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Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [8]
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- Product number
- ABIN117931 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Signal Transducer and Activator of Transcription 4 (STAT4) (AA 730-749) antibody
- Antibody type
- Polyclonal
- Antigen
- This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 730-749 of Mouse STAT -4. Swiss Prot accession number P42228.
- Description
- Delipidation and defibrination.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Antigen sequence
Peptide sequence: R-E-N-L-S-P-T-T-I
-E-T-A-M-N-S-P-Y-S-A-E Protein sequ
ence: Mouse STAT4 protein is compos
ed of 749 amino acids (85.9 kDa) 1
msqwnqvqql eikfleqvdq fyddnfpmei rh
llaqwiet dwevasnne tmatillqnl 61 li
qldeqlgr vskeknllli hnlkrirkvl qgkf
hgnpmh vavvisnclr eerrilaaan 121 mp
iqgpleks lqsssvserq rnvehkvsai knsv
qmteqd tkyledlqde fdyryktiqt 181 md
qgdknsil vnqevltllq emlnsldfkr keal
skmtqi vnetdllmns mlleelqdwk 241 kr
qqiacigg plhngldqlq ncftllaesl fqlr
qqlekl qeqstkmtye gdpipaqrah 301 ll
eratfliy nlfknsfvve qpcmpthpq rpmvl
ktliq tvklrllik lpelnyqvkv 361 kasi
dknvst lsnrrfvlcg thvkamssee ssngsl
svef rhlqpkemkc stgskgnegc 421 hmvt
eelhsi tfetqiclyg ltinletssl pvvmis
nvsq lpnawasiiw ynvstndsqn 481 lvff
nnppsv tlgqllevms wqfssyvgrg lnseql
nmla ekltvqsnyn dghltwakfc 541 kehl
pgktft fwtwleaild likkhilplw idgyim
gfvs kekerlllkd kmpgtfllrf 601 sesh
lggitf twvdqsenge vrfhsvepyn kgrlsa
lafa dilrdykvim aenipenplk 661 ylyp
dipkdk afgkhyssqp cevsrpterg dkgyvp
svfi pistirsdst epqspsdllp 721 msps
ayavlr enlspttiet amnspysae- Epitope
- AA 730-749
- Vial size
- 0.1 mL
- Concentration
- 85 mg/mL (by refractometry)
- Storage
- Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Centrifuge product if not completely clear after standing at room temperature. This product is stable for one month at 2-8°C as an undiluted liquid.
- Handling
- Dilute only prior to immediate use. Avoid cycles of freezing and thawing.
Submitted references STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus.
Synthesis and reactions of aminoporphyrazines with annulated five- and seven-membered rings.
Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling.
The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4.
A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice.
Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells.
Stat3 and Stat4: members of the family of signal transducers and activators of transcription.
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.
O'Sullivan A, Chang HC, Yu Q, Kaplan MH
The Journal of biological chemistry 2004 Feb 20;279(8):7339-45
The Journal of biological chemistry 2004 Feb 20;279(8):7339-45
Synthesis and reactions of aminoporphyrazines with annulated five- and seven-membered rings.
Baum SM, Trabanco AA, Montalban AG, Micallef AS, Zhong C, Meunier HG, Suhling K, Phillips D, White AJ, Williams DJ, Barrett AG, Hoffman BM
The Journal of organic chemistry 2003 Mar 7;68(5):1665-70
The Journal of organic chemistry 2003 Mar 7;68(5):1665-70
Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling.
Freudenberg MA, Merlin T, Kalis C, Chvatchko Y, Stübig H, Galanos C
Journal of immunology (Baltimore, Md. : 1950) 2002 Aug 15;169(4):1665-8
Journal of immunology (Baltimore, Md. : 1950) 2002 Aug 15;169(4):1665-8
The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4.
Schindler H, Lutz MB, Röllinghoff M, Bogdan C
Journal of immunology (Baltimore, Md. : 1950) 2001 Mar 1;166(5):3075-82
Journal of immunology (Baltimore, Md. : 1950) 2001 Mar 1;166(5):3075-82
A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice.
Poltorak A, Merlin T, Nielsen PJ, Sandra O, Smirnova I, Schupp I, Boehm T, Galanos C, Freudenberg MA
Journal of immunology (Baltimore, Md. : 1950) 2001 Aug 15;167(4):2106-11
Journal of immunology (Baltimore, Md. : 1950) 2001 Aug 15;167(4):2106-11
Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells.
Matikainen S, Sareneva T, Ronni T, Lehtonen A, Koskinen PJ, Julkunen I
Blood 1999 Mar 15;93(6):1980-91
Blood 1999 Mar 15;93(6):1980-91
Stat3 and Stat4: members of the family of signal transducers and activators of transcription.
Zhong Z, Wen Z, Darnell JE Jr
Proceedings of the National Academy of Sciences of the United States of America 1994 May 24;91(11):4806-10
Proceedings of the National Academy of Sciences of the United States of America 1994 May 24;91(11):4806-10
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.
Yamamoto K, Quelle FW, Thierfelder WE, Kreider BL, Gilbert DJ, Jenkins NA, Copeland NG, Silvennoinen O, Ihle JN
Molecular and cellular biology 1994 Jul;14(7):4342-9
Molecular and cellular biology 1994 Jul;14(7):4342-9
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