Antibody data
- Antibody Data
- Antigen structure
- References [136]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 10144-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10144-2-AP, RRID:AB_2286875
- Product name
- STAT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated STAT1 antibody (Cat. #10144-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: FC, IF, IP, WB, ELISA.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation.
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65.
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis.
CD8(+) T cell infiltration and proliferation in the brainstem during experimental cerebral malaria.
Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells.
Sodium Butyrate Ameliorates Atopic Dermatitis-Induced Inflammation by Inhibiting HDAC3-Mediated STAT1 and NF-κB Pathway.
Irradiated tumour cell-derived microparticles upregulate MHC-I expression in cancer cells via DNA double-strand break repair pathway.
Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus.
IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects.
HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block PD-L1 for colorectal cancer immunotherapy.
Differential Regulation of the STING Pathway in Human Papillomavirus-Positive and -Negative Head and Neck Cancers.
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
ENO2 promotes anoikis resistance in anaplastic thyroid cancer by maintaining redox homeostasis.
SMG9 is a novel prognostic-related biomarker in glioma correlating with ferroptosis and immune infiltrates.
Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3.
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
TRIM65 knockout inhibits the development of HCC by polarization tumor-associated macrophages towards M1 phenotype via JAK1/STAT1 signaling pathway.
Role of Interleukin-21 in retinal ischemia-reperfusion injury: Unveiling the impact on retinal ganglion cell apoptosis.
The long noncoding RNA loc107053557 acts as a gga-miR-3530-5p sponge to suppress the replication of vvIBDV through regulating STAT1 expression.
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma.
FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins.
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression.
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.
A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases.
PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models.
Combining network pharmacology and in vitro and in vivo experiments to study the mechanism of Keluoxin in the treatment of radiation nephropathy†.
Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism.
The RhoA GTPase regulates Type I Interferon Signaling in Systemic lupus erythematosus.
SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway.
Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury.
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection.
ID1 expressing macrophages support cancer cell stemness and limit CD8(+) T cell infiltration in colorectal cancer.
Pretreatment of UC-MSCs with IFN-α2 improves treatment of liver fibrosis by recruiting neutrophils.
Erythropoietin suppresses osteoblast apoptosis and ameliorates steroid-induced necrosis of the femoral head in rats by inhibition of STAT1-caspase 3 signaling pathway.
EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling.
Neutrophil-derived interleukin-17A participates in neuroinflammation induced by traumatic brain injury.
C9ORF72 suppresses JAK-STAT mediated inflammation.
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.
Influenza A virus inhibits TET2 expression by endoribonuclease PA-X to attenuate type I interferon signaling and promote viral replication.
Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Role of SUMOylation of STAT1 in tubular epithelial‑mesenchymal transition induced by high glucose.
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
Opioid-induced fragile-like regulatory T cells contribute to withdrawal.
IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.
The Activation of Reticulophagy by ER Stress through the ATF4-MAP1LC3A-CCPG1 Pathway in Ovarian Granulosa Cells Is Linked to Apoptosis and Necroptosis.
Integrated analysis of murine cornea identifies JAK/STAT signaling pathway upregulated specifically in female Vitamin A Deficient mice.
KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.
Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase.
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
The role of IBV PL1pro in virus replication and suppression of host innate immune responses.
P4HA1, transcriptionally activated by STAT1, promotes esophageal cancer progression.
BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.
The mechanism of colon tissue damage mediated by HIF-1α/NF-κB/STAT1 in high-altitude environment.
ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.
RPS3 Promotes the Metastasis and Cisplatin Resistance of Adenoid Cystic Carcinoma.
E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.
Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3.
Polygalaxanthone III, an Active Ingredient in Polygala japonica Houtt., Repaired Malassezia-Stimulated Skin Injury via STAT3 Phosphorylated Activation.
Long noncoding RNA GAS5 inhibits proliferation and metastasis in papillary thyroid carcinoma through the IFN/STAT1 signaling pathway.
RUNX1 inhibits the antiviral immune response against influenza A virus through attenuating type I interferon signaling.
LncRNA RP5-998N21.4 promotes immune defense through upregulation of IFIT2 and IFIT3 in schizophrenia.
Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer.
IL-10 contributes to gemcitabine resistance in extranodal NK/T-cell lymphoma cells via ABCC4.
Hepatoprotective Polysaccharides from Geranium wilfordii: Purification, Structural Characterization, and Their Mechanism.
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Activation of STAT6 by intranasal allergens correlated with the development of eosinophilic chronic rhinosinusitis in a mouse model.
TRIB3 reduces CD8(+) T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer.
Extracellular domain of semaphorin 5A serves a tumor‑suppressing role by activating interferon signaling pathways in lung adenocarcinoma cells.
Structural optimization of Imidazo[1, 2-a]pyridine derivatives for the treatment of gastric cancer via STAT3 signaling pathway.
Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes.
Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity.
Cell-Free Extracts from Human Fat Tissue with a Hyaluronan-Based Hydrogel Attenuate Inflammation in a Spinal Cord Injury Model through M2 Microglia/Microphage Polarization.
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Acer Truncatum Seed Oil Alleviates Learning and Memory Impairments of Aging Mice.
Bioinformatics Analysis for Identification of Key Genes in Salivary Gland and the Potential of a Combination of Biomarkers for the Diagnosis of SS.
Chitosan Protects Immunosuppressed Mice Against Cryptosporidium parvum Infection Through TLR4/STAT1 Signaling Pathways and Gut Microbiota Modulation.
A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance.
CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways.
The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection.
Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus with MEK Inhibitor Trametinib in Some BRAF or KRAS-Mutated Colorectal or Lung Carcinoma Models.
Establishment of incontinence-associated dermatitis rat models and assessment of the therapeutic effects of zinc oxide, painless skin protective film and silicone dressing.
Polygalaxanthone III downregulates inflammation in the lipopolysaccharide-stimulated RAW264.7 macrophages: A quantibody array analysis.
Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3).
Tumour microenvironment-based molecular profiling reveals ideal candidates for high-grade serous ovarian cancer immunotherapy.
Serum proteome profiling provides a deep understanding of the 'gut-liver axis' in relation to liver injury and regeneration.
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Baicalein Delays H(2)O(2)-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.
Evaluation of piggyBac-mediated anti-CD19 CAR-T cells after ex vivo expansion with aAPCs or magnetic beads.
Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.
MAGE-C3 promotes cancer metastasis by inducing epithelial-mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma.
Cypermethrin triggers YY1-mediated testosterone biosynthesis suppression.
The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.
Curcumin prevents osteocyte apoptosis by inhibiting M1-type macrophage polarization in mice model of glucocorticoid-associated osteonecrosis of the femoral head.
IL-27 Rα(+) cells promoted allorejection via enhancing STAT1/3/5 phosphorylation.
CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway.
Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.
m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
miR-142-5p/DAX1-dependent regulation of P450c17 contributes to triclosan-mediated testosterone suppression.
Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.
TRIM59 suppresses NO production by promoting the binding of PIAS1 and STAT1 in macrophages.
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.
Rhein attenuates renal inflammatory injury of uric acid nephropathy via lincRNA-Cox2/miR-150-5p/STAT1 axis.
Silica particles disorganize the polarization of pulmonary macrophages in mice.
USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression.
Severe Fever With Thrombocytopenia Syndrome Virus-Induced Macrophage Differentiation Is Regulated by miR-146.
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
IL-27 Promotes Human Placenta-Derived Mesenchymal Stromal Cell Ability To Induce the Generation of CD4(+)IL-10(+)IFN-γ(+) T Cells via the JAK/STAT Pathway in the Treatment of Experimental Graft-versus-Host Disease.
Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated mouse prone 8 (SAMP8).
MicroRNA-204-5p suppresses IL6-mediated inflammatory response and chemokine generation in HK-2 renal tubular epithelial cells by targeting IL6R.
Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis.
Alcohol attenuates anti-HCV function of IFN-λ1 through up-regulation of PLASy expression in human hepatic cells.
Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
MicroRNA gga-miR-130b Suppresses Infectious Bursal Disease Virus Replication via Targeting of the Viral Genome and Cellular Suppressors of Cytokine Signaling 5.
The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression.
l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia.
Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis.
Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection.
Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
Global quantitative proteomic analysis profiles host protein expression in response to Sendai virus infection.
Quantitative Proteomic analysis on Activated Hepatic Stellate Cells reversion Reveal STAT1 as a key regulator between Liver Fibrosis and recovery.
Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.
IL-27 regulates the adherence, proliferation, and migration of MSCs and enhances their regulatory effects on Th1 and Th2 subset generations.
IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis.
iTRAQ-based Proteomic Analysis of Porcine Kidney Epithelial PK15 cells Infected with Pseudorabies virus.
Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone.
Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake.
IL-27 alleviates the bleomycin-induced pulmonary fibrosis by regulating the Th17 cell differentiation.
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Up-regulation of intestinal epithelial cell derived IL-7 expression by keratinocyte growth factor through STAT1/IRF-1, IRF-2 pathway.
Identification and analysis of glycogen synthase kinase 3 beta1 interactome.
Li Y, Dong X, He W, Quan H, Chen K, Cen C, Wei W
Obesity facts 2024;17(1):24-36
Obesity facts 2024;17(1):24-36
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65.
Gao X, Xuan Y, Zhou Z, Chen C, Wen Wang D, Wen Z
International immunopharmacology 2024 May 30;133:112073
International immunopharmacology 2024 May 30;133:112073
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis.
Chen H, Fu X, Wu X, Zhao J, Qiu F, Wang Z, Wang Z, Chen X, Xie D, Huang J, Fan J, Yang X, Song Y, Li J, He D, Xiao G, Lu A, Liang C
Bone research 2024 May 23;12(1):31
Bone research 2024 May 23;12(1):31
CD8(+) T cell infiltration and proliferation in the brainstem during experimental cerebral malaria.
Wang J, Zhu Q, Shen Y, Liang J, Wang Y, Huang Y, Tong G, Wang X, Zhang N, Yu K, Li Y, Zhao Y
CNS neuroscience & therapeutics 2024 Mar;30(3):e14431
CNS neuroscience & therapeutics 2024 Mar;30(3):e14431
Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells.
Jing ZL, Liu GL, Zhou N, Xu DY, Feng N, Lei Y, Ma LL, Tang MS, Tong GH, Tang N, Deng YJ
Scientific reports 2024 Mar 13;14(1):6053
Scientific reports 2024 Mar 13;14(1):6053
Sodium Butyrate Ameliorates Atopic Dermatitis-Induced Inflammation by Inhibiting HDAC3-Mediated STAT1 and NF-κB Pathway.
Hu C, Zeng D, Huang Y, Deng Q, Liu S, Zhou W, Zhou W
Inflammation 2024 Jun;47(3):989-1001
Inflammation 2024 Jun;47(3):989-1001
Irradiated tumour cell-derived microparticles upregulate MHC-I expression in cancer cells via DNA double-strand break repair pathway.
Deng S, Wang J, Hu Y, Sun Y, Yang X, Zhang B, Deng Y, Wei W, Zhang Z, Wen L, Qin Y, Huang F, Sheng Y, Wan C, Yang K
Cancer letters 2024 Jun 28;592:216898
Cancer letters 2024 Jun 28;592:216898
Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus.
Fan W, Wei B, Chen X, Zhang Y, Xiao P, Li K, Zhang YQ, Huang J, Leng L, Bucala R
Arthritis research & therapy 2024 Jan 20;26(1):31
Arthritis research & therapy 2024 Jan 20;26(1):31
IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects.
Liu Y, Dang Y, Zhang C, Liu L, Cai W, Li L, Fang L, Wang M, Xu S, Wang G, Zheng J, Li H
iScience 2024 Jan 19;27(1):108597
iScience 2024 Jan 19;27(1):108597
HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block PD-L1 for colorectal cancer immunotherapy.
Wen Y, Ye S, Li Z, Zhang X, Liu C, Wu Y, Zheng R, Xu C, Tian J, Shu L, Yan Q, Ai F, Ma J
Cancer immunology, immunotherapy : CII 2024 Jan 17;73(1):7
Cancer immunology, immunotherapy : CII 2024 Jan 17;73(1):7
Differential Regulation of the STING Pathway in Human Papillomavirus-Positive and -Negative Head and Neck Cancers.
