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- References [129]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 60199-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60199-1-Ig, RRID:AB_10913811
- Product name
- STAT3 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated STAT3 antibody (Cat. #60199-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3G2D12
- Vial size
- 20ul, 150ul
Submitted references Abnormal mechanical load aggravates subchondral bone remodeling and uneven tibial plateau settlement in knee osteoarthritis via activation of osteoblast Piezo1-Ca²⁺-JAK2/STAT3 signaling.
Smoking promotes colorectal cancer via the CKAP2L/AREG axis.
LncRNA GAS5 regulates apoptosis in ovarian cancer cells by regulating O-GlcNAcylation of GOLGA8B.
TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease.
Crocetin suppresses colorectal cancer progression by targeting TGM2 and inhibiting the JAK2/STAT3 pathway.
Phosphatidylserine Decarboxylase Promotes Ferroptosis Through STAT3/GPX4 Signaling in Gastric Cancer.
The Tetradium ruticarpum-Zingiber officinale Roscoe herb pair inhibits atherogenic events: A study of the synergistic effects and active ingredient combination of a two-herb formula.
Fibroblast-derived POSTN promotes colorectal cancer progression under high-fat diet by reprogramming fatty acid metabolism in tumor cell.
Network pharmacology approach and experimental validation of Lamei pills in treating ischemic stroke based on UHPLC-QE-MS.
Targeting Fgr-STAT3 Mediated Autophagy Inhibition in the Spinal Cord Alleviates Neuropathic Pain in Rats.
Saikosaponin D Alleviates Liver Ischemia-Reperfusion Injury by Inhibiting Mitophagy-Associated Ferroptosis via the STAT3/PINK1 Pathway.
Exploration and verification of the therapeutic mechanism of shenfu injection in sepsis-induced myocardial injury.
Modified Sijunzi Decoction Inhibits Pancreatic Cancer Progression and Improves Immune Suppression: Network Pharmacology and Experimental Validation.
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells.
Glycoprotein M6B suppresses the maintenance of glioma stem cell stemness and proliferation via the integrin β1/β-catenin pathway.
Development of Adamantane-based hydrophobic tags targeting anaplastic lymphoma kinase with enhanced antitumor activities.
S100A9 promotes resistance to anti-PD-1 immunotherapy in hepatocellular carcinoma by degrading PARP1 and activating the STAT3/PD-L1 pathway.
Lipin3 deficiency promotes hepatocyte ferroptosis and pyroptosis via activating JAK1-STAT3 pathway during acetaminophen induced acute liver injury.
Yuzhi Zhixue Granules regulate the JAK/STAT pathway to affect T-cell differentiation in the colon of ulcerative colitis.
Ruxolitinib alleviated muscle atrophy in cancer cachexia by inhibiting IL-6/JAK/STAT3 signaling pathway in mice.
The novel sphingosine-1-phosphate receptor modulator KRP-203 prevents myocardial ischemia-reperfusion injury by preserving mitochondrial function through activation of the RISK and SAFE signaling pathways.
MOF-Engineered Platelet-Mimicking Nanocarrier-Encapsulated Cascade Enzymes for ROS Scavenging and Anti-Inflammation in Cerebral Ischemia-Reperfusion Injury.
Empagliflozin alleviates hepatic ischemia-reperfusion injury by inhibiting c-Myc through the JAK1-STAT3 signaling pathway.
TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in resident bone marrow cells.
The key regulator circPDE3B promotes arsenic-induced bladder carcinogenesis by affecting STAT3 and NF-κB stability.
Bone marrow mesenchymal stem cells alleviate liver fibrosis after rat liver transplantation through JAK1/STAT5 pathway.
Niacin Ester Derivative of Brefeldin A as a Potential Dual-Target Arf1/BMX Inhibitor for Bladder Cancer.
iPSC-derived cardiomyocytes and engineered heart tissues reveal suppressed JAK2/STAT3 signaling in LMNA-related emery-dreifuss muscular dystrophy.
STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma.
STEAP3 promotes triple-negative breast cancer growth through the FGFR1-mediated activation of PI3K/AKT/mTOR signaling.
Arsenic-induced circASXL1 regulates 16HBE cell proliferation through the P65 signaling axis.
Dual-Action Tocilizumab-Conjugated Cisplatin Nanoparticles Overcome Chemoresistance and Metastasis in Non-Small-Cell Lung Cancer.
Exploring PU.1 as a Therapeutic Target to Mitigate Oxidative Stress and Inflammation in Peritoneal Dialysis-Induced Peritoneal Fibrosis.
Faecalibacterium prausnitzii promotes anti-PD-L1 efficacy in natural killer/T-cell lymphoma by enhancing antitumor immunity.
Zuojin Wan Suppresses the Progression of Colorectal Cancer by Inhibiting M2 Tumor-Associated Macrophages Through JAK2/STAT3 Signaling Pathway and In Vivo and In Vitro.
Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway.
PKM2-mediated collagen XVII expression is critical for wound repair.
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice.
L3MBTL3 and STAT3 collaboratively upregulate SNAIL expression to promote metastasis in female breast cancer.
Bufalin Regulates STAT3 Signaling Pathway to Inhibit Corneal Neovascularization and Fibrosis After Alkali Burn in Rats.
Interleukin-6 trans-signalling regulates monocyte chemoattractant protein-1 production in immune-mediated necrotizing myopathy.
P4HB regulates tumor-associated macrophage polarization and chemotaxis by enhancing IL-6 cytokine secretion in glioblastoma.
The CDK9-targeting degrader PO-8 alleviates LPS-induced inflammation by inhibiting JAK-STAT signaling in vitro and in vivo.
Pegmolesatide ameliorates indoxyl sulfate-induced cardiomyocyte hypertrophy through modulating the EPOR-CD131-dependent JAK2/STAT3 signaling pathway.
Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.
Neutralization of IL-17 and CXCR1 Protects Septic Arthritis by Regulating CXCL8-CXCR1 Pathway Along With Functional Activities in Neutrophils.
Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.
Enhanced amphiregulin exposure promotes modulation of the high grade serous ovarian cancer tumor immune microenvironment.
Expression and clinical significance of interleukin-6 pathway in cholangiocarcinoma.
TLR4/TNFR1 blockade suppresses STAT1/STAT3 expression and increases SOCS3 expression in modulation of LPS-induced macrophage responses.
Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis.
Integration of proteomics and metabolomics analysis investigate mechanism of As-induced immune injury in rat spleen.
Neutralization of TLR2 in combination with either TNF-α or IL-1β antibody reduces the severity of septic arthritis through STAT3/mTOR signalling in lymphocytes.
Vasorin promotes endothelial differentiation of glioma stem cells via stimulating the transcription of VEGFR2.
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.
Mechanic study based on untargeted metabolomics of Pi-pa-run-fei-tang on pepper combined with ammonia induced chronic cough model mice.
Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways.
Deep whole-genome analysis of 494 hepatocellular carcinomas.
RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
Interleukin-22 Contributes to Blood-Brain Barrier Disruption via STAT3/VEGFA Activation in Escherichia coli Meningitis.
Urocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway.
SIPA1 promotes epithelial-mesenchymal transition in colorectal cancer through STAT3 activation.
Solid lipid nanoparticle: A potent vehicle of the kaempferol for brain delivery through the blood-brain barrier in the focal cerebral ischemic rat.
SIPA1 promotes angiogenesis by regulating VEGF secretion in Müller cells through STAT3 activation.
NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.
Microfluidic Organoid Cultures Derived from Pancreatic Cancer Biopsies for Personalized Testing of Chemotherapy and Immunotherapy.
Quercetin-loaded Human Umbilical cord Mesenchymal Stem Cell-derived sEVs for Spinal Cord Injury Recovery.
IFITM10 Enhance Tumor Angiogenesis and Promotes Cancer Progression through STAT3 Activation.
Testis-Specific Protein, Y-Encoded-Like 2 Activates JAK2/STAT3 Pathway in Hypothalamic Paraventricular Nucleus to Sustain Hypertension.
Sclareol attenuates liver fibrosis through SENP1-mediated VEGFR2 SUMOylation and inhibition of downstream STAT3 signaling.
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway.
STAT3 promotes differentiation of monocytes to MDSCs via CD39/CD73-adenosine signal pathway in oral squamous cell carcinoma.
Pan-cancer analysis of PCAT6 and its effect on oesophageal squamous cell carcinoma cell proliferation and migration.
Nifuroxazide Activates the Parthanatos to Overcome TMPRSS2:ERG Fusion-Positive Prostate Cancer.
LC-MS Analysis of Ginsenosides in Different Parts of Panax quinquefolius and Their Potential for Coronary Disease Improvement.
Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3-mediated ZO-1 expression.
5'-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I.
Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.
A Bioinspired Manganese-Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes.
A novel GRK2 inhibitor alleviates experimental arthritis through restraining Th17 cell differentiation.
Babao Dan Alleviates Cancer Cachexia in Mice Via Inhibiting IL-6/STAT3 Signaling Pathway.
POR overexpression induces tamoxifen-resistance in breast cancer through the STAT1/c-Myc pathway.
Aging-accelerated differential production and aggregation of STAT3 protein in neuronal cells and neural stem cells in the male mouse spinal cord.
Exosomal lncRNA HOTAIR induces PDL1(+) B cells to impede anti-tumor immunity in colorectal cancer.
miR-653-3p promotes genomic instability of colorectal cancer cells via targeting SIRT1/TWIST1 signaling pathway.
Pi-Pa-Run-Fei-Tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and Treg in murine model of OVA-induced asthma.
Fetal anemia and elevated hepcidin in a mouse model of fetal alcohol spectrum disorder.
Folate Deficiency Enhanced Inflammation and Exacerbated Renal Fibrosis in High-Fat High-Fructose Diet-Fed Mice.
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
Pathological Changes and Expression of JAK-STAT Signaling Pathway Hallmark Proteins in Rat Retinas at Different Time Points After Retinal Ischemia Reperfusion Injury.
Leptin activates the JAK/STAT pathway to promote angiogenesis in RF/6A cells in vitro.
YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.
Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway.
Comprehensive serum metabolomics and network analysis to reveal the mechanism of gypenosides in treating lung cancer and enhancing the pharmacological effects of cisplatin.
Anemoside B4 ameliorates experimental autoimmune encephalomyelitis in mice by modulating inflammatory responses and the gut microbiota.
Nicotinamide N-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE(2) Pathway.
Transcription factor NFE2L3 promotes the proliferation of esophageal squamous cell carcinoma cells and causes radiotherapy resistance by regulating IL-6.
Anemoside B4 protects against chronic relapsing colitis in mice by modulating inflammatory response, colonic transcriptome and the gut microbiota.
Identification of potential immunomodulators from Pulsatilla decoction that act on therapeutic targets for ulcerative colitis based on pharmacological activity, absorbed ingredients, and in-silico molecular docking.
Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.
Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells.
Mucin 16 Promotes Colorectal Cancer Development and Progression Through Activation of Janus Kinase 2.
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer.
PRRX1 promotes colorectal cancer stemness and chemoresistance via the JAK2/STAT3 axis by targeting IL-6.
Afatinib Reverses EMT via Inhibiting CD44-Stat3 Axis to Promote Radiosensitivity in Nasopharyngeal Carcinoma.
Exposure to short-chain chlorinated paraffins induces astrocyte activation via JAK2/STAT3 signaling pathway.
Intestinal Flora Changes Induced by a High-Fat Diet Promote Activation of Primordial Follicles through Macrophage Infiltration and Inflammatory Factor Secretion in Mouse Ovaries.
Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC.
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.
Elevated Serum FGG Levels Prognosticate and Promote the Disease Progression in Prostate Cancer.
Propofol inhibited gastric cancer proliferation via the hsa-miR-328-3p/STAT3 pathway.
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Noncanonical Wnt5a signaling regulates tendon stem/progenitor cells senescence.
Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells.
Uncovering the anti-NSCLC effects and mechanisms of gypenosides by metabolomics and network pharmacology analysis.
Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief.
CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling.
Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin.
Alcohol's Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status.
Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice.
Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways.
Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways.
Postoperative resveratrol administration improves prognosis of rat orthotopic glioblastomas.
CEP55 Promotes Cell Motility via JAK2⁻STAT3⁻MMPs Cascade in Hepatocellular Carcinoma.
Effect of modified Xiaochaihu decoction‑containing serum on HepG2.2.15 cells via the JAK2/STAT3 signaling pathway.
CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells.
Li H, Zhang S, Feng C, Cheng F, Han Y, Wang M, Zhou S, Shao W, Chen W, Chen J, Liu K, Zhang Y, Wang J
International journal of biological sciences 2026;22(4):1834-1851
International journal of biological sciences 2026;22(4):1834-1851
Smoking promotes colorectal cancer via the CKAP2L/AREG axis.
Wu S, Wu F, Li X, Jiang Z, Liu F, Jiang Z
International journal of oncology 2026 May;68(5)
International journal of oncology 2026 May;68(5)
LncRNA GAS5 regulates apoptosis in ovarian cancer cells by regulating O-GlcNAcylation of GOLGA8B.
Chen R, Wang J, Wang Z, Zhao G, Zhang J, Liu W, Wang Y
Gene 2026 May 15;991:150084
Gene 2026 May 15;991:150084
TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease.
Tian Y, Liu Y, Feng X, Wu L, Song W, Zhao T, Liu J, Miao X, Ma H, Jia B, Kang L, Liu Q, Zhang W, Guo H, Yang L, Xu J, Liu S
Cell death discovery 2026 Mar 7;12(1)
Cell death discovery 2026 Mar 7;12(1)
Crocetin suppresses colorectal cancer progression by targeting TGM2 and inhibiting the JAK2/STAT3 pathway.
