NAALAD2

This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Description

N-acetylated alpha-linked acidic dipeptidase 2

Tissue specificity

Tissue enhanced (pituitary gland, testis)

Subcell location

Nucleoplasm

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (90131515 - 90192894)

Ensembl ID

ENSG00000077616  (ver. 103.38)

Orthologs

Mouse Naalad2: ENSMUSG00000043943

UniProt

Q9Y3Q0

neXtProt

NX_Q9Y3Q0

Human splice variants
Mouse splice variants

Protein structure