Saulters EL, Kennedy PT, Carter RJ, Alsufyani A, Jones TM, Woolley JF, Dahal LN
Cancer research communications 2024 Jan 16;4(1):118-133
Cancer research communications 2024 Jan 16;4(1):118-133
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
Luan X, Lei T, Fang J, Liu X, Fu H, Li Y, Chu W, Jiang P, Tong C, Qi H, Fu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
ENO2 promotes anoikis resistance in anaplastic thyroid cancer by maintaining redox homeostasis.
Zhang Y, Ji X, Wang Y
Gland surgery 2024 Feb 29;13(2):209-224
Gland surgery 2024 Feb 29;13(2):209-224
SMG9 is a novel prognostic-related biomarker in glioma correlating with ferroptosis and immune infiltrates.
Dai Y, Zhang H, Feng S, Guo C, Tian W, Sun Y, Zhang Y
Heliyon 2024 Feb 29;10(4):e25716
Heliyon 2024 Feb 29;10(4):e25716
Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3.
Huang H, Lei X, Zhao C, Qin Y, Li Y, Zhang X, Li C, Lan T, Zhao B, Sun W, Lu H, Jin N
Journal of virology 2024 Feb 20;98(2):e0168223
Journal of virology 2024 Feb 20;98(2):e0168223
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Zhang H, Xia T, Xia Z, Zhou H, Li Z, Wang W, Zhai X, Jin B
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
TRIM65 knockout inhibits the development of HCC by polarization tumor-associated macrophages towards M1 phenotype via JAK1/STAT1 signaling pathway.
Jiang M, Wang D, Su N, Lou W, Chen Y, Yang H, Chen C, Xi F, Chen Y, Deng L, Tang X
International immunopharmacology 2024 Feb 15;128:111494
International immunopharmacology 2024 Feb 15;128:111494
Role of Interleukin-21 in retinal ischemia-reperfusion injury: Unveiling the impact on retinal ganglion cell apoptosis.
Zhang X, Hu Q, Jiang B, Xie F, Zhang Z, Hafezi-Moghadam A, Sun D
International immunopharmacology 2024 Feb 15;128:111480
International immunopharmacology 2024 Feb 15;128:111480
The long noncoding RNA loc107053557 acts as a gga-miR-3530-5p sponge to suppress the replication of vvIBDV through regulating STAT1 expression.
Huang X, Li Y, Li J, Jiang Y, Cui W, Zhou H, Tang L
Virulence 2024 Dec;15(1):2333237
Virulence 2024 Dec;15(1):2333237
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma.
Zhang QY, Ding W, Mo JS, Ou-Yang SM, Lin ZY, Peng KR, Liu GP, Lu JJ, Yue PB, Lei JP, Wang YD, Zhang XL
Acta pharmacologica Sinica 2024 Aug;45(8):1701-1714
Acta pharmacologica Sinica 2024 Aug;45(8):1701-1714
FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins.
Rex EA, Seo D, Chappidi S, Pinkham C, Brito Oliveira S, Embry A, Heisler D, Liu Y, Munir M, Luger K, Alto NM, da Fonseca FG, Orchard R, Hancks DC, Gammon DB
Nature microbiology 2024 Apr;9(4):988-1006
Nature microbiology 2024 Apr;9(4):988-1006
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
Fu Y, Li L, Zhang X, Deng Z, Wu Y, Chen W, Liu Y, He S, Wang J, Xie Y, Tu Z, Lyu Y, Wei Y, Wang S, Cui CP, Liu CH, Zhang L
Nature communications 2024 Apr 6;15(1):2974
Nature communications 2024 Apr 6;15(1):2974
PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression.
Tang J, He J, Guo H, Lin H, Li M, Yang T, Wang HY, Li D, Liu J, Li L, Xia H, Zhuo Z, Miao L
Research (Washington, D.C.) 2023;6:0033
Research (Washington, D.C.) 2023;6:0033
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.
Huang HX, Zhao CC, Lei XX, Zhang XY, Li YY, Lan T, Zhao BP, Lu JY, Sun WC, Lu HJ, Jin NY
Frontiers in immunology 2023;14:1196031
Frontiers in immunology 2023;14:1196031
A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases.
Tao G, Liu F, Jin Z, Liu B, Wang H, Li D, Tang W, Chen Y, He Q, Qin S
Theranostics 2023;13(8):2455-2470
Theranostics 2023;13(8):2455-2470
PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models.
Wong CW, Evangelou C, Sefton KN, Leshem R, Zhang W, Gopalan V, Chattrakarn S, Fernandez Carro ML, Uzuner E, Mole H, Wilcock DJ, Smith MP, Sergiou K, Telfer BA, Isaac DT, Liu C, Perl NR, Marie K, Lorigan P, Williams KJ, Rao PE, Nagaraju RT, Niepel M, Hurlstone AFL
Nature communications 2023 Sep 26;14(1):5983
Nature communications 2023 Sep 26;14(1):5983
Combining network pharmacology and in vitro and in vivo experiments to study the mechanism of Keluoxin in the treatment of radiation nephropathy†.
Deng L, Wang S, Leng X, Yao P, Li C, Zheng Y
Journal of radiation research 2023 Sep 22;64(5):769-782
Journal of radiation research 2023 Sep 22;64(5):769-782
Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism.
Huang L, Zhang J, Wei B, Chen S, Zhu S, Qi W, Pei X, Li L, Liu W, Wang Y, Xu X, Xie LG, Chen L
Cell chemical biology 2023 Sep 21;30(9):1076-1089.e11
Cell chemical biology 2023 Sep 21;30(9):1076-1089.e11
The RhoA GTPase regulates Type I Interferon Signaling in Systemic lupus erythematosus.
Fan W, Wei B, Chen X, Zhang Y, Xiao P, Li K, Zhang YQ, Huang J, Leng L, Bucala R
Research square 2023 Sep 20;
Research square 2023 Sep 20;
SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway.
Gu W, Qi G, Chen L
Iranian journal of immunology : IJI 2023 Sep 1;20(3):335-347
Iranian journal of immunology : IJI 2023 Sep 1;20(3):335-347
Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury.
Kong P, Yang M, Wang Y, Yu KN, Wu L, Han W
Redox biology 2023 Oct;66:102857
Redox biology 2023 Oct;66:102857
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
Huangfu N, Ma H, Tian M, Zhang J, Wang Y, Li Z, Chen X, Cui H
Inflammation 2023 Oct;46(5):1725-1738
Inflammation 2023 Oct;46(5):1725-1738
Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection.
