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Protein structure
STAT1
Signal transducer and activator of transcription 1ISGF-3, STAT91
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]
Top validated antibodies |
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| Invitrogen Antibodies |  AHO0832 |
11 references | Monoclonal |
WB
ICC
IP
IHC
FC
ChIP
OA
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| Cell Signaling Technology, Inc | 9167 |
1 references | Monoclonal |
WB
ICC
IP
IHC
FC
ChIP
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| Proteintech Group | 10144-2-AP |
Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Boster Biological Technology | M00036-2 |
4 references | Monoclonal |
WB
ICC
IHC
FC
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| LSBio | LS-C747274 |
Polyclonal |
WB
ICC
IP
IHC
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