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- Product number
- 10144-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10144-2-AP, RRID:AB_2286875
- Product name
- STAT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated STAT1 antibody (Cat. #10144-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: FC, IF, IP, WB, ELISA.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrated network analysis and experimental validation identify CCNA2, CD44, and STAT1 as clinically relevant hub genes in oral squamous cell carcinoma.
Ursodeoxycholic acid against TGEV infection via the JAK-STAT1 signaling pathway.
AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy.
O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular matrix to facilitate tumor growth.
ALKBH3 suppresses ischemia/reperfusion-induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m(1)A demethylation.
Network toxicology integrated with machine learning and SHAP analysis identifies overlapping immune signatures between Di(2-ethylhexyl) phthalate (DEHP) and Sjögren's syndrome.
Matrine improves bile acid metabolism and reduces inflammatory and oxidative stress in colitis via the JAK2 pathway.
RUNX1 restrains STAT1-GITRL signaling to shape an immunosuppressive CRC microenvironment.
Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis.
A feedback mechanism from prostate cancer cells to macrophages, reinforced by STAT1, regulates tumor progression and resistance to radiotherapy.
Diabetic Kidney Disease Progression Alleviated in Mice by ALKBH5-Mediated UC-MSCs-Derived Exosomes That Inhibit TRAF6 m6A Modification and Promote M2 Macrophage Polarisation.
Transcriptomic analysis identifies CXCL12 as a novel candidate gene for litter size in rabbits.
Luteolin ameliorates steroid-induced osteonecrosis of the femoral head via a gut microbiota-L-Carnitine-IFIH1 axis.
Targeting macrophage glycogen metabolism attenuates ulcerative colitis by suppressing IL-1β production through UDPG-P2Y(14) signaling.
Targeting G9a Exerts Pleiotropic Suppression in Triple-Negative Breast Cancer Cells: Cooperatively Inducing Pyroptosis and Apoptosis.
Ly93 Inhibits Sphingomyelin Synthesis and Attenuates Inflammation and Injury in Dry Eye Conjunctival Organoids.
Simulated microgravity induces cerebral dysfunction by disturbing protective microbiota-metabolite-microglia signaling across the gut‒brain axis.
GPX1 expression promotes stemness and aggressiveness in myxoid liposarcomas.
Novel Duck Orthoreovirus σA Protein Inhibits Interferon Signaling by Impeding STAT1/STAT2 Nuclear Translocation.
ZnO NPs Attenuate LPS-Induced Inflammation in RAW264.7 Macrophages by Inhibiting NF-κB and JAK1-STAT1/STAT3 Pathways and Reducing ROS.
Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production.
Reciprocal activation between M1 macrophages and trophoblasts through CXCL9/STAT1/ZEB1/CCL2 axis promotes recurrent spontaneous abortion.
Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization.
STAT1-IFITM3 promotes autophagy in epithelial cells to control Cryptosporidium parvum infection.
STAT1-mediated epigenetic regulation of LIN28A controls iPSC-derived platelet production through the let-7-RALB axis.
STAT3 operates as an inflammation-dependent transcriptional switch.
MED12-STAT1-TAP2 axis regulates CD8 + T cell cytotoxicity and mediates immunotherapy outcome in non-small cell lung cancer.
Ferroptosis triggers anti-tumor immunity via promoting chaperone-mediated autophagic degradation of SHP2.
Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.
TAP1 promotes immune escape by activating JNK/STAT1/PD-L1 signaling in EBV-associated gastric cancer.
Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer.
GSDME-dependent astrocyte pyroptosis promotes the progression of neuroinflammation in experimental cerebral malaria.
M6A-mediated uc003pes.1 stability regulates proliferation and migration of human coronary artery smooth muscle cells via scaffolding STAT1 and USP10.
IL27RA promotes the proliferation and metastasis of hepatocellular carcinoma cells by regulating TGFβR1.
Protective Effect of Mesaconate on Autoimmune Hepatitis via Suppression of Inflammatory Response and Oxidative Stress.
Identifying a novel region in the Tembusu virus NS5 protein antagonizing type I interferon signaling.
An IFN/STAT1/CYBB axis defines protective plasmacytoid DC-neutrophil crosstalk in Aspergillus fumigatus-infected mice.
Fedratinib inhibits ovarian cancer progression by downregulating QPCT expression.
Myricetin alleviates DNCB-induced atopic dermatitis by modulating macrophage M1/M2 polarization.
Exosomal CagA induces macrophage polarization and ferroptosis by JAK1-2/STAT1 signaling pathway in Helicobacter pylori-associated gastritis.
Huaier overcomes tumor-induced immunosuppression in colorectal cancer by activating MHC I and CD8+ T cells.
Kaempferide enhances type I interferon signaling as a novel broad-spectrum antiviral agent.
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.
Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications.
Xiaoqinglong decoction combined with Yupingfeng powder alleviates combined allergic rhinitis and asthma syndrome by regulating the JAK2-STAT1-MHC II signaling pathway to suppress B lymphocyte activation.
Human genetic variation shapes the response of neurons to interferons.
Proteome-wide ligandability maps of drugs with diverse cysteine-reactive chemotypes.
Ultrasound Visualization of Spatiotemporal Autophagy-Regulated Nanodroplets for Amplifying ICB in Melanoma via Remodeling Tumor Inflammatory Microenvironment.
AUP1 and UBE2G2 complex targets STING signaling and regulates virus-induced innate immunity.
The role of Morin in attenuating atherosclerosis via STAT1 pathway inhibition.
Bardoxolone displays potent activity against triple negative breast cancer by inhibiting the TRIP13/STAT3 circuit.
Tanshinone IIA promotes ferroptosis in cutaneous melanoma via STAT1-mediated upregulation of PTGS2 expression.
Discovery of novel STAT3 inhibitors with anti-breast cancer activity: structure-based virtual screening, molecular dynamics and biological evaluation.
Astragalus injection antagonizes the efficacy of anti-PD-1 against melanoma through down-regulating MHC-II expression.
Cyclophilin D knockdown/knockout promotes microglia M2 polarization by inhibiting STAT1 to alleviate neuroinflammation in neonatal white matter injury.
Estradiol (E2) concentration shapes the chromatin binding landscape of estrogen receptor alpha.
African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.
Formin protein DAAM1 positively regulates PD-L1 expression via mediating the JAK1/STAT1 axis in pancreatic cancer.
Efficacy of caerulomycin A in modulating macrophage polarization and cytokine response in a murine model of lipopolysaccharide-induced sepsis.
CircKat6b Mediates the Antidepressant Effect of Esketamine by Regulating Astrocyte Function.
Low-dose SAHA enhances CD8(+) T cell-mediated antitumor immunity by boosting MHC I expression in non-small cell lung cancer.
Protein kinase a suppresses antiproliferative effect of interferon-α in hepatocellular carcinoma by activation of protein tyrosine phosphatase SHP2.
VSIG4(+) tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1.
Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1.
FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma.
MA104 cell line is permissive for human bocavirus 1 infection.
Administration of a Recombinant Fusion Protein of IFN-γ and CD154 Inhibited the Infection of Chicks with Salmonella enterica.
IFN-γ-mediated inhibition of JAK/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis.
Cepharanthine relieves nonalcoholic steatohepatitis through inhibiting STAT1/CXCL10 axis-mediated lipogenesis and inflammatory responses.
YBX1 is required for maintaining PD-L1 expression in intrahepatic cholangiocarcinoma by regulating STAT1 stability in an m5C-dependent manner.
STAT2 Promotes Tumor Growth in Colorectal Cancer Independent of Type I IFN Receptor Signaling.
LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity.
Lactate-functionalized 3D-printed PCL/nHA scaffold drives BMSC osteogenesis via metabolic-epigenetic crosstalk.
The alpha-coronavirus E protein inhibits the JAK-STAT pathway signaling by triggering STAT2 degradation through OPTN- and NBR1-mediated selective autophagy.
Next-generation probiotics Alistipes onderdonkii enhances the efficacy of anti-PD-1 therapy in colorectal cancer.
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod-induced psoriasiform inflammation via STAT1/S100A9 signalling pathway.
Evidence that mitochondria in macrophages are destroyed by microautophagy.
STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences.
Deletion of SH2D5 alleviates epileptic seizures and NMDAR expression via autophagic degradation of STAT1.
OASL activates MAPK to drive psoriatic pathogenesis: Astilbin targeting this axis improves metabolic-inflammation crosstalk.
Kinsenoside alleviates experimental acute pancreatitis by suppressing M1 macrophage polarization via the TLR4/STAT1 signaling pathway.
Potential of CLSPN as a therapeutic target in melanoma: a key player in melanoma progression and tumor microenvironment.
o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis.
Human long noncoding RNA VILMIR is induced by major respiratory viral infections and modulates the host interferon response.
Machine learning-assisted analysis of serum metabolomics and network pharmacology reveals the effective compound from herbal formula against alcoholic liver injury.
Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes.
PLA2G7 promotes immune evasion of bladder cancer through the JAK-STAT-PDL1 axis.
IRF9 and STAT1 as biomarkers involved in T-cell immunity in atherosclerosis.
Quercetin of huoxuehuayu tongluo decoction and azithromycin combination therapy effectively improves rat tubal factor infertility by inhibiting inflammation.
Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation.
Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor.
MiR-301b-3p promotes breast cancer development through inhibiting the expression of transforming growth factor-beta receptor 2.
ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
MAPK pathway orchestrates gallid alphaherpesvirus 1 infection through the biphasic activation of MEK/ERK and p38 MAPK signaling.
Exploring the molecular mechanism of ginseng against anthracycline-induced cardiotoxicity based on network pharmacology, molecular docking and molecular dynamics simulation.
Palmatine ameliorates N-methyl-N'-nitrosoguanidine-induced chronic atrophic gastritis through the STAT1/CXCL10 axis.
Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling.
Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8(+) T cell infiltration.
Proteomic Analysis Reveals Oxidative Phosphorylation and JAK-STAT Pathways Mediated Pathogenesis of Pemphigus Vulgaris.
pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection.
Macrophage P2Y(6)R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses.
Sodium butyrate alleviates lipopolysaccharide-induced inflammation through JAK/STAT signalling in primary human corneal fibroblasts.
Glycolysis inhibition induces anti-tumor central memory CD8(+)T cell differentiation upon combination with microwave ablation therapy.
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65.
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis.
CD8(+) T cell infiltration and proliferation in the brainstem during experimental cerebral malaria.
Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells.
Sodium Butyrate Ameliorates Atopic Dermatitis-Induced Inflammation by Inhibiting HDAC3-Mediated STAT1 and NF-κB Pathway.
Fangchinoline induces antiviral response by suppressing STING degradation.
Irradiated tumour cell-derived microparticles upregulate MHC-I expression in cancer cells via DNA double-strand break repair pathway.
Combined Proteomic and Metabolomic Analysis Reveals Comprehensive Regulation of Somatostatin DNA Vaccine in Goats.
PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation.
African swine fever virus pB475L evades host antiviral innate immunity via targeting STAT2 to inhibit IFN-I signaling.
MCM8 promotes gastric cancer progression through RPS15A and predicts poor prognosis.
Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver.
Synergistic activity of Enterococcus Faecium-induced ferroptosis via expansion of IFN-γ(+)CD8(+) T cell population in advanced hepatocellular carcinoma treated with sorafenib.
Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus.
IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects.
HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block PD-L1 for colorectal cancer immunotherapy.
Differential Regulation of the STING Pathway in Human Papillomavirus-Positive and -Negative Head and Neck Cancers.
A suitable and efficient optimization system for the culture of Chlamydia trachomatis in adult inclusion conjunctivitis.
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
ENO2 promotes anoikis resistance in anaplastic thyroid cancer by maintaining redox homeostasis.
SMG9 is a novel prognostic-related biomarker in glioma correlating with ferroptosis and immune infiltrates.
Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3.
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
TRIM65 knockout inhibits the development of HCC by polarization tumor-associated macrophages towards M1 phenotype via JAK1/STAT1 signaling pathway.
Role of Interleukin-21 in retinal ischemia-reperfusion injury: Unveiling the impact on retinal ganglion cell apoptosis.
Sodium houttuyfonate modulates the lung Th1/Th2 balance and gut microbiota to protect against pathological changes in lung of ovalbumin-induced asthmatic mice.
The long noncoding RNA loc107053557 acts as a gga-miR-3530-5p sponge to suppress the replication of vvIBDV through regulating STAT1 expression.
Xuanfei Baidu decoction ameliorates bleomycin-elicited idiopathic pulmonary fibrosis in mice by regulating the lung-gut crosstalk via IFNγ/STAT1/STAT3 axis.
An IFN-STAT1-CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk During Aspergillus fumigatus Infection.
Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling.
Diammonium glycyrrhizinate ameliorates alcohol-induced liver injury by reducing oxidative stress, steatosis, and inflammation.
The STAT1-SLC31A1 axis: Potential regulation of cuproptosis in diabetic retinopathy.
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma.
Silicone dressing combined with topical oxygen therapy alleviates incontinence-associated dermatitis via NF-κB p65/STAT1 signaling pathway.
Blockade of the mitochondrial DNA release ameliorates hepatic ischemia-reperfusion injury through avoiding the activation of cGAS-Sting pathway.