Zhang MQ, Jia X, Cheng CQ, Wang YX, Li YY, Kong LD, Li QQ, Xie F, Yu YL, He YT, Dong QT, Jia ZH, Wang Y, Xu AL
Acta pharmacologica Sinica 2023 Nov;44(11):2253-2264
Acta pharmacologica Sinica 2023 Nov;44(11):2253-2264
ID1 expressing macrophages support cancer cell stemness and limit CD8(+) T cell infiltration in colorectal cancer.
Shang S, Yang C, Chen F, Xiang RS, Zhang H, Dai SY, Liu J, Lv XX, Zhang C, Liu XT, Zhang Q, Lu SB, Song JW, Yu JJ, Zhou JC, Zhang XW, Cui B, Li PP, Zhu ST, Zhang HZ, Hua F
Nature communications 2023 Nov 23;14(1):7661
Nature communications 2023 Nov 23;14(1):7661
Pretreatment of UC-MSCs with IFN-α2 improves treatment of liver fibrosis by recruiting neutrophils.
Xie Y, Yao J, Yan M, Lin Y, Wei J, Wang H, Mao Y, Liu P, Li X
Journal of translational medicine 2023 Nov 18;21(1):832
Journal of translational medicine 2023 Nov 18;21(1):832
Erythropoietin suppresses osteoblast apoptosis and ameliorates steroid-induced necrosis of the femoral head in rats by inhibition of STAT1-caspase 3 signaling pathway.
Cai T, Chen S, Wu C, Lou C, Wang W, Lin C, Jiang H, Xu X
BMC musculoskeletal disorders 2023 Nov 17;24(1):894
BMC musculoskeletal disorders 2023 Nov 17;24(1):894
EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling.
Luo Y, Ali T, Liu Z, Gao R, Li A, Yang C, Ling L, He L, Li S
Life sciences 2023 Nov 15;333:122102
Life sciences 2023 Nov 15;333:122102
Neutrophil-derived interleukin-17A participates in neuroinflammation induced by traumatic brain injury.
Xu XJ, Ge QQ, Yang MS, Zhuang Y, Zhang B, Dong JQ, Niu F, Li H, Liu BY
Neural regeneration research 2023 May;18(5):1046-1051
Neural regeneration research 2023 May;18(5):1046-1051
C9ORF72 suppresses JAK-STAT mediated inflammation.
Pang W, Hu F
iScience 2023 May 19;26(5):106579
iScience 2023 May 19;26(5):106579
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.
Zhang W, Pan X, Xu Y, Guo H, Zheng M, Chen X, Wu H, Luan F, He Q, Ding L, Yang B
Acta pharmaceutica Sinica. B 2023 Jun;13(6):2585-2600
Acta pharmaceutica Sinica. B 2023 Jun;13(6):2585-2600
Influenza A virus inhibits TET2 expression by endoribonuclease PA-X to attenuate type I interferon signaling and promote viral replication.
Hu Y, Chen X, Ling Y, Zhou K, Han M, Wang X, Yue M, Li Y
PLoS pathogens 2023 Jul;19(7):e1011550
PLoS pathogens 2023 Jul;19(7):e1011550
Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.
Li L, Sun H, Chen J, Ding C, Yang X, Han H, Sun Q
Cell reports 2023 Jul 25;42(7):112697
Cell reports 2023 Jul 25;42(7):112697
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Pan C, Fei Q, Jin J, Zheng J, Wu D, Li H, Huang X, Kong X
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
Role of SUMOylation of STAT1 in tubular epithelial‑mesenchymal transition induced by high glucose.
Gu C, Gao F, Zhang S, Kang L, Zhang W, Feng X, Liu J, Tian Y, Wei Q, Du Y, Xing Y, Liu Q, Liu S
Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
Jing B, Guo F, An R, Gao Y, Li Y, Xie Y, Wang J, Chen Y, Li H, Gao T, Jin Q, Zhang L, Xie M
Journal of nanobiotechnology 2023 Feb 2;21(1):37
Journal of nanobiotechnology 2023 Feb 2;21(1):37
Opioid-induced fragile-like regulatory T cells contribute to withdrawal.
Zhu Y, Yan P, Wang R, Lai J, Tang H, Xiao X, Yu R, Bao X, Zhu F, Wang K, Lu Y, Dang J, Zhu C, Zhang R, Dang W, Zhang B, Fu Q, Zhang Q, Kang C, Chen Y, Chen X, Liang Q, Wang K
Cell 2023 Feb 2;186(3):591-606.e23
Cell 2023 Feb 2;186(3):591-606.e23
IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.
Zeng Y, Chen HQ, Zhang Z, Fan J, Li JZ, Zhou SM, Wang N, Yan SP, Cao J, Liu JY, Zhou ZY, Liu WB
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120943
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120943
The Activation of Reticulophagy by ER Stress through the ATF4-MAP1LC3A-CCPG1 Pathway in Ovarian Granulosa Cells Is Linked to Apoptosis and Necroptosis.
Li H, Jing Y, Qu X, Yang J, Pan P, Liu X, Gao H, Pei X, Zhang C, Yang Y
International journal of molecular sciences 2023 Feb 1;24(3)
International journal of molecular sciences 2023 Feb 1;24(3)
Integrated analysis of murine cornea identifies JAK/STAT signaling pathway upregulated specifically in female Vitamin A Deficient mice.
Yu H, Wu J, Li K, Huang Y, Wu T, Wang L, Huang Y
Experimental eye research 2023 Dec;237:109714
Experimental eye research 2023 Dec;237:109714
KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.
Pan X, Zhang W, Wang L, Guo H, Zheng M, Wu H, Weng Q, He Q, Ding L, Yang B
Molecular oncology 2023 Dec;17(12):2659-2674
Molecular oncology 2023 Dec;17(12):2659-2674
Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase.
Yao YL, Luo Y, Wang Q, Geng R, Chen Y, Liu MQ, Li B, Chen J, Wu CG, Jia JK, Luo JY, He YT, Jiang TT, Zhu Y, Hu B, Zhou P, Shi ZL
Emerging microbes & infections 2023 Dec;12(2):2249120
Emerging microbes & infections 2023 Dec;12(2):2249120
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
Tang F, Lu C, He X, Lin W, Xie B, Gao X, Peng Y, Yang D, Sun L, Weng L
Cell reports 2023 Dec 26;42(12):113477
Cell reports 2023 Dec 26;42(12):113477
The role of IBV PL1pro in virus replication and suppression of host innate immune responses.
