Antibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [2]
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- Product number
- ABIN2844100 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 389-417) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- AA 389-417
- Antibody clone number
- RB01906
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation.
OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases.
Functional switching of TGF-beta1 signaling in liver cancer via epigenetic modulation of a single CpG site in TTP promoter.
Systems-level dynamic analyses of fate change in murine embryonic stem cells.
DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen.
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo.
Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein.
Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo.
Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis.
Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus.
Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
Li C, Ebert PJ, Li QJ
The Journal of biological chemistry 2013 Jun 28;288(26):19127-39
The Journal of biological chemistry 2013 Jun 28;288(26):19127-39
OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases.
Chen KC, Wang YS, Hu CY, Chang WC, Liao YC, Dai CY, Juo SH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 May;25(5):1718-28
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 May;25(5):1718-28
Functional switching of TGF-beta1 signaling in liver cancer via epigenetic modulation of a single CpG site in TTP promoter.
Sohn BH, Park IY, Lee JJ, Yang SJ, Jang YJ, Park KC, Kim DJ, Lee DC, Sohn HA, Kim TW, Yoo HS, Choi JY, Bae YS, Yeom YI
Gastroenterology 2010 May;138(5):1898-908
Gastroenterology 2010 May;138(5):1898-908
Systems-level dynamic analyses of fate change in murine embryonic stem cells.
Lu R, Markowetz F, Unwin RD, Leek JT, Airoldi EM, MacArthur BD, Lachmann A, Rozov R, Ma'ayan A, Boyer LA, Troyanskaya OG, Whetton AD, Lemischka IR
Nature 2009 Nov 19;462(7271):358-62
Nature 2009 Nov 19;462(7271):358-62
DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen.
Yamagata Y, Asada H, Tamura I, Lee L, Maekawa R, Taniguchi K, Taketani T, Matsuoka A, Tamura H, Sugino N
Human reproduction (Oxford, England) 2009 May;24(5):1126-32
Human reproduction (Oxford, England) 2009 May;24(5):1126-32
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, Liu S, Alder H, Costinean S, Fernandez-Cymering C, Volinia S, Guler G, Morrison CD, Chan KK, Marcucci G, Calin GA, Huebner K, Croce CM
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 2;104(40):15805-10
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 2;104(40):15805-10
Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo.
Koturbash I, Boyko A, Rodriguez-Juarez R, McDonald RJ, Tryndyak VP, Kovalchuk I, Pogribny IP, Kovalchuk O
Carcinogenesis 2007 Aug;28(8):1831-8
Carcinogenesis 2007 Aug;28(8):1831-8
Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein.
Park IY, Sohn BH, Yu E, Suh DJ, Chung YH, Lee JH, Surzycki SJ, Lee YI
Gastroenterology 2007 Apr;132(4):1476-94
Gastroenterology 2007 Apr;132(4):1476-94
Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo.
Koturbash I, Rugo RE, Hendricks CA, Loree J, Thibault B, Kutanzi K, Pogribny I, Yanch JC, Engelward BP, Kovalchuk O
Oncogene 2006 Jul 20;25(31):4267-75
Oncogene 2006 Jul 20;25(31):4267-75
Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis.
Tryndyak VP, Muskhelishvili L, Kovalchuk O, Rodriguez-Juarez R, Montgomery B, Churchwell MI, Ross SA, Beland FA, Pogribny IP
Carcinogenesis 2006 Aug;27(8):1713-20
Carcinogenesis 2006 Aug;27(8):1713-20
Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus.
Pogribny I, Koturbash I, Tryndyak V, Hudson D, Stevenson SM, Sedelnikova O, Bonner W, Kovalchuk O
Molecular cancer research : MCR 2005 Oct;3(10):553-61
Molecular cancer research : MCR 2005 Oct;3(10):553-61
Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.
Brueckner B, Garcia Boy R, Siedlecki P, Musch T, Kliem HC, Zielenkiewicz P, Suhai S, Wiessler M, Lyko F
Cancer research 2005 Jul 15;65(14):6305-11
Cancer research 2005 Jul 15;65(14):6305-11
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
Okano M, Bell DW, Haber DA, Li E
Cell 1999 Oct 29;99(3):247-57
Cell 1999 Oct 29;99(3):247-57
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Supportive validation
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- IHC
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- Experimental details
- IHC