Biomineralization-Tuned Nanounits Reprogram the Signal Transducer and Activator of Transcription 3 Signaling for Ferroptosis-Immunotherapy in Cancer Stem Cells.
FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins.
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression.
Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.
A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases.
PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models.
Combining network pharmacology and in vitro and in vivo experiments to study the mechanism of Keluoxin in the treatment of radiation nephropathy†.
Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism.
The RhoA GTPase regulates Type I Interferon Signaling in Systemic lupus erythematosus.
SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway.
Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury.
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection.
ID1 expressing macrophages support cancer cell stemness and limit CD8(+) T cell infiltration in colorectal cancer.
Pretreatment of UC-MSCs with IFN-α2 improves treatment of liver fibrosis by recruiting neutrophils.
Erythropoietin suppresses osteoblast apoptosis and ameliorates steroid-induced necrosis of the femoral head in rats by inhibition of STAT1-caspase 3 signaling pathway.
EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling.
Neutrophil-derived interleukin-17A participates in neuroinflammation induced by traumatic brain injury.
C9ORF72 suppresses JAK-STAT mediated inflammation.
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.
Influenza A virus inhibits TET2 expression by endoribonuclease PA-X to attenuate type I interferon signaling and promote viral replication.
Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Role of SUMOylation of STAT1 in tubular epithelial‑mesenchymal transition induced by high glucose.
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
Opioid-induced fragile-like regulatory T cells contribute to withdrawal.
IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.
The Activation of Reticulophagy by ER Stress through the ATF4-MAP1LC3A-CCPG1 Pathway in Ovarian Granulosa Cells Is Linked to Apoptosis and Necroptosis.
Integrated analysis of murine cornea identifies JAK/STAT signaling pathway upregulated specifically in female Vitamin A Deficient mice.
KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.
Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase.
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
The role of IBV PL1pro in virus replication and suppression of host innate immune responses.
P4HA1, transcriptionally activated by STAT1, promotes esophageal cancer progression.
BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.
The mechanism of colon tissue damage mediated by HIF-1α/NF-κB/STAT1 in high-altitude environment.
ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.
RPS3 Promotes the Metastasis and Cisplatin Resistance of Adenoid Cystic Carcinoma.
E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.
Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3.
Polygalaxanthone III, an Active Ingredient in Polygala japonica Houtt., Repaired Malassezia-Stimulated Skin Injury via STAT3 Phosphorylated Activation.
Long noncoding RNA GAS5 inhibits proliferation and metastasis in papillary thyroid carcinoma through the IFN/STAT1 signaling pathway.
RUNX1 inhibits the antiviral immune response against influenza A virus through attenuating type I interferon signaling.
LncRNA RP5-998N21.4 promotes immune defense through upregulation of IFIT2 and IFIT3 in schizophrenia.
Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer.
IL-10 contributes to gemcitabine resistance in extranodal NK/T-cell lymphoma cells via ABCC4.
Hepatoprotective Polysaccharides from Geranium wilfordii: Purification, Structural Characterization, and Their Mechanism.
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Activation of STAT6 by intranasal allergens correlated with the development of eosinophilic chronic rhinosinusitis in a mouse model.
TRIB3 reduces CD8(+) T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer.
Extracellular domain of semaphorin 5A serves a tumor‑suppressing role by activating interferon signaling pathways in lung adenocarcinoma cells.
Structural optimization of Imidazo[1, 2-a]pyridine derivatives for the treatment of gastric cancer via STAT3 signaling pathway.
Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes.
Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity.
Cell-Free Extracts from Human Fat Tissue with a Hyaluronan-Based Hydrogel Attenuate Inflammation in a Spinal Cord Injury Model through M2 Microglia/Microphage Polarization.
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Acer Truncatum Seed Oil Alleviates Learning and Memory Impairments of Aging Mice.
Bioinformatics Analysis for Identification of Key Genes in Salivary Gland and the Potential of a Combination of Biomarkers for the Diagnosis of SS.
Chitosan Protects Immunosuppressed Mice Against Cryptosporidium parvum Infection Through TLR4/STAT1 Signaling Pathways and Gut Microbiota Modulation.
A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance.
CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways.
The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection.
Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus with MEK Inhibitor Trametinib in Some BRAF or KRAS-Mutated Colorectal or Lung Carcinoma Models.
Establishment of incontinence-associated dermatitis rat models and assessment of the therapeutic effects of zinc oxide, painless skin protective film and silicone dressing.
Polygalaxanthone III downregulates inflammation in the lipopolysaccharide-stimulated RAW264.7 macrophages: A quantibody array analysis.
Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3).
Tumour microenvironment-based molecular profiling reveals ideal candidates for high-grade serous ovarian cancer immunotherapy.
Serum proteome profiling provides a deep understanding of the 'gut-liver axis' in relation to liver injury and regeneration.
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Baicalein Delays H(2)O(2)-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.
Evaluation of piggyBac-mediated anti-CD19 CAR-T cells after ex vivo expansion with aAPCs or magnetic beads.
Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.
MAGE-C3 promotes cancer metastasis by inducing epithelial-mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma.
Cypermethrin triggers YY1-mediated testosterone biosynthesis suppression.
The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.
Curcumin prevents osteocyte apoptosis by inhibiting M1-type macrophage polarization in mice model of glucocorticoid-associated osteonecrosis of the femoral head.
IL-27 Rα(+) cells promoted allorejection via enhancing STAT1/3/5 phosphorylation.
CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway.
Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.
m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
miR-142-5p/DAX1-dependent regulation of P450c17 contributes to triclosan-mediated testosterone suppression.
Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.
TRIM59 suppresses NO production by promoting the binding of PIAS1 and STAT1 in macrophages.
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.
Rhein attenuates renal inflammatory injury of uric acid nephropathy via lincRNA-Cox2/miR-150-5p/STAT1 axis.
Silica particles disorganize the polarization of pulmonary macrophages in mice.
USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression.
Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water.
Severe Fever With Thrombocytopenia Syndrome Virus-Induced Macrophage Differentiation Is Regulated by miR-146.
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
IL-27 Promotes Human Placenta-Derived Mesenchymal Stromal Cell Ability To Induce the Generation of CD4(+)IL-10(+)IFN-γ(+) T Cells via the JAK/STAT Pathway in the Treatment of Experimental Graft-versus-Host Disease.
Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated mouse prone 8 (SAMP8).
MicroRNA-204-5p suppresses IL6-mediated inflammatory response and chemokine generation in HK-2 renal tubular epithelial cells by targeting IL6R.
Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis.
Alcohol attenuates anti-HCV function of IFN-λ1 through up-regulation of PLASy expression in human hepatic cells.
Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
MicroRNA gga-miR-130b Suppresses Infectious Bursal Disease Virus Replication via Targeting of the Viral Genome and Cellular Suppressors of Cytokine Signaling 5.
The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression.
l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia.
Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis.
Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection.
Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
Global quantitative proteomic analysis profiles host protein expression in response to Sendai virus infection.
Quantitative Proteomic analysis on Activated Hepatic Stellate Cells reversion Reveal STAT1 as a key regulator between Liver Fibrosis and recovery.
Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.
IL-27 regulates the adherence, proliferation, and migration of MSCs and enhances their regulatory effects on Th1 and Th2 subset generations.
IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis.
iTRAQ-based Proteomic Analysis of Porcine Kidney Epithelial PK15 cells Infected with Pseudorabies virus.
Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone.
Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1.
Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake.
Interferon-stimulated gene factor 3 complex is required for the induction of sterile α motif and HD domain-containing protein 1 expression by interferon-α in SMMC-7721 cells.
IL-27 alleviates the bleomycin-induced pulmonary fibrosis by regulating the Th17 cell differentiation.
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Up-regulation of intestinal epithelial cell derived IL-7 expression by keratinocyte growth factor through STAT1/IRF-1, IRF-2 pathway.
Identification and analysis of glycogen synthase kinase 3 beta1 interactome.
Bu M, Gu Y, Meng Y, Cui Y, Wu Q, Kong Y, Liu H, Chen Y, Zhang J, Guo L, Yang Y, Huang D, Ma Z
Frontiers in molecular biosciences 2026;13:1748821
Frontiers in molecular biosciences 2026;13:1748821
Ursodeoxycholic acid against TGEV infection via the JAK-STAT1 signaling pathway.
Sun Z, Liu A, Zhong Y, Song Z, Liao G, Li Y, Song Y, Li Q, Zhang X, Song Z
Veterinary microbiology 2026 May;316:110973
Veterinary microbiology 2026 May;316:110973
AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy.
Hong J, Xu H, Yu L, Yu Z, Chen X, Meng Z, Zhu J, Li J, Zhu M
Cell death and differentiation 2026 Mar;33(3):589-604
Cell death and differentiation 2026 Mar;33(3):589-604
O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular matrix to facilitate tumor growth.
Lin B, Zhou J, Geng D, Chai S, Zhang X, Zhang Z, Hu J, Tang Q, Chen X, Yi W, Wu L
Cell death and differentiation 2026 Mar;33(3):574-588
Cell death and differentiation 2026 Mar;33(3):574-588
ALKBH3 suppresses ischemia/reperfusion-induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m(1)A demethylation.
Diao H, Wang C, Xiong Y, Zhao Q, Zhang X, Qi X, Zou Y, Li J, Zeng L, Si W, Zhang F, Pang P, Wang N, Bian Y, Yang B
Clinical and translational medicine 2026 Mar;16(3):e70632
Clinical and translational medicine 2026 Mar;16(3):e70632
Network toxicology integrated with machine learning and SHAP analysis identifies overlapping immune signatures between Di(2-ethylhexyl) phthalate (DEHP) and Sjögren's syndrome.
Lili C, Zhongfu T, Ming L, Huang C
BMC pharmacology & toxicology 2026 Mar 7;27(1)
BMC pharmacology & toxicology 2026 Mar 7;27(1)
Matrine improves bile acid metabolism and reduces inflammatory and oxidative stress in colitis via the JAK2 pathway.
Jiang ZX, Chen XL, Sun Q, Yang LC, Zhang YW, Wu Q, Yao HC, Zhang D, Yuan LW
Chinese medicine 2026 Mar 26;21(1)
Chinese medicine 2026 Mar 26;21(1)
RUNX1 restrains STAT1-GITRL signaling to shape an immunosuppressive CRC microenvironment.
He W, Zheng L, Huang W, Li K, Chen Y, Zeng R, Lin Z, Xu Y, Hu S, Zhang Q
Cell death discovery 2026 Mar 25;12(1)
Cell death discovery 2026 Mar 25;12(1)
Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis.
Zhang L, Gui X, Hou R, Jia L, Xia S, Zhang X, Fu Y, Meng QF, Luo Q, Shi X, Guo B, Liang R, Yue L, Chen X, Xu H, Wang P, Tong X, Liu L, Wang L, Li B, Chen Z, Zhou L, Zhang L, Chen R, Sun C, Xu W, Rao L, Zhou H, Ding BS, Chen S
Nature communications 2026 Mar 20;17(1)
Nature communications 2026 Mar 20;17(1)
A feedback mechanism from prostate cancer cells to macrophages, reinforced by STAT1, regulates tumor progression and resistance to radiotherapy.
Chen JY, Xue YT, Lin B, Huang XY, Lin F, Chen DN, Zhang WJ, Wei Y, Xue XY, Zheng QS, Ke ZB, Xu N
Cell death & disease 2026 Mar 19;17(1)
Cell death & disease 2026 Mar 19;17(1)
Diabetic Kidney Disease Progression Alleviated in Mice by ALKBH5-Mediated UC-MSCs-Derived Exosomes That Inhibit TRAF6 m6A Modification and Promote M2 Macrophage Polarisation.
Li L, Liu H, Wang H, Mao Y, Song L, Kang Z
Endocrinology, diabetes & metabolism 2026 Jan;9(1):e70131
Endocrinology, diabetes & metabolism 2026 Jan;9(1):e70131
Transcriptomic analysis identifies CXCL12 as a novel candidate gene for litter size in rabbits.
Bao Z, Yang J, Li J, Cai J, Zhai P, Zhao P, Zhao B, Chen Y, Wu X
Animal bioscience 2026 Jan;39(1):240640
Animal bioscience 2026 Jan;39(1):240640
Luteolin ameliorates steroid-induced osteonecrosis of the femoral head via a gut microbiota-L-Carnitine-IFIH1 axis.
Li T, Li Y, Gao J, Ma R, Peng Y, Zhang Q, Chen Y, Wang W
Journal of translational medicine 2026 Feb 6;24(1)
Journal of translational medicine 2026 Feb 6;24(1)
Targeting macrophage glycogen metabolism attenuates ulcerative colitis by suppressing IL-1β production through UDPG-P2Y(14) signaling.
Tong S, Zhu T, Liang S, Cui Y, Ma Y, Zhang X, Bian Y, Wei K, Wu S, Ma J
Molecular medicine (Cambridge, Mass.) 2026 Feb 4;32(1):15
Molecular medicine (Cambridge, Mass.) 2026 Feb 4;32(1):15
Targeting G9a Exerts Pleiotropic Suppression in Triple-Negative Breast Cancer Cells: Cooperatively Inducing Pyroptosis and Apoptosis.
