Tissue expression
Cell line expression
Protein structure
APP
Amyloid beta precursor proteinAD1
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Top validated antibodies |
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Invitrogen Antibodies | 36-6900 | 20 references | Polyclonal |
WB
ICC
IP
IHC
FC
OA |
|
Novus Biologicals | NBP2-13075 | 24 references | Monoclonal |
WB
EL
ICC
IP
IHC
|
|
Atlas Antibodies | HPA001462 | 1 references | Polyclonal |
WB
IHC |
|
antibodies-online | ABIN95037 | 1 references | Polyclonal |
WB
EL
ICC
IHC |
|
LSBio | LS-C745284 | Polyclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
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Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider