Antibody data
- Antibody Data
- Antigen structure
- References [71]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
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- Product number
- 60199-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60199-1-Ig, RRID:AB_10913811
- Product name
- STAT3 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated STAT3 antibody (Cat. #60199-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3G2D12
- Vial size
- 20ul, 150ul
Submitted references Vasorin promotes endothelial differentiation of glioma stem cells via stimulating the transcription of VEGFR2.
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.
Mechanic study based on untargeted metabolomics of Pi-pa-run-fei-tang on pepper combined with ammonia induced chronic cough model mice.
Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways.
Deep whole-genome analysis of 494 hepatocellular carcinomas.
RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
Interleukin-22 Contributes to Blood-Brain Barrier Disruption via STAT3/VEGFA Activation in Escherichia coli Meningitis.
Urocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway.
NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.
Microfluidic Organoid Cultures Derived from Pancreatic Cancer Biopsies for Personalized Testing of Chemotherapy and Immunotherapy.
Interleukin-6 trans-signaling regulates monocyte chemoattractant protein-1 production in immune-mediated necrotizing myopathy.
Sclareol attenuates liver fibrosis through SENP1-mediated VEGFR2 SUMOylation and inhibition of downstream STAT3 signaling.
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway.
STAT3 promotes differentiation of monocytes to MDSCs via CD39/CD73-adenosine signal pathway in oral squamous cell carcinoma.
Pan-cancer analysis of PCAT6 and its effect on oesophageal squamous cell carcinoma cell proliferation and migration.
Nifuroxazide Activates the Parthanatos to Overcome TMPRSS2:ERG Fusion-Positive Prostate Cancer.
LC-MS Analysis of Ginsenosides in Different Parts of Panax quinquefolius and Their Potential for Coronary Disease Improvement.
Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3-mediated ZO-1 expression.
5'-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I.
Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.
A Bioinspired Manganese-Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes.
A novel GRK2 inhibitor alleviates experimental arthritis through restraining Th17 cell differentiation.
Babao Dan Alleviates Cancer Cachexia in Mice Via Inhibiting IL-6/STAT3 Signaling Pathway.
POR overexpression induces tamoxifen-resistance in breast cancer through the STAT1/c-Myc pathway.
Aging-accelerated differential production and aggregation of STAT3 protein in neuronal cells and neural stem cells in the male mouse spinal cord.
Exosomal lncRNA HOTAIR induces PDL1(+) B cells to impede anti-tumor immunity in colorectal cancer.
miR-653-3p promotes genomic instability of colorectal cancer cells via targeting SIRT1/TWIST1 signaling pathway.
Pi-Pa-Run-Fei-Tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and Treg in murine model of OVA-induced asthma.
Fetal anemia and elevated hepcidin in a mouse model of fetal alcohol spectrum disorder.
Folate Deficiency Enhanced Inflammation and Exacerbated Renal Fibrosis in High-Fat High-Fructose Diet-Fed Mice.
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
Pathological Changes and Expression of JAK-STAT Signaling Pathway Hallmark Proteins in Rat Retinas at Different Time Points After Retinal Ischemia Reperfusion Injury.
Leptin activates the JAK/STAT pathway to promote angiogenesis in RF/6A cells in vitro.
YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.
Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway.
Comprehensive serum metabolomics and network analysis to reveal the mechanism of gypenosides in treating lung cancer and enhancing the pharmacological effects of cisplatin.
Anemoside B4 ameliorates experimental autoimmune encephalomyelitis in mice by modulating inflammatory responses and the gut microbiota.
Nicotinamide N-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE(2) Pathway.
Transcription factor NFE2L3 promotes the proliferation of esophageal squamous cell carcinoma cells and causes radiotherapy resistance by regulating IL-6.
Anemoside B4 protects against chronic relapsing colitis in mice by modulating inflammatory response, colonic transcriptome and the gut microbiota.
Identification of potential immunomodulators from Pulsatilla decoction that act on therapeutic targets for ulcerative colitis based on pharmacological activity, absorbed ingredients, and in-silico molecular docking.
Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.
Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells.