Li J, Zhang G, Liu T, Yan X, Ma M
Biomolecules 2026 Feb 25;16(3)
Biomolecules 2026 Feb 25;16(3)
Ly93 Inhibits Sphingomyelin Synthesis and Attenuates Inflammation and Injury in Dry Eye Conjunctival Organoids.
Chen Q, Wei Y, Wang L, Liang J, Pang J, Han Y, Qudsi AI, Liang Q
Investigative ophthalmology & visual science 2026 Feb 2;67(2):58
Investigative ophthalmology & visual science 2026 Feb 2;67(2):58
Simulated microgravity induces cerebral dysfunction by disturbing protective microbiota-metabolite-microglia signaling across the gut‒brain axis.
Zhang B, Si Y, Liu Y, Wei J, Li M, Si D, Li H, Wang X, Han P, Wang W, Bao J, Cheng L, Lei Y, Ma H, Liu Y
Gut microbes 2026 Dec 31;18(1):2635820
Gut microbes 2026 Dec 31;18(1):2635820
GPX1 expression promotes stemness and aggressiveness in myxoid liposarcomas.
Huergo C, Tornín J, Estupiñán O, Díez P, Gallego B, Gao J, Creskey M, Muradia G, González MV, Murillo D, Rey V, Martínez-Cruzado L, Menéndez ST, Rodríguez-Santamaría M, Blanco V, Quirós I, Sáinz RM, Rosu-Myles M, Lavoie JR, Rodríguez R
International journal of biological sciences 2025;21(13):5609-5627
International journal of biological sciences 2025;21(13):5609-5627
Novel Duck Orthoreovirus σA Protein Inhibits Interferon Signaling by Impeding STAT1/STAT2 Nuclear Translocation.
Xu B, Jiang C, Di L, Zhou L, Wang Z, Tang Y, Fang R, Wang H
Transboundary and emerging diseases 2025;2025:8440800
Transboundary and emerging diseases 2025;2025:8440800
ZnO NPs Attenuate LPS-Induced Inflammation in RAW264.7 Macrophages by Inhibiting NF-κB and JAK1-STAT1/STAT3 Pathways and Reducing ROS.
Tang H, Zhang L, Deng C, Li Y, Ren G, Sun Z, Chang L, Xu M, Xiao D, Zhang H
Journal of inflammation research 2025;18:14075-14096
Journal of inflammation research 2025;18:14075-14096
Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production.
Tang W, Chen W, Li N, Li W, Lei Z, Sun W, Xie X, Jiang Y, Chen Y, Xu L, Zhu J, Li Y, Sha J, Dai Y, Zhou S, Chen X, Su C
Frontiers in immunology 2025;16:1684836
Frontiers in immunology 2025;16:1684836
Reciprocal activation between M1 macrophages and trophoblasts through CXCL9/STAT1/ZEB1/CCL2 axis promotes recurrent spontaneous abortion.
Yan S, Wang X, Wu Q, Ding J, Qiu H
Frontiers in immunology 2025;16:1629370
Frontiers in immunology 2025;16:1629370
Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization.
Wang G, Yang F, Zang G, Shen N, Huang L, Ma Z, Li M
Frontiers in immunology 2025;16:1551892
Frontiers in immunology 2025;16:1551892
STAT1-IFITM3 promotes autophagy in epithelial cells to control Cryptosporidium parvum infection.
Cui L, Li T, Zhang J, Shen Y, Cao J
Life science alliance 2025 Sep;8(9)
Life science alliance 2025 Sep;8(9)
STAT1-mediated epigenetic regulation of LIN28A controls iPSC-derived platelet production through the let-7-RALB axis.
Hashimoto K, Chen SJ, Fujio K, Kayama A, Sugimoto N, Takayama N, Egi M, Eto K
Blood advances 2025 Sep 9;9(17):4345-4356
Blood advances 2025 Sep 9;9(17):4345-4356
STAT3 operates as an inflammation-dependent transcriptional switch.
Grassmann S, Kim H, Friedrich C, Pujol M, Fan S, Zhang J, Beroshvili G, Buchholz VR, Gasteiger G, Sun JC
bioRxiv : the preprint server for biology 2025 Sep 28;
bioRxiv : the preprint server for biology 2025 Sep 28;
MED12-STAT1-TAP2 axis regulates CD8 + T cell cytotoxicity and mediates immunotherapy outcome in non-small cell lung cancer.
Feng M, Niu Y, Liu J, Liu G
Functional & integrative genomics 2025 Sep 1;25(1):182
Functional & integrative genomics 2025 Sep 1;25(1):182
Ferroptosis triggers anti-tumor immunity via promoting chaperone-mediated autophagic degradation of SHP2.
Zhu J, Li X, Chen W, Zuo Z, Gong Q, Hu J, Huang K, Liu W, Gu Y, Xu Q, Guo W
Redox biology 2025 Oct;86:103796
Redox biology 2025 Oct;86:103796
Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.
Zhang M, Liu S, Wu Z, Wang C, Zhang H, Yang J, Guo C, Dai M, Wang X, Ren W
Science China. Life sciences 2025 Oct;68(10):3037-3050
Science China. Life sciences 2025 Oct;68(10):3037-3050
TAP1 promotes immune escape by activating JNK/STAT1/PD-L1 signaling in EBV-associated gastric cancer.
Shan W, Li G, Zhang H, Zhang R, Liu J, Gao L, Li Y, Fan L, Yang C, Liu J
Molecular and cellular biochemistry 2025 Oct;480(10):5429-5446
Molecular and cellular biochemistry 2025 Oct;480(10):5429-5446
Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer.
Shi QL, Feng CR, Li HY, Wang PL, Chen P, Wei X, Kuang WH, Li GJ, Qin SJ, Liu R, Chen RX, Zhang JZ, Song P, Yuan Y, Wang JG, Huang L
Acta pharmacologica Sinica 2025 Oct;46(10):2765-2778
Acta pharmacologica Sinica 2025 Oct;46(10):2765-2778
GSDME-dependent astrocyte pyroptosis promotes the progression of neuroinflammation in experimental cerebral malaria.
Wang J, Zhu Q, Tong G, Yu K, Liang J, Huang Y, Wang Y, Yang C, Li T, Liang W, Li G, Liu X, Sun J, Li Y, Shen Y, Zhao Y
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2385-2400
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2385-2400
M6A-mediated uc003pes.1 stability regulates proliferation and migration of human coronary artery smooth muscle cells via scaffolding STAT1 and USP10.
Jiang R, Jia Q, Li C, He S, Zhou H, Ren M, Liang L, Jia E
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120023
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120023
IL27RA promotes the proliferation and metastasis of hepatocellular carcinoma cells by regulating TGFβR1.
Zhang Y, Wu Y, Zhang Q, Xiong J, Xiao B, Zuo S
Scientific reports 2025 Oct 30;15(1):37959
Scientific reports 2025 Oct 30;15(1):37959
Protective Effect of Mesaconate on Autoimmune Hepatitis via Suppression of Inflammatory Response and Oxidative Stress.
Zhang Q, Wang J, He Y, Zhang K, Hong W, Han T
Journal of clinical and translational hepatology 2025 Oct 28;13(10):847-856
Journal of clinical and translational hepatology 2025 Oct 28;13(10):847-856
Identifying a novel region in the Tembusu virus NS5 protein antagonizing type I interferon signaling.
Zhang J, Fan Y, An D, Mao M, Guo Z, Yang J, Li Q, Zhu S, Li G, Chen X, Zhou Z, Hou S, Diao Y, Tang Y
Journal of virology 2025 Oct 23;99(10):e0131025
Journal of virology 2025 Oct 23;99(10):e0131025
An IFN/STAT1/CYBB axis defines protective plasmacytoid DC-neutrophil crosstalk in Aspergillus fumigatus-infected mice.
Guo Y, Aufiero MA, Mills KA, Grassmann SA, Kim H, Gjonbalaj M, Zumbo P, Billips A, Mar KB, Yu Y, Tirado LCE, Heung L, Rivera A, Betel D, Sun JC, Hohl TM
The Journal of clinical investigation 2025 Oct 15;135(20)
The Journal of clinical investigation 2025 Oct 15;135(20)
Fedratinib inhibits ovarian cancer progression by downregulating QPCT expression.
Dong Y, Deng Y, Zhu L, Li R, Yang H, Yang L
Discover oncology 2025 Oct 14;16(1):1865
Discover oncology 2025 Oct 14;16(1):1865
Myricetin alleviates DNCB-induced atopic dermatitis by modulating macrophage M1/M2 polarization.
Zhang X, Li J, Liu Y, Ma R, Li C, Xu Z, Wang R, Zhang L, Zhang Y
International immunopharmacology 2025 Oct 10;163:115212
International immunopharmacology 2025 Oct 10;163:115212
Exosomal CagA induces macrophage polarization and ferroptosis by JAK1-2/STAT1 signaling pathway in Helicobacter pylori-associated gastritis.
Lin J, Lu W, Cheng S, Zhang Z, Hu Y, Chen S, Li H, Chi J, Liu X, Guo Y, Xu C
Free radical biology & medicine 2025 Nov;239:91-103
Free radical biology & medicine 2025 Nov;239:91-103
Huaier overcomes tumor-induced immunosuppression in colorectal cancer by activating MHC I and CD8+ T cells.
Chen J, Li Y, Sun Q, Wang Y, Qiu Z, He X, Zhong X, Chen F, Huang H, Chen K, Zhu Y, Yao Y, Hu Z, Wang X, Tang J, Zhao S, Wei P, Li D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157157
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157157
Kaempferide enhances type I interferon signaling as a novel broad-spectrum antiviral agent.
Du R, Sun J, Zhang C, Chen C, Chen Z, Anirudhan V, Cui Q, Wang H, Rong L, Ning YJ
Antiviral research 2025 May;237:106141
Antiviral research 2025 May;237:106141
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.
Lan W, Chen X, Yu H, Ruan J, Kang J, Nie X, Cao Y, Tang S, Ding C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413709
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413709
Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications.
Fonseca KL, Lozano JJ, Despuig A, Habgood-Coote D, Sidorova J, Aznar D, Arias L, Del Río-Álvarez Á, Carrillo-Reixach J, Goff A, Wildner LM, Gogishvili S, Nikolaishvili K, Shubladze N, Avaliani Z, Tapia G, Rodríguez-Martínez P, Cardona PJ, Martinón-Torres F, Salas A, Gómez-Carballa A, Armengol C, Waddell SJ, Kaforou M, O'Garra A, Vashakidze S, Vilaplana C
Nature communications 2025 May 30;16(1):5028
Nature communications 2025 May 30;16(1):5028
Xiaoqinglong decoction combined with Yupingfeng powder alleviates combined allergic rhinitis and asthma syndrome by regulating the JAK2-STAT1-MHC II signaling pathway to suppress B lymphocyte activation.
Wang R, Xiao Z, Shi X, Ye F, Chen J, Dong M, Qiu H, Zhang Y, Shi J, Zhou M, Yang Q
Journal of ethnopharmacology 2025 May 28;348:119789
Journal of ethnopharmacology 2025 May 28;348:119789
Human genetic variation shapes the response of neurons to interferons.
Andzelm MM, Bolshakova S, Pettinari N, Tegtmeyer M, Meyer D, Johnson A, Mello CJ, Yu CT, Mazureac I, Genovese G, Maglieri A, Ichihara K, Hogan M, Hawes D, McCarroll SA, Nehme R
bioRxiv : the preprint server for biology 2025 May 28;
bioRxiv : the preprint server for biology 2025 May 28;
Proteome-wide ligandability maps of drugs with diverse cysteine-reactive chemotypes.
Tian C, Sun L, Liu K, Fu L, Zhang Y, Chen W, He F, Yang J
Nature communications 2025 May 26;16(1):4863
Nature communications 2025 May 26;16(1):4863
Ultrasound Visualization of Spatiotemporal Autophagy-Regulated Nanodroplets for Amplifying ICB in Melanoma via Remodeling Tumor Inflammatory Microenvironment.
Wu N, Zhang Q, Tang R, Deng L, Cao Y, Fu B, Dong H, Huang Z, Wan L, He H, Lin Y, Liu J, Xia C, Li P
ACS applied materials & interfaces 2025 May 21;17(20):29364-29378
ACS applied materials & interfaces 2025 May 21;17(20):29364-29378
AUP1 and UBE2G2 complex targets STING signaling and regulates virus-induced innate immunity.
Wang X-T, Zhu X, Lian Z-H, Liu Q, Yan H-H, Qiu Y, Ge X-Y
mBio 2025 May 14;16(5):e0060225
mBio 2025 May 14;16(5):e0060225
The role of Morin in attenuating atherosclerosis via STAT1 pathway inhibition.
Ji X, Dong Q, Li W, Luo W, Zhou N, Li H, Yang X
Biochemical and biophysical research communications 2025 Mar 25;754:151537
Biochemical and biophysical research communications 2025 Mar 25;754:151537
Bardoxolone displays potent activity against triple negative breast cancer by inhibiting the TRIP13/STAT3 circuit.
