Tissue expression
Cell line expression
Protein structure
DEPDC5
DEP domain containing 5, GATOR1 subcomplex subunitDEP.5, KIAA0645
This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Top validated antibodies |
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NovoPro Bioscience Inc. | 124098 | Polyclonal |
WB
EL
FC
|
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antibodies-online | ABIN951887 | 2 references | Polyclonal |
WB
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Abgent | AP12010b | Polyclonal |
WB
FC |
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Atlas Antibodies | HPA055619 | Polyclonal |
ICC
IHC |
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LSBio | LS-B9330 | Polyclonal |
WB
IHC |
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Supportive data in Antibodypedia
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Recommended by provider