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LearnTissue expression
Cell line expression
Protein structure
TCL1A
TCL1 family AKT coactivator ATCL1
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]). [supplied by OMIM, Jul 2010]
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| Invitrogen Antibodies |  39-4800 |
2 references | Monoclonal |
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| Atlas Antibodies | HPA016604 |
2 references | Polyclonal |
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| NSJ Bioreagents | V7368 |
Monoclonal |
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| Proteintech Group | 10475-1-AP |
1 references | Polyclonal |
WB
EL
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| Biorbyt | orb197799 |
Monoclonal |
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