Deng JH, Li HY, Liu ZY, Liang JP, Ren Y, Zeng YY, Wang YL, Mao XL
Acta pharmacologica Sinica 2025 Jun;46(6):1733-1741
Acta pharmacologica Sinica 2025 Jun;46(6):1733-1741
Tanshinone IIA promotes ferroptosis in cutaneous melanoma via STAT1-mediated upregulation of PTGS2 expression.
Chen S, Li P, Shi K, Tang S, Zhang W, Peng C, Li T, Xie H, Liu C, Zhou J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156702
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156702
Discovery of novel STAT3 inhibitors with anti-breast cancer activity: structure-based virtual screening, molecular dynamics and biological evaluation.
Wang J, Zhang P, Yu Y, Yi Y, Jiang Y, Hu S
RSC medicinal chemistry 2025 Jun 18;16(6):2848-2865
RSC medicinal chemistry 2025 Jun 18;16(6):2848-2865
Astragalus injection antagonizes the efficacy of anti-PD-1 against melanoma through down-regulating MHC-II expression.
Lei R, Li Q, Wang R, Wu Z, Kong Q, Liu S, Luo Z, Liu X, Zhu X, Wu J
Journal of ethnopharmacology 2025 Jun 12;349:119966
Journal of ethnopharmacology 2025 Jun 12;349:119966
Cyclophilin D knockdown/knockout promotes microglia M2 polarization by inhibiting STAT1 to alleviate neuroinflammation in neonatal white matter injury.
Zhou J, Gao T, Tang W, Wang Z, Zhao L, Wang L
Brain research 2025 Jun 1;1856:149596
Brain research 2025 Jun 1;1856:149596
Estradiol (E2) concentration shapes the chromatin binding landscape of estrogen receptor alpha.
Han AL, Vinod Paul K, Rao S, Brechbuhl HM, Sartorius CA, Ramachandran S, Kabos P
The Journal of biological chemistry 2025 Jul;301(7):108499
The Journal of biological chemistry 2025 Jul;301(7):108499
African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.
Yao M, Li P, Li X, Li W, Qian P
Veterinary research 2025 Jul 5;56(1):137
Veterinary research 2025 Jul 5;56(1):137
Formin protein DAAM1 positively regulates PD-L1 expression via mediating the JAK1/STAT1 axis in pancreatic cancer.
Xu R, Wan M, Pan J, Mei J, Zhou J, Shen Y, Yang J, Zhu Y, Sun J
Cancer cell international 2025 Jan 29;25(1):28
Cancer cell international 2025 Jan 29;25(1):28
Efficacy of caerulomycin A in modulating macrophage polarization and cytokine response in a murine model of lipopolysaccharide-induced sepsis.
Zhang J, Tang S
European journal of medical research 2025 Jan 10;30(1):22
European journal of medical research 2025 Jan 10;30(1):22
CircKat6b Mediates the Antidepressant Effect of Esketamine by Regulating Astrocyte Function.
Hu N, Zheng Y, Liu X, Jia J, Feng J, Zhang C, Liu L, Wang X
Molecular neurobiology 2025 Feb;62(2):2587-2600
Molecular neurobiology 2025 Feb;62(2):2587-2600
Low-dose SAHA enhances CD8(+) T cell-mediated antitumor immunity by boosting MHC I expression in non-small cell lung cancer.
Dong W, He B, Cao Y, Yang R, Zhang S, Kong Y, Lu D, Zheng X, Hou Y, Zhu M, Wang C, Yu S, Cui D, Wang H, Wang B
Cellular oncology (Dordrecht, Netherlands) 2025 Feb;48(1):249-264
Cellular oncology (Dordrecht, Netherlands) 2025 Feb;48(1):249-264
Protein kinase a suppresses antiproliferative effect of interferon-α in hepatocellular carcinoma by activation of protein tyrosine phosphatase SHP2.
Sheng Y, Lin Y, Qiang Z, Shen X, He Y, Li L, Li S, Zhang G, Wang F
The Journal of biological chemistry 2025 Feb;301(2):108195
The Journal of biological chemistry 2025 Feb;301(2):108195
VSIG4(+) tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1.
Pan Z, Chen J, Xu T, Cai A, Han B, Li Y, Fang Z, Yu D, Wang S, Zhou J, Gong Y, Che Y, Zou X, Cheng L, Tan Z, Ge M, Huang P
Journal of experimental & clinical cancer research : CR 2025 Feb 7;44(1):45
Journal of experimental & clinical cancer research : CR 2025 Feb 7;44(1):45
Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1.
Xie B, Wu P, Liu H, Yang X, Huang L
Journal of translational medicine 2025 Feb 7;23(1):165
Journal of translational medicine 2025 Feb 7;23(1):165
FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma.
Gao X, Huang D, Liu Y, Zhang G, Zheng X, Guan B, Chen A, Wu J, Luo SM, Liu Z, Chen L, Liu X, Jin J, Yin X, Sun Z, Zhang Y, Lu M, Zhang G, Liu W, Liu L
Cell death & disease 2025 Feb 3;16(1):63
Cell death & disease 2025 Feb 3;16(1):63
MA104 cell line is permissive for human bocavirus 1 infection.
Tang J, Chen S, Deng Y, Liu J, Huang D, Fu M, Xue B, Liu C, Wu C, Wang F, Zhou Y, Yang Q, Chen X
Journal of virology 2025 Feb 25;99(2):e0153924
Journal of virology 2025 Feb 25;99(2):e0153924
Administration of a Recombinant Fusion Protein of IFN-γ and CD154 Inhibited the Infection of Chicks with Salmonella enterica.
Zhang J, Ren G, Li W, Xie H, Yang Z, Wang J, Zhou Y, Wang X
Veterinary sciences 2025 Feb 2;12(2)
Veterinary sciences 2025 Feb 2;12(2)
IFN-γ-mediated inhibition of JAK/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis.
Wang T, Liu B, Huang J, Zhao Q, Shen H, Bi T, Liu Z, Dai Y, Sun Q
Journal of translational medicine 2025 Feb 17;23(1):195
Journal of translational medicine 2025 Feb 17;23(1):195
Cepharanthine relieves nonalcoholic steatohepatitis through inhibiting STAT1/CXCL10 axis-mediated lipogenesis and inflammatory responses.
Li P, Zhang R, Hu P, Wang T, Wang J
Journal of ethnopharmacology 2025 Feb 11;341:119358
Journal of ethnopharmacology 2025 Feb 11;341:119358
YBX1 is required for maintaining PD-L1 expression in intrahepatic cholangiocarcinoma by regulating STAT1 stability in an m5C-dependent manner.
Sun XY, Yu B, Yu J, Wang YP, Li XB, Sun RR, Tian X, Kan QC
Hepatobiliary & pancreatic diseases international : HBPD INT 2025 Dec;24(6):643-655
Hepatobiliary & pancreatic diseases international : HBPD INT 2025 Dec;24(6):643-655
STAT2 Promotes Tumor Growth in Colorectal Cancer Independent of Type I IFN Receptor Signaling.
Canar J, Bono M, Alvarado A, Slifker M, Sitia G, Gamero AM
Current oncology (Toronto, Ont.) 2025 Dec 16;32(12)
Current oncology (Toronto, Ont.) 2025 Dec 16;32(12)
LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity.
Li JY, Li YQ, Dai JH, Gong S, He QM, Bai JW, Huang SW, Lu YQ, Duan YF, Feng SY, Tan XR, Liang XY, Ma J, Guo R, Liu N
The Journal of clinical investigation 2025 Dec 1;135(23)
The Journal of clinical investigation 2025 Dec 1;135(23)
Lactate-functionalized 3D-printed PCL/nHA scaffold drives BMSC osteogenesis via metabolic-epigenetic crosstalk.
Zeng M, Liu H, Lu W, Chen C, Lin Z, Zhao R
Materials today. Bio 2025 Aug;33:102101
Materials today. Bio 2025 Aug;33:102101
The alpha-coronavirus E protein inhibits the JAK-STAT pathway signaling by triggering STAT2 degradation through OPTN- and NBR1-mediated selective autophagy.
Huang Z, Gao C, Huang S, Lin S, Zhang W, You J, Chen X, Zhou P, Zhang G, Gong L
Autophagy 2025 Aug;21(8):1644-1661
Autophagy 2025 Aug;21(8):1644-1661
Next-generation probiotics Alistipes onderdonkii enhances the efficacy of anti-PD-1 therapy in colorectal cancer.
Xin J, Xiang Y, Jiang J, Jiang Z, Yi B
Biochimica et biophysica acta. Molecular basis of disease 2025 Aug;1871(6):167891
Biochimica et biophysica acta. Molecular basis of disease 2025 Aug;1871(6):167891
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod-induced psoriasiform inflammation via STAT1/S100A9 signalling pathway.
Nie YW, Liu X, Peng Y, Zhang CY, Xi RF, Jiang XX, Wang Y, Lu HZ, Guo DJ, Guo WJ, Duan YJ, Nian H, Wang K, Chen JY, Li FL, Zhu JY
British journal of pharmacology 2025 Aug;182(16):3884-3902
British journal of pharmacology 2025 Aug;182(16):3884-3902
Evidence that mitochondria in macrophages are destroyed by microautophagy.
Lu SL, Chen S, Noda K, Li Y, Tsai CY, Omori H, Kato Y, Zhang Z, Chen B, Tokuda K, Zheng T, Wakita M, Hara E, Fukuda M, Wada Y, Morita E, Uzawa N, Murakami S, Noda T
Nature communications 2025 Aug 30;16(1):8123
Nature communications 2025 Aug 30;16(1):8123
STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences.
Lan N, Li X, Qiao Y, Zhang S, Chen M, Yang X, Zou Y, Ren J, Pei M
Journal of ovarian research 2025 Aug 23;18(1):192
Journal of ovarian research 2025 Aug 23;18(1):192
Deletion of SH2D5 alleviates epileptic seizures and NMDAR expression via autophagic degradation of STAT1.
Guo H, Zhang H, Zhang C, Shen Y, Jiang L, Yang M, Zhang Y, Zhang N, Zhang R, Yu R, Yang Y, Tian X
JCI insight 2025 Aug 22;10(16)
JCI insight 2025 Aug 22;10(16)
OASL activates MAPK to drive psoriatic pathogenesis: Astilbin targeting this axis improves metabolic-inflammation crosstalk.
Xia Q, Huang X, Li A, Zhuang Z, Zhou X, Yang Y, Zuo X, Liu Y, Sheng Y, Xu J, Cui Y
Life sciences 2025 Aug 15;375:123698
Life sciences 2025 Aug 15;375:123698
Kinsenoside alleviates experimental acute pancreatitis by suppressing M1 macrophage polarization via the TLR4/STAT1 signaling pathway.
Wang R, Jiang J, Song P, Peng Q, Jin X, Li B, Shen J, Han X, Ni J, Hu G
Journal of ethnopharmacology 2025 Apr 9;345:119551
Journal of ethnopharmacology 2025 Apr 9;345:119551
Potential of CLSPN as a therapeutic target in melanoma: a key player in melanoma progression and tumor microenvironment.
Xie Y, Wang R, Xu M, Chen J, Tan W, Chen Y, Bai Y, Wu N, Wu F, Xu X, Ma X, Liu Y
Journal of translational medicine 2025 Apr 24;23(1):470
Journal of translational medicine 2025 Apr 24;23(1):470
o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis.
Xu H, Zhao Q, Cai D, Chen X, Zhou X, Gao Y, Wu J, Yuan S, Li D, Zhang R, Peng W, Li G, Nan A
Journal of experimental & clinical cancer research : CR 2025 Apr 2;44(1):110
Journal of experimental & clinical cancer research : CR 2025 Apr 2;44(1):110
Human long noncoding RNA VILMIR is induced by major respiratory viral infections and modulates the host interferon response.
John K, Huntress I, Smith E, Chou H, Tollison TS, Covarrubias S, Crisci E, Carpenter S, Peng X
Journal of virology 2025 Apr 15;99(4):e0014125
Journal of virology 2025 Apr 15;99(4):e0014125
Machine learning-assisted analysis of serum metabolomics and network pharmacology reveals the effective compound from herbal formula against alcoholic liver injury.
Ma J, Wei P, Xu X, Dong R, Deng X, Zhang F, Sun M, Li M, Liu W, Yao J, Cao Y, Ying L, Yang Y, Yang Y, Wu X, She G
Chinese medicine 2025 Apr 11;20(1):48
Chinese medicine 2025 Apr 11;20(1):48
Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes.
Wang W, Cheng Z, Yu M, Liu K, Duan H, Zhang Y, Huang X, Li M, Li C, Hu Y, Luo Z, Liu M
Nature communications 2025 Apr 1;16(1):3131
Nature communications 2025 Apr 1;16(1):3131
PLA2G7 promotes immune evasion of bladder cancer through the JAK-STAT-PDL1 axis.
Peng D, Yang W, Tang T, He A, Xu X, Jing T, Xia D
Cell death & disease 2025 Apr 1;16(1):234
Cell death & disease 2025 Apr 1;16(1):234
IRF9 and STAT1 as biomarkers involved in T-cell immunity in atherosclerosis.
Xie W, Gao X, Zhao L, Song S, Li NA, Liu J
Journal of biosciences 2024;49
Journal of biosciences 2024;49
Quercetin of huoxuehuayu tongluo decoction and azithromycin combination therapy effectively improves rat tubal factor infertility by inhibiting inflammation.