Mucin 16 Promotes Colorectal Cancer Development and Progression Through Activation of Janus Kinase 2.
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer.
PRRX1 promotes colorectal cancer stemness and chemoresistance via the JAK2/STAT3 axis by targeting IL-6.
Afatinib Reverses EMT via Inhibiting CD44-Stat3 Axis to Promote Radiosensitivity in Nasopharyngeal Carcinoma.
Exposure to short-chain chlorinated paraffins induces astrocyte activation via JAK2/STAT3 signaling pathway.
Intestinal Flora Changes Induced by a High-Fat Diet Promote Activation of Primordial Follicles through Macrophage Infiltration and Inflammatory Factor Secretion in Mouse Ovaries.
Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC.
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.
Elevated Serum FGG Levels Prognosticate and Promote the Disease Progression in Prostate Cancer.
Propofol inhibited gastric cancer proliferation via the hsa-miR-328-3p/STAT3 pathway.
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Noncanonical Wnt5a signaling regulates tendon stem/progenitor cells senescence.
Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells.
Uncovering the anti-NSCLC effects and mechanisms of gypenosides by metabolomics and network pharmacology analysis.
Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief.
CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling.
Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin.
Alcohol's Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status.
Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice.
Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways.
Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways.
Postoperative resveratrol administration improves prognosis of rat orthotopic glioblastomas.
CEP55 Promotes Cell Motility via JAK2⁻STAT3⁻MMPs Cascade in Hepatocellular Carcinoma.
Effect of modified Xiaochaihu decoction‑containing serum on HepG2.2.15 cells via the JAK2/STAT3 signaling pathway.
CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells.
Qin Z, Zhong Y, Li P, Ma Z, Kang H, Huang Y, Zhong Y, Wang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23682
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23682
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.
Kundu A, Ghosh P, Bishayi B
International immunopharmacology 2024 May 30;133:112153
International immunopharmacology 2024 May 30;133:112153
Mechanic study based on untargeted metabolomics of Pi-pa-run-fei-tang on pepper combined with ammonia induced chronic cough model mice.
Jie XL, Tong ZR, Xu XY, Wu JH, Jiang XL, Tao Y, Feng PS, Yu J, Lan JP, Wang P
Journal of ethnopharmacology 2024 May 23;326:117905
Journal of ethnopharmacology 2024 May 23;326:117905
Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways.
Yan Y, Bai S, Han H, Dai J, Niu L, Wang H, Dong Q, Yin H, Yuan G, Pan Y
Cell communication and signaling : CCS 2024 May 15;22(1):272
Cell communication and signaling : CCS 2024 May 15;22(1):272
Deep whole-genome analysis of 494 hepatocellular carcinomas.
Chen L, Zhang C, Xue R, Liu M, Bai J, Bao J, Wang Y, Jiang N, Li Z, Wang W, Wang R, Zheng B, Yang A, Hu J, Liu K, Shen S, Zhang Y, Bai M, Wang Y, Zhu Y, Yang S, Gao Q, Gu J, Gao D, Wang XW, Nakagawa H, Zhang N, Wu L, Rozen SG, Bai F, Wang H
Nature 2024 Mar;627(8004):586-593
Nature 2024 Mar;627(8004):586-593
RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
He S, Lu M, Zhang L, Wang Z
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):166996
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):166996
Interleukin-22 Contributes to Blood-Brain Barrier Disruption via STAT3/VEGFA Activation in Escherichia coli Meningitis.
Yang R, Chen J, Qu X, Liu H, Wang X, Tan C, Chen H, Wang X
ACS infectious diseases 2024 Mar 8;10(3):988-999
ACS infectious diseases 2024 Mar 8;10(3):988-999
Urocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway.
Guo X, Li Y, Chen X, Sun B, Guo X
Journal of cancer research and clinical oncology 2024 Mar 28;150(3):163
Journal of cancer research and clinical oncology 2024 Mar 28;150(3):163
NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
Hu H, Li B, Chen H, Fan G, Ye Z, Ji S, Yu X, Xu X, Qin Y
Molecular carcinogenesis 2024 Feb;63(2):195-208
Molecular carcinogenesis 2024 Feb;63(2):195-208
Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.
