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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Product number
- ABIN362166 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) (pTyr493) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around phosphorylation site of pTyr493 (S-Y-Y (p) -T-A) derived from Human Zap-70. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pTyr493
- Isotype
- IgG
- Vial size
- 100 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function.
Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.
Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC
Proceedings of the National Academy of Sciences of the United States of America 2003 Jan 21;100(2):443-8
Proceedings of the National Academy of Sciences of the United States of America 2003 Jan 21;100(2):443-8
Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function.
Kong G, Dalton M, Bubeck Wardenburg J, Straus D, Kurosaki T, Chan AC
Molecular and cellular biology 1996 Sep;16(9):5026-35
Molecular and cellular biology 1996 Sep;16(9):5026-35
Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.
Chan AC, Dalton M, Johnson R, Kong GH, Wang T, Thoma R, Kurosaki T
The EMBO journal 1995 Jun 1;14(11):2499-508
The EMBO journal 1995 Jun 1;14(11):2499-508
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