Shao L, Wang N, Yan Y, Tan Y, Wu Q, Lei L, Wang M, Liu L
Iranian journal of basic medical sciences 2024;27(6):685-694
Iranian journal of basic medical sciences 2024;27(6):685-694
Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation.
Li Y, Dong X, He W, Quan H, Chen K, Cen C, Wei W
Obesity facts 2024;17(1):24-36
Obesity facts 2024;17(1):24-36
Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor.
Li W, Mou S, Ali T, Li T, Liu Y, Li S, Yu X, Yu ZJ
Frontiers in pharmacology 2024;15:1422693
Frontiers in pharmacology 2024;15:1422693
MiR-301b-3p promotes breast cancer development through inhibiting the expression of transforming growth factor-beta receptor 2.
Lou J, Liu X, Xie Y, Wu M, Mao W, Ying X
PeerJ 2024;12:e18324
PeerJ 2024;12:e18324
ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
Li C, Cai Y, Chen Y, Tong J, Li Y, Liu D, Wang Y, Li Z, Wang Y, Li Q
Redox biology 2024 Sep;75:103262
Redox biology 2024 Sep;75:103262
MAPK pathway orchestrates gallid alphaherpesvirus 1 infection through the biphasic activation of MEK/ERK and p38 MAPK signaling.
Cui L, Li X, Liu Z, Liu X, Zhu Y, Zhang Y, Han Z, Zhang Y, Liu S, Li H
Virology 2024 Sep;597:110159
Virology 2024 Sep;597:110159
Exploring the molecular mechanism of ginseng against anthracycline-induced cardiotoxicity based on network pharmacology, molecular docking and molecular dynamics simulation.
Xie L, Liu H, Zhang K, Pan Y, Chen M, Xue X, Wan G
Hereditas 2024 Sep 6;161(1):31
Hereditas 2024 Sep 6;161(1):31
Palmatine ameliorates N-methyl-N'-nitrosoguanidine-induced chronic atrophic gastritis through the STAT1/CXCL10 axis.
Zhou Y, Wang Q, Tang W, Ma Z, Yang Z, Li X, Chen W, Ma H, Ye X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 30;38(18):e70037
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 30;38(18):e70037
Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling.
Shi Y, Wu Z, Liu S, Zuo D, Niu Y, Qiu Y, Qiao L, He W, Qiu J, Yuan Y, Wang G, Li B
Nature communications 2024 Sep 10;15(1):7930
Nature communications 2024 Sep 10;15(1):7930
Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8(+) T cell infiltration.
Gan L, Lu T, Lu Y, Song H, Zhang J, Zhang K, Lu S, Wu X, Nie F, Di S, Han D, Yang F, Qin W, Wen W
Journal for immunotherapy of cancer 2024 Sep 10;12(9)
Journal for immunotherapy of cancer 2024 Sep 10;12(9)
Proteomic Analysis Reveals Oxidative Phosphorylation and JAK-STAT Pathways Mediated Pathogenesis of Pemphigus Vulgaris.
Cheng Y, Zhao M, Zhu C, Tang X, Wang W, Tang H, Zheng X, Zhu Z, Sheng Y, Wang Z, Zhou F, Gao J
Experimental dermatology 2024 Oct;33(10):e15184
Experimental dermatology 2024 Oct;33(10):e15184
pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection.
Huang Z, Kong C, Zhang W, You J, Gao C, Yi J, Mai Z, Chen X, Zhou P, Gong L, Zhang G, Wang H
PLoS pathogens 2024 Oct;20(10):e1012613
PLoS pathogens 2024 Oct;20(10):e1012613
Macrophage P2Y(6)R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses.
Yin L, Zhang E, Mao T, Zhu Y, Ni S, Li Y, Liu C, Fang Y, Ni K, Lu Y, Li H, Zhou M, Hu Q
Acta pharmaceutica Sinica. B 2024 Oct;14(10):4360-4377
Acta pharmaceutica Sinica. B 2024 Oct;14(10):4360-4377
Sodium butyrate alleviates lipopolysaccharide-induced inflammation through JAK/STAT signalling in primary human corneal fibroblasts.
Wang HF, Shen JR, Han XK, Song XJ
European journal of pharmacology 2024 Nov 15;983:176998
European journal of pharmacology 2024 Nov 15;983:176998
Glycolysis inhibition induces anti-tumor central memory CD8(+)T cell differentiation upon combination with microwave ablation therapy.
Tang X, Mao X, Ling P, Yu M, Pan H, Wang J, Liu M, Pan H, Qiu W, Che N, Zhang K, Bao F, Peng H, Ding Q, Wang S, Zhou W
Nature communications 2024 May 31;15(1):4665
Nature communications 2024 May 31;15(1):4665
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65.
Gao X, Xuan Y, Zhou Z, Chen C, Wen Wang D, Wen Z
International immunopharmacology 2024 May 30;133:112073
International immunopharmacology 2024 May 30;133:112073
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis.
Chen H, Fu X, Wu X, Zhao J, Qiu F, Wang Z, Wang Z, Chen X, Xie D, Huang J, Fan J, Yang X, Song Y, Li J, He D, Xiao G, Lu A, Liang C
Bone research 2024 May 23;12(1):31
Bone research 2024 May 23;12(1):31
CD8(+) T cell infiltration and proliferation in the brainstem during experimental cerebral malaria.
Wang J, Zhu Q, Shen Y, Liang J, Wang Y, Huang Y, Tong G, Wang X, Zhang N, Yu K, Li Y, Zhao Y
CNS neuroscience & therapeutics 2024 Mar;30(3):e14431
CNS neuroscience & therapeutics 2024 Mar;30(3):e14431
Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells.
Jing ZL, Liu GL, Zhou N, Xu DY, Feng N, Lei Y, Ma LL, Tang MS, Tong GH, Tang N, Deng YJ
Scientific reports 2024 Mar 13;14(1):6053
Scientific reports 2024 Mar 13;14(1):6053
Sodium Butyrate Ameliorates Atopic Dermatitis-Induced Inflammation by Inhibiting HDAC3-Mediated STAT1 and NF-κB Pathway.
Hu C, Zeng D, Huang Y, Deng Q, Liu S, Zhou W, Zhou W
Inflammation 2024 Jun;47(3):989-1001
Inflammation 2024 Jun;47(3):989-1001
Fangchinoline induces antiviral response by suppressing STING degradation.
Wang J, Xie F, Jia X, Wang X, Kong L, Li Y, Liang X, Zhang M, He Y, Feng W, Luo T, Wang Y, Xu A
Journal of pharmaceutical analysis 2024 Jun;14(6):100972
Journal of pharmaceutical analysis 2024 Jun;14(6):100972
Irradiated tumour cell-derived microparticles upregulate MHC-I expression in cancer cells via DNA double-strand break repair pathway.
Deng S, Wang J, Hu Y, Sun Y, Yang X, Zhang B, Deng Y, Wei W, Zhang Z, Wen L, Qin Y, Huang F, Sheng Y, Wan C, Yang K
Cancer letters 2024 Jun 28;592:216898
Cancer letters 2024 Jun 28;592:216898
Combined Proteomic and Metabolomic Analysis Reveals Comprehensive Regulation of Somatostatin DNA Vaccine in Goats.
Qin G, Zhang L, Guo J, Fang S, E G, Zeng Y, Huang Y, Han Y
International journal of molecular sciences 2024 Jun 23;25(13)
International journal of molecular sciences 2024 Jun 23;25(13)
PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation.
Ribeiro VC, Russo LC, Hoch NC
The EMBO journal 2024 Jul;43(14):2908-2928
The EMBO journal 2024 Jul;43(14):2908-2928
African swine fever virus pB475L evades host antiviral innate immunity via targeting STAT2 to inhibit IFN-I signaling.
Huang Z, Mai Z, Kong C, You J, Lin S, Gao C, Zhang W, Chen X, Xie Q, Wang H, Tang S, Zhou P, Gong L, Zhang G
The Journal of biological chemistry 2024 Jul;300(7):107472
The Journal of biological chemistry 2024 Jul;300(7):107472
MCM8 promotes gastric cancer progression through RPS15A and predicts poor prognosis.
Ding L, Sun M, Sun Y, Li J, Zhang Z, Dang S, Zhang J, Yang B, Dai Y, Zhou Q, Zhou D, Li E, Peng S, Li G
Cancer medicine 2024 Jul;13(13):e7424
Cancer medicine 2024 Jul;13(13):e7424
Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver.
Gan WL, Ren X, Ng VHE, Ng L, Song Y, Tano V, Han J, An O, Xie J, Ng BYL, Tay DJT, Tang SJ, Shen H, Khare S, Chong KHC, Young DY, Wu B, DasGupta R, Chen L
Cell reports 2024 Jul 23;43(7):114400
Cell reports 2024 Jul 23;43(7):114400
Synergistic activity of Enterococcus Faecium-induced ferroptosis via expansion of IFN-γ(+)CD8(+) T cell population in advanced hepatocellular carcinoma treated with sorafenib.
Yu H, Lin G, Jiang J, Yao J, Pan Z, Xie H, Bo Z, He Q, Yang J, Chen Z, Li J, Wang Y, Yu Z, Assaraf YG, Chen G
Gut microbes 2024 Jan-Dec;16(1):2410474
Gut microbes 2024 Jan-Dec;16(1):2410474
Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus.
Fan W, Wei B, Chen X, Zhang Y, Xiao P, Li K, Zhang YQ, Huang J, Leng L, Bucala R
Arthritis research & therapy 2024 Jan 20;26(1):31
Arthritis research & therapy 2024 Jan 20;26(1):31
IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects.
Liu Y, Dang Y, Zhang C, Liu L, Cai W, Li L, Fang L, Wang M, Xu S, Wang G, Zheng J, Li H
iScience 2024 Jan 19;27(1):108597
iScience 2024 Jan 19;27(1):108597
HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block PD-L1 for colorectal cancer immunotherapy.
Wen Y, Ye S, Li Z, Zhang X, Liu C, Wu Y, Zheng R, Xu C, Tian J, Shu L, Yan Q, Ai F, Ma J
Cancer immunology, immunotherapy : CII 2024 Jan 17;73(1):7
Cancer immunology, immunotherapy : CII 2024 Jan 17;73(1):7
Differential Regulation of the STING Pathway in Human Papillomavirus-Positive and -Negative Head and Neck Cancers.
Saulters EL, Kennedy PT, Carter RJ, Alsufyani A, Jones TM, Woolley JF, Dahal LN
Cancer research communications 2024 Jan 16;4(1):118-133
Cancer research communications 2024 Jan 16;4(1):118-133
A suitable and efficient optimization system for the culture of Chlamydia trachomatis in adult inclusion conjunctivitis.
Wei Y, Xu X, Wang L, Chen Q, Li J, Liu X, Wei Z, Pang J, Peng Y, Guo X, Cheng Z, Wang Z, Zhang Y, Chen K, Lu X, Liang Q
Pathogens and disease 2024 Feb 7;82
Pathogens and disease 2024 Feb 7;82
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
Luan X, Lei T, Fang J, Liu X, Fu H, Li Y, Chu W, Jiang P, Tong C, Qi H, Fu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
ENO2 promotes anoikis resistance in anaplastic thyroid cancer by maintaining redox homeostasis.
Zhang Y, Ji X, Wang Y
Gland surgery 2024 Feb 29;13(2):209-224
Gland surgery 2024 Feb 29;13(2):209-224
SMG9 is a novel prognostic-related biomarker in glioma correlating with ferroptosis and immune infiltrates.
Dai Y, Zhang H, Feng S, Guo C, Tian W, Sun Y, Zhang Y
Heliyon 2024 Feb 29;10(4):e25716
Heliyon 2024 Feb 29;10(4):e25716
Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3.
Huang H, Lei X, Zhao C, Qin Y, Li Y, Zhang X, Li C, Lan T, Zhao B, Sun W, Lu H, Jin N
Journal of virology 2024 Feb 20;98(2):e0168223
Journal of virology 2024 Feb 20;98(2):e0168223
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Zhang H, Xia T, Xia Z, Zhou H, Li Z, Wang W, Zhai X, Jin B
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
TRIM65 knockout inhibits the development of HCC by polarization tumor-associated macrophages towards M1 phenotype via JAK1/STAT1 signaling pathway.
Jiang M, Wang D, Su N, Lou W, Chen Y, Yang H, Chen C, Xi F, Chen Y, Deng L, Tang X
International immunopharmacology 2024 Feb 15;128:111494
International immunopharmacology 2024 Feb 15;128:111494
Role of Interleukin-21 in retinal ischemia-reperfusion injury: Unveiling the impact on retinal ganglion cell apoptosis.
Zhang X, Hu Q, Jiang B, Xie F, Zhang Z, Hafezi-Moghadam A, Sun D
International immunopharmacology 2024 Feb 15;128:111480
International immunopharmacology 2024 Feb 15;128:111480
Sodium houttuyfonate modulates the lung Th1/Th2 balance and gut microbiota to protect against pathological changes in lung of ovalbumin-induced asthmatic mice.