Chen S, Su W, Wang K, Xu M, Su B
Investigational new drugs 2026 Mar 14;
Investigational new drugs 2026 Mar 14;
Phosphatidylserine Decarboxylase Promotes Ferroptosis Through STAT3/GPX4 Signaling in Gastric Cancer.
Wang L, Wang Y, Shao M, Wang T, Zheng W, Cao J, Luo R, Tu Y, Xia Y, Wei Y, Liu N, Lu W, Xu Y
Current issues in molecular biology 2026 Mar 11;48(3)
Current issues in molecular biology 2026 Mar 11;48(3)
The Tetradium ruticarpum-Zingiber officinale Roscoe herb pair inhibits atherogenic events: A study of the synergistic effects and active ingredient combination of a two-herb formula.
Chi C, Yang X, Li C, Li Z, Yang S, Du Y, Huang W, Liu R
Fitoterapia 2026 Jan;188:107030
Fitoterapia 2026 Jan;188:107030
Fibroblast-derived POSTN promotes colorectal cancer progression under high-fat diet by reprogramming fatty acid metabolism in tumor cell.
Li B, Hou S, Tian T, Yuan S, Li A, Feng Y, Liu Z, Mi J, Cheng Z, Lv S, Yang J, Lu Y, Qi X, Song S, Zha Z, Yuan Q
Cell communication and signaling : CCS 2026 Jan 8;24(1):91
Cell communication and signaling : CCS 2026 Jan 8;24(1):91
Network pharmacology approach and experimental validation of Lamei pills in treating ischemic stroke based on UHPLC-QE-MS.
Li C, Liu C, Xia Y, Liu X, Wang F, Zhuo G, Ren Q
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120578
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120578
Targeting Fgr-STAT3 Mediated Autophagy Inhibition in the Spinal Cord Alleviates Neuropathic Pain in Rats.
He L, Zhang Y, Yang C, Huang Z, Zou K, Deng Q, Zhang J, Mulati M, Sun B, Guo Q, Huang C
Neuroscience bulletin 2026 Apr 9;
Neuroscience bulletin 2026 Apr 9;
Saikosaponin D Alleviates Liver Ischemia-Reperfusion Injury by Inhibiting Mitophagy-Associated Ferroptosis via the STAT3/PINK1 Pathway.
Liu X, Xu Y, Yu X, Feng X, Han Y, Cai H, Du J, Chen L
Phytotherapy research : PTR 2026 Apr 12;
Phytotherapy research : PTR 2026 Apr 12;
Exploration and verification of the therapeutic mechanism of shenfu injection in sepsis-induced myocardial injury.
Yuan HJ, Xiang GH, Liu Y, Li Y, Liu WL, Wei JX, Xue YT, Hao H
PloS one 2025;20(1):e0317738
PloS one 2025;20(1):e0317738
Modified Sijunzi Decoction Inhibits Pancreatic Cancer Progression and Improves Immune Suppression: Network Pharmacology and Experimental Validation.
Zhang Y, Ruan L, Li X, Si W, Yang P, Ba H, Chen Z
Drug design, development and therapy 2025;19:8949-8966
Drug design, development and therapy 2025;19:8949-8966
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells.
Liu J, Shu T, Mu Y, Zheng W, Lu X, Tao H
Frontiers in immunology 2025;16:1503355
Frontiers in immunology 2025;16:1503355
Glycoprotein M6B suppresses the maintenance of glioma stem cell stemness and proliferation via the integrin β1/β-catenin pathway.
Chen Y, Fan Y, Run X, Liu M, Jiang S, Miao Z, Tian W
Frontiers in molecular biosciences 2025;12:1731116
Frontiers in molecular biosciences 2025;12:1731116
Development of Adamantane-based hydrophobic tags targeting anaplastic lymphoma kinase with enhanced antitumor activities.
Zhu J, Zhan F, Xie J, Fang T, Sun Y, Zhan F, Gao T, Liu J, Feng J, Zhou P, Zhu H, Yao H, Zhu Z, Xu S, Xu J, Xie S
Bioorganic chemistry 2025 Sep;164:108876
Bioorganic chemistry 2025 Sep;164:108876
S100A9 promotes resistance to anti-PD-1 immunotherapy in hepatocellular carcinoma by degrading PARP1 and activating the STAT3/PD-L1 pathway.
Zhou X, Qiao C, Chu X, Yang Y, Man H, Liu J, Li Y, Xu Z, Li H, Shan X, Lian Z, Lu Y, Wang W, Yu D, Sun X, Li B
Cellular oncology (Dordrecht, Netherlands) 2025 Oct;48(5):1433-1447
Cellular oncology (Dordrecht, Netherlands) 2025 Oct;48(5):1433-1447
Lipin3 deficiency promotes hepatocyte ferroptosis and pyroptosis via activating JAK1-STAT3 pathway during acetaminophen induced acute liver injury.
Liu YX, Wang Q, Xiangyang ZY, Long JY, Huang H, Fan LL
Molecular biomedicine 2025 Oct 10;6(1):78
Molecular biomedicine 2025 Oct 10;6(1):78
Yuzhi Zhixue Granules regulate the JAK/STAT pathway to affect T-cell differentiation in the colon of ulcerative colitis.
Zhang Y, He C, Zhao Y, Jiang M, Yao J, Cheng G, Niu D, Zeng Z, Dai E, Liu R, Shang G, Qu X, Kong H, Zhang Y, Qu H, Zhao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157198
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157198
Ruxolitinib alleviated muscle atrophy in cancer cachexia by inhibiting IL-6/JAK/STAT3 signaling pathway in mice.
Li C, Gu X, Zhu Z, Pan X, Fan M, Liu X, Zhang X
The Journal of pharmacy and pharmacology 2025 Nov 28;77(12):1715-1725
The Journal of pharmacy and pharmacology 2025 Nov 28;77(12):1715-1725
The novel sphingosine-1-phosphate receptor modulator KRP-203 prevents myocardial ischemia-reperfusion injury by preserving mitochondrial function through activation of the RISK and SAFE signaling pathways.
Wu N, Wang L, Yu S, Wei X, Xu H, Xu S, Jia P, Zhang X
Cell biology and toxicology 2025 Nov 27;41(1):159
Cell biology and toxicology 2025 Nov 27;41(1):159
MOF-Engineered Platelet-Mimicking Nanocarrier-Encapsulated Cascade Enzymes for ROS Scavenging and Anti-Inflammation in Cerebral Ischemia-Reperfusion Injury.
Li H, Xie X, Zhang Y, Han X, Shi T, Li J, Chen W, Wei Q, Pan H, Xu S, Chen Q, Yin L, Qin C
Pharmaceutics 2025 Nov 16;17(11)
Pharmaceutics 2025 Nov 16;17(11)
Empagliflozin alleviates hepatic ischemia-reperfusion injury by inhibiting c-Myc through the JAK1-STAT3 signaling pathway.