Liu W, Mu G, Jia Y, Yu M, Zhang S, Wang Z, Fang S
BMC veterinary research 2023 Dec 13;19(1):270
BMC veterinary research 2023 Dec 13;19(1):270
P4HA1, transcriptionally activated by STAT1, promotes esophageal cancer progression.
Gou W, Yang Y, Shan Q, Xia S, Ma Y
Pathology international 2023 Apr;73(4):147-158
Pathology international 2023 Apr;73(4):147-158
BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.
Shan F, Shen S, Wang X, Chen G
International journal of oncology 2023 Apr;62(4)
International journal of oncology 2023 Apr;62(4)
The mechanism of colon tissue damage mediated by HIF-1α/NF-κB/STAT1 in high-altitude environment.
Cheng J, Sun Y, He J, Wang Z, Li W, Wang R
Frontiers in physiology 2022;13:933659
Frontiers in physiology 2022;13:933659
ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.
Wen X, Chen S, Chen X, Qiu H, Wang W, Zhang N, Liu W, Wang T, Ding X, Zhang L
Frontiers in oncology 2022;12:887068
Frontiers in oncology 2022;12:887068
RPS3 Promotes the Metastasis and Cisplatin Resistance of Adenoid Cystic Carcinoma.
Rui X, Huang Z, Chen R, Chen Y, Wang Y, Huang Z
Frontiers in oncology 2022;12:804439
Frontiers in oncology 2022;12:804439
E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.
Sun W, Hua X, Gu Y, Xu Q, Zhu S, Lv T, Song Y
Clinical immunology (Orlando, Fla.) 2022 Sep;242:109099
Clinical immunology (Orlando, Fla.) 2022 Sep;242:109099
Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3.
Deng L, Mo J, Zhang Y, Peng K, Li H, Ouyang S, Feng Z, Fang W, Wei J, Rong D, Zhang X, Wang Y
Journal of medicinal chemistry 2022 Oct 13;65(19):13094-13111
Journal of medicinal chemistry 2022 Oct 13;65(19):13094-13111
Polygalaxanthone III, an Active Ingredient in Polygala japonica Houtt., Repaired Malassezia-Stimulated Skin Injury via STAT3 Phosphorylated Activation.
Yang X, Xiong B, Yuan Z, Liao H, Liu X, Wu Y, Zhang S, Xiang Q
Molecules (Basel, Switzerland) 2022 Nov 3;27(21)
Molecules (Basel, Switzerland) 2022 Nov 3;27(21)
Long noncoding RNA GAS5 inhibits proliferation and metastasis in papillary thyroid carcinoma through the IFN/STAT1 signaling pathway.
Xu Y, Lu J, Lou N, Lu W, Xu J, Jiang H, Ye G
Pathology, research and practice 2022 May;233:153856
Pathology, research and practice 2022 May;233:153856
RUNX1 inhibits the antiviral immune response against influenza A virus through attenuating type I interferon signaling.
Hu Y, Pan Q, Zhou K, Ling Y, Wang H, Li Y
Virology journal 2022 Mar 5;19(1):39
Virology journal 2022 Mar 5;19(1):39
LncRNA RP5-998N21.4 promotes immune defense through upregulation of IFIT2 and IFIT3 in schizophrenia.
Guo B, Jiang T, Wu F, Ni H, Ye J, Wu X, Ni C, Jiang M, Ye L, Li Z, Zheng X, Li S, Yang Q, Wang Z, Huang X, Zhao C
Schizophrenia (Heidelberg, Germany) 2022 Mar 1;8(1):11
Schizophrenia (Heidelberg, Germany) 2022 Mar 1;8(1):11
Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer.
Ouyang S, Li H, Lou L, Huang Q, Zhang Z, Mo J, Li M, Lu J, Zhu K, Chu Y, Ding W, Zhu J, Lin Z, Zhong L, Wang J, Yue P, Turkson J, Liu P, Wang Y, Zhang X
Redox biology 2022 Jun;52:102317
Redox biology 2022 Jun;52:102317
IL-10 contributes to gemcitabine resistance in extranodal NK/T-cell lymphoma cells via ABCC4.
Huo J, Fu L, Jin M, Li Z, Zhang M
Investigational new drugs 2022 Jun;40(3):537-545
Investigational new drugs 2022 Jun;40(3):537-545
Hepatoprotective Polysaccharides from Geranium wilfordii: Purification, Structural Characterization, and Their Mechanism.
Feng JY, Xie YQ, Zhang P, Zhou Q, Khan A, Zhou ZH, Xia XS, Liu L
Molecules (Basel, Switzerland) 2022 Jun 3;27(11)
Molecules (Basel, Switzerland) 2022 Jun 3;27(11)
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Activation of STAT6 by intranasal allergens correlated with the development of eosinophilic chronic rhinosinusitis in a mouse model.
Wei H, Xu L, Sun P, Xing H, Zhu Z, Liu J
International journal of immunopathology and pharmacology 2022 Jan-Dec;36:3946320221109529
International journal of immunopathology and pharmacology 2022 Jan-Dec;36:3946320221109529
TRIB3 reduces CD8(+) T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer.
Shang S, Yang YW, Chen F, Yu L, Shen SH, Li K, Cui B, Lv XX, Zhang C, Yang C, Liu J, Yu JJ, Zhang XW, Li PP, Zhu ST, Zhang HZ, Hua F
Science translational medicine 2022 Jan 5;14(626):eabf0992
Science translational medicine 2022 Jan 5;14(626):eabf0992
Extracellular domain of semaphorin 5A serves a tumor‑suppressing role by activating interferon signaling pathways in lung adenocarcinoma cells.
Chen MZ, Su LY, Ko PH, Hsu MH, Chuang LL, Chen LH, Lu TP, Chuang EY, Chow LP, Tsai MH, Hsu HH, Lai LC
International journal of oncology 2022 Feb;60(2)
International journal of oncology 2022 Feb;60(2)
Structural optimization of Imidazo[1, 2-a]pyridine derivatives for the treatment of gastric cancer via STAT3 signaling pathway.
Li H, Ouyang S, Zhang Y, Peng K, Fang W, Liu Z, Wang CY, Zhang X, Wang Y
European journal of medicinal chemistry 2022 Dec 15;244:114858
European journal of medicinal chemistry 2022 Dec 15;244:114858
Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes.
