HPR

This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]

Description

Haptoglobin-related protein

Tissue specificity

Tissue enriched (liver)

Subcell location

Vesicles

Predicted location

Intracellular, Secreted to blood

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (72063148 - 72077246)

Ensembl ID

ENSG00000261701  (ver. 103.38)

Orthologs

-

UniProt

P00739

neXtProt

NX_P00739

Human splice variants

Protein structure