RA0023

antibody from Oursmab

Targeting: APP AD1

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0023

Provider

Oursmab

Product name

Gantenerumab (Biosimilar Reference Antibody) (APP)

Antibody type

Monoclonal

Description

Gantenerumab is an investigational, fully human monoclonal IgG1 antibody developed for the treatment of Alzheimer's disease (AD). It functions as a targeted immunotherapeutic agent designed to promote the clearance of amyloid-beta (A¦Â) plaques from the brain. Gantenerumab is unique in that it is a conformational antibody; it specifically binds to a conformational epitope present on aggregated, fibrillar forms of A¦Â, which constitute the core of senile plaques. By binding to these plaques, the antibody aims to engage microglia, the brain's resident immune cells, via its IgG1 Fc region. This engagement facilitates phagocytosis and clearance of the plaques, thereby reducing the amyloid burden, a core pathological hallmark of Alzheimer's disease, with the goal of slowing clinical decline.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Gantenerumab (Biosimilar Reference Antibody) (APP)-RA0023-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Gantenerumab (Biosimilar Reference Antibody) (APP)-RA0023 in a linear range of 0.18¨C15 ng/mL.