Tulahong A, Xu X, Zhou T, Ruze R, Yuan Z, Qiao P, Jiang T, Aji T, Shao Y
International immunopharmacology 2025 Nov 14;165:115508
International immunopharmacology 2025 Nov 14;165:115508
TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in resident bone marrow cells.
Mukherjee G, Samanta S, Bishayi B
Microbial pathogenesis 2025 May;202:107416
Microbial pathogenesis 2025 May;202:107416
The key regulator circPDE3B promotes arsenic-induced bladder carcinogenesis by affecting STAT3 and NF-κB stability.
Gao Y, Xu H, Zhao Q, Cai D, Zhou X, Chen X, Yuan S, Li D, Ning T, Dong X, Li M, Li G, Nan A
Cell biology and toxicology 2025 May 28;41(1):91
Cell biology and toxicology 2025 May 28;41(1):91
Bone marrow mesenchymal stem cells alleviate liver fibrosis after rat liver transplantation through JAK1/STAT5 pathway.
Si Z, Zhao S, Zhang Z, Chen T, Wang R, Dong C, Wang K, Sun C, Song Z, Shen Z, Gao W
Stem cell research & therapy 2025 May 1;16(1):217
Stem cell research & therapy 2025 May 1;16(1):217
Niacin Ester Derivative of Brefeldin A as a Potential Dual-Target Arf1/BMX Inhibitor for Bladder Cancer.
Liu JY, Song YJ, Li PJ, Gao Y, Wei MY, Shao CL
Journal of natural products 2025 Mar 28;88(3):830-841
Journal of natural products 2025 Mar 28;88(3):830-841
iPSC-derived cardiomyocytes and engineered heart tissues reveal suppressed JAK2/STAT3 signaling in LMNA-related emery-dreifuss muscular dystrophy.
Fan H, Yang Z, Ying H, Zhao J, Wang X, Gong J, Li L, Liu X, Gong T, Ke Q, Zhuang L, Liang P
Redox biology 2025 Jun;83:103638
Redox biology 2025 Jun;83:103638
STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma.
Yu W, Gui S, Peng L, Luo H, Xie J, Xiao J, Yilamu Y, Sun Y, Cai S, Cheng Z, Tao Z
Developmental cell 2025 Jun 23;60(12):1751-1767.e9
Developmental cell 2025 Jun 23;60(12):1751-1767.e9
STEAP3 promotes triple-negative breast cancer growth through the FGFR1-mediated activation of PI3K/AKT/mTOR signaling.
Yuan L, Bao Y, Liu J, Sun P
iScience 2025 Jun 20;28(6):112526
iScience 2025 Jun 20;28(6):112526
Arsenic-induced circASXL1 regulates 16HBE cell proliferation through the P65 signaling axis.
Yang X, Tan J, Zhao R, Duan T, Yang J, Chen B, Yang X, Wang J, Jiang C, Ni G, Zhang Y, He Y
Ecotoxicology and environmental safety 2025 Jun 15;298:118298
Ecotoxicology and environmental safety 2025 Jun 15;298:118298
Dual-Action Tocilizumab-Conjugated Cisplatin Nanoparticles Overcome Chemoresistance and Metastasis in Non-Small-Cell Lung Cancer.
Wang Y, Wu F, Yang T, Li B, Wang H, Ye P, Li W
Pharmaceutics 2025 Jul 21;17(7)
Pharmaceutics 2025 Jul 21;17(7)
Exploring PU.1 as a Therapeutic Target to Mitigate Oxidative Stress and Inflammation in Peritoneal Dialysis-Induced Peritoneal Fibrosis.
Zhong S, Su W, Wang Y, Liu D, Li X, Ma F, Xu L, Gao J, Wang H, Sun J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70766
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70766
Faecalibacterium prausnitzii promotes anti-PD-L1 efficacy in natural killer/T-cell lymphoma by enhancing antitumor immunity.
Shi Z, Jiang W, Li H, Zhang Y, Xue W, Wang Y, Zhang M, Li Z
BMC medicine 2025 Jul 1;23(1):387
BMC medicine 2025 Jul 1;23(1):387
Zuojin Wan Suppresses the Progression of Colorectal Cancer by Inhibiting M2 Tumor-Associated Macrophages Through JAK2/STAT3 Signaling Pathway and In Vivo and In Vitro.
Nong F, Xing S, Cheng W, Deng S
Integrative cancer therapies 2025 Jan-Dec;24:15347354251375951
Integrative cancer therapies 2025 Jan-Dec;24:15347354251375951
Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway.
Liu H, Li Q, Chen Y, Dong M, Liu H, Zhang J, Yang L, Yin G, Xie Q
Arthritis research & therapy 2025 Jan 21;27(1):12
Arthritis research & therapy 2025 Jan 21;27(1):12
PKM2-mediated collagen XVII expression is critical for wound repair.
Liu Y, Ho C, Wen D, Sun J, Liu Y, Li Q, Zhang Y, Gao Y
JCI insight 2025 Jan 21;10(4)
JCI insight 2025 Jan 21;10(4)
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice.
Pramanik R, Chattopadhyay S, Bishayi B
Immunologic research 2025 Jan 20;73(1):38
Immunologic research 2025 Jan 20;73(1):38
L3MBTL3 and STAT3 collaboratively upregulate SNAIL expression to promote metastasis in female breast cancer.
Xiao J, Wang J, Li J, Xiao J, Liu C, Tan L, Tu Y, Yang R, Pei Y, Wang M, Wong J, Zhou BP, Li J, Feng J
Nature communications 2025 Jan 2;16(1):231
Nature communications 2025 Jan 2;16(1):231
Bufalin Regulates STAT3 Signaling Pathway to Inhibit Corneal Neovascularization and Fibrosis After Alkali Burn in Rats.
Wu C, Shi L, Deng Y, Chen H, Lu Y, Xiong X, Yin X
Current eye research 2025 Feb;50(2):139-147
Current eye research 2025 Feb;50(2):139-147
Interleukin-6 trans-signalling regulates monocyte chemoattractant protein-1 production in immune-mediated necrotizing myopathy.
Ma X, Gao HJ, Ge HZ, Zhang Q, Bu BT
Rheumatology (Oxford, England) 2025 Feb 1;64(2):849-859
Rheumatology (Oxford, England) 2025 Feb 1;64(2):849-859
P4HB regulates tumor-associated macrophage polarization and chemotaxis by enhancing IL-6 cytokine secretion in glioblastoma.
Wang M, Ma Z, Wang X, Wang Z, Wang W, Zhang Z, Li R, Liu X, Pei D
Annals of medicine and surgery (2012) 2025 Dec;87(12):8245-8256
Annals of medicine and surgery (2012) 2025 Dec;87(12):8245-8256
The CDK9-targeting degrader PO-8 alleviates LPS-induced inflammation by inhibiting JAK-STAT signaling in vitro and in vivo.