Ghosh R, Bishayi B
Microbial pathogenesis 2024 Feb;187:106518
Microbial pathogenesis 2024 Feb;187:106518
Microfluidic Organoid Cultures Derived from Pancreatic Cancer Biopsies for Personalized Testing of Chemotherapy and Immunotherapy.
Choi D, Gonzalez-Suarez AM, Dumbrava MG, Medlyn M, de Hoyos-Vega JM, Cichocki F, Miller JS, Ding L, Zhu M, Stybayeva G, Gaspar-Maia A, Billadeau DD, Ma WW, Revzin A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(5):e2303088
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(5):e2303088
Interleukin-6 trans-signaling regulates monocyte chemoattractant protein-1 production in immune-mediated necrotizing myopathy.
Ma X, Gao HJ, Ge HZ, Zhang Q, Bu BT
Rheumatology (Oxford, England) 2024 Feb 23;
Rheumatology (Oxford, England) 2024 Feb 23;
Sclareol attenuates liver fibrosis through SENP1-mediated VEGFR2 SUMOylation and inhibition of downstream STAT3 signaling.
Ge MX, Niu WX, Bao YY, Lu ZN, He HW
Phytotherapy research : PTR 2023 Sep;37(9):3898-3912
Phytotherapy research : PTR 2023 Sep;37(9):3898-3912
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway.
Li Y, Fan S, Kong L, Hao Z, Zhou Y, Shangguan J, Gao L, Wang M, Kang Y, Li X, Huang K, Zhang C, Liu Z
iScience 2023 Nov 17;26(11):108070
iScience 2023 Nov 17;26(11):108070
STAT3 promotes differentiation of monocytes to MDSCs via CD39/CD73-adenosine signal pathway in oral squamous cell carcinoma.
Cui H, Lan Z, Zou KL, Zhao YY, Yu GT
Cancer immunology, immunotherapy : CII 2023 May;72(5):1315-1326
Cancer immunology, immunotherapy : CII 2023 May;72(5):1315-1326
Pan-cancer analysis of PCAT6 and its effect on oesophageal squamous cell carcinoma cell proliferation and migration.
Luo Q, Kuang Y, Tao X, Zhu X, Zhao X, Lu G, Zhang W, Sun E, Chen B
Medical oncology (Northwood, London, England) 2023 Mar 22;40(4):125
Medical oncology (Northwood, London, England) 2023 Mar 22;40(4):125
Nifuroxazide Activates the Parthanatos to Overcome TMPRSS2:ERG Fusion-Positive Prostate Cancer.
Li C, Zhang J, Wu Q, Kumar A, Pan G, Kelvin DJ
Molecular cancer therapeutics 2023 Mar 2;22(3):306-316
Molecular cancer therapeutics 2023 Mar 2;22(3):306-316
LC-MS Analysis of Ginsenosides in Different Parts of Panax quinquefolius and Their Potential for Coronary Disease Improvement.
Zhang X, Kong C, Wang X, Hou H, Yu H, Wang L, Li P, Li X, Zhang Y, Han L, Liu K
Planta medica 2023 Jun;89(7):764-772
Planta medica 2023 Jun;89(7):764-772
Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3-mediated ZO-1 expression.
Yang F, Li L, Zhou Y, Pan W, Liang X, Huang L, Huang J, Cheng Y, Geng L, Xu W, Gong S
Clinical and experimental pharmacology & physiology 2023 Jun;50(6):516-526
Clinical and experimental pharmacology & physiology 2023 Jun;50(6):516-526
5'-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I.
Wu C, Liu D, Zhang L, Wang J, Ding Y, Sun Z, Wang W
Frontiers of medicine 2023 Jun;17(3):476-492
Frontiers of medicine 2023 Jun;17(3):476-492
Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.
Xian Z, Tian J, Zhao Y, Yi Y, Li C, Han J, Zhang Y, Wang Y, Wang L, Liu S, Pan C, Liu C, Wang D, Meng J, Tang X, Wang F, Liang A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154815
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154815
A Bioinspired Manganese-Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes.
