14517-1-AP

antibody from Proteintech Group

Targeting: USP14 TGT

Provider product page for 14517-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [17]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 14517-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14517-1-AP, RRID:AB_2257124
Product name: USP14 antibody
Antibody type: Polyclonal
Description: KD/KO validated USP14 antibody (Cat. #14517-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

USP14 protein structure - 14517-1-AP shown in red.

Submitted references USP14 promotes the cancer stem-like cell properties of OSCC via promoting SOX2 deubiquitination.

Liu C, Zhou S, Tang W
Oral diseases 2024 Oct;30(7):4255-4265

GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.

Chen Y, Feng Y, Lin Y, Zhou X, Wang L, Zhou Y, Lin K, Cai L
British journal of cancer 2024 Mar;130(5):755-768

Triptolide attenuates cardiac remodeling by inhibiting pyroptosis and EndMT via modulating USP14/Keap1/Nrf2 pathway.

Ba L, E M, Wang R, Wu N, Wang R, Liu R, Feng X, Qi H, Sun H, Qiao G
Heliyon 2024 Jan 30;10(2):e24010

PKCiota Inhibits the Ferroptosis of Esophageal Cancer Cells via Suppressing USP14-Mediated Autophagic Degradation of GPX4.

Tao H, Song SJ, Fan ZW, Li WT, Jin X, Jiang W, Bai J, Shi ZZ
Antioxidants (Basel, Switzerland) 2024 Jan 17;13(1)

USP14 promotes the proliferation of cervical cancer via upregulating β-catenin.

Song H, Qiu J, Hua K
Environmental toxicology 2024 Feb;39(2):1031-1043

USP14 Positively Modulates Head and Neck Squamous Carcinoma Tumorigenesis and Potentiates Heat Shock Pathway through HSF1 Stabilization.

Wang J, Xiang Y, Xie Z, Fan M, Fang S, Wan H, Zhao R, Zeng F, Hua Q
Cancers 2023 Sep 1;15(17)

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway.

Hunter JE, Campbell AE, Hannaway NL, Kerridge S, Luli S, Butterworth JA, Sellier H, Mukherjee R, Dhillon N, Sudhindar PD, Shukla R, Brownridge PJ, Bell HL, Coxhead J, Taylor L, Leary P, Hasoon MSR, Collins I, Garrett MD, Eyers CE, Perkins ND
The Biochemical journal 2022 Oct 14;479(19):2063-2086

Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.

Han Z, Liu M, Xie Y, Zeng K, Zhan Z, Chen Y, Wang L, Chen X, Luo Y, Zeng Y, Zhan H, Lin Y, Zhang K, Zhu X, Liu S, Luo X, Zhou A
Cell death discovery 2022 Nov 4;8(1):445

Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.

Ming SL, Zhang S, Wang Q, Zeng L, Zhou LY, Wang MD, Ma YX, Han LQ, Zhong K, Zhu HS, Bai YL, Yang GY, Wang J, Chu BB
Autophagy 2022 Aug;18(8):1801-1821

SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis.

Zhu T, Wang Z, Zou T, Xu L, Zhang S, Chen Y, Chen C, Zhang W, Wang S, Ding Q, Xu G
Frontiers in pharmacology 2021;12:769647

The USP14-NLRC5 pathway inhibits titanium particle-induced osteolysis in mice by suppressing NF-κB and PI3K/AKT activities.

Fang G, Fu Y, Li S, Qiu J, Kuang M, Lin S, Li C, Ding Y
The Journal of biological chemistry 2020 May 15;295(20):7018-7032

SPAG5-AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway.

Xu J, Deng Y, Wang Y, Sun X, Chen S, Fu G
Cell proliferation 2020 Feb;53(2):e12738

CyclinB1 deubiquitination by USP14 regulates cell cycle progression in breast cancer.

Liu B, Liu Y, Wang Y, Xie C, Gan M, Han T, Cao J, Wang J
Pathology, research and practice 2019 Oct;215(10):152592

Proteasome-associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds.

Castro I, Ekinci E, Huang X, Cheaito HA, Ahn YH, Olivero-Verbel J, Dou QP
Journal of cellular biochemistry 2019 Aug;120(8):14065-14075

USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination.

Sharma A, Alswillah T, Singh K, Chatterjee P, Willard B, Venere M, Summers MK, Almasan A
Autophagy 2018;14(11):1976-1990

USP14 as a novel prognostic marker promotes cisplatin resistance via Akt/ERK signaling pathways in gastric cancer.

Fu Y, Ma G, Liu G, Li B, Li H, Hao X, Liu L
Cancer medicine 2018 Nov;7(11):5577-5588

Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma.

Zhang B, Li M, Huang P, Guan XY, Zhu YH
Thoracic cancer 2017 Jul;8(4):344-349

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse kidney tissue were subjected to SDS PAGE followed by western blot with 14517-1-AP(USP14 antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using USP14 antibody 14517-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line