Kwon JTW, Mordmüller B, Amulic B
Journal of leukocyte biology 2022 Jun;111(6):1235-1242

Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.

Wizenty J, Müllerke S, Kolesnichenko M, Heuberger J, Lin M, Fischer AS, Mollenkopf HJ, Berger H, Tacke F, Sigal M
The EMBO journal 2022 Jul 4;41(13):e109996

Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease.

Chen JA, Ma H, Liu Z, Tian J, Lu S, Fang W, Ze S, Lu W, Xie Q, Huang J, Wang Y
Journal of medicinal chemistry 2022 Jan 13;65(1):592-615

Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging.

Chen J, Fan ZX, Zhu DC, Guo YL, Ye K, Dai D, Guo Z, Hu ZQ, Miao Y, Qu Q
Frontiers in cell and developmental biology 2021;9:728188

The CXCL1-CXCR2 Axis Mediates Tubular Injury in Diabetic Nephropathy Through the Regulation of the Inflammatory Response.

Tang H, Yang M, Liu Y, Liu H, Sun L, Song P
Frontiers in physiology 2021;12:782677

Aiduqing formula suppresses breast cancer metastasis via inhibiting CXCL1-mediated autophagy.

Yang B, Peng F, Zhang Y, Wang X, Wang S, Zheng Y, Zhang J, Zeng Y, Wang N, Peng C, Wang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Sep;90:153628

Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.

Yuan SJ, Wang C, Xu HZ, Liu Y, Zheng MY, Li K, Sun SK, Komatsu N, Zhao L, Chen X
International journal of pharmaceutics 2021 Sep 5;606:120872

Oral microbiota affects the efficacy and prognosis of radiotherapy for colorectal cancer in mouse models.

Dong J, Li Y, Xiao H, Zhang S, Wang B, Wang H, Li Y, Fan S, Cui M
Cell reports 2021 Oct 26;37(4):109886

Treatment of severe pneumonia by hinokitiol in a murine antimicrobial-resistant pneumococcal pneumonia model.

Isono T, Domon H, Nagai K, Maekawa T, Tamura H, Hiyoshi T, Yanagihara K, Kunitomo E, Takenaka S, Noiri Y, Terao Y
PloS one 2020;15(10):e0240329

Low-Dose Radiation Promotes Invasion and Migration of A549 Cells by Activating the CXCL1/NF-κB Signaling Pathway.

Li J, Wu DM, Han R, Yu Y, Deng SH, Liu T, Zhang T, Xu Y
OncoTargets and therapy 2020;13:3619-3629

The P72R Polymorphism in R248Q/W p53 Mutants Modifies the Mutant Effect on Epithelial to Mesenchymal Transition Phenotype and Cell Invasion via CXCL1 Expression.

De Souza C, Madden JA, Minn D, Kumar VE, Montoya DJ, Nambiar R, Zhu Z, Xiao WW, Tahmassebi N, Kathi H, Nelson N, Karnezis AN, Chien J
International journal of molecular sciences 2020 Oct 28;21(21)

CXCL1 as an Unfavorable Prognosis Factor Negatively Regulated by DACH1 in Non-small Cell Lung Cancer.

Yu S, Yi M, Xu L, Qin S, Li A, Wu K
Frontiers in oncology 2019;9:1515

Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain.

Chen WC, Chang LH, Huang SS, Huang YJ, Chih CL, Kuo HC, Lee YH, Lee IH
Journal of neuroinflammation 2019 Oct 12;16(1):187

Unsaturated Aldehyde Acrolein Promotes Retinal Glial Cell Migration.

Murata M, Noda K, Yoshida S, Saito M, Fujiya A, Kanda A, Ishida S
Investigative ophthalmology & visual science 2019 Oct 1;60(13):4425-4435

Nur77 limits endothelial barrier disruption to LPS in the mouse lung.

Zhu N, Zhang GX, Yi B, Guo ZF, Jang S, Yin Y, Yang F, Summer R, Sun J
American journal of physiology. Lung cellular and molecular physiology 2019 Nov 1;317(5):L615-L624

Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer.

Zhang R, Qi F, Zhao F, Li G, Shao S, Zhang X, Yuan L, Feng Y
Cell death & disease 2019 Mar 20;10(4):273

The antagonist of CXCR1 and CXCR2 protects db/db mice from metabolic diseases through modulating inflammation.