Wang J, Wang Y, Xiaohalati X, Su Q, Liu J, Cai B, Yang W, Wang Z, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(20):e2206854
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(20):e2206854
A novel GRK2 inhibitor alleviates experimental arthritis through restraining Th17 cell differentiation.
Tao J, Jiang C, Guo P, Chen H, Zhu Z, Su T, Zhou W, Tai Y, Han C, Ma Y, Chen J, Sun W, Wang Y, Wei W, Wang Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:113997
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:113997
Babao Dan Alleviates Cancer Cachexia in Mice Via Inhibiting IL-6/STAT3 Signaling Pathway.
Qiu Z, Wo D, Zhong X, Chen J, Ma E, He J, Peng J, Zhu W, Ren DN
Integrative cancer therapies 2023 Jan-Dec;22:15347354231168369
Integrative cancer therapies 2023 Jan-Dec;22:15347354231168369
POR overexpression induces tamoxifen-resistance in breast cancer through the STAT1/c-Myc pathway.
Chen S, Wu D, Liu Q, Jin F, Yao F, Fang Y
Molecular carcinogenesis 2023 Feb;62(2):249-260
Molecular carcinogenesis 2023 Feb;62(2):249-260
Aging-accelerated differential production and aggregation of STAT3 protein in neuronal cells and neural stem cells in the male mouse spinal cord.
Zhao T, Liu C, Liu L, Wang X, Liu C
Biogerontology 2023 Feb;24(1):137-148
Biogerontology 2023 Feb;24(1):137-148
Exosomal lncRNA HOTAIR induces PDL1(+) B cells to impede anti-tumor immunity in colorectal cancer.
Xie Z, Xia J, Jiao M, Zhao P, Wang Z, Lin S, Xing Y, Li Y, Lu Z, Zhong Z, Miao C, Zhou P, Qian J, Wang L, Zhang D, Gu J, Chu Y, Liu R
Biochemical and biophysical research communications 2023 Feb 12;644:112-121
Biochemical and biophysical research communications 2023 Feb 12;644:112-121
miR-653-3p promotes genomic instability of colorectal cancer cells via targeting SIRT1/TWIST1 signaling pathway.
Wang H, Liang Y, Zhao L, Deng J, Li Y, Zhao H, Zhang X, Zou F
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166821
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166821
Pi-Pa-Run-Fei-Tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and Treg in murine model of OVA-induced asthma.
Jie XL, Luo ZR, Yu J, Tong ZR, Li QQ, Wu JH, Tao Y, Feng PS, Lan JP, Wang P
Journal of ethnopharmacology 2023 Dec 5;317:116719
Journal of ethnopharmacology 2023 Dec 5;317:116719
Fetal anemia and elevated hepcidin in a mouse model of fetal alcohol spectrum disorder.
Helfrich KK, Saini N, Kwan STC, Rivera OC, Mooney SM, Smith SM
Pediatric research 2023 Aug;94(2):503-511
Pediatric research 2023 Aug;94(2):503-511
Folate Deficiency Enhanced Inflammation and Exacerbated Renal Fibrosis in High-Fat High-Fructose Diet-Fed Mice.
Chan CW, Lin BF
Nutrients 2023 Aug 17;15(16)
Nutrients 2023 Aug 17;15(16)
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
Xu L, Cai J, Li C, Yang M, Duan T, Zhao Q, Xi Y, Sun L, He L, Tang C, Sun L
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):58
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):58
Pathological Changes and Expression of JAK-STAT Signaling Pathway Hallmark Proteins in Rat Retinas at Different Time Points After Retinal Ischemia Reperfusion Injury.
Wang S, Yu A, Han M, Chen X, Li Z, Ke M, Cai X, Ai M, Xing Y
Pathology oncology research : POR 2022;28:1610385
Pathology oncology research : POR 2022;28:1610385
Leptin activates the JAK/STAT pathway to promote angiogenesis in RF/6A cells in vitro.
