- GTX104616 - GeneTex STAT3 antibody

Submitted references Anti-Metastatic Effects of Antrodan with and without Cisplatin on Lewis Lung Carcinomas in a Mouse Xenograft Model.

Chen PC, Chen CC, Ker YB, Chang CH, Chyau CC, Hu ML
International journal of molecular sciences 2018 May 24;19(6)

Galectin-1 Reduces Neuroinflammation via Modulation of Nitric Oxide-Arginase Signaling in HIV-1 Transfected Microglia: a Gold Nanoparticle-Galectin-1 "Nanoplex" a Possible Neurotherapeutic?

Aalinkeel R, Mangum CS, Abou-Jaoude E, Reynolds JL, Liu M, Sundquist K, Parikh NU, Chaves LD, Mammen MJ, Schwartz SA, Mahajan SD
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2017 Mar;12(1):133-151

Molecular mechanisms of the effects of the ethanolic extract of Muntingia calabura Linn. fruit on lipopolysaccharide-induced pro-inflammatory mediators in macrophages.

Lin JT, Chang YY, Chen YC, Shen BY, Yang DJ
Food & function 2017 Mar 22;8(3):1245-1253

Targeting of cell cycle and let-7a/STAT3 pathway by niclosamide inhibits proliferation, migration and invasion in oral squamous cell carcinoma cells.

Li X, Ding R, Han Z, Ma Z, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:434-442

The Synthetic β-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 Pathways.

Chiu WC, Lee YC, Su YH, Wang YY, Tsai CH, Hou YA, Wang CH, Huang YF, Huang CJ, Chou SH, Hsieh PW, Yuan SF
PloS one 2016;11(11):e0166453

Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation.

Hung AC, Lo S, Hou MF, Lee YC, Tsai CH, Chen YY, Liu W, Su YH, Lo YH, Wang CH, Wu SC, Hsieh YC, Hu SC, Tai MH, Wang YM, Yuan SS
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Sep 1;22(17):4478-90

MicroRNA miR-204 and miR-1236 inhibit hepatitis B virus replication via two different mechanisms.

Huang JY, Chen HL, Shih C
Scientific reports 2016 Oct 13;6:34740

PTPRD silencing by DNA hypermethylation decreases insulin receptor signaling and leads to type 2 diabetes.

Chen YT, Lin WD, Liao WL, Lin YJ, Chang JG, Tsai FJ
Oncotarget 2015 May 30;6(15):12997-3005

PTPRD silencing by DNA hypermethylation decreases insulin receptor signaling and leads to type 2 diabetes.

Chen YT, Lin WD, Liao WL, Lin YJ, Chang JG, Tsai FJ
Oncotarget 2015 May 30;6(15):12997-3005

Estrogen receptor α represses transcription of HBV genes via interaction with hepatocyte nuclear factor 4α.

Wang SH, Yeh SH, Lin WH, Yeh KH, Yuan Q, Xia NS, Chen DS, Chen PJ
Gastroenterology 2012 Apr;142(4):989-998.e4

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Enhanced validation

Submitted by: GeneTex (provider)
Enhanced method: Genetic validation
Main image
Experimental details: Non-transfected (¡V) and transfected (+) OC3 whole cell extracts (30 ?g) were separated by 7.5% SDS-PAGE, and the membrane was blotted with STAT3 antibody [C3], C-term (GTX104616) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
KD Reagent Type: siRNA
Downregulation: >50%
KD Reagent Prod page: KD Reagent Prod page
KD Reagent Prod no: Proprietary.
KD Reagent Provider: shRNA reagents was provided courtesy of cooperative labs.
Antibody Lot Number: 41983

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Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Sample (20 ?g of whole cell lysate) A: human ESC 7.5% SDS PAGE GTX104616 diluted at 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: STAT3 antibody [C3], C-term detects STAT3 protein by western blot analysis.A. 30 ?g NIH-3T3 whole cell lysate/extract B. 30 ?g BCL-1 whole cell lysate/extract7.5% SDS-PAGESTAT3 antibody [C3], C-term (GTX104616) dilution: 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: STAT3 antibody [C3], C-term detects STAT3 protein by western blot analysis.A. 30 ?g Rat2 whole cell lysate/extract7.5% SDS-PAGESTAT3 antibody [C3], C-term (GTX104616) dilution: 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Sample(30 ?g whole cell lysate)A: 293TB: A431 (GTX27909)C: H1299D: HeLa S3 (GTX14654)E: HepG2 (GTX27900)F: MOLT4 (GTX27912)7.5% SDS PAGEGTX104616 diluted at 1:1000The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Non-transfected (¡V) and transfected (+) OC3 whole cell extracts (30 ?g) were separated by 7.5% SDS-PAGE, and the membrane was blotted with STAT3 antibody [C3], C-term (GTX104616) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Wild-type (WT) and STAT3 knockout (KO) HeLa cell extracts (30 ?g) were separated by 7.5% SDS-PAGE, and the membrane was blotted with STAT3 antibody [C3], C-term (GTX104616) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Wild-type (WT) and STAT3 knockout (KO) HeLa cell extracts (30 ?g) were separated by 7.5% SDS-PAGE, and the membrane was blotted with STAT3 antibody [C3], C-term (GTX104616) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using STAT3(GTX104616) antibody at 1:200 dilution.

GTX104616

Antibody data