M00081

antibody from Boster Biological Technology
Targeting: APP AD1
Provider product page for M00081
Western blot
Immunocytochemistry
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
M00081 - Provider product page
Provider
Boster Biological Technology
Product name
Anti-Amyloid beta A4 APP Rabbit Monoclonal Antibody
Antibody type
Monoclonal
Description
Monoclonal antibody for APP detection. Host: Rabbit.Size: 100ug/vial. Tested applications: Flow Cytometry, IP, IF, IHC, ICC, WB. Reactive species: Human, Mouse, Rat APP information: Molecular Weight: 86943 MW; Subcellular Localization: Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65). Beta-APP42 associates with FRPL1 at the cell surface and the complex is then rapidly internalized. APP sorts to the basolateral surface in epithelial cells. During neuronal
Reactivity
Human, Mouse, Rat
Host
Rabbit
Antibody clone number
BGC-1
Vial size
100ug/vial
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage
At -20°C for one year. Avoid repeated freezing and thawing.
APP protein structure - M00081 shown in red.