Zhang L, Li R, Wu BH, Liang TT, Liu Z, Ju W, Wang Y, Wen YT, Liu MC, Du JH
International journal of ophthalmology 2022;15(4):554-559
International journal of ophthalmology 2022;15(4):554-559
YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.
Li Z, Teng M, Jiang Y, Zhang L, Luo X, Liao Y, Yang B
Frontiers in immunology 2022;13:857727
Frontiers in immunology 2022;13:857727
Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway.
Li Z, Geng J, Xie B, He J, Wang J, Peng L, Hu Y, Dai H, Wang C
Frontiers in pharmacology 2022;13:834604
Frontiers in pharmacology 2022;13:834604
Comprehensive serum metabolomics and network analysis to reveal the mechanism of gypenosides in treating lung cancer and enhancing the pharmacological effects of cisplatin.
Qi YS, Xiao MY, Xie P, Xie JB, Guo M, Li FF, Piao XL
Frontiers in pharmacology 2022;13:1070948
Frontiers in pharmacology 2022;13:1070948
Anemoside B4 ameliorates experimental autoimmune encephalomyelitis in mice by modulating inflammatory responses and the gut microbiota.
Zou M, Chen FJ, Deng LR, Han Q, Huang CY, Shen SS, Tomlinson B, Li YH
European journal of pharmacology 2022 Sep 15;931:175185
European journal of pharmacology 2022 Sep 15;931:175185
Nicotinamide N-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE(2) Pathway.
Yang C, Wang T, Zhu S, Zong Z, Luo C, Zhao Y, Liu J, Li T, Liu X, Liu C, Deng H
ACS omega 2022 Oct 25;7(42):37509-37519
ACS omega 2022 Oct 25;7(42):37509-37519
Transcription factor NFE2L3 promotes the proliferation of esophageal squamous cell carcinoma cells and causes radiotherapy resistance by regulating IL-6.
Chen T, Xu B, Chen H, Sun Y, Song J, Sun X, Zhang X, Hua W
Computer methods and programs in biomedicine 2022 Nov;226:107102
Computer methods and programs in biomedicine 2022 Nov;226:107102
Anemoside B4 protects against chronic relapsing colitis in mice by modulating inflammatory response, colonic transcriptome and the gut microbiota.
Han Q, Deng LR, Zou M, Tang HZ, Huang CY, Chen FJ, Tomlinson B, Li YH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Nov;106:154416
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Nov;106:154416
Identification of potential immunomodulators from Pulsatilla decoction that act on therapeutic targets for ulcerative colitis based on pharmacological activity, absorbed ingredients, and in-silico molecular docking.
Deng LR, Han Q, Zou M, Chen FJ, Huang CY, Zhong YM, Wu QY, Tomlinson B, Li YH
Chinese medicine 2022 Nov 24;17(1):132
Chinese medicine 2022 Nov 24;17(1):132
Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.
Huo Y, Yang J, Zheng J, Xu D, Yang M, Tao L, Yao H, Fu X, Yang J, Liu D, Hua R, Zhang J, Sun Y, Hu L, Liu W
Cell proliferation 2022 May;55(5):e13237
Cell proliferation 2022 May;55(5):e13237
Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells.
Fan LL, Du R, Liu JS, Jin JY, Wang CY, Dong Y, He WX, Yan RQ, Xiang R
Experimental & molecular medicine 2022 May;54(5):653-661
Experimental & molecular medicine 2022 May;54(5):653-661
Mucin 16 Promotes Colorectal Cancer Development and Progression Through Activation of Janus Kinase 2.
Liu Z, Gu Y, Li X, Zhou L, Cheng X, Jiang H, Huang Y, Zhang Y, Xu T, Yang W, Huang Q
Digestive diseases and sciences 2022 Jun;67(6):2195-2208
Digestive diseases and sciences 2022 Jun;67(6):2195-2208
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
Wang H, Ai J, Shopit A, Niu M, Ahmed N, Tesfaldet T, Tang Z, Li X, Jamalat Y, Chu P, Peng J, Ma X, Qaed E, Han G, Zhang W, Wang J, Tang Z
Cell biology and toxicology 2022 Jun;38(3):531-551
Cell biology and toxicology 2022 Jun;38(3):531-551
KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
Zhou Q, Gong J, Bi J, Yang X, Zhang L, Lu C, Li L, Chen M, Cai J, Yang R, Li X, Li Z, Wang X
The Journal of investigative dermatology 2022 Jul;142(7):2003-2013.e5
The Journal of investigative dermatology 2022 Jul;142(7):2003-2013.e5
PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer.