Guo Y, Cai W, Xie W, Xu Y, Li X, Yu C, Wu Q
The Journal of asthma : official journal of the Association for the Care of Asthma 2024 Dec;61(12):1759-1771
The Journal of asthma : official journal of the Association for the Care of Asthma 2024 Dec;61(12):1759-1771
The long noncoding RNA loc107053557 acts as a gga-miR-3530-5p sponge to suppress the replication of vvIBDV through regulating STAT1 expression.
Huang X, Li Y, Li J, Jiang Y, Cui W, Zhou H, Tang L
Virulence 2024 Dec;15(1):2333237
Virulence 2024 Dec;15(1):2333237
Xuanfei Baidu decoction ameliorates bleomycin-elicited idiopathic pulmonary fibrosis in mice by regulating the lung-gut crosstalk via IFNγ/STAT1/STAT3 axis.
Jia M, Liu Y, Liu J, Meng J, Cao J, Miao L, Zhang H, Zhu Y, Sun M, Yang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:155997
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:155997
An IFN-STAT1-CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk During Aspergillus fumigatus Infection.
Guo Y, Aufiero MA, Mills KAM, Grassmann SA, Kim H, Zumbo P, Gjonbalaj M, Billips A, Mar KB, Yu Y, Betel D, Sun JC, Hohl TM
bioRxiv : the preprint server for biology 2024 Dec 4;
bioRxiv : the preprint server for biology 2024 Dec 4;
Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling.
Su P, Liu L, Gong Y, Peng S, Yan X, Bai M, Xu E, Li Y
International immunopharmacology 2024 Dec 25;143(Pt 3):113538
International immunopharmacology 2024 Dec 25;143(Pt 3):113538
Diammonium glycyrrhizinate ameliorates alcohol-induced liver injury by reducing oxidative stress, steatosis, and inflammation.
Wang X, Gao X, Xu F, Niu J, Wang Z
International immunopharmacology 2024 Dec 25;143(Pt 2):113374
International immunopharmacology 2024 Dec 25;143(Pt 2):113374
The STAT1-SLC31A1 axis: Potential regulation of cuproptosis in diabetic retinopathy.
Hu Q, Zhang X, Huang J, Peng H, Sun Y, Sang W, Jiang B, Sun D
Gene 2024 Dec 20;930:148861
Gene 2024 Dec 20;930:148861
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma.
Zhang QY, Ding W, Mo JS, Ou-Yang SM, Lin ZY, Peng KR, Liu GP, Lu JJ, Yue PB, Lei JP, Wang YD, Zhang XL
Acta pharmacologica Sinica 2024 Aug;45(8):1701-1714
Acta pharmacologica Sinica 2024 Aug;45(8):1701-1714
Silicone dressing combined with topical oxygen therapy alleviates incontinence-associated dermatitis via NF-κB p65/STAT1 signaling pathway.
Chen GA, Chen Y, Zhang Y, Zheng S, Zhu L, Ding M
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024 Aug;30(8):e13888
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024 Aug;30(8):e13888
Blockade of the mitochondrial DNA release ameliorates hepatic ischemia-reperfusion injury through avoiding the activation of cGAS-Sting pathway.
Xiong Y, Chen J, Liang W, Li K, Huang Y, Song J, Zhang B, Qiu X, Qiu D, Zhang Q, Qin Y
Journal of translational medicine 2024 Aug 28;22(1):796
Journal of translational medicine 2024 Aug 28;22(1):796
Biomineralization-Tuned Nanounits Reprogram the Signal Transducer and Activator of Transcription 3 Signaling for Ferroptosis-Immunotherapy in Cancer Stem Cells.
Zhao Y, Fei Y, Zhao Y, Li M, Hu Y, Cai K, Yu SH, Luo Z
ACS nano 2024 Aug 13;18(32):21268-21287
ACS nano 2024 Aug 13;18(32):21268-21287
FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins.
Rex EA, Seo D, Chappidi S, Pinkham C, Brito Oliveira S, Embry A, Heisler D, Liu Y, Munir M, Luger K, Alto NM, da Fonseca FG, Orchard R, Hancks DC, Gammon DB
Nature microbiology 2024 Apr;9(4):988-1006
Nature microbiology 2024 Apr;9(4):988-1006
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
Fu Y, Li L, Zhang X, Deng Z, Wu Y, Chen W, Liu Y, He S, Wang J, Xie Y, Tu Z, Lyu Y, Wei Y, Wang S, Cui CP, Liu CH, Zhang L
Nature communications 2024 Apr 6;15(1):2974
Nature communications 2024 Apr 6;15(1):2974
PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression.
Tang J, He J, Guo H, Lin H, Li M, Yang T, Wang HY, Li D, Liu J, Li L, Xia H, Zhuo Z, Miao L
Research (Washington, D.C.) 2023;6:0033
Research (Washington, D.C.) 2023;6:0033
Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
Yu C, Zhu Q, Ma C, Luo C, Nie L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Zhang C, Lu G, Lu Z, Zhu Y, Liu S
Frontiers in immunology 2023;14:1289795
Frontiers in immunology 2023;14:1289795
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.
Huang HX, Zhao CC, Lei XX, Zhang XY, Li YY, Lan T, Zhao BP, Lu JY, Sun WC, Lu HJ, Jin NY
Frontiers in immunology 2023;14:1196031
Frontiers in immunology 2023;14:1196031
A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases.
Tao G, Liu F, Jin Z, Liu B, Wang H, Li D, Tang W, Chen Y, He Q, Qin S
Theranostics 2023;13(8):2455-2470
Theranostics 2023;13(8):2455-2470
PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models.
Wong CW, Evangelou C, Sefton KN, Leshem R, Zhang W, Gopalan V, Chattrakarn S, Fernandez Carro ML, Uzuner E, Mole H, Wilcock DJ, Smith MP, Sergiou K, Telfer BA, Isaac DT, Liu C, Perl NR, Marie K, Lorigan P, Williams KJ, Rao PE, Nagaraju RT, Niepel M, Hurlstone AFL
Nature communications 2023 Sep 26;14(1):5983
Nature communications 2023 Sep 26;14(1):5983
Combining network pharmacology and in vitro and in vivo experiments to study the mechanism of Keluoxin in the treatment of radiation nephropathy†.
Deng L, Wang S, Leng X, Yao P, Li C, Zheng Y
Journal of radiation research 2023 Sep 22;64(5):769-782
Journal of radiation research 2023 Sep 22;64(5):769-782
Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism.
Huang L, Zhang J, Wei B, Chen S, Zhu S, Qi W, Pei X, Li L, Liu W, Wang Y, Xu X, Xie LG, Chen L
Cell chemical biology 2023 Sep 21;30(9):1076-1089.e11
Cell chemical biology 2023 Sep 21;30(9):1076-1089.e11
The RhoA GTPase regulates Type I Interferon Signaling in Systemic lupus erythematosus.
Fan W, Wei B, Chen X, Zhang Y, Xiao P, Li K, Zhang YQ, Huang J, Leng L, Bucala R
Research square 2023 Sep 20;
Research square 2023 Sep 20;
SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway.
Gu W, Qi G, Chen L
Iranian journal of immunology : IJI 2023 Sep 1;20(3):335-347
Iranian journal of immunology : IJI 2023 Sep 1;20(3):335-347
Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury.
Kong P, Yang M, Wang Y, Yu KN, Wu L, Han W
Redox biology 2023 Oct;66:102857
Redox biology 2023 Oct;66:102857
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
Huangfu N, Ma H, Tian M, Zhang J, Wang Y, Li Z, Chen X, Cui H
Inflammation 2023 Oct;46(5):1725-1738
Inflammation 2023 Oct;46(5):1725-1738
Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection.
Zhang MQ, Jia X, Cheng CQ, Wang YX, Li YY, Kong LD, Li QQ, Xie F, Yu YL, He YT, Dong QT, Jia ZH, Wang Y, Xu AL
Acta pharmacologica Sinica 2023 Nov;44(11):2253-2264
Acta pharmacologica Sinica 2023 Nov;44(11):2253-2264
ID1 expressing macrophages support cancer cell stemness and limit CD8(+) T cell infiltration in colorectal cancer.
Shang S, Yang C, Chen F, Xiang RS, Zhang H, Dai SY, Liu J, Lv XX, Zhang C, Liu XT, Zhang Q, Lu SB, Song JW, Yu JJ, Zhou JC, Zhang XW, Cui B, Li PP, Zhu ST, Zhang HZ, Hua F
Nature communications 2023 Nov 23;14(1):7661
Nature communications 2023 Nov 23;14(1):7661
Pretreatment of UC-MSCs with IFN-α2 improves treatment of liver fibrosis by recruiting neutrophils.
Xie Y, Yao J, Yan M, Lin Y, Wei J, Wang H, Mao Y, Liu P, Li X
Journal of translational medicine 2023 Nov 18;21(1):832
Journal of translational medicine 2023 Nov 18;21(1):832
Erythropoietin suppresses osteoblast apoptosis and ameliorates steroid-induced necrosis of the femoral head in rats by inhibition of STAT1-caspase 3 signaling pathway.
Cai T, Chen S, Wu C, Lou C, Wang W, Lin C, Jiang H, Xu X
BMC musculoskeletal disorders 2023 Nov 17;24(1):894
BMC musculoskeletal disorders 2023 Nov 17;24(1):894
EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling.
Luo Y, Ali T, Liu Z, Gao R, Li A, Yang C, Ling L, He L, Li S
Life sciences 2023 Nov 15;333:122102
Life sciences 2023 Nov 15;333:122102
Neutrophil-derived interleukin-17A participates in neuroinflammation induced by traumatic brain injury.
Xu XJ, Ge QQ, Yang MS, Zhuang Y, Zhang B, Dong JQ, Niu F, Li H, Liu BY
Neural regeneration research 2023 May;18(5):1046-1051
Neural regeneration research 2023 May;18(5):1046-1051
C9ORF72 suppresses JAK-STAT mediated inflammation.
Pang W, Hu F
iScience 2023 May 19;26(5):106579
iScience 2023 May 19;26(5):106579
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.
Zhang W, Pan X, Xu Y, Guo H, Zheng M, Chen X, Wu H, Luan F, He Q, Ding L, Yang B
Acta pharmaceutica Sinica. B 2023 Jun;13(6):2585-2600
Acta pharmaceutica Sinica. B 2023 Jun;13(6):2585-2600
Influenza A virus inhibits TET2 expression by endoribonuclease PA-X to attenuate type I interferon signaling and promote viral replication.
Hu Y, Chen X, Ling Y, Zhou K, Han M, Wang X, Yue M, Li Y
PLoS pathogens 2023 Jul;19(7):e1011550
PLoS pathogens 2023 Jul;19(7):e1011550
Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.
Li L, Sun H, Chen J, Ding C, Yang X, Han H, Sun Q
Cell reports 2023 Jul 25;42(7):112697
Cell reports 2023 Jul 25;42(7):112697
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Pan C, Fei Q, Jin J, Zheng J, Wu D, Li H, Huang X, Kong X
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
Role of SUMOylation of STAT1 in tubular epithelial‑mesenchymal transition induced by high glucose.
Gu C, Gao F, Zhang S, Kang L, Zhang W, Feng X, Liu J, Tian Y, Wei Q, Du Y, Xing Y, Liu Q, Liu S
Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
Jing B, Guo F, An R, Gao Y, Li Y, Xie Y, Wang J, Chen Y, Li H, Gao T, Jin Q, Zhang L, Xie M
Journal of nanobiotechnology 2023 Feb 2;21(1):37
Journal of nanobiotechnology 2023 Feb 2;21(1):37
Opioid-induced fragile-like regulatory T cells contribute to withdrawal.
Zhu Y, Yan P, Wang R, Lai J, Tang H, Xiao X, Yu R, Bao X, Zhu F, Wang K, Lu Y, Dang J, Zhu C, Zhang R, Dang W, Zhang B, Fu Q, Zhang Q, Kang C, Chen Y, Chen X, Liang Q, Wang K
Cell 2023 Feb 2;186(3):591-606.e23
Cell 2023 Feb 2;186(3):591-606.e23
IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.
Zeng Y, Chen HQ, Zhang Z, Fan J, Li JZ, Zhou SM, Wang N, Yan SP, Cao J, Liu JY, Zhou ZY, Liu WB
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120943
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120943
The Activation of Reticulophagy by ER Stress through the ATF4-MAP1LC3A-CCPG1 Pathway in Ovarian Granulosa Cells Is Linked to Apoptosis and Necroptosis.
Li H, Jing Y, Qu X, Yang J, Pan P, Liu X, Gao H, Pei X, Zhang C, Yang Y
International journal of molecular sciences 2023 Feb 1;24(3)
International journal of molecular sciences 2023 Feb 1;24(3)
Integrated analysis of murine cornea identifies JAK/STAT signaling pathway upregulated specifically in female Vitamin A Deficient mice.
Yu H, Wu J, Li K, Huang Y, Wu T, Wang L, Huang Y
Experimental eye research 2023 Dec;237:109714
Experimental eye research 2023 Dec;237:109714
KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.
Pan X, Zhang W, Wang L, Guo H, Zheng M, Wu H, Weng Q, He Q, Ding L, Yang B
Molecular oncology 2023 Dec;17(12):2659-2674
Molecular oncology 2023 Dec;17(12):2659-2674
Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase.