Cui L, Wang Y, Ren L, Li Z, Jiang Y, Wang C, Liu X, Ren Y, Hu X
Parasites & vectors 2022 Dec 13;15(1):464
Parasites & vectors 2022 Dec 13;15(1):464
Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity.
Li C, He WF, Li LX, Chen J, Yang GQ, Chang HT, Liu HM
Viruses 2022 Aug 24;14(9)
Viruses 2022 Aug 24;14(9)
Cell-Free Extracts from Human Fat Tissue with a Hyaluronan-Based Hydrogel Attenuate Inflammation in a Spinal Cord Injury Model through M2 Microglia/Microphage Polarization.
Xu GY, Xu S, Zhang YX, Yu ZY, Zou F, Ma XS, Xia XL, Zhang WJ, Jiang JY, Song J
Small (Weinheim an der Bergstrasse, Germany) 2022 Apr;18(17):e2107838
Small (Weinheim an der Bergstrasse, Germany) 2022 Apr;18(17):e2107838
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Liu Z, Xu B, Ding Y, Ding X, Yang Z
Bioengineered 2022 Apr;13(4):9357-9368
Bioengineered 2022 Apr;13(4):9357-9368
Acer Truncatum Seed Oil Alleviates Learning and Memory Impairments of Aging Mice.
Li X, Li T, Hong XY, Liu JJ, Yang XF, Liu GP
Frontiers in cell and developmental biology 2021;9:680386
Frontiers in cell and developmental biology 2021;9:680386
Bioinformatics Analysis for Identification of Key Genes in Salivary Gland and the Potential of a Combination of Biomarkers for the Diagnosis of SS.
Chen L, Lu D, Yu K, He S, Liu L, Zhang X, Feng B, Wang X
Journal of inflammation research 2021;14:4143-4153
Journal of inflammation research 2021;14:4143-4153
Chitosan Protects Immunosuppressed Mice Against Cryptosporidium parvum Infection Through TLR4/STAT1 Signaling Pathways and Gut Microbiota Modulation.
Rahman SU, Gong H, Mi R, Huang Y, Han X, Chen Z
Frontiers in immunology 2021;12:784683
Frontiers in immunology 2021;12:784683
A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance.
Zheng Q, Dong H, Mo J, Zhang Y, Huang J, Ouyang S, Shi S, Zhu K, Qu X, Hu W, Liu P, Wang Y, Zhang X
Theranostics 2021;11(2):824-840
Theranostics 2021;11(2):824-840
CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways.
Chen X, He H, Xiao Y, Hasim A, Yuan J, Ye M, Li X, Hao Y, Guo X
Frontiers in oncology 2021;11:629350
Frontiers in oncology 2021;11:629350
The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection.
Li T, Cui L, Xu X, Zhang H, Jiang Y, Ren L, Yang C, Liu X, Hu X
Frontiers in cellular and infection microbiology 2021;11:587150
Frontiers in cellular and infection microbiology 2021;11:587150
Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus with MEK Inhibitor Trametinib in Some BRAF or KRAS-Mutated Colorectal or Lung Carcinoma Models.
Zhou X, Zhao J, Zhang JV, Wu Y, Wang L, Chen X, Ji D, Zhou GG
Viruses 2021 Sep 3;13(9)
Viruses 2021 Sep 3;13(9)
Establishment of incontinence-associated dermatitis rat models and assessment of the therapeutic effects of zinc oxide, painless skin protective film and silicone dressing.
Chen G, Huang L, Chen Y, Zheng S, Zhu L, Ding M
Experimental and therapeutic medicine 2021 Oct;22(4):1058
Experimental and therapeutic medicine 2021 Oct;22(4):1058
Polygalaxanthone III downregulates inflammation in the lipopolysaccharide-stimulated RAW264.7 macrophages: A quantibody array analysis.
Wu Y, Fu H, Yang X, Leng F, Huang Y, Deng H, Xiang Q, Zhang S
Journal of pharmacological sciences 2021 Oct;147(2):184-191
Journal of pharmacological sciences 2021 Oct;147(2):184-191
Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3).
Huang Q, Zhong Y, Li B, Ouyang S, Deng L, Mo J, Shi S, Lv N, Wu R, Liu P, Hu W, Zhang X, Wang Y
European journal of medicinal chemistry 2021 Oct 5;221:113525
European journal of medicinal chemistry 2021 Oct 5;221:113525
Tumour microenvironment-based molecular profiling reveals ideal candidates for high-grade serous ovarian cancer immunotherapy.
Lu X, Ji C, Jiang L, Zhu Y, Zhou Y, Meng J, Gao J, Lu T, Ye J, Yan F
Cell proliferation 2021 Mar;54(3):e12979
Cell proliferation 2021 Mar;54(3):e12979
Serum proteome profiling provides a deep understanding of the 'gut-liver axis' in relation to liver injury and regeneration.
Leng L, Ma J, Lv L, Gao D, Li M, Wang Y, Zhu Y
Acta biochimica et biophysica Sinica 2021 Mar 2;53(3):372-380
Acta biochimica et biophysica Sinica 2021 Mar 2;53(3):372-380
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Zhou Z, Li Y, Ma X, Cao B, Peng T, Sheng Y, Peng H, Li R, Cao Y, Xi R, Li F, Wang M, Sun H, Zhang G, Zhang H, Hu K, Xiao W, Wang F
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Baicalein Delays H(2)O(2)-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.
Gao L, Zheng WG, Wu XK, Du GH, Qin XM
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335
Evaluation of piggyBac-mediated anti-CD19 CAR-T cells after ex vivo expansion with aAPCs or magnetic beads.
Yang LR, Li L, Meng MY, Wang WJ, Yang SL, Zhao YY, Wang RQ, Gao H, Tang WW, Yang Y, Yang LL, Liao LW, Hou ZL
Journal of cellular and molecular medicine 2021 Jan;25(2):686-700
Journal of cellular and molecular medicine 2021 Jan;25(2):686-700
Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.
Luo N, Yang C, Zhu Y, Chen Q, Zhang B
Journal of agricultural and food chemistry 2021 Jan 20;69(2):655-667
Journal of agricultural and food chemistry 2021 Jan 20;69(2):655-667
MAGE-C3 promotes cancer metastasis by inducing epithelial-mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma.