Wan D, Wang S, Xu Z, Zan X, Liu F, Han Y, Jiang M, Wu A, Zhi Q
Clinical and translational medicine 2022 Feb;12(2):e683
Clinical and translational medicine 2022 Feb;12(2):e683
PRRX1 promotes colorectal cancer stemness and chemoresistance via the JAK2/STAT3 axis by targeting IL-6.
Zhong L, Tan W, Yang Q, Zou Z, Zhou R, Huang Y, Qiu Z, Zheng K, Huang Z
Journal of gastrointestinal oncology 2022 Dec;13(6):2989-3008
Journal of gastrointestinal oncology 2022 Dec;13(6):2989-3008
Afatinib Reverses EMT via Inhibiting CD44-Stat3 Axis to Promote Radiosensitivity in Nasopharyngeal Carcinoma.
Huang H, Huang F, Liang X, Fu Y, Cheng Z, Huang Y, Chen Z, Duan Y, Chen Y
Pharmaceuticals (Basel, Switzerland) 2022 Dec 27;16(1)
Pharmaceuticals (Basel, Switzerland) 2022 Dec 27;16(1)
Exposure to short-chain chlorinated paraffins induces astrocyte activation via JAK2/STAT3 signaling pathway.
Ding W, Zhao Z, Zheng Y, Wang R, Zhang Z, Zhang Z, Wang X, Yu S, Liu L, Huang R, Zhao X, Wu Q
Ecotoxicology and environmental safety 2022 Dec 15;248:114268
Ecotoxicology and environmental safety 2022 Dec 15;248:114268
Intestinal Flora Changes Induced by a High-Fat Diet Promote Activation of Primordial Follicles through Macrophage Infiltration and Inflammatory Factor Secretion in Mouse Ovaries.
Fan Z, Zhang X, Shang Y, Zou M, Zhou M, E Q, Fei S, Chen W, Li J, Zhang X, Liu X
International journal of molecular sciences 2022 Apr 27;23(9)
International journal of molecular sciences 2022 Apr 27;23(9)
Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC.
Zhou KX, Huang S, Hu LP, Zhang XL, Qin WT, Zhang YL, Yao LL, Yu Y, Zhou YQ, Zhu L, Ji J, Zhang ZG
Journal of immunology research 2021;2021:6694392
Journal of immunology research 2021;2021:6694392
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.
Pei W, Huang X, Ni B, Zhang R, Niu G, You H
Frontiers in pharmacology 2021;12:730312
Frontiers in pharmacology 2021;12:730312
Elevated Serum FGG Levels Prognosticate and Promote the Disease Progression in Prostate Cancer.
Peng HH, Wang JN, Xiao LF, Yan M, Chen SP, Wang L, Yang K
Frontiers in genetics 2021;12:651647
Frontiers in genetics 2021;12:651647
Propofol inhibited gastric cancer proliferation via the hsa-miR-328-3p/STAT3 pathway.
Bai ZM, Li XF, Yang Y, Yang YF, Lv DR, Tang LL
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1866-1873
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1866-1873
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Jiang M, Li X, Zhang J, Lu Y, Shi Y, Zhu C, Liu Y, Qin B, Luo Z, Du Y, Luo L, Peng L, You J
ACS nano 2021 Sep 28;15(9):14522-14534
ACS nano 2021 Sep 28;15(9):14522-14534
Noncanonical Wnt5a signaling regulates tendon stem/progenitor cells senescence.
Chen M, Li Y, Xiao L, Dai G, Lu P, Rui Y
Stem cell research & therapy 2021 Oct 18;12(1):544
Stem cell research & therapy 2021 Oct 18;12(1):544
Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells.
