ZAP70

gene product
SRK, STD, ZAP-70
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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GeneTex
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Antibodies.com
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Arigo
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ProSci
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RabMAbs
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Spring Bioscience
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Abbkine Scientific Co.Ltd.
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Bethyl Laboratories
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Creative Biolabs
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Everest Biotech
1 antibody
MyBioSource
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EMD Millipore
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Sigma-Aldrich
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Miltenyi Biotec
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Abbexa
1 antibody
eBioscience, An Affymetrix Company
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GenWay
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Abbiotec
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