CXCL1

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]

Description

C-X-C motif chemokine ligand 1

Protein family

Cancer-related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted secreted proteins, Protein evidence (Peptideatlas)

Chromosome

4:q13.3 (73869393 - 73871308)

Ensembl ID

ENSG00000163739  (ver. 99.38)

Orthologs

-

UniProt

P09341

neXtProt

NX_P09341

Human splice variants