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STAT4
Signal transducer and activator of transcription 4The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
Top validated antibodies |
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| Invitrogen Antibodies |  71-7900 |
13 references | Polyclonal |
WB
EL
ICC
OA
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| Novus Biologicals | H00006775-M01 |
Monoclonal |
WB
EL
ICC
IP
IHC
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| Abnova Corporation | H00006775-M01 |
Monoclonal |
WB
EL
ICC
IP
IHC
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| antibodies-online | ABIN393475 |
Monoclonal |
WB
EL
ICC
IP
IHC
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| OriGene | AM31022PU-N |
Monoclonal |
WB
EL
ICC
IP
IHC
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