Ao MT, Wang XM, Cao Y, Li XD, Zhang YX, Li JY, Li MY, Huang MX, Qiu YK, Hu HY, Wang LJ, Fang H, Li BC, Fang MJ
Biochemical pharmacology 2025 Dec;242(Pt 3):117341
Biochemical pharmacology 2025 Dec;242(Pt 3):117341
Pegmolesatide ameliorates indoxyl sulfate-induced cardiomyocyte hypertrophy through modulating the EPOR-CD131-dependent JAK2/STAT3 signaling pathway.
Zhang X, Li S, Lin T, Gan L, Zhu L, Zuo L
International immunopharmacology 2025 Dec 10;167:115643
International immunopharmacology 2025 Dec 10;167:115643
Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.
Zhang H, Shi H, Li X, Zhou S, Song X, Ma N, Meng M, Chang G, Shen X
Redox biology 2025 Apr;81:103557
Redox biology 2025 Apr;81:103557
Neutralization of IL-17 and CXCR1 Protects Septic Arthritis by Regulating CXCL8-CXCR1 Pathway Along With Functional Activities in Neutrophils.
Ghosh S, Bishayi B
International journal of rheumatic diseases 2025 Apr;28(4):e70144
International journal of rheumatic diseases 2025 Apr;28(4):e70144
Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.
Hu Y, Li Y, Xiong H, Zhang Y, Wang F, Zhuo W, Zeng Z, Zhao Y, Wang H, Hu P, Han S, Huang Y, Lv G, Zhao G
International journal of biological sciences 2024;20(11):4341-4363
International journal of biological sciences 2024;20(11):4341-4363
Enhanced amphiregulin exposure promotes modulation of the high grade serous ovarian cancer tumor immune microenvironment.
Ebott J, McAdams J, Kim C, Jansen C, Woodman M, De La Cruz P, Schrol C, Ribeiro J, James N
Frontiers in pharmacology 2024;15:1375421
Frontiers in pharmacology 2024;15:1375421
Expression and clinical significance of interleukin-6 pathway in cholangiocarcinoma.
Gu D, Zhao X, Song J, Xiao J, Zhang L, Deng G, Li D
Frontiers in immunology 2024;15:1374967
Frontiers in immunology 2024;15:1374967
TLR4/TNFR1 blockade suppresses STAT1/STAT3 expression and increases SOCS3 expression in modulation of LPS-induced macrophage responses.
Sawoo R, Bishayi B
Immunobiology 2024 Sep;229(5):152840
Immunobiology 2024 Sep;229(5):152840
Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis.
Yang L, Hu C, Chen X, Zhang J, Feng Z, Xiao Y, He W, Cui T, Zhang X, Yang Y, Zhang Y, Yan Y
eLife 2024 Sep 12;13
eLife 2024 Sep 12;13
Integration of proteomics and metabolomics analysis investigate mechanism of As-induced immune injury in rat spleen.
Ran X, Yan X, Ma G, Liang Z, Zhuang H, Tang X, Chen X, Cao X, Liu X, Huang Y, Wang Y, Zhang X, Luo P, Shen L
Ecotoxicology and environmental safety 2024 Oct 1;284:116913
Ecotoxicology and environmental safety 2024 Oct 1;284:116913
Neutralization of TLR2 in combination with either TNF-α or IL-1β antibody reduces the severity of septic arthritis through STAT3/mTOR signalling in lymphocytes.
Ghosh R, Bishayi B
Cellular immunology 2024 Nov-Dec;405-406:104878
Cellular immunology 2024 Nov-Dec;405-406:104878
Vasorin promotes endothelial differentiation of glioma stem cells via stimulating the transcription of VEGFR2.
Qin Z, Zhong Y, Li P, Ma Z, Kang H, Huang Y, Zhong Y, Wang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23682
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23682
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.
Kundu A, Ghosh P, Bishayi B
International immunopharmacology 2024 May 30;133:112153
International immunopharmacology 2024 May 30;133:112153
Mechanic study based on untargeted metabolomics of Pi-pa-run-fei-tang on pepper combined with ammonia induced chronic cough model mice.
Jie XL, Tong ZR, Xu XY, Wu JH, Jiang XL, Tao Y, Feng PS, Yu J, Lan JP, Wang P
Journal of ethnopharmacology 2024 May 23;326:117905
Journal of ethnopharmacology 2024 May 23;326:117905
Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways.
Yan Y, Bai S, Han H, Dai J, Niu L, Wang H, Dong Q, Yin H, Yuan G, Pan Y
Cell communication and signaling : CCS 2024 May 15;22(1):272
Cell communication and signaling : CCS 2024 May 15;22(1):272
Deep whole-genome analysis of 494 hepatocellular carcinomas.
Chen L, Zhang C, Xue R, Liu M, Bai J, Bao J, Wang Y, Jiang N, Li Z, Wang W, Wang R, Zheng B, Yang A, Hu J, Liu K, Shen S, Zhang Y, Bai M, Wang Y, Zhu Y, Yang S, Gao Q, Gu J, Gao D, Wang XW, Nakagawa H, Zhang N, Wu L, Rozen SG, Bai F, Wang H
Nature 2024 Mar;627(8004):586-593
Nature 2024 Mar;627(8004):586-593
RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
He S, Lu M, Zhang L, Wang Z
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):166996
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):166996
Interleukin-22 Contributes to Blood-Brain Barrier Disruption via STAT3/VEGFA Activation in Escherichia coli Meningitis.
Yang R, Chen J, Qu X, Liu H, Wang X, Tan C, Chen H, Wang X
ACS infectious diseases 2024 Mar 8;10(3):988-999
ACS infectious diseases 2024 Mar 8;10(3):988-999
Urocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway.
Guo X, Li Y, Chen X, Sun B, Guo X
Journal of cancer research and clinical oncology 2024 Mar 28;150(3):163
Journal of cancer research and clinical oncology 2024 Mar 28;150(3):163
SIPA1 promotes epithelial-mesenchymal transition in colorectal cancer through STAT3 activation.
Li Y, Wang M, Jiang L, Jia J, Pan F, Li W, Wang B, Huang K, Luo J
Heliyon 2024 Jul 30;10(14):e34527
Heliyon 2024 Jul 30;10(14):e34527
Solid lipid nanoparticle: A potent vehicle of the kaempferol for brain delivery through the blood-brain barrier in the focal cerebral ischemic rat.
Ghosh A, Khanam N, Nath D
Chemico-biological interactions 2024 Jul 1;397:111084
Chemico-biological interactions 2024 Jul 1;397:111084
SIPA1 promotes angiogenesis by regulating VEGF secretion in Müller cells through STAT3 activation.
Fang Y, Wang Q, Zhang L, Xie L
Heliyon 2024 Jan 30;10(2):e24869
Heliyon 2024 Jan 30;10(2):e24869
NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
Hu H, Li B, Chen H, Fan G, Ye Z, Ji S, Yu X, Xu X, Qin Y
Molecular carcinogenesis 2024 Feb;63(2):195-208
Molecular carcinogenesis 2024 Feb;63(2):195-208
Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.