Wu Q, Zhang W, Wang Y, Min Q, Zhang H, Dong D, Zhan Q
Cancer communications (London, England) 2021 Dec;41(12):1354-1372
Cancer communications (London, England) 2021 Dec;41(12):1354-1372
Cypermethrin triggers YY1-mediated testosterone biosynthesis suppression.
Liu C, Qu J, Wu M, Huang X, Li L
Ecotoxicology and environmental safety 2021 Dec 1;225:112792
Ecotoxicology and environmental safety 2021 Dec 1;225:112792
The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.
Yan Z, Zhan J, Qi W, Lin J, Huang Y, Xue X, Pan X
Frontiers in pharmacology 2020;11:1195
Frontiers in pharmacology 2020;11:1195
Curcumin prevents osteocyte apoptosis by inhibiting M1-type macrophage polarization in mice model of glucocorticoid-associated osteonecrosis of the femoral head.
Jin S, Meng C, He Y, Wang X, Zhang Q, Wang Z, Huang W, Wang H
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Sep;38(9):2020-2030
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Sep;38(9):2020-2030
IL-27 Rα(+) cells promoted allorejection via enhancing STAT1/3/5 phosphorylation.
Zhao S, Liang T, Zhang C, Shi D, Jiang W, Su C, Hou G
Journal of cellular and molecular medicine 2020 Sep;24(18):10756-10767
Journal of cellular and molecular medicine 2020 Sep;24(18):10756-10767
CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway.
Chen Y, Shao Z, Jiang E, Zhou X, Wang L, Wang H, Luo X, Chen Q, Liu K, Shang Z
Journal of cellular physiology 2020 Sep;235(9):5995-6009
Journal of cellular physiology 2020 Sep;235(9):5995-6009
Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.
Zhang M, Fu M, Li M, Hu H, Gong S, Hu Q
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 1;205(5):1281-1292
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 1;205(5):1281-1292
m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana TM
The EMBO journal 2020 Oct 15;39(20):e104514
The EMBO journal 2020 Oct 15;39(20):e104514
miR-142-5p/DAX1-dependent regulation of P450c17 contributes to triclosan-mediated testosterone suppression.
Duan P, Huang X, Ha M, Li L, Liu C
The Science of the total environment 2020 May 15;717:137280
The Science of the total environment 2020 May 15;717:137280
Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.
Fan Z, Chen X, Liu L, Zhu C, Xu J, Yin X, Sheng Y, Zhu Z, Wen L, Zuo X, Zheng X, Zhang Y, Xu J, Huang H, Zhou F, Sun L, Luo J, Zhang D, Chen X, Cui Y, Hao Y, Cui Y, Zhang X, Chen R
Arthritis & rheumatology (Hoboken, N.J.) 2020 Jun;72(6):985-996
Arthritis & rheumatology (Hoboken, N.J.) 2020 Jun;72(6):985-996
TRIM59 suppresses NO production by promoting the binding of PIAS1 and STAT1 in macrophages.
Su X, Zhang Q, Yue J, Wang Y, Zhang Y, Yang R
International immunopharmacology 2020 Dec;89(Pt A):107030
International immunopharmacology 2020 Dec;89(Pt A):107030
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.
Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X
Investigative ophthalmology & visual science 2020 Dec 1;61(14):24
Investigative ophthalmology & visual science 2020 Dec 1;61(14):24
Rhein attenuates renal inflammatory injury of uric acid nephropathy via lincRNA-Cox2/miR-150-5p/STAT1 axis.
Hu J, Yang Z, Wu H, Wang D
International immunopharmacology 2020 Aug;85:106620
International immunopharmacology 2020 Aug;85:106620
Silica particles disorganize the polarization of pulmonary macrophages in mice.
Zhao Y, Hao C, Bao L, Wang D, Li Y, Qu Y, Ding M, Zhao A, Yao W
Ecotoxicology and environmental safety 2020 Apr 15;193:110364
Ecotoxicology and environmental safety 2020 Apr 15;193:110364
USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression.
Han B, Sun Y, Yang D, Zhang H, Mo S, Chen X, Lu H, Mao X, Hu J
Aging 2020 Apr 15;12(8):6990-7005
Aging 2020 Apr 15;12(8):6990-7005
Severe Fever With Thrombocytopenia Syndrome Virus-Induced Macrophage Differentiation Is Regulated by miR-146.
Zhang L, Fu Y, Wang H, Guan Y, Zhu W, Guo M, Zheng N, Wu Z
Frontiers in immunology 2019;10:1095
Frontiers in immunology 2019;10:1095
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
Zhang YZ, Zhang ZM, Zhou LT, Zhu J, Zhang XH, Qi W, Ding S, Xu Q, Han X, Zhao YM, Song XY, Zhao TY, Ye L
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
Yuan J, Tan L, Yin Z, Zhu W, Tao K, Wang G, Shi W, Gao J
Cell death & disease 2019 Jun 11;10(6):454
Cell death & disease 2019 Jun 11;10(6):454
IL-27 Promotes Human Placenta-Derived Mesenchymal Stromal Cell Ability To Induce the Generation of CD4(+)IL-10(+)IFN-γ(+) T Cells via the JAK/STAT Pathway in the Treatment of Experimental Graft-versus-Host Disease.
Yi J, Chen Z, Xu F, Wang Z, Zhang A, Liu T, Zhao N, Xiong Y, Jiang G, Ma J, Luan X
Journal of immunology (Baltimore, Md. : 1950) 2019 Feb 15;202(4):1124-1136
Journal of immunology (Baltimore, Md. : 1950) 2019 Feb 15;202(4):1124-1136
Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated mouse prone 8 (SAMP8).
Li J, Zhou Y, Du G, Qin X, Gao L
European journal of pharmacology 2019 Dec 15;865:172789
European journal of pharmacology 2019 Dec 15;865:172789
MicroRNA-204-5p suppresses IL6-mediated inflammatory response and chemokine generation in HK-2 renal tubular epithelial cells by targeting IL6R.
Li H, Wang J, Liu X, Cheng Q
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Apr;97(2):109-117
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Apr;97(2):109-117
Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis.
Wu J, Wang A, Wang X, Li G, Jia P, Shen G, Chen B, Yuan Y, Zhang H, Yang F, Xu Y
Bone 2019 Apr;121:16-28
Bone 2019 Apr;121:16-28
Alcohol attenuates anti-HCV function of IFN-λ1 through up-regulation of PLASy expression in human hepatic cells.
