Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations [0]
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- Product number
- P00007-1 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-Phospho-STAT3 (S727) Rabbit Monoclonal Antibody
- Antibody type
- Monoclonal
- Description
- Monoclonal antibody for STAT3 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IP, IF, IHC, ICC, WB. Reactive species: Human, Rat STAT3 information: Molecular Weight: 88068 MW; Subcellular Localization: Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1; Tissue Specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Antibody clone number
- CAA-19
- Vial size
- 100ug/vial
- Concentration
- 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
- Storage
- At -20°C for one year. Avoid repeated freezing and thawing.
Submitted references α-Linolenic acid ameliorates pentylenetetrazol-induced neuron apoptosis and neurological impairment in mice with seizures via down-regulating JAK2/STAT3 pathway.
Modified Biejia Jianwan decoction restrains PD-L1-mediated immune evasion through the HIF-1α/STAT3/NF-κB signaling pathway.
Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.
Synthesis, biological activity and mechanism of action of novel allosecurinine derivatives as potential antitumor agents.
Cryptotanshinone ameliorates MPP(+)-induced oxidative stress and apoptosis of SH-SY5Y neuroblastoma cells: the role of STAT3 in Parkinson's disease.
TIAM2 promotes proliferation and invasion of osteosarcoma cells by activating the JAK2/STAT3 signaling pathway.
Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway.
Prognostic role of STAT3 in solid tumors: a systematic review and meta-analysis.
Protein expression under sustained activation of signal transducer and activator of transcription-3 in diethylnitrosamine-induced rat liver carcinogenesis.
Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction.
Delivery of the co-expression plasmid pEndo-Si-Stat3 by attenuated Salmonella serovar typhimurium for prostate cancer treatment.
Puerarin partly counteracts the inflammatory response after cerebral ischemia/reperfusion via activating the cholinergic anti-inflammatory pathway.
Zeng X, Luo F, Cheng YH, Gao J, Hong D
The British journal of nutrition 2024 May 22;:1-12
The British journal of nutrition 2024 May 22;:1-12
Modified Biejia Jianwan decoction restrains PD-L1-mediated immune evasion through the HIF-1α/STAT3/NF-κB signaling pathway.
Tian X, Liu F, Wang Z, Zhang J, Liu Q, Zhang Y, Zhang D, Huang C, Zhao J, Jiang S
Journal of ethnopharmacology 2024 Mar 25;322:117577
Journal of ethnopharmacology 2024 Mar 25;322:117577
Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.
Zhang X, Su J, Lin J, Liu L, Wu J, Yuan W, Zhang Y, Chen Q, Su ZJ, Xu G, Sun M, Zhang Y, Chen X, Zhang W
Journal of ethnopharmacology 2023 Oct 5;314:116633
Journal of ethnopharmacology 2023 Oct 5;314:116633
Synthesis, biological activity and mechanism of action of novel allosecurinine derivatives as potential antitumor agents.
Xu XL, Lan JX, Huang H, Dai W, Peng XP, Liu SL, Chen WM, Huang LJ, Liu J, Li XJ, Zeng JL, Huang XH, Zhao GN, Hou W
Bioorganic & medicinal chemistry 2023 Mar 15;82:117234
Bioorganic & medicinal chemistry 2023 Mar 15;82:117234
Cryptotanshinone ameliorates MPP(+)-induced oxidative stress and apoptosis of SH-SY5Y neuroblastoma cells: the role of STAT3 in Parkinson's disease.
Wang Q, Liu Y
Metabolic brain disease 2022 Jun;37(5):1477-1485
Metabolic brain disease 2022 Jun;37(5):1477-1485
TIAM2 promotes proliferation and invasion of osteosarcoma cells by activating the JAK2/STAT3 signaling pathway.
Cheng S, Huang X, Guo W
Journal of bone oncology 2022 Dec;37:100461
Journal of bone oncology 2022 Dec;37:100461
Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway.
Jin W, Shen Y
Evidence-based complementary and alternative medicine : eCAM 2019;2019:3909468
Evidence-based complementary and alternative medicine : eCAM 2019;2019:3909468
Prognostic role of STAT3 in solid tumors: a systematic review and meta-analysis.
Wu P, Wu D, Zhao L, Huang L, Shen G, Huang J, Chai Y
Oncotarget 2016 Apr 12;7(15):19863-83
Oncotarget 2016 Apr 12;7(15):19863-83
Protein expression under sustained activation of signal transducer and activator of transcription-3 in diethylnitrosamine-induced rat liver carcinogenesis.
Cui LM, Zhang K, Ma DJ, Liu SP, Zhang XW
Oncology letters 2014 Aug;8(2):608-614
Oncology letters 2014 Aug;8(2):608-614
Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction.
Khan M, Li T, Ahmad Khan MK, Rasul A, Nawaz F, Sun M, Zheng Y, Ma T
BioMed research international 2013;2013:719858
BioMed research international 2013;2013:719858
Delivery of the co-expression plasmid pEndo-Si-Stat3 by attenuated Salmonella serovar typhimurium for prostate cancer treatment.
Li X, Li Y, Wang B, Ji K, Liang Z, Guo B, Hu J, Yin D, Du Y, Kopecko DJ, Kalvakolanu DV, Zhao X, Xu D, Zhang L
Journal of cancer research and clinical oncology 2013 Jun;139(6):971-80
Journal of cancer research and clinical oncology 2013 Jun;139(6):971-80
Puerarin partly counteracts the inflammatory response after cerebral ischemia/reperfusion via activating the cholinergic anti-inflammatory pathway.
Liu X, Mei Z, Qian J, Zeng Y, Wang M
Neural regeneration research 2013 Dec 5;8(34):3203-15
Neural regeneration research 2013 Dec 5;8(34):3203-15
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