Ghosh R, Bishayi B
Microbial pathogenesis 2024 Feb;187:106518
Microbial pathogenesis 2024 Feb;187:106518
Microfluidic Organoid Cultures Derived from Pancreatic Cancer Biopsies for Personalized Testing of Chemotherapy and Immunotherapy.
Choi D, Gonzalez-Suarez AM, Dumbrava MG, Medlyn M, de Hoyos-Vega JM, Cichocki F, Miller JS, Ding L, Zhu M, Stybayeva G, Gaspar-Maia A, Billadeau DD, Ma WW, Revzin A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(5):e2303088
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(5):e2303088
Quercetin-loaded Human Umbilical cord Mesenchymal Stem Cell-derived sEVs for Spinal Cord Injury Recovery.
Yang C, Xu T, Lu Y, Liu J, Chen C, Wang H, Chen X
Neuroscience 2024 Aug 6;552:14-28
Neuroscience 2024 Aug 6;552:14-28
IFITM10 Enhance Tumor Angiogenesis and Promotes Cancer Progression through STAT3 Activation.
Li Y, Wang M, Li X, Jia J, Pan F, Li W, Chen Z, Tang D, Ou K
Frontiers in bioscience (Landmark edition) 2024 Aug 16;29(8):283
Frontiers in bioscience (Landmark edition) 2024 Aug 16;29(8):283
Testis-Specific Protein, Y-Encoded-Like 2 Activates JAK2/STAT3 Pathway in Hypothalamic Paraventricular Nucleus to Sustain Hypertension.
Li Y, Xu YF, Chi HL, Yu JY, Gao YN, Li HB, Kang YM, Yu XJ
American journal of hypertension 2024 Aug 14;37(9):682-691
American journal of hypertension 2024 Aug 14;37(9):682-691
Sclareol attenuates liver fibrosis through SENP1-mediated VEGFR2 SUMOylation and inhibition of downstream STAT3 signaling.
Ge MX, Niu WX, Bao YY, Lu ZN, He HW
Phytotherapy research : PTR 2023 Sep;37(9):3898-3912
Phytotherapy research : PTR 2023 Sep;37(9):3898-3912
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway.
Li Y, Fan S, Kong L, Hao Z, Zhou Y, Shangguan J, Gao L, Wang M, Kang Y, Li X, Huang K, Zhang C, Liu Z
iScience 2023 Nov 17;26(11):108070
iScience 2023 Nov 17;26(11):108070
STAT3 promotes differentiation of monocytes to MDSCs via CD39/CD73-adenosine signal pathway in oral squamous cell carcinoma.
Cui H, Lan Z, Zou KL, Zhao YY, Yu GT
Cancer immunology, immunotherapy : CII 2023 May;72(5):1315-1326
Cancer immunology, immunotherapy : CII 2023 May;72(5):1315-1326
Pan-cancer analysis of PCAT6 and its effect on oesophageal squamous cell carcinoma cell proliferation and migration.
Luo Q, Kuang Y, Tao X, Zhu X, Zhao X, Lu G, Zhang W, Sun E, Chen B
Medical oncology (Northwood, London, England) 2023 Mar 22;40(4):125
Medical oncology (Northwood, London, England) 2023 Mar 22;40(4):125
Nifuroxazide Activates the Parthanatos to Overcome TMPRSS2:ERG Fusion-Positive Prostate Cancer.
Li C, Zhang J, Wu Q, Kumar A, Pan G, Kelvin DJ
Molecular cancer therapeutics 2023 Mar 2;22(3):306-316
Molecular cancer therapeutics 2023 Mar 2;22(3):306-316
LC-MS Analysis of Ginsenosides in Different Parts of Panax quinquefolius and Their Potential for Coronary Disease Improvement.
Zhang X, Kong C, Wang X, Hou H, Yu H, Wang L, Li P, Li X, Zhang Y, Han L, Liu K
Planta medica 2023 Jun;89(7):764-772
Planta medica 2023 Jun;89(7):764-772
Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3-mediated ZO-1 expression.
Yang F, Li L, Zhou Y, Pan W, Liang X, Huang L, Huang J, Cheng Y, Geng L, Xu W, Gong S
Clinical and experimental pharmacology & physiology 2023 Jun;50(6):516-526
Clinical and experimental pharmacology & physiology 2023 Jun;50(6):516-526
5'-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I.
Wu C, Liu D, Zhang L, Wang J, Ding Y, Sun Z, Wang W
Frontiers of medicine 2023 Jun;17(3):476-492
Frontiers of medicine 2023 Jun;17(3):476-492
Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.
Xian Z, Tian J, Zhao Y, Yi Y, Li C, Han J, Zhang Y, Wang Y, Wang L, Liu S, Pan C, Liu C, Wang D, Meng J, Tang X, Wang F, Liang A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154815
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154815
A Bioinspired Manganese-Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes.
Wang J, Wang Y, Xiaohalati X, Su Q, Liu J, Cai B, Yang W, Wang Z, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(20):e2206854
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(20):e2206854
A novel GRK2 inhibitor alleviates experimental arthritis through restraining Th17 cell differentiation.
Tao J, Jiang C, Guo P, Chen H, Zhu Z, Su T, Zhou W, Tai Y, Han C, Ma Y, Chen J, Sun W, Wang Y, Wei W, Wang Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:113997
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:113997
Babao Dan Alleviates Cancer Cachexia in Mice Via Inhibiting IL-6/STAT3 Signaling Pathway.
Qiu Z, Wo D, Zhong X, Chen J, Ma E, He J, Peng J, Zhu W, Ren DN
Integrative cancer therapies 2023 Jan-Dec;22:15347354231168369
Integrative cancer therapies 2023 Jan-Dec;22:15347354231168369
POR overexpression induces tamoxifen-resistance in breast cancer through the STAT1/c-Myc pathway.
Chen S, Wu D, Liu Q, Jin F, Yao F, Fang Y
Molecular carcinogenesis 2023 Feb;62(2):249-260
Molecular carcinogenesis 2023 Feb;62(2):249-260
Aging-accelerated differential production and aggregation of STAT3 protein in neuronal cells and neural stem cells in the male mouse spinal cord.
Zhao T, Liu C, Liu L, Wang X, Liu C
Biogerontology 2023 Feb;24(1):137-148
Biogerontology 2023 Feb;24(1):137-148
Exosomal lncRNA HOTAIR induces PDL1(+) B cells to impede anti-tumor immunity in colorectal cancer.
Xie Z, Xia J, Jiao M, Zhao P, Wang Z, Lin S, Xing Y, Li Y, Lu Z, Zhong Z, Miao C, Zhou P, Qian J, Wang L, Zhang D, Gu J, Chu Y, Liu R
Biochemical and biophysical research communications 2023 Feb 12;644:112-121
Biochemical and biophysical research communications 2023 Feb 12;644:112-121
miR-653-3p promotes genomic instability of colorectal cancer cells via targeting SIRT1/TWIST1 signaling pathway.
Wang H, Liang Y, Zhao L, Deng J, Li Y, Zhao H, Zhang X, Zou F
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166821
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166821
Pi-Pa-Run-Fei-Tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and Treg in murine model of OVA-induced asthma.
Jie XL, Luo ZR, Yu J, Tong ZR, Li QQ, Wu JH, Tao Y, Feng PS, Lan JP, Wang P
Journal of ethnopharmacology 2023 Dec 5;317:116719
Journal of ethnopharmacology 2023 Dec 5;317:116719
Fetal anemia and elevated hepcidin in a mouse model of fetal alcohol spectrum disorder.
Helfrich KK, Saini N, Kwan STC, Rivera OC, Mooney SM, Smith SM
Pediatric research 2023 Aug;94(2):503-511
Pediatric research 2023 Aug;94(2):503-511
Folate Deficiency Enhanced Inflammation and Exacerbated Renal Fibrosis in High-Fat High-Fructose Diet-Fed Mice.
Chan CW, Lin BF
Nutrients 2023 Aug 17;15(16)
Nutrients 2023 Aug 17;15(16)
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
Xu L, Cai J, Li C, Yang M, Duan T, Zhao Q, Xi Y, Sun L, He L, Tang C, Sun L
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):58
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):58
Pathological Changes and Expression of JAK-STAT Signaling Pathway Hallmark Proteins in Rat Retinas at Different Time Points After Retinal Ischemia Reperfusion Injury.
Wang S, Yu A, Han M, Chen X, Li Z, Ke M, Cai X, Ai M, Xing Y
Pathology oncology research : POR 2022;28:1610385
Pathology oncology research : POR 2022;28:1610385
Leptin activates the JAK/STAT pathway to promote angiogenesis in RF/6A cells in vitro.
Zhang L, Li R, Wu BH, Liang TT, Liu Z, Ju W, Wang Y, Wen YT, Liu MC, Du JH
International journal of ophthalmology 2022;15(4):554-559
International journal of ophthalmology 2022;15(4):554-559
YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.
Li Z, Teng M, Jiang Y, Zhang L, Luo X, Liao Y, Yang B
Frontiers in immunology 2022;13:857727
Frontiers in immunology 2022;13:857727
Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway.
Li Z, Geng J, Xie B, He J, Wang J, Peng L, Hu Y, Dai H, Wang C
Frontiers in pharmacology 2022;13:834604
Frontiers in pharmacology 2022;13:834604
Comprehensive serum metabolomics and network analysis to reveal the mechanism of gypenosides in treating lung cancer and enhancing the pharmacological effects of cisplatin.
Qi YS, Xiao MY, Xie P, Xie JB, Guo M, Li FF, Piao XL
Frontiers in pharmacology 2022;13:1070948
Frontiers in pharmacology 2022;13:1070948
Anemoside B4 ameliorates experimental autoimmune encephalomyelitis in mice by modulating inflammatory responses and the gut microbiota.
Zou M, Chen FJ, Deng LR, Han Q, Huang CY, Shen SS, Tomlinson B, Li YH
European journal of pharmacology 2022 Sep 15;931:175185
European journal of pharmacology 2022 Sep 15;931:175185
Nicotinamide N-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE(2) Pathway.
Yang C, Wang T, Zhu S, Zong Z, Luo C, Zhao Y, Liu J, Li T, Liu X, Liu C, Deng H
ACS omega 2022 Oct 25;7(42):37509-37519
ACS omega 2022 Oct 25;7(42):37509-37519
Transcription factor NFE2L3 promotes the proliferation of esophageal squamous cell carcinoma cells and causes radiotherapy resistance by regulating IL-6.
Chen T, Xu B, Chen H, Sun Y, Song J, Sun X, Zhang X, Hua W
Computer methods and programs in biomedicine 2022 Nov;226:107102
Computer methods and programs in biomedicine 2022 Nov;226:107102
Anemoside B4 protects against chronic relapsing colitis in mice by modulating inflammatory response, colonic transcriptome and the gut microbiota.
Han Q, Deng LR, Zou M, Tang HZ, Huang CY, Chen FJ, Tomlinson B, Li YH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Nov;106:154416
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Nov;106:154416
Identification of potential immunomodulators from Pulsatilla decoction that act on therapeutic targets for ulcerative colitis based on pharmacological activity, absorbed ingredients, and in-silico molecular docking.
Deng LR, Han Q, Zou M, Chen FJ, Huang CY, Zhong YM, Wu QY, Tomlinson B, Li YH
Chinese medicine 2022 Nov 24;17(1):132
Chinese medicine 2022 Nov 24;17(1):132
Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.
Huo Y, Yang J, Zheng J, Xu D, Yang M, Tao L, Yao H, Fu X, Yang J, Liu D, Hua R, Zhang J, Sun Y, Hu L, Liu W
Cell proliferation 2022 May;55(5):e13237
Cell proliferation 2022 May;55(5):e13237
Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells.
Fan LL, Du R, Liu JS, Jin JY, Wang CY, Dong Y, He WX, Yan RQ, Xiang R
Experimental & molecular medicine 2022 May;54(5):653-661
Experimental & molecular medicine 2022 May;54(5):653-661
Mucin 16 Promotes Colorectal Cancer Development and Progression Through Activation of Janus Kinase 2.
Liu Z, Gu Y, Li X, Zhou L, Cheng X, Jiang H, Huang Y, Zhang Y, Xu T, Yang W, Huang Q
Digestive diseases and sciences 2022 Jun;67(6):2195-2208
Digestive diseases and sciences 2022 Jun;67(6):2195-2208
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
Wang H, Ai J, Shopit A, Niu M, Ahmed N, Tesfaldet T, Tang Z, Li X, Jamalat Y, Chu P, Peng J, Ma X, Qaed E, Han G, Zhang W, Wang J, Tang Z
Cell biology and toxicology 2022 Jun;38(3):531-551
Cell biology and toxicology 2022 Jun;38(3):531-551
KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
Zhou Q, Gong J, Bi J, Yang X, Zhang L, Lu C, Li L, Chen M, Cai J, Yang R, Li X, Li Z, Wang X
The Journal of investigative dermatology 2022 Jul;142(7):2003-2013.e5
The Journal of investigative dermatology 2022 Jul;142(7):2003-2013.e5
PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer.
Wan D, Wang S, Xu Z, Zan X, Liu F, Han Y, Jiang M, Wu A, Zhi Q
Clinical and translational medicine 2022 Feb;12(2):e683
Clinical and translational medicine 2022 Feb;12(2):e683
PRRX1 promotes colorectal cancer stemness and chemoresistance via the JAK2/STAT3 axis by targeting IL-6.
Zhong L, Tan W, Yang Q, Zou Z, Zhou R, Huang Y, Qiu Z, Zheng K, Huang Z
Journal of gastrointestinal oncology 2022 Dec;13(6):2989-3008
Journal of gastrointestinal oncology 2022 Dec;13(6):2989-3008
Afatinib Reverses EMT via Inhibiting CD44-Stat3 Axis to Promote Radiosensitivity in Nasopharyngeal Carcinoma.