Ran M, Huang J, Liang H, Jiang J, Liang B, Ning C, Zang N, Liao W, Liu H, Qin F, Yang Q, Ho W, Ye L, Chen H
Journal of medical virology 2018 Jun;90(6):1112-1120
Journal of medical virology 2018 Jun;90(6):1112-1120
Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.
Wang H, Xin X, Wang M, Han L, Li J, Hao Y, Zheng C, Shen C
Archives of virology 2018 Jun;163(6):1429-1438
Archives of virology 2018 Jun;163(6):1429-1438
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
Shen H, Zhan M, Zhang Y, Huang S, Xu S, Huang X, He M, Yao Y, Man M, Wang J
Cell death & disease 2018 Jan 22;9(2):71
Cell death & disease 2018 Jan 22;9(2):71
MicroRNA gga-miR-130b Suppresses Infectious Bursal Disease Virus Replication via Targeting of the Viral Genome and Cellular Suppressors of Cytokine Signaling 5.
Fu M, Wang B, Chen X, He Z, Wang Y, Li X, Cao H, Zheng SJ
Journal of virology 2018 Jan 1;92(1)
Journal of virology 2018 Jan 1;92(1)
The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression.
Kueck T, Cassella E, Holler J, Kim B, Bieniasz PD
eLife 2018 Aug 22;7
eLife 2018 Aug 22;7
l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia.
Leng YP, Ma YS, Li XG, Chen RF, Zeng PY, Li XH, Qiu CF, Li YP, Zhang Z, Chen AF
British journal of pharmacology 2018 Apr;175(8):1157-1172
British journal of pharmacology 2018 Apr;175(8):1157-1172
Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis.
Liu Q, Du Y, Li K, Zhang W, Feng X, Hao J, Li H, Liu S
Mediators of inflammation 2017;2017:3038514
Mediators of inflammation 2017;2017:3038514
Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection.
Fu Y, Zhang L, Zhang F, Tang T, Zhou Q, Feng C, Jin Y, Wu Z
PLoS pathogens 2017 Sep;13(9):e1006611
PLoS pathogens 2017 Sep;13(9):e1006611
Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, Hao H, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704
Global quantitative proteomic analysis profiles host protein expression in response to Sendai virus infection.
Zhu SL, Chen X, Wang LJ, Wan WW, Xin QL, Wang W, Xiao G, Zhang LK
Proteomics 2017 Mar;17(5)
Proteomics 2017 Mar;17(5)
Quantitative Proteomic analysis on Activated Hepatic Stellate Cells reversion Reveal STAT1 as a key regulator between Liver Fibrosis and recovery.
Zhang H, Chen F, Fan X, Lin C, Hao Y, Wei H, Lin W, Jiang Y, He F
Scientific reports 2017 Mar 21;7:44910
Scientific reports 2017 Mar 21;7:44910
Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.
Igbe I, Shen XF, Jiao W, Qiang Z, Deng T, Li S, Liu WL, Liu HW, Zhang GL, Wang F
Oncotarget 2017 Dec 26;8(69):113734-113748
Oncotarget 2017 Dec 26;8(69):113734-113748
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.
Wonganan O, He YJ, Shen XF, Wongkrajang K, Suksamrarn A, Zhang GL, Wang F
Toxicology and applied pharmacology 2017 Dec 1;336:31-39
Toxicology and applied pharmacology 2017 Dec 1;336:31-39
IL-27 regulates the adherence, proliferation, and migration of MSCs and enhances their regulatory effects on Th1 and Th2 subset generations.
Xu F, Yi J, Wang Z, Hu Y, Han C, Xue Q, Zhang X, Luan X
Immunologic research 2017 Aug;65(4):903-912
Immunologic research 2017 Aug;65(4):903-912
IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis.
Shen P, Li Q, Ma J, Tian M, Hong F, Zhai X, Li J, Huang H, Shi C
BMC microbiology 2017 Aug 23;17(1):185
BMC microbiology 2017 Aug 23;17(1):185
iTRAQ-based Proteomic Analysis of Porcine Kidney Epithelial PK15 cells Infected with Pseudorabies virus.
Yang S, Pei Y, Zhao A
Scientific reports 2017 Apr 4;7:45922
Scientific reports 2017 Apr 4;7:45922
Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone.
Huang B, Wang W, Li Q, Wang Z, Yan B, Zhang Z, Wang L, Huang M, Jia C, Lu J, Liu S, Chen H, Li M, Cai D, Jiang Y, Jin D, Bai X
Nature communications 2016 Dec 14;7:13885
Nature communications 2016 Dec 14;7:13885
Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake.
Yang X, Yao H, Chen Y, Sun L, Li Y, Ma X, Duan S, Li X, Xiang R, Han J, Duan Y
The Journal of biological chemistry 2015 Sep 4;290(36):21788-99
The Journal of biological chemistry 2015 Sep 4;290(36):21788-99
IL-27 alleviates the bleomycin-induced pulmonary fibrosis by regulating the Th17 cell differentiation.
Dong Z, Lu X, Yang Y, Zhang T, Li Y, Chai Y, Lei W, Li C, Ai L, Tai W
BMC pulmonary medicine 2015 Feb 18;15:13
BMC pulmonary medicine 2015 Feb 18;15:13
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Wang X, Liu J, Zhen J, Zhang C, Wan Q, Liu G, Wei X, Zhang Y, Wang Z, Han H, Xu H, Bao C, Song Z, Zhang X, Li N, Yi F
Kidney international 2014 Oct;86(4):712-25
Kidney international 2014 Oct;86(4):712-25
Up-regulation of intestinal epithelial cell derived IL-7 expression by keratinocyte growth factor through STAT1/IRF-1, IRF-2 pathway.
Cai YJ, Wang WS, Yang Y, Sun LH, Teitelbaum DH, Yang H
PloS one 2013;8(3):e58647
PloS one 2013;8(3):e58647
Identification and analysis of glycogen synthase kinase 3 beta1 interactome.
Gao X, Wang JY, Gao LM, Yin XF, Liu L
Cell biology international 2013 Aug;37(8):768-79
Cell biology international 2013 Aug;37(8):768-79
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 10144-2-AP(STAT1 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The STAT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human STAT1. This antibody recognizes human,mouse,rat antigen. The STAT1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.