Cui S, Qiao L, Yu S, Men L, Li Y, Li F, Du J
American journal of physiology. Endocrinology and metabolism 2019 Dec 1;317(6):E1205-E1217

Maresin1 regulates neutrophil recruitment and IL-10 expression in Aspergillus fumigatus keratitis.

Tang Q, Che C, Lin J, He H, Zhao W, Lv L, Zhao G
International immunopharmacology 2019 Apr;69:103-108

Metformin blocks myeloid-derived suppressor cell accumulation through AMPK-DACH1-CXCL1 axis.

Qin G, Lian J, Huang L, Zhao Q, Liu S, Zhang Z, Chen X, Yue D, Li L, Li F, Wang L, Umansky V, Zhang B, Yang S, Zhang Y
Oncoimmunology 2018;7(7):e1442167

Protective function of interleukin 27 in colitis-associated cancer via suppression of inflammatory cytokines in intestinal epithelial cells.

Cui B, Lu S, Lai L, Xie Y, He J, Xue Y, Xiao P, Pan T, Chen L, Liu Y, Cao X, Wang Q
Oncoimmunology 2017;6(2):e1268309

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.

Young HL, Rowling EJ, Bugatti M, Giurisato E, Luheshi N, Arozarena I, Acosta JC, Kamarashev J, Frederick DT, Cooper ZA, Reuben A, Gil J, Flaherty KT, Wargo JA, Vermi W, Smith MP, Wellbrock C, Hurlstone A
The Journal of experimental medicine 2017 Jun 5;214(6):1691-1710

SLC39A4 expression is associated with enhanced cell migration, cisplatin resistance, and poor survival in non-small cell lung cancer.

Wu DM, Liu T, Deng SH, Han R, Xu Y
Scientific reports 2017 Aug 3;7(1):7211

Activated human valvular interstitial cells sustain interleukin-17 production to recruit neutrophils in infective endocarditis.

Yeh CY, Shun CT, Kuo YM, Jung CJ, Hsieh SC, Chiu YL, Chen JW, Hsu RB, Yang CJ, Chia JS
Infection and immunity 2015 Jun;83(6):2202-12

Overexpression of Chemokine (C-X-C) ligand 1 (CXCL1) associated with tumor progression and poor prognosis in hepatocellular carcinoma.

Cao Z, Fu B, Deng B, Zeng Y, Wan X, Qu L
Cancer cell international 2014;14(1):86

Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo.

Grgic I, Hofmeister AF, Genovese G, Bernhardy AJ, Sun H, Maarouf OH, Bijol V, Pollak MR, Humphreys BD
Kidney international 2014 Dec;86(6):1116-29

IL-1 alpha regulates CXCL1, CXCL10 and ICAM1 in network form in oral keratinocytes.

Wu T, Du R, Hong Y, Jia L, Zeng Q, Cheng B
Clinical laboratory 2013;59(9-10):1105-11

Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity.

Jiao Y, Darzi Y, Tawaratsumida K, Marchesan JT, Hasegawa M, Moon H, Chen GY, Núñez G, Giannobile WV, Raes J, Inohara N
Cell host & microbe 2013 May 15;13(5):595-601

Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors.

Erez N, Glanz S, Raz Y, Avivi C, Barshack I
Biochemical and biophysical research communications 2013 Aug 2;437(3):397-402

CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy.

Sapoznik S, Ortenberg R, Galore-Haskel G, Kozlovski S, Levy D, Avivi C, Barshack I, Cohen CJ, Besser MJ, Schachter J, Markel G
Cancer immunology, immunotherapy : CII 2012 Oct;61(10):1833-47

Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses.

Peng W, Ye Y, Rabinovich BA, Liu C, Lou Y, Zhang M, Whittington M, Yang Y, Overwijk WW, Lizée G, Hwu P
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Nov 15;16(22):5458-68

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: COLO 320 cells were subjected to SDS PAGE followed by western blot with 12335-1-AP(CXCL1 antibody) at dilution of 1:300
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CXCL1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CXCL1. This antibody recognizes human, mouse antigen. The CXCL1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 12335-1-AP.pdf

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