Zhao S, Wang C, Lu P, Lou Y, Liu H, Wang T, Yang S, Bao Z, Han L, Liang X, Ma C, Gao L
Journal for immunotherapy of cancer 2021 Nov;9(12)
Journal for immunotherapy of cancer 2021 Nov;9(12)
Uncovering the anti-NSCLC effects and mechanisms of gypenosides by metabolomics and network pharmacology analysis.
Qi YS, Xie JB, Xie P, Duan Y, Ling YQ, Gu YL, Piao XL
Journal of ethnopharmacology 2021 Dec 5;281:114506
Journal of ethnopharmacology 2021 Dec 5;281:114506
Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief.
Zhang J, Zhu S, Tan Q, Cheng D, Dai Q, Yang Z, Zhang L, Li F, Zuo Y, Dai W, Chen L, Gu E, Xu G, Wei Z, Cao Y, Liu X
Theranostics 2020;10(11):4885-4899
Theranostics 2020;10(11):4885-4899
CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling.
Huang R, Wang S, Wang N, Zheng Y, Zhou J, Yang B, Wang X, Zhang J, Guo L, Wang S, Chen Z, Wang Z, Xiang S
Cell death & disease 2020 Apr 16;11(4):234
Cell death & disease 2020 Apr 16;11(4):234
Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin.
Zhang S, Zhou L, Zhang M, Wang Y, Wang M, Du J, Gu W, Kui F, Li J, Geng S, Du G
Frontiers in pharmacology 2019;10:1658
Frontiers in pharmacology 2019;10:1658
Alcohol's Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status.
Saini N, Helfrich KK, Kwan STC, Huebner SM, Abazi J, Flentke GR, Blohowiak SE, Kling PJ, Smith SM
Alcoholism, clinical and experimental research 2019 Nov;43(11):2332-2343
Alcoholism, clinical and experimental research 2019 Nov;43(11):2332-2343
Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice.
Chen B, Yang L, Chen J, Chen Y, Zhang L, Wang L, Li X, Li Y, Yu H
Brain research bulletin 2019 Mar;146:124-135
Brain research bulletin 2019 Mar;146:124-135
Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways.
Zhu B, Ren C, Du K, Zhu H, Ai Y, Kang F, Luo Y, Liu W, Wang L, Xu Y, Jiang X, Zhang Y
Biochemical pharmacology 2019 Dec;170:113642
Biochemical pharmacology 2019 Dec;170:113642
Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways.
Cheng Z, Lei Z, Yang P, Si A, Xiang D, Tang X, Guo G, Zhou J, Hüser N
Molecular carcinogenesis 2019 Aug;58(8):1389-1399
Molecular carcinogenesis 2019 Aug;58(8):1389-1399
Postoperative resveratrol administration improves prognosis of rat orthotopic glioblastomas.
Song X, Shu XH, Wu ML, Zheng X, Jia B, Kong QY, Liu J, Li H
BMC cancer 2018 Sep 3;18(1):871
BMC cancer 2018 Sep 3;18(1):871
CEP55 Promotes Cell Motility via JAK2⁻STAT3⁻MMPs Cascade in Hepatocellular Carcinoma.
Li M, Gao J, Li D, Yin Y
Cells 2018 Aug 8;7(8)
Cells 2018 Aug 8;7(8)
Effect of modified Xiaochaihu decoction‑containing serum on HepG2.2.15 cells via the JAK2/STAT3 signaling pathway.
Chen S, Wang Z, Wan S, Huang H, Liang H
Molecular medicine reports 2017 Nov;16(5):7416-7422
Molecular medicine reports 2017 Nov;16(5):7416-7422
CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells.
Wang SJ, Cui HY, Liu YM, Zhao P, Zhang Y, Fu ZG, Chen ZN, Jiang JL
Oncotarget 2015 Jan 1;6(1):243-57
Oncotarget 2015 Jan 1;6(1):243-57
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 60199-1-Ig(STAT3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The STAT3 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human STAT3. This antibody recognizes human,mouse, rat antigen. The STAT3 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 60199-1-Ig(STAT3 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 60199-1-Ig(STAT3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue