STAT3

gene product
APRF
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
2308 antibodies from 50 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Invitrogen Antibodies
32 antibodies
Novus Biologicals
56 antibodies
Cell Signaling Technology, Inc
34 antibodies
GeneTex
29 antibodies
R&D Systems
15 antibodies
Abnova Corporation
28 antibodies
Acris Antibodies GmbH
42 antibodies
NovoPro Bioscience Inc.
23 antibodies
Proteintech Group
3 antibodies
St John's Laboratory
26 antibodies
antibodies-online
805 antibodies
Atlas Antibodies
4 antibodies
Boster Biological Technology
9 antibodies
Affinity Biosciences
10 antibodies
Enzo Life Sciences
9 antibodies
Biorbyt
125 antibodies
Abgent
27 antibodies
Arigo
6 antibodies
OriGene
56 antibodies
LifeSpan BioSciences, Inc.
358 antibodies
Aviva Systems Biology
23 antibodies
NSJ Bioreagents
16 antibodies
Signalway Antibody LLC
5 antibodies
BioLegend
55 antibodies
Bioworld Technology, Inc
9 antibodies
ProSci
8 antibodies
Antibodies.com
2 antibodies
Rockland Immunochemicals, Inc.
6 antibodies
SignalChem
5 antibodies
Everest Biotech
2 antibodies
Creative Diagnostics
16 antibodies
Abbkine Scientific Co.Ltd.
11 antibodies
RabMAbs
14 antibodies
Abbexa
7 antibodies
Creative Biolabs
48 antibodies
Bethyl Laboratories
1 antibody
United States Biological
264 antibodies
MyBioSource
34 antibodies
FabGennix
6 antibodies
GenWay
12 antibodies
Miltenyi Biotec
6 antibodies
EMD Millipore
9 antibodies
Spring Bioscience
4 antibodies
Abbiotec
3 antibodies
RayBiotech, Inc.
6 antibodies
Abiocode, Inc.
1 antibody
Sigma-Aldrich
9 antibodies
Active Motif
2 antibodies
Exalpha Biologicals, Inc.
1 antibody