Tissue expression
Cell line expression
Protein structure
TCL1A
TCL1 family AKT coactivator ATCL1
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]). [supplied by OMIM, Jul 2010]
Top validated antibodies |
|||||
Invitrogen Antibodies | 39-4800 | 2 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC |
|
Atlas Antibodies | HPA016604 | 2 references | Polyclonal |
WB
IHC |
|
NSJ Bioreagents | V7368 | Monoclonal |
WB
IHC
PA
OA |
||
Proteintech Group | 10475-1-AP | 1 references | Polyclonal |
WB
EL
IHC
|
|
Novus Biologicals | NBP1-43253-0.1mg | Monoclonal |
WB
IP
IHC
FC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider