25524-1-AP

antibody from Proteintech Group

Targeting: APP AD1

Provider product page for 25524-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [68]
Comments [0]
Validations [0]

Submit

Product number: 25524-1-AP - Provider product page
Provider: Proteintech Group
Product name: APP antibody
Antibody type: Polyclonal
Description: APP antibody (Cat. #25524-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

APP protein structure - 25524-1-AP shown in red.

Submitted references Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system.

Li K, Feng Z, Xiong Z, Pan J, Zhou M, Li W, Ou Y, Wu G, Che M, Gong H, Peng J, Wang X, Qi S, Peng J
Neural regeneration research 2024 Oct 1;19(10):2249-2258

Total ginsenosides decrease Aβ production through activating PPARγ.

He S, Shi J, Ma L, Pei H, Zhang P, Shi D, Li H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116577

Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by CD8(+) T cells in cerebral malaria.

Wang Y, Shen Y, Liang J, Wang S, Huang Y, Zhu Q, Zhang X, Yu K, Tong G, Yang C, Li Y, Wang J, Zhao Y
Journal of neuroinflammation 2024 May 7;21(1):119

The changes of neurogenesis in the hippocampal dentate gyrus of SAMP8 mice and the effects of acupuncture and moxibustion.

Liu X, Chen J, Du Y, Tian Q, Wang L, Li W, Liu G, Tan Q, Wang J, Deng X
Brain research 2024 May 15;1831:148814

A Multisystemic Approach Revealed Aminated Polystyrene Nanoparticles-Induced Neurotoxicity.

Schröter L, Jentsch L, Maglioni S, Muñoz-Juan A, Wahle T, Limke A, von Mikecz A, Laromaine A, Ventura N
Small (Weinheim an der Bergstrasse, Germany) 2024 Mar;20(10):e2302907

Neuroprotective effects of Shenghui decoction via inhibition of the JNK/p38 MAPK signaling pathway in an AlCl(3)-induced zebrafish (Danio rerio) model of Alzheimer's disease.

Lu H, Tan A, Zhang Y, Chen Y, Ran S, Wang P
Journal of ethnopharmacology 2024 Jun 28;328:117993

Chronic pain exacerbates memory impairment and pathology of Aβ and tau by upregulating IL-1β and p-65 signaling in a mouse model of Alzheimer's disease.

Wang W, Zheng WQ, Du X, Chen SC, Chen YH, Ma QY, Wang H, Gao S, Tan R, Zhang HT, Zhou YM, Zhang FF
Brain research 2024 Jun 1;1832:148843

ApoE Mimic Peptide COG1410 Reduces Aβ Deposition and Improves Cognitive Function by Inducing the Transformation of A1/A2 Reactive Astrocytes and Increasing the BDNF Concentration in Brain of APP/PS1 Double Transgenic Mice.

Qiao Y, Liu H, He C, Ma Y
Neuroscience 2024 Jan 26;537:116-125

Antioxidant Efficacy of Hwangryunhaedok-tang through Nrf2 and AMPK Signaling Pathway against Neurological Disorders In Vivo and In Vitro.

Bae SJ, Lee WY, Bak SB, Lee SJ, Hwang SJ, Kim GW, Koo BS, Park SD, Yoo HH, Kim CO, Kang HW, Oh TW, Kim YW
International journal of molecular sciences 2024 Feb 15;25(4)

Peripheral amyloid-β clearance mediates cognitive impairment in non-alcoholic fatty liver disease.

Peng X, Zhang X, Xu Z, Li L, Mo X, Peng Z, Shan Z, Yan H, Xu J, Liu L
EBioMedicine 2024 Apr;102:105079

Electropositive Citric Acid-Polyethyleneimine Carbon Dots Carrying the PINK1 Gene Regulate ATP-Related Metabolic Dysfunction in APP/PS1-N2a Cells.

Yu S, Guo F, Luo Y, Zhang X, Wang C, Liu Y, Zhang H
Molecules (Basel, Switzerland) 2024 Apr 23;29(9)

Suppression of hnRNP A1 binding to HK1 RNA leads to glycolytic dysfunction in Alzheimer's disease models.

Ji XH, Liu TT, Wei AH, Lei HP, Chen Y, Wu LN, Liu J, Zhang Y, Yan F, Chen MX, Jin H, Shi JS, Zhou SY, Jin F
Frontiers in aging neuroscience 2023;15:1218267

Rolipram Ameliorates Memory Deficits and Depression-Like Behavior in APP/PS1/tau Triple Transgenic Mice: Involvement of Neuroinflammation and Apoptosis via cAMP Signaling.

Cong YF, Liu FW, Xu L, Song SS, Shen XR, Liu D, Hou XQ, Zhang HT
The international journal of neuropsychopharmacology 2023 Sep 25;26(9):585-598

Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease.

Guo Y, Zhang L
In vitro cellular & developmental biology. Animal 2023 Oct;59(9):665-673

Controlled release of Clenbuterol from a hydroxyapatite carrier for the treatment of Alzheimer's Disease.

Lin YW, Fang CH, Liang YJ, Yang CY, Kuo WT, Lin FH
Biomaterials research 2023 Oct 5;27(1):98

Application of Dominant Gut Microbiota Promises to Replace Fecal Microbiota Transplantation as a New Treatment for Alzheimer's Disease.

Li M, Yang H, Shao C, Liu Y, Wen S, Tang L
Microorganisms 2023 Nov 24;11(12)

Therapeutic Mechanism of Kai Xin San on Alzheimer's Disease Based on Network Pharmacology and Experimental Validation.

Wang K, Yang R, Chen TT, Qin MR, Wang P, Kong MW
Chinese journal of integrative medicine 2023 May;29(5):413-423

Depletion of gut microbiota resistance in 5×FAD mice enhances the therapeutic effect of mesenchymal stem cell-derived exosomes.

Hou X, Jiang H, Liu T, Yan J, Zhang F, Zhang X, Zhao J, Mu X, Jiang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114455

Gastrodin and Gastrodigenin Improve Energy Metabolism Disorders and Mitochondrial Dysfunction to Antagonize Vascular Dementia.

Wu S, Huang R, Zhang R, Xiao C, Wang L, Luo M, Song N, Zhang J, Yang F, Liu X, Yang W
Molecules (Basel, Switzerland) 2023 Mar 13;28(6)

Reduced expression of APLP2 in spinal GABAergic inhibitory neurons contributed to nerve injury-induced microglial activation and pain sensitization.

Li YZ, Zhu YB, Ge AN, Gao M, Wang KL, Zeng XR, Li J, Li Y, Xu JY, Bai HH, Wu SJ
Neuropharmacology 2023 Feb 15;224:109334

miRNA-137-5p improves spatial memory and cognition in Alzheimer's mice by targeting ubiquitin-specific peptidase 30.

Jiang Y, Bian W, Chen J, Cao X, Dong C, Xiao Y, Xu B, Sun X
Animal models and experimental medicine 2023 Dec;6(6):526-536

Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model.

Ding Y, Li L, Wang S, Cao Y, Yang M, Dai Y, Lin H, Li J, Liu Y, Wang Z, Liu W, Tao J
Biological research 2023 Dec 2;56(1):65

Brain-targeted lycopene-loaded microemulsion modulates neuroinflammation, oxidative stress, apoptosis and synaptic plasticity in β-amyloid-induced Alzheimer's disease mice.

Guo Y, Fan Z, Zhao S, Yu W, Hou X, Nie S, Xu S, Zhao C, Han J, Liu X
Neurological research 2023 Aug;45(8):753-764

Transfer of Tumor-Bearing Mice Intestinal Flora Can Ameliorate Cognition in Alzheimer's Disease Mice.

Hang Z, Cai S, Lei T, Zhang X, Xiao Z, Wang D, Li Y, Bi W, Yang Y, Deng S, Wang L, Li Q, Du H
Journal of Alzheimer's disease : JAD 2022;86(3):1287-1300

Baicalin Attenuates Continuous Activation of β-Catenin Induced by Lipopolysaccharide (LPS) and Depression Complicated by Infertility in Male Rats.

Fan R, Dai F, Zhang C, Zhou L, Qiu X, Li Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2112359

Activation of the RMTg Nucleus by Chemogenetic Techniques Alleviates the Learning and Memory Impairment in APP/PS1 Mice.

Zheng L, Wang Z, Liu Y, Zhao J, Huang S
Neuropsychiatric disease and treatment 2022;18:2957-2965

Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer's Disease.

Qi YY, Heng X, Yao ZY, Qu SY, Ge PY, Zhao X, Ni SJ, Guo R, Yang NY, Zhang QC, Zhu HX
Drug design, development and therapy 2022;16:931-950

Bilateral intracerebroventricular injection of streptozotocin induces AD-like behavioral impairments and neuropathological features in mice: Involved with the fundamental role of neuroinflammation.

Fan M, Liu S, Sun HM, Ma MD, Gao YJ, Qi CC, Xia QR, Ge JF
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113375

Resveratrol ameliorates learning and memory impairments induced by bilateral hippocampal injection of streptozotocin in mice.

Wei YD, Chen XX, Yang LJ, Gao XR, Xia QR, Qi CC, Ge JF
Neurochemistry international 2022 Oct;159:105385

Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway.

Yao Y, Ren Z, Yang R, Mei Y, Dai Y, Cheng Q, Xu C, Xu X, Wang S, Kim KM, Noh JH, Zhu J, Zhao N, Liu YU, Mao G, Sima J
Cell & bioscience 2022 Nov 4;12(1):180

Effects of the Notch Signaling Pathway on Secondary Brain Changes Caused by Spinal Cord Injury in Mice.

Li C, Huang S, Zhou W, Xie Z, Xie S, Li M
Neurochemical research 2022 Jun;47(6):1651-1663

Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8(+) T cells.

Liang J, Shen Y, Wang Y, Huang Y, Wang J, Zhu Q, Tong G, Yu K, Cao W, Wang Q, Li Y, Zhao Y
Molecular brain 2022 Jun 20;15(1):57

Astragalin attenuates AlCl(3)/D-galactose-induced aging-like disorders by inhibiting oxidative stress and neuroinflammation.

Hu Y, Fang X, Wang J, Ren TT, Zhao YY, Dai JF, Qin XY, Lan R
Neurotoxicology 2022 Jul;91:60-68

The immunomodulatory effect of microglia on ECM neuroinflammation via the PD-1/PD-L1 pathway.

Shen Y, Li Y, Zhu Q, Wang J, Huang Y, Liang J, Wu X, Zhao Y
CNS neuroscience & therapeutics 2022 Jan;28(1):46-63

Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation.

Li L, Li WJ, Zheng XR, Liu QL, Du Q, Lai YJ, Liu SQ
Molecular medicine (Cambridge, Mass.) 2022 Jan 29;28(1):11

Isoorientin Affects Markers of Alzheimer's Disease via Effects on the Oral and Gut Microbiota in APP/PS1 Mice.

Zhang Z, Tan X, Sun X, Wei J, Li QX, Wu Z
The Journal of nutrition 2022 Jan 11;152(1):140-152

GPNMB mitigates Alzheimer's disease and enhances autophagy via suppressing the mTOR signal.

Zhu Z, Liu Y, Li X, Zhang L, Liu H, Cui Y, Wang Y, Zhao D
Neuroscience letters 2022 Jan 10;767:136300

Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology.

Liu S, Fan M, Xu JX, Yang LJ, Qi CC, Xia QR, Ge JF
Journal of neuroinflammation 2022 Feb 7;19(1):35

The neuroprotective effects of phosphocreatine on amyloid beta 25-35-induced differentiated neuronal cell death through inhibition of AKT/GSK-3β /Tau/APP/CDK5 pathways in vivo and vitro.

Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Han QJ, Han G, Peng J, Tang Z
Free radical biology & medicine 2022 Feb 1;179:416-417

Stem cells from human exfoliated deciduous teeth relieves Alzheimer's disease symptoms in SAMP8 mice by up-regulating the PPARγ pathway.

Zhang X, Lei T, Wang D, Cai S, Hang Z, Yang Y, Bi W, Xiao Z, Du H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113169

Cognitive enhancement and neuroprotective effects of OABL, a sesquiterpene lactone in 5xFAD Alzheimer's disease mice model.

Tang JJ, Huang LF, Deng JL, Wang YM, Guo C, Peng XN, Liu Z, Gao JM
Redox biology 2022 Apr;50:102229

Long-term running exercise alleviates cognitive dysfunction in APP/PSEN1 transgenic mice via enhancing brain lysosomal function.

Wang X, Zhu YT, Zhu Y, Sun YL, Huang J, Li Z, Wang Y, Wu JC, Qin ZH, Lin F
Acta pharmacologica Sinica 2022 Apr;43(4):850-861

Brain-Penetration and Neuron-Targeting DNA Nanoflowers Co-Delivering miR-124 and Rutin for Synergistic Therapy of Alzheimer's Disease.

Ouyang Q, Liu K, Zhu Q, Deng H, Le Y, Ouyang W, Yan X, Zhou W, Tong J
Small (Weinheim an der Bergstrasse, Germany) 2022 Apr;18(14):e2107534

Investigating a Curcumin-Loaded PLGA-PEG-PLGA Thermo-Sensitive Hydrogel for the Prevention of Alzheimer's Disease.

Lin YW, Fang CH, Yang CY, Liang YJ, Lin FH
Antioxidants (Basel, Switzerland) 2022 Apr 7;11(4)

Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis.

Cai Y, Chai Y, Fu Y, Wang Y, Zhang Y, Zhang X, Zhu L, Miao M, Yan T
Frontiers in aging neuroscience 2021;13:809433

Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity.

Qi CC, Chen XX, Gao XR, Xu JX, Liu S, Ge JF
Frontiers in aging neuroscience 2021;13:633495

Comprehensive analysis of O-glycosylation of amyloid precursor protein (APP) using targeted and multi-fragmentation MS strategy.

Shi J, Ku X, Zou X, Hou J, Yan W, Zhang Y
Biochimica et biophysica acta. General subjects 2021 Oct;1865(10):129954

LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction.

Ma Y, Wang L, He F, Yang J, Ding Y, Ge S, Fan X, Zhou Y, Xu X, Jia R
Cancer letters 2021 May 28;506:67-82

Functional genomics study of protein inhibitor of activated STAT1 in mouse hippocampal neuronal cells revealed by RNA sequencing.

He K, Zhang J, Liu J, Cui Y, Liu LG, Ye S, Ban Q, Pan R, Liu D
Aging 2021 Mar 24;13(6):9011-9027

The effects of antimony on Alzheimer's disease-like pathological changes in mice brain.

Xu S, Yang Z, Zhi Y, Yu S, Zhang T, Jiang J, Tang J, He H, Lu M, Wang X, Wu Q, Zhao X
The Science of the total environment 2021 Mar 15;760:143235

A network-based analysis and experimental validation of traditional Chinese medicine Yuanhu Zhitong Formula in treating neuropathic pain.

Liu T, Li T, Chen X, Zhang K, Li M, Yao W, Zhang C, Wan L
Journal of ethnopharmacology 2021 Jun 28;274:114037

A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses.

Du H, Wong MY, Zhang T, Santos MN, Hsu C, Zhang J, Yu H, Luo W, Hu F
Life science alliance 2021 Jul;4(7)

Integrated bioinformatics analysis revealed the regulation of angiogenesis by tumor cells in hepatocellular carcinoma.

Huo M, Yu K, Zheng Y, Liu L, Zhao H, Li X, Huang C, Zhang J
Bioscience reports 2021 Jul 30;41(7)

The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.

Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Qing Ju Han, Han G, Peng J, Tang Z
Free radical biology & medicine 2021 Jan;162:181-190

Bottom up proteomics identifies neuronal differentiation pathway networks activated by cathepsin inhibition treatment in neuroblastoma cells that are enhanced by concurrent 13-cis retinoic acid treatment.

Halakos EG, Connell AJ, Glazewski L, Wei S, Mason RW
Journal of proteomics 2021 Feb 10;232:104068

Endogenous Aβ induces osteoporosis through an mTOR-dependent inhibition of autophagy in bone marrow mesenchymal stem cells (BMSCs).

Lin Y, Chen T, Chen J, Fang Y, Zeng C
Annals of translational medicine 2021 Dec;9(24):1794

N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy.

Long CM, Zheng QX, Zhou Y, Liu YT, Gong LP, Zeng YC, Liu S
Journal of pharmacological sciences 2021 Dec;147(4):315-324

Tetramethylpyrazine Attenuated Sevoflurane-Induced Neurotoxicity by Enhancing Autophagy through GPR50/CREB Pathway in SH-SY5Y Cells.

Xu L, Shen J, Dai S, Sun L, Chen X
The American journal of Chinese medicine 2020;48(4):945-966

Serum Exosomal Proteins F9 and TSP-1 as Potential Diagnostic Biomarkers for Newly Diagnosed Epilepsy.

Lin Z, Gu Y, Zhou R, Wang M, Guo Y, Chen Y, Ma J, Xiao F, Wang X, Tian X
Frontiers in neuroscience 2020;14:737

Activating transcription factor 6 reduces Aβ1-42 and restores memory in Alzheimer's disease model mice.

Du Y, Liu X, Zhu X, Liu Y, Wang X, Wu X
The International journal of neuroscience 2020 Oct;130(10):1015-1023

A transcriptomic analysis of Nsmce1 overexpression in mouse hippocampal neuronal cell by RNA sequencing.

Gong M, Wang Z, Liu Y, Li W, Ye S, Zhu J, Zhang H, Wang J, He K
Functional & integrative genomics 2020 May;20(3):459-470

Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells.

Gong M, Ye S, Li WX, Zhang J, Liu Y, Zhu J, Lv W, Zhang H, Wang J, Lu A, He K
American journal of physiology. Cell physiology 2020 Jun 1;318(6):C1123-C1135

Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.

Wei H, Zhang HL, Wang XC, Xie JZ, An DD, Wan L, Wang JZ, Zeng Y, Shu XJ, Westermarck J, Lu YM, Ohlmeyer M, Liu R
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jul;17(3):1087-1103

Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.

Escande-Beillard N, Loh A, Saleem SN, Kanata K, Hashimoto Y, Altunoglu U, Metoska A, Grandjean J, Ng FM, Pomp O, Baburajendran N, Wong J, Hill J, Beillard E, Cozzone P, Zaki M, Kayserili H, Hamada H, Shiratori H, Reversade B
Neuron 2020 Jul 8;107(1):82-94.e6

siRNA knockdown of alanine aminopeptidase impairs myoblast proliferation and differentiation.

Osana S, Kitajima Y, Suzuki N, Xu Y, Murayama K, Nagatomi R
Experimental cell research 2020 Dec 1;397(1):112337

Ginsenoside compound K ameliorates Alzheimer's disease in HT22 cells by adjusting energy metabolism.

Chen X, Li H, Yang Q, Lan X, Wang J, Cao Z, Shi X, Li J, Kan M, Qu X, Li N
Molecular biology reports 2019 Oct;46(5):5323-5332

Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.

Zhang Y, Xie JZ, Xu XY, Hu J, Xu T, Jin S, Yang SJ, Wang JZ
Neuroscience bulletin 2019 Aug;35(4):724-734

Schisandrin B protects PC12 cells by decreasing the expression of amyloid precursor protein and vacuolar protein sorting 35.

Yan M, Mao S, Dong H, Liu B, Zhang Q, Pan G, Fu Z
Neural regeneration research 2012 Mar 25;7(9):652-8

No comments: Submit comment

No validations: Submit validation data