Huang H, Huang F, Liang X, Fu Y, Cheng Z, Huang Y, Chen Z, Duan Y, Chen Y
Pharmaceuticals (Basel, Switzerland) 2022 Dec 27;16(1)
Pharmaceuticals (Basel, Switzerland) 2022 Dec 27;16(1)
Exposure to short-chain chlorinated paraffins induces astrocyte activation via JAK2/STAT3 signaling pathway.
Ding W, Zhao Z, Zheng Y, Wang R, Zhang Z, Zhang Z, Wang X, Yu S, Liu L, Huang R, Zhao X, Wu Q
Ecotoxicology and environmental safety 2022 Dec 15;248:114268
Ecotoxicology and environmental safety 2022 Dec 15;248:114268
Intestinal Flora Changes Induced by a High-Fat Diet Promote Activation of Primordial Follicles through Macrophage Infiltration and Inflammatory Factor Secretion in Mouse Ovaries.
Fan Z, Zhang X, Shang Y, Zou M, Zhou M, E Q, Fei S, Chen W, Li J, Zhang X, Liu X
International journal of molecular sciences 2022 Apr 27;23(9)
International journal of molecular sciences 2022 Apr 27;23(9)
Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC.
Zhou KX, Huang S, Hu LP, Zhang XL, Qin WT, Zhang YL, Yao LL, Yu Y, Zhou YQ, Zhu L, Ji J, Zhang ZG
Journal of immunology research 2021;2021:6694392
Journal of immunology research 2021;2021:6694392
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.
Pei W, Huang X, Ni B, Zhang R, Niu G, You H
Frontiers in pharmacology 2021;12:730312
Frontiers in pharmacology 2021;12:730312
Elevated Serum FGG Levels Prognosticate and Promote the Disease Progression in Prostate Cancer.
Peng HH, Wang JN, Xiao LF, Yan M, Chen SP, Wang L, Yang K
Frontiers in genetics 2021;12:651647
Frontiers in genetics 2021;12:651647
Propofol inhibited gastric cancer proliferation via the hsa-miR-328-3p/STAT3 pathway.
Bai ZM, Li XF, Yang Y, Yang YF, Lv DR, Tang LL
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1866-1873
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1866-1873
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Jiang M, Li X, Zhang J, Lu Y, Shi Y, Zhu C, Liu Y, Qin B, Luo Z, Du Y, Luo L, Peng L, You J
ACS nano 2021 Sep 28;15(9):14522-14534
ACS nano 2021 Sep 28;15(9):14522-14534
Noncanonical Wnt5a signaling regulates tendon stem/progenitor cells senescence.
Chen M, Li Y, Xiao L, Dai G, Lu P, Rui Y
Stem cell research & therapy 2021 Oct 18;12(1):544
Stem cell research & therapy 2021 Oct 18;12(1):544
Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells.
Zhao S, Wang C, Lu P, Lou Y, Liu H, Wang T, Yang S, Bao Z, Han L, Liang X, Ma C, Gao L
Journal for immunotherapy of cancer 2021 Nov;9(12)
Journal for immunotherapy of cancer 2021 Nov;9(12)
Uncovering the anti-NSCLC effects and mechanisms of gypenosides by metabolomics and network pharmacology analysis.
Qi YS, Xie JB, Xie P, Duan Y, Ling YQ, Gu YL, Piao XL
Journal of ethnopharmacology 2021 Dec 5;281:114506
Journal of ethnopharmacology 2021 Dec 5;281:114506
Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief.
Zhang J, Zhu S, Tan Q, Cheng D, Dai Q, Yang Z, Zhang L, Li F, Zuo Y, Dai W, Chen L, Gu E, Xu G, Wei Z, Cao Y, Liu X
Theranostics 2020;10(11):4885-4899
Theranostics 2020;10(11):4885-4899
CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling.
Huang R, Wang S, Wang N, Zheng Y, Zhou J, Yang B, Wang X, Zhang J, Guo L, Wang S, Chen Z, Wang Z, Xiang S
Cell death & disease 2020 Apr 16;11(4):234
Cell death & disease 2020 Apr 16;11(4):234
Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin.
Zhang S, Zhou L, Zhang M, Wang Y, Wang M, Du J, Gu W, Kui F, Li J, Geng S, Du G
Frontiers in pharmacology 2019;10:1658
Frontiers in pharmacology 2019;10:1658
Alcohol's Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status.
Saini N, Helfrich KK, Kwan STC, Huebner SM, Abazi J, Flentke GR, Blohowiak SE, Kling PJ, Smith SM
Alcoholism, clinical and experimental research 2019 Nov;43(11):2332-2343
Alcoholism, clinical and experimental research 2019 Nov;43(11):2332-2343
Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice.
Chen B, Yang L, Chen J, Chen Y, Zhang L, Wang L, Li X, Li Y, Yu H
Brain research bulletin 2019 Mar;146:124-135
Brain research bulletin 2019 Mar;146:124-135
Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways.
Zhu B, Ren C, Du K, Zhu H, Ai Y, Kang F, Luo Y, Liu W, Wang L, Xu Y, Jiang X, Zhang Y
Biochemical pharmacology 2019 Dec;170:113642
Biochemical pharmacology 2019 Dec;170:113642
Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways.
Cheng Z, Lei Z, Yang P, Si A, Xiang D, Tang X, Guo G, Zhou J, Hüser N
Molecular carcinogenesis 2019 Aug;58(8):1389-1399
Molecular carcinogenesis 2019 Aug;58(8):1389-1399
Postoperative resveratrol administration improves prognosis of rat orthotopic glioblastomas.
Song X, Shu XH, Wu ML, Zheng X, Jia B, Kong QY, Liu J, Li H
BMC cancer 2018 Sep 3;18(1):871
BMC cancer 2018 Sep 3;18(1):871
CEP55 Promotes Cell Motility via JAK2⁻STAT3⁻MMPs Cascade in Hepatocellular Carcinoma.
Li M, Gao J, Li D, Yin Y
Cells 2018 Aug 8;7(8)
Cells 2018 Aug 8;7(8)
Effect of modified Xiaochaihu decoction‑containing serum on HepG2.2.15 cells via the JAK2/STAT3 signaling pathway.
Chen S, Wang Z, Wan S, Huang H, Liang H
Molecular medicine reports 2017 Nov;16(5):7416-7422
Molecular medicine reports 2017 Nov;16(5):7416-7422
CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells.
Wang SJ, Cui HY, Liu YM, Zhao P, Zhang Y, Fu ZG, Chen ZN, Jiang JL
Oncotarget 2015 Jan 1;6(1):243-57
Oncotarget 2015 Jan 1;6(1):243-57
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 60199-1-Ig(STAT3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The STAT3 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human STAT3. This antibody recognizes human,mouse, rat antigen. The STAT3 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 60199-1-Ig(STAT3 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 60199-1-Ig(STAT3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