Yao YL, Luo Y, Wang Q, Geng R, Chen Y, Liu MQ, Li B, Chen J, Wu CG, Jia JK, Luo JY, He YT, Jiang TT, Zhu Y, Hu B, Zhou P, Shi ZL
Emerging microbes & infections 2023 Dec;12(2):2249120
Emerging microbes & infections 2023 Dec;12(2):2249120
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
Tang F, Lu C, He X, Lin W, Xie B, Gao X, Peng Y, Yang D, Sun L, Weng L
Cell reports 2023 Dec 26;42(12):113477
Cell reports 2023 Dec 26;42(12):113477
The role of IBV PL1pro in virus replication and suppression of host innate immune responses.
Liu W, Mu G, Jia Y, Yu M, Zhang S, Wang Z, Fang S
BMC veterinary research 2023 Dec 13;19(1):270
BMC veterinary research 2023 Dec 13;19(1):270
P4HA1, transcriptionally activated by STAT1, promotes esophageal cancer progression.
Gou W, Yang Y, Shan Q, Xia S, Ma Y
Pathology international 2023 Apr;73(4):147-158
Pathology international 2023 Apr;73(4):147-158
BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.
Shan F, Shen S, Wang X, Chen G
International journal of oncology 2023 Apr;62(4)
International journal of oncology 2023 Apr;62(4)
The mechanism of colon tissue damage mediated by HIF-1α/NF-κB/STAT1 in high-altitude environment.
Cheng J, Sun Y, He J, Wang Z, Li W, Wang R
Frontiers in physiology 2022;13:933659
Frontiers in physiology 2022;13:933659
ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.
Wen X, Chen S, Chen X, Qiu H, Wang W, Zhang N, Liu W, Wang T, Ding X, Zhang L
Frontiers in oncology 2022;12:887068
Frontiers in oncology 2022;12:887068
RPS3 Promotes the Metastasis and Cisplatin Resistance of Adenoid Cystic Carcinoma.
Rui X, Huang Z, Chen R, Chen Y, Wang Y, Huang Z
Frontiers in oncology 2022;12:804439
Frontiers in oncology 2022;12:804439
E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.
Sun W, Hua X, Gu Y, Xu Q, Zhu S, Lv T, Song Y
Clinical immunology (Orlando, Fla.) 2022 Sep;242:109099
Clinical immunology (Orlando, Fla.) 2022 Sep;242:109099
Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3.
Deng L, Mo J, Zhang Y, Peng K, Li H, Ouyang S, Feng Z, Fang W, Wei J, Rong D, Zhang X, Wang Y
Journal of medicinal chemistry 2022 Oct 13;65(19):13094-13111
Journal of medicinal chemistry 2022 Oct 13;65(19):13094-13111
Polygalaxanthone III, an Active Ingredient in Polygala japonica Houtt., Repaired Malassezia-Stimulated Skin Injury via STAT3 Phosphorylated Activation.
Yang X, Xiong B, Yuan Z, Liao H, Liu X, Wu Y, Zhang S, Xiang Q
Molecules (Basel, Switzerland) 2022 Nov 3;27(21)
Molecules (Basel, Switzerland) 2022 Nov 3;27(21)
Long noncoding RNA GAS5 inhibits proliferation and metastasis in papillary thyroid carcinoma through the IFN/STAT1 signaling pathway.
Xu Y, Lu J, Lou N, Lu W, Xu J, Jiang H, Ye G
Pathology, research and practice 2022 May;233:153856
Pathology, research and practice 2022 May;233:153856
RUNX1 inhibits the antiviral immune response against influenza A virus through attenuating type I interferon signaling.
Hu Y, Pan Q, Zhou K, Ling Y, Wang H, Li Y
Virology journal 2022 Mar 5;19(1):39
Virology journal 2022 Mar 5;19(1):39
LncRNA RP5-998N21.4 promotes immune defense through upregulation of IFIT2 and IFIT3 in schizophrenia.
Guo B, Jiang T, Wu F, Ni H, Ye J, Wu X, Ni C, Jiang M, Ye L, Li Z, Zheng X, Li S, Yang Q, Wang Z, Huang X, Zhao C
Schizophrenia (Heidelberg, Germany) 2022 Mar 1;8(1):11
Schizophrenia (Heidelberg, Germany) 2022 Mar 1;8(1):11
Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer.
Ouyang S, Li H, Lou L, Huang Q, Zhang Z, Mo J, Li M, Lu J, Zhu K, Chu Y, Ding W, Zhu J, Lin Z, Zhong L, Wang J, Yue P, Turkson J, Liu P, Wang Y, Zhang X
Redox biology 2022 Jun;52:102317
Redox biology 2022 Jun;52:102317
IL-10 contributes to gemcitabine resistance in extranodal NK/T-cell lymphoma cells via ABCC4.
Huo J, Fu L, Jin M, Li Z, Zhang M
Investigational new drugs 2022 Jun;40(3):537-545
Investigational new drugs 2022 Jun;40(3):537-545
Hepatoprotective Polysaccharides from Geranium wilfordii: Purification, Structural Characterization, and Their Mechanism.
Feng JY, Xie YQ, Zhang P, Zhou Q, Khan A, Zhou ZH, Xia XS, Liu L
Molecules (Basel, Switzerland) 2022 Jun 3;27(11)
Molecules (Basel, Switzerland) 2022 Jun 3;27(11)
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Activation of STAT6 by intranasal allergens correlated with the development of eosinophilic chronic rhinosinusitis in a mouse model.
Wei H, Xu L, Sun P, Xing H, Zhu Z, Liu J
International journal of immunopathology and pharmacology 2022 Jan-Dec;36:3946320221109529
International journal of immunopathology and pharmacology 2022 Jan-Dec;36:3946320221109529
TRIB3 reduces CD8(+) T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer.
Shang S, Yang YW, Chen F, Yu L, Shen SH, Li K, Cui B, Lv XX, Zhang C, Yang C, Liu J, Yu JJ, Zhang XW, Li PP, Zhu ST, Zhang HZ, Hua F
Science translational medicine 2022 Jan 5;14(626):eabf0992
Science translational medicine 2022 Jan 5;14(626):eabf0992
Extracellular domain of semaphorin 5A serves a tumor‑suppressing role by activating interferon signaling pathways in lung adenocarcinoma cells.
Chen MZ, Su LY, Ko PH, Hsu MH, Chuang LL, Chen LH, Lu TP, Chuang EY, Chow LP, Tsai MH, Hsu HH, Lai LC
International journal of oncology 2022 Feb;60(2)
International journal of oncology 2022 Feb;60(2)
Structural optimization of Imidazo[1, 2-a]pyridine derivatives for the treatment of gastric cancer via STAT3 signaling pathway.
Li H, Ouyang S, Zhang Y, Peng K, Fang W, Liu Z, Wang CY, Zhang X, Wang Y
European journal of medicinal chemistry 2022 Dec 15;244:114858
European journal of medicinal chemistry 2022 Dec 15;244:114858
Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes.
Cui L, Wang Y, Ren L, Li Z, Jiang Y, Wang C, Liu X, Ren Y, Hu X
Parasites & vectors 2022 Dec 13;15(1):464
Parasites & vectors 2022 Dec 13;15(1):464
Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity.
Li C, He WF, Li LX, Chen J, Yang GQ, Chang HT, Liu HM
Viruses 2022 Aug 24;14(9)
Viruses 2022 Aug 24;14(9)
Cell-Free Extracts from Human Fat Tissue with a Hyaluronan-Based Hydrogel Attenuate Inflammation in a Spinal Cord Injury Model through M2 Microglia/Microphage Polarization.
Xu GY, Xu S, Zhang YX, Yu ZY, Zou F, Ma XS, Xia XL, Zhang WJ, Jiang JY, Song J
Small (Weinheim an der Bergstrasse, Germany) 2022 Apr;18(17):e2107838
Small (Weinheim an der Bergstrasse, Germany) 2022 Apr;18(17):e2107838
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Liu Z, Xu B, Ding Y, Ding X, Yang Z
Bioengineered 2022 Apr;13(4):9357-9368
Bioengineered 2022 Apr;13(4):9357-9368
Acer Truncatum Seed Oil Alleviates Learning and Memory Impairments of Aging Mice.
Li X, Li T, Hong XY, Liu JJ, Yang XF, Liu GP
Frontiers in cell and developmental biology 2021;9:680386
Frontiers in cell and developmental biology 2021;9:680386
Bioinformatics Analysis for Identification of Key Genes in Salivary Gland and the Potential of a Combination of Biomarkers for the Diagnosis of SS.
Chen L, Lu D, Yu K, He S, Liu L, Zhang X, Feng B, Wang X
Journal of inflammation research 2021;14:4143-4153
Journal of inflammation research 2021;14:4143-4153
Chitosan Protects Immunosuppressed Mice Against Cryptosporidium parvum Infection Through TLR4/STAT1 Signaling Pathways and Gut Microbiota Modulation.
Rahman SU, Gong H, Mi R, Huang Y, Han X, Chen Z
Frontiers in immunology 2021;12:784683
Frontiers in immunology 2021;12:784683
A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance.
Zheng Q, Dong H, Mo J, Zhang Y, Huang J, Ouyang S, Shi S, Zhu K, Qu X, Hu W, Liu P, Wang Y, Zhang X
Theranostics 2021;11(2):824-840
Theranostics 2021;11(2):824-840
CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways.
Chen X, He H, Xiao Y, Hasim A, Yuan J, Ye M, Li X, Hao Y, Guo X
Frontiers in oncology 2021;11:629350
Frontiers in oncology 2021;11:629350
The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection.
Li T, Cui L, Xu X, Zhang H, Jiang Y, Ren L, Yang C, Liu X, Hu X
Frontiers in cellular and infection microbiology 2021;11:587150
Frontiers in cellular and infection microbiology 2021;11:587150
Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus with MEK Inhibitor Trametinib in Some BRAF or KRAS-Mutated Colorectal or Lung Carcinoma Models.
Zhou X, Zhao J, Zhang JV, Wu Y, Wang L, Chen X, Ji D, Zhou GG
Viruses 2021 Sep 3;13(9)
Viruses 2021 Sep 3;13(9)
Establishment of incontinence-associated dermatitis rat models and assessment of the therapeutic effects of zinc oxide, painless skin protective film and silicone dressing.
Chen G, Huang L, Chen Y, Zheng S, Zhu L, Ding M
Experimental and therapeutic medicine 2021 Oct;22(4):1058
Experimental and therapeutic medicine 2021 Oct;22(4):1058
Polygalaxanthone III downregulates inflammation in the lipopolysaccharide-stimulated RAW264.7 macrophages: A quantibody array analysis.
Wu Y, Fu H, Yang X, Leng F, Huang Y, Deng H, Xiang Q, Zhang S
Journal of pharmacological sciences 2021 Oct;147(2):184-191
Journal of pharmacological sciences 2021 Oct;147(2):184-191
Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3).
Huang Q, Zhong Y, Li B, Ouyang S, Deng L, Mo J, Shi S, Lv N, Wu R, Liu P, Hu W, Zhang X, Wang Y
European journal of medicinal chemistry 2021 Oct 5;221:113525
European journal of medicinal chemistry 2021 Oct 5;221:113525
Tumour microenvironment-based molecular profiling reveals ideal candidates for high-grade serous ovarian cancer immunotherapy.
Lu X, Ji C, Jiang L, Zhu Y, Zhou Y, Meng J, Gao J, Lu T, Ye J, Yan F
Cell proliferation 2021 Mar;54(3):e12979
Cell proliferation 2021 Mar;54(3):e12979
Serum proteome profiling provides a deep understanding of the 'gut-liver axis' in relation to liver injury and regeneration.
Leng L, Ma J, Lv L, Gao D, Li M, Wang Y, Zhu Y
Acta biochimica et biophysica Sinica 2021 Mar 2;53(3):372-380
Acta biochimica et biophysica Sinica 2021 Mar 2;53(3):372-380
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Zhou Z, Li Y, Ma X, Cao B, Peng T, Sheng Y, Peng H, Li R, Cao Y, Xi R, Li F, Wang M, Sun H, Zhang G, Zhang H, Hu K, Xiao W, Wang F
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Baicalein Delays H(2)O(2)-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.
Gao L, Zheng WG, Wu XK, Du GH, Qin XM
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335
Evaluation of piggyBac-mediated anti-CD19 CAR-T cells after ex vivo expansion with aAPCs or magnetic beads.
Yang LR, Li L, Meng MY, Wang WJ, Yang SL, Zhao YY, Wang RQ, Gao H, Tang WW, Yang Y, Yang LL, Liao LW, Hou ZL
Journal of cellular and molecular medicine 2021 Jan;25(2):686-700
Journal of cellular and molecular medicine 2021 Jan;25(2):686-700
Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.
Luo N, Yang C, Zhu Y, Chen Q, Zhang B
Journal of agricultural and food chemistry 2021 Jan 20;69(2):655-667
Journal of agricultural and food chemistry 2021 Jan 20;69(2):655-667
MAGE-C3 promotes cancer metastasis by inducing epithelial-mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma.
Wu Q, Zhang W, Wang Y, Min Q, Zhang H, Dong D, Zhan Q
Cancer communications (London, England) 2021 Dec;41(12):1354-1372
Cancer communications (London, England) 2021 Dec;41(12):1354-1372
Cypermethrin triggers YY1-mediated testosterone biosynthesis suppression.
Liu C, Qu J, Wu M, Huang X, Li L
Ecotoxicology and environmental safety 2021 Dec 1;225:112792
Ecotoxicology and environmental safety 2021 Dec 1;225:112792
The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.
Yan Z, Zhan J, Qi W, Lin J, Huang Y, Xue X, Pan X
Frontiers in pharmacology 2020;11:1195
Frontiers in pharmacology 2020;11:1195
Curcumin prevents osteocyte apoptosis by inhibiting M1-type macrophage polarization in mice model of glucocorticoid-associated osteonecrosis of the femoral head.
Jin S, Meng C, He Y, Wang X, Zhang Q, Wang Z, Huang W, Wang H
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Sep;38(9):2020-2030
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Sep;38(9):2020-2030
IL-27 Rα(+) cells promoted allorejection via enhancing STAT1/3/5 phosphorylation.
Zhao S, Liang T, Zhang C, Shi D, Jiang W, Su C, Hou G
Journal of cellular and molecular medicine 2020 Sep;24(18):10756-10767
Journal of cellular and molecular medicine 2020 Sep;24(18):10756-10767
CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway.
Chen Y, Shao Z, Jiang E, Zhou X, Wang L, Wang H, Luo X, Chen Q, Liu K, Shang Z
Journal of cellular physiology 2020 Sep;235(9):5995-6009
Journal of cellular physiology 2020 Sep;235(9):5995-6009
Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.
Zhang M, Fu M, Li M, Hu H, Gong S, Hu Q
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 1;205(5):1281-1292
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 1;205(5):1281-1292
m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana TM
The EMBO journal 2020 Oct 15;39(20):e104514
The EMBO journal 2020 Oct 15;39(20):e104514
miR-142-5p/DAX1-dependent regulation of P450c17 contributes to triclosan-mediated testosterone suppression.
Duan P, Huang X, Ha M, Li L, Liu C
The Science of the total environment 2020 May 15;717:137280
The Science of the total environment 2020 May 15;717:137280
Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.
Fan Z, Chen X, Liu L, Zhu C, Xu J, Yin X, Sheng Y, Zhu Z, Wen L, Zuo X, Zheng X, Zhang Y, Xu J, Huang H, Zhou F, Sun L, Luo J, Zhang D, Chen X, Cui Y, Hao Y, Cui Y, Zhang X, Chen R
Arthritis & rheumatology (Hoboken, N.J.) 2020 Jun;72(6):985-996
Arthritis & rheumatology (Hoboken, N.J.) 2020 Jun;72(6):985-996
TRIM59 suppresses NO production by promoting the binding of PIAS1 and STAT1 in macrophages.
Su X, Zhang Q, Yue J, Wang Y, Zhang Y, Yang R
International immunopharmacology 2020 Dec;89(Pt A):107030
International immunopharmacology 2020 Dec;89(Pt A):107030
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.
Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X
Investigative ophthalmology & visual science 2020 Dec 1;61(14):24
Investigative ophthalmology & visual science 2020 Dec 1;61(14):24
Rhein attenuates renal inflammatory injury of uric acid nephropathy via lincRNA-Cox2/miR-150-5p/STAT1 axis.
Hu J, Yang Z, Wu H, Wang D
International immunopharmacology 2020 Aug;85:106620
International immunopharmacology 2020 Aug;85:106620
Silica particles disorganize the polarization of pulmonary macrophages in mice.
Zhao Y, Hao C, Bao L, Wang D, Li Y, Qu Y, Ding M, Zhao A, Yao W
Ecotoxicology and environmental safety 2020 Apr 15;193:110364
Ecotoxicology and environmental safety 2020 Apr 15;193:110364
USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression.
Han B, Sun Y, Yang D, Zhang H, Mo S, Chen X, Lu H, Mao X, Hu J
Aging 2020 Apr 15;12(8):6990-7005
Aging 2020 Apr 15;12(8):6990-7005
Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water.
Li X, Li L, Liu X, Wu J, Sun X, Li Z, Geng YJ, Liu F, Zhou Y
Current molecular medicine 2019;19(4):294-302
Current molecular medicine 2019;19(4):294-302
Severe Fever With Thrombocytopenia Syndrome Virus-Induced Macrophage Differentiation Is Regulated by miR-146.
Zhang L, Fu Y, Wang H, Guan Y, Zhu W, Guo M, Zheng N, Wu Z
Frontiers in immunology 2019;10:1095
Frontiers in immunology 2019;10:1095
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
Zhang YZ, Zhang ZM, Zhou LT, Zhu J, Zhang XH, Qi W, Ding S, Xu Q, Han X, Zhao YM, Song XY, Zhao TY, Ye L
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
Yuan J, Tan L, Yin Z, Zhu W, Tao K, Wang G, Shi W, Gao J
Cell death & disease 2019 Jun 11;10(6):454
Cell death & disease 2019 Jun 11;10(6):454
IL-27 Promotes Human Placenta-Derived Mesenchymal Stromal Cell Ability To Induce the Generation of CD4(+)IL-10(+)IFN-γ(+) T Cells via the JAK/STAT Pathway in the Treatment of Experimental Graft-versus-Host Disease.
Yi J, Chen Z, Xu F, Wang Z, Zhang A, Liu T, Zhao N, Xiong Y, Jiang G, Ma J, Luan X
Journal of immunology (Baltimore, Md. : 1950) 2019 Feb 15;202(4):1124-1136
Journal of immunology (Baltimore, Md. : 1950) 2019 Feb 15;202(4):1124-1136
Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated mouse prone 8 (SAMP8).
Li J, Zhou Y, Du G, Qin X, Gao L
European journal of pharmacology 2019 Dec 15;865:172789
European journal of pharmacology 2019 Dec 15;865:172789
MicroRNA-204-5p suppresses IL6-mediated inflammatory response and chemokine generation in HK-2 renal tubular epithelial cells by targeting IL6R.
Li H, Wang J, Liu X, Cheng Q
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Apr;97(2):109-117
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Apr;97(2):109-117
Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis.
Wu J, Wang A, Wang X, Li G, Jia P, Shen G, Chen B, Yuan Y, Zhang H, Yang F, Xu Y
Bone 2019 Apr;121:16-28
Bone 2019 Apr;121:16-28
Alcohol attenuates anti-HCV function of IFN-λ1 through up-regulation of PLASy expression in human hepatic cells.
Ran M, Huang J, Liang H, Jiang J, Liang B, Ning C, Zang N, Liao W, Liu H, Qin F, Yang Q, Ho W, Ye L, Chen H
Journal of medical virology 2018 Jun;90(6):1112-1120
Journal of medical virology 2018 Jun;90(6):1112-1120
Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.
Wang H, Xin X, Wang M, Han L, Li J, Hao Y, Zheng C, Shen C
Archives of virology 2018 Jun;163(6):1429-1438
Archives of virology 2018 Jun;163(6):1429-1438
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
Shen H, Zhan M, Zhang Y, Huang S, Xu S, Huang X, He M, Yao Y, Man M, Wang J
Cell death & disease 2018 Jan 22;9(2):71
Cell death & disease 2018 Jan 22;9(2):71
MicroRNA gga-miR-130b Suppresses Infectious Bursal Disease Virus Replication via Targeting of the Viral Genome and Cellular Suppressors of Cytokine Signaling 5.
Fu M, Wang B, Chen X, He Z, Wang Y, Li X, Cao H, Zheng SJ
Journal of virology 2018 Jan 1;92(1)
Journal of virology 2018 Jan 1;92(1)
The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression.
Kueck T, Cassella E, Holler J, Kim B, Bieniasz PD
eLife 2018 Aug 22;7
eLife 2018 Aug 22;7
l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia.
Leng YP, Ma YS, Li XG, Chen RF, Zeng PY, Li XH, Qiu CF, Li YP, Zhang Z, Chen AF
British journal of pharmacology 2018 Apr;175(8):1157-1172
British journal of pharmacology 2018 Apr;175(8):1157-1172
Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis.
Liu Q, Du Y, Li K, Zhang W, Feng X, Hao J, Li H, Liu S
Mediators of inflammation 2017;2017:3038514
Mediators of inflammation 2017;2017:3038514
Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection.
Fu Y, Zhang L, Zhang F, Tang T, Zhou Q, Feng C, Jin Y, Wu Z
PLoS pathogens 2017 Sep;13(9):e1006611
PLoS pathogens 2017 Sep;13(9):e1006611
Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, Hao H, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704
Global quantitative proteomic analysis profiles host protein expression in response to Sendai virus infection.
Zhu SL, Chen X, Wang LJ, Wan WW, Xin QL, Wang W, Xiao G, Zhang LK
Proteomics 2017 Mar;17(5)
Proteomics 2017 Mar;17(5)
Quantitative Proteomic analysis on Activated Hepatic Stellate Cells reversion Reveal STAT1 as a key regulator between Liver Fibrosis and recovery.
Zhang H, Chen F, Fan X, Lin C, Hao Y, Wei H, Lin W, Jiang Y, He F
Scientific reports 2017 Mar 21;7:44910
Scientific reports 2017 Mar 21;7:44910
Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.
Igbe I, Shen XF, Jiao W, Qiang Z, Deng T, Li S, Liu WL, Liu HW, Zhang GL, Wang F
Oncotarget 2017 Dec 26;8(69):113734-113748
Oncotarget 2017 Dec 26;8(69):113734-113748
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.
Wonganan O, He YJ, Shen XF, Wongkrajang K, Suksamrarn A, Zhang GL, Wang F
Toxicology and applied pharmacology 2017 Dec 1;336:31-39
Toxicology and applied pharmacology 2017 Dec 1;336:31-39
IL-27 regulates the adherence, proliferation, and migration of MSCs and enhances their regulatory effects on Th1 and Th2 subset generations.
Xu F, Yi J, Wang Z, Hu Y, Han C, Xue Q, Zhang X, Luan X
Immunologic research 2017 Aug;65(4):903-912
Immunologic research 2017 Aug;65(4):903-912
IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis.
Shen P, Li Q, Ma J, Tian M, Hong F, Zhai X, Li J, Huang H, Shi C
BMC microbiology 2017 Aug 23;17(1):185
BMC microbiology 2017 Aug 23;17(1):185
iTRAQ-based Proteomic Analysis of Porcine Kidney Epithelial PK15 cells Infected with Pseudorabies virus.
Yang S, Pei Y, Zhao A
Scientific reports 2017 Apr 4;7:45922
Scientific reports 2017 Apr 4;7:45922
Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone.
Huang B, Wang W, Li Q, Wang Z, Yan B, Zhang Z, Wang L, Huang M, Jia C, Lu J, Liu S, Chen H, Li M, Cai D, Jiang Y, Jin D, Bai X
Nature communications 2016 Dec 14;7:13885
Nature communications 2016 Dec 14;7:13885
Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1.
Liu L, Ma Y, Zhou H, Wu M
International journal of molecular sciences 2016 Aug 27;17(9)
International journal of molecular sciences 2016 Aug 27;17(9)
Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake.
Yang X, Yao H, Chen Y, Sun L, Li Y, Ma X, Duan S, Li X, Xiang R, Han J, Duan Y
The Journal of biological chemistry 2015 Sep 4;290(36):21788-99
The Journal of biological chemistry 2015 Sep 4;290(36):21788-99
Interferon-stimulated gene factor 3 complex is required for the induction of sterile α motif and HD domain-containing protein 1 expression by interferon-α in SMMC-7721 cells.
Zhu M, Lu J, Dong X, Zheng N, Li T, Chen Z, Pan X, Zhu Y, Yan H, Shen Y, Ying S, Hu C
Molecular medicine reports 2015 Nov;12(5):7176-80
Molecular medicine reports 2015 Nov;12(5):7176-80
IL-27 alleviates the bleomycin-induced pulmonary fibrosis by regulating the Th17 cell differentiation.
Dong Z, Lu X, Yang Y, Zhang T, Li Y, Chai Y, Lei W, Li C, Ai L, Tai W
BMC pulmonary medicine 2015 Feb 18;15:13
BMC pulmonary medicine 2015 Feb 18;15:13
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Wang X, Liu J, Zhen J, Zhang C, Wan Q, Liu G, Wei X, Zhang Y, Wang Z, Han H, Xu H, Bao C, Song Z, Zhang X, Li N, Yi F
Kidney international 2014 Oct;86(4):712-25
Kidney international 2014 Oct;86(4):712-25
Up-regulation of intestinal epithelial cell derived IL-7 expression by keratinocyte growth factor through STAT1/IRF-1, IRF-2 pathway.
Cai YJ, Wang WS, Yang Y, Sun LH, Teitelbaum DH, Yang H
PloS one 2013;8(3):e58647
PloS one 2013;8(3):e58647
Identification and analysis of glycogen synthase kinase 3 beta1 interactome.
Gao X, Wang JY, Gao LM, Yin XF, Liu L
Cell biology international 2013 Aug;37(8):768-79
Cell biology international 2013 Aug;37(8):768-79
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 10144-2-AP(STAT1 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The STAT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human STAT1. This antibody recognizes human,mouse,rat